Reducing Short-Wavelength Blue Light in Dry Eye Patients with Unstable Tear Film Improves Performance on Tests of Visual Acuity

Abstract Background: To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.Methods: Firstly we observed Schirmer Ⅰ test and 6 tear compositions detected by ELISA in 34 eyes of dry eye patients and 34 eyes of normal subjects before and after AE. Then we observed 30 eyes of dry eye patients and 30 eyes of normal subjects before and after AE, the evaluated variables included tear meniscus height (TMH), first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness (LLT), number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity.Results: In dry eye group, compared with baseline, Schirmer Ⅰ test at 0 minutes after AE increased significantly (P < 0.001), F-NITBUT and A-NITBUT at every time point after AE prolonged significantly (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 minutes after AE decreased significantly (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001), visual acuity at 10 and 20 minutes after AE improved significantly (P = 0.017, P = 0.021). The overall oxidative stress marker 8-hydroxy-2’-deoxyguanosine at 0 minutes after AE decreased significantly compared with baseline (P = 0.040).Conclusion: AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020, http://www.chictr.org.cn/showproj.aspx?proj=57282

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Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients

Case Medical Research ◽

10.31525/ct1-nct04063644 ◽

2019 ◽

Author(s):

Keyword(s):

Quality Of Life ◽

Visual Acuity ◽

Dry Eye ◽

Eye Drops

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Ayurvedic Management of Dry Eye Sydrome - A Case Study

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i4.9375 ◽

2017 ◽

Vol 2 (4) ◽

Author(s):

Hemalatha S. ◽

Rati S.

Keyword(s):

Dry Eye ◽

Treatment Modality ◽

Similar Condition ◽

Symptomatic Relief ◽

Tear Film ◽

Modern Medicine ◽

Common Condition ◽

Dry Out ◽

Tear Substitute

Dry eye syndrome is a common condition that results from reduced tear production or excessive tear evaporation or an abnormality in the production of mucus or lipids normally found in the tear layer or combination of these. If blinking is decreased or if the eyelids cannot be closed, they may dry out leading to dry eye. It is accompanied by increased osmolarity of the tear film and inflammation on the surface of the eye may occur of left untreated leading to pain, ulcers or scars on the cornea and loss of vision. Prevalence of dry eye range from 5% to 35% worldwide while in India it is 29.25%. Tear substitute are the only treatment modality with modern medicine, only providing symptomatic relief. Ayurveda describes similar condition called Sushkakshi Paka and this patient was treated with Tarpana and Nasya with Jeevantyadi Ghrita.

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Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

International Journal of Molecular Sciences ◽

10.3390/ijms22010422 ◽

2021 ◽

Vol 22 (1) ◽

pp. 422

Author(s):

Ming-Tse Kuo ◽

Po-Chiung Fang ◽

Shu-Fang Kuo ◽

Alexander Chen ◽

Yu-Ting Huang

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Dry Eye Disease ◽

Eye Disease ◽

Mechanistic Studies ◽

Clinical Tests ◽

Tear Proteins ◽

Proteomic Data ◽

Surface Performance

Most studies about dry eye disease (DED) chose unilateral eye for investigation and drew conclusions based on monocular results, whereas most studies involving tear proteomics were based on the results of pooling tears from a group of DED patients. Patients with DED were consecutively enrolled for binocular clinical tests, tear biochemical markers of DED, and tear proteome. We found that bilateral eyes of DED patients may have similar but different ocular surface performance and tear proteome. Most ocular surface homeostatic markers and tear biomarkers were not significantly different in the bilateral eyes of DED subjects, and most clinical parameters and tear biomarkers were correlated significantly between bilateral eyes. However, discrepant binocular presentation in the markers of ocular surface homeostasis and the associations with tear proteins suggested that one eye’s performance cannot represent that of the other eye or both eyes. Therefore, in studies for elucidating tear film homeostasis of DED, we may lose some important messages hidden in the fellow eye if we collected clinical and proteomic data only from a unilateral eye. For mechanistic studies, it is recommended that researchers collect tear samples from the eye with more severe DED under sensitive criteria for identifying the more severe eye and evaluating the tear biochemical and proteomic markers with binocular concordance drawn in prior binocular studies.

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A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection

Cytokine ◽

10.1016/j.cyto.2016.08.026 ◽

2016 ◽

Vol 88 ◽

pp. 77-84 ◽

Cited By ~ 12

Author(s):

Rupesh Agrawal ◽

Praveen Kumar Balne ◽

Anuradha Veerappan ◽

Veonice Bijin Au ◽

Bernett Lee ◽

...

Keyword(s):

Hiv Infection ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Disease ◽

Eye Disease

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Corneal topography and classical test in the diagnosis of dry eye syndrome in patients with myopia and myopic astigmatism before keratorefractive surgery

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-39-43 ◽

2021 ◽

pp. 39-43

Author(s):

Y.V. Kutuzova ◽

◽

I.V. Dutchin ◽

E.L. Sorokin ◽

◽

...

