Clinical Relevance of VPAC1 Receptor Expression in Early Arthritis: Association with IL-6 and Disease Activity

AbstractBackground: Osteoarthritis (OA) and rheumatoid arthritis (RA) can overlap and the presence of OA can interfere with the evaluation of patients with RA.Objectives: The aim of this study was to evaluate the possible impact of OA on the clinical, laboratory and ultrasound parameters currently evaluated in patients with early RA (ERA).Methods: We have evaluated the data obtained from patients with ERA referred to our Early Arthritis Research Center (EARC). Only data from patients who fulfilled EULAR/ ACR 2010 criteria for RA and had symptom duration of less than 12 months were analyzed. All patients underwent clinical examination, laboratory tests and ultrasound (US) examination.Results: There was a clear predominance of women (62.8%). The mean age was 55.47±13.71 years. At baseline, 21 patients (48.8%) were diagnosed with OA. Hand OA did not influence the values of any of the parameters assessed (p>0.05). For patients with knee OA, significantly higher values were observed only for DAS28 at baseline (p=0.018) as well as after 12 months of observation (p=0.031).Conclusions: Significantly higher values of DAS28 were observed in patients with ERA who associated knee OA, while the values of SDAI were not influenced, suggesting that SDAI may be superior to DAS28 in evaluating patients with ERA and knee OA. The values of patient’s VAS were not influenced by the presence of hand or knee OA suggesting that these types of OA do not influence the patients’ perception of the disease activity. Moreover, the values of ultrasound scores were not influenced by the presence of OA.

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Vitamin D receptor expression in SLE peripheral blood CD4+T cells is associated with disease activity and cell apoptosis

Modern Rheumatology ◽

10.1093/mr/roab023 ◽

2021 ◽

Author(s):

Ying Zhang ◽

Lingying Niu ◽

Fan Wang ◽

Xiaojun Tang ◽

Chun Wang ◽

...

Keyword(s):

Vitamin D ◽

T Cells ◽

Disease Activity ◽

Vitamin D Receptor ◽

Cell Apoptosis ◽

Cd4 T Cells ◽

Activity Index ◽

Receptor Expression ◽

Th2 Cells ◽

Tfh Cells

ABSTRACT Objectives Systemic lupus erythematosus (SLE) is characterised by accumulated cell apoptosis. Vitamin D receptor (VDR) has immunomodulatory effect and potent anti-apoptosis activities. The aim of this study was to examine the correlation between CD4+T cells VDR expression, cell apoptosis, and disease activity in patients with SLE. Methods Forty-five SLE patients were recruited and 50 healthy individuals served as controls. The expression of VDR in CD4+T cells and their subsets were determined by flow cytometry. The correlations between VDR expression and cell apoptosis or disease parameters in SLE patients were analysed. Results VDR expression in CD4+T cells and their subsets were upregulated in SLE patients, especially in help T (Th)1, regulatory T (Treg), and follicular helper T (Tfh) cells. Frequency of VDR-positive CD4+T cells was positively associated with SLE disease activity index (SLEDAI)-2K values and inversely correlated with serum C3 concentration. The frequency of VDR-positive CD4+T cells, Th1 cells, Th2 cells, Th17 cells, Treg cells, and Tfh cells was positively correlated with cells apoptosis. Conclusion VDR expression in CD4+T cells and their subsets were increased in SLE. VDR expression was positively associated with disease activity and cell apoptosis in SLE patients.

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Low clinical relevance of the nonalcoholic fatty liver disease activity score (NAS) in predicting fibrosis progression

Scandinavian Journal of Gastroenterology ◽

10.3109/00365521.2011.634024 ◽

2011 ◽

Vol 47 (1) ◽

pp. 108-115 ◽

Cited By ~ 30

Author(s):

Mattias Ekstedt ◽

Lennart E. Franzén ◽

Ulrik L. Mathiesen ◽

Stergios Kechagias

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Disease Activity ◽

Nonalcoholic Fatty Liver Disease ◽

Clinical Relevance ◽

Fatty Liver Disease ◽

Disease Activity Score ◽

Activity Score ◽

Nonalcoholic Fatty Liver ◽

Fibrosis Progression

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Development and Validation of a New Disease Activity Index as a Numerical Sum of Four Variables in Patients With Early Arthritis

Arthritis Care & Research ◽

10.1002/acr.21854 ◽

2013 ◽

Vol 65 (4) ◽

pp. 518-525 ◽

Cited By ~ 8

Author(s):

Isabel Castrejón ◽

Loreto Carmona ◽

Ana M. Ortiz ◽

Miguel A. Belmonte ◽

Juan A. Martínez-López ◽

...

Keyword(s):

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Early Arthritis ◽

New Disease ◽

Development And Validation

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Prediction of Remission in a French Early Arthritis Cohort by RAPID3 and other Core Data Set Measures, but Not by the Absence of Rheumatoid Factor, Anticitrullinated Protein Antibodies, or Radiographic Erosions

The Journal of Rheumatology ◽

10.3899/jrheum.141586 ◽

2016 ◽

Vol 43 (7) ◽

pp. 1285-1291 ◽

Cited By ~ 17

Author(s):

Isabel Castrejón ◽

Maxime Dougados ◽

Bernard Combe ◽

Bruno Fautrel ◽

Francis Guillemin ◽

...

Keyword(s):

Disease Activity ◽

Rheumatoid Factor ◽

Poor Prognosis ◽

Activity Index ◽

Disease Activity Index ◽

Early Arthritis ◽

Global Estimate ◽

Core Dataset ◽

Younger Age ◽

Anticitrullinated Protein Antibodies

Objective.To identify baseline variables that predict remission according to different criteria in rheumatoid arthritis (RA) in a comprehensive French ESPOIR early arthritis database.Methods.Individual variables and indices at baseline were analyzed in 664 patients for capacity to predict remission either 6 or 12 months later according to 4 criteria that require a formal joint count: the American College of Rheumatology/European League Against Rheumatism Boolean criteria, the Simplified Disease Activity Index, the Clinical Disease Activity Index, and the 28-joint Disease Activity Score; and 2 remission criteria that do not require a formal joint count: the Routine Assessment of Patient Index Data 3 (RAPID3) and the RAPID3 ≤ 3 + swollen joint, using univariate and multivariate logistic regressions.Results.Remission was predicted significantly 6 and/or 12 months later in 26.8%–51.4% of patients, according to all 6 criteria by younger age, low index scores, and better status for the 6/7 clinical RA core dataset measures: tender joint count, swollen joint count (SJC), physician’s global estimate, patient self-report Health Assessment Questionnaire (HAQ) physical function, pain, and patient’s global estimate. Remission was not predicted by the absence of “poor prognosis RA” indicators, rheumatoid factor (RF), anticitrullinated protein antibodies (ACPA), or radiographic erosions. In multivariate regressions that included only 3 variables, low HAQ function predicted remission by all criteria as effectively as SJC, erythrocyte sedimentation rate, or C-reactive protein.Conclusion.Younger age and 6 core dataset clinical measures, but not the absence of traditional “poor prognosis RA” indicators, RF, ACPA, or radiographic erosions, predicted remission according to 6 criteria, including 2 without a formal joint count.

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OP0092 Indicators of Depression are Stronger Predictors of Work Disability in Early Arthritis than Disease Activity or Response to Therapy

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.297 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A81.2-A81 ◽

Cited By ~ 1

Author(s):

G. Westhoff ◽

J. Callhoff ◽

M. Schneider ◽

A. Zink

Keyword(s):

Disease Activity ◽

Work Disability ◽

Early Arthritis ◽

Response To Therapy

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Patient-reported Outcomes as Predictors of Change in Disease Activity and Disability in Early Rheumatoid Arthritis: Results from the Yorkshire Early Arthritis Register

The Journal of Rheumatology ◽

10.3899/jrheum.161214 ◽

2017 ◽

Vol 44 (9) ◽

pp. 1331-1340 ◽

Cited By ~ 2

Author(s):

Sarah Twigg ◽

Elizabeth M.A. Hensor ◽

Paul Emery ◽

Alan Tennant ◽

Ann W. Morgan ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Early Rheumatoid Arthritis ◽

Multilevel Models ◽

Early Arthritis ◽

Joint Disease ◽

Symptom Duration ◽

Rates Of Change ◽

Patient Reported ◽

Predictors Of Change

Objective.To assess patient-reported variables as predictors of change in disease activity and disability in early rheumatoid arthritis (RA).Methods.Cases were recruited to the Yorkshire Early Arthritis Register (YEAR) between 1997 and 2009 (n = 1415). Predictors of the 28-joint Disease Activity Score (DAS28) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) at baseline and change over 12 months were identified using multilevel models. Baseline predictors were sex, age, symptom duration, autoantibody status, pain and fatigue visual analog scales (VAS), duration of early morning stiffness (EMS), DAS28, and HAQ-DI.Results.Rates of change were slower in women than men: DAS28 fell by 0.19 and 0.17 units/month, and HAQ-DI by 0.028 and 0.023 units/month in men and women, respectively. Baseline pain and EMS had small effects on rates of change, whereas fatigue VAS was only associated with DAS28 and HAQ-DI at baseline. In patients recruited up to 2002, DAS28 reduced more quickly in those with greater pain at baseline (by 0.01 units/mo of DAS28 per cm pain VAS, p = 0.024); in patients recruited after 2002, the effect for pain was stronger (by 0.01 units/mo, p = 0.087). DAS28 reduction was greater with longer EMS. In both cohorts, fall in HAQ-DI (p = 0.006) was greater in patients with longer EMS duration, but pain and fatigue were not significant predictors of change in HAQ-DI.Conclusion.Patient-reported fatigue, pain, and stiffness at baseline are of limited value for the prediction of RA change in disease activity (DAS28) and activity limitation (HAQ-DI).

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