Keyword(s):

Dry Eye ◽

Tear Film ◽

Risk Groups ◽

Corneal Topography ◽

Dry Eye Syndrome ◽

Film Rupture ◽

Keratorefractive Surgery ◽

The Stability ◽

High Degree ◽

Myopic Astigmatism

Purpose.To conduct a comparative analysis of the effectiveness of assessing the stability of the tear film using corneotopography and the classic Norn test in patients with myopia and myopic astigmatism before keratorefractive surgery. Material and methods. The study included 26 patients planned for keratorefractive surgery for myopia and myopic astigmatism, aged 18 to 47 years. 7 people there was a mild degree of myopia, in 14 people – medium degree, in 5 people – high degree. The average degree of corneal astigmatism was 2.25 diopters. The stability of the pre-corneal tear film was assessed using computed keratotopography and Norn's test – the tear film rupture time (TFRT) was deter- mined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome. A comparison was made of the indicators of the stability of the tear film obtained by the methods of corneotopography and the Norn's test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4%), the TFRT index corresponded to the age norm. In the remaining 9 people (34.6%), indicators of stability of the tear film were reduced both by corneotopography (12±4 sec) and by Norn's test (13.5±4.5 sec), and there were also subjective signs of dry eye syndrome according to data questionnaire. The data turned out to be comparable. Conclusions. 1. Among the total population of patients, 34.6% were persons with impaired tear film stability and subjective manifestations of dry eye syndrome. 2. Assessment of the stability of the tear film, determined using the method of corneal topography, showed a high degree of comparability with the results of Norn's test. A significant advantage of the keratotopography method is its non-invasiveness. 3. It is necessary to pay attention to the condition of the ocular surface and identify risk groups to avoid chronicity or aggravation of existing disorders. Key words: dry eye syndrome, tear film, keratotopography, Norn's test.

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«Dry eye» syndrome and primary glaucoma: possibilities of treatment

Reflection ◽

10.25276/2686-6986-2020-1-42-44 ◽

2020 ◽

Vol 10 (1) ◽

pp. 42-44

Author(s):

L.I. Solovyova ◽

◽

T.V. Gavrilova ◽

F.G. Mugumova ◽

◽

...

Keyword(s):

Dry Eye ◽

Open Angle Glaucoma ◽

Tear Film ◽

Dry Eye Syndrome ◽

Rupture Time ◽

Eye Drops ◽

Film Rupture ◽

Good Tolerability ◽

Primary Glaucoma ◽

The Stability

The article presents the results of Ocuhyl C using in the treatment of «dry eye syndrome» (DES) in 47 eyes of 26 patients with different stages of compensated primary open-angle glaucoma. Experience of instillation of hypotensive eye drops with preservatives was from 1 year to 35 years. Assessment of subjective signs of DES was performed by questioning. Functional tests were performed (for the stability of the precorneal tear film –Norn test, for the level of total tear production –Shirmer test). Examinations were carried out at the first examination before prescribing the drug, then after 4 and 8 weeks of its use. All the patients noted good tolerability of the drug, no side effects. Indicators characterizing the feeling of a foreign body, dryness and redness of the eyes have significantly decreased. Precorneal tear film rupture time has significantly increased. Ocuhyl C can be recommended for clinical use. Key words: primary glaucoma; “dry eye” syndrome; tear forming; tear film rupture time; Ocuhyl C.

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Tear Film–Oriented Diagnosis and Tear Film–Oriented Therapy for Dry Eye Based on Tear Film Dynamics

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.17-23700 ◽

2018 ◽

Vol 59 (14) ◽

pp. DES13 ◽

Cited By ~ 25

Author(s):

Norihiko Yokoi ◽

Georgi As Georgiev

Keyword(s):

Dry Eye ◽

Tear Film

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The RELIEF study: Tolerability and efficacy of preservative-free latanoprost in the treatment of glaucoma or ocular hypertension

European Journal of Ophthalmology ◽

10.1177/1120672118785280 ◽

2018 ◽

Vol 29 (2) ◽

pp. 210-215 ◽

Cited By ~ 6

Author(s):

Marta Misiuk-Hojlo ◽

Maria Pomorska ◽

Malgorzata Mulak ◽

Marek Rekas ◽

Joanna Wierzbowska ◽

...

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Standard Deviation ◽

Ocular Hypertension ◽

Benzalkonium Chloride ◽

Tear Film ◽

Corrected Visual Acuity ◽

Break Up ◽

Preservative Free ◽

Best Corrected Visual Acuity

Purpose: To assess tolerability and efficacy following a switch from benzalkonium chloride–latanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension. Methods: A total of 140 patients with glaucoma or ocular hypertension controlled with benzalkonium chloride-latanoprost for at least 3 months were switched to treatment with preservative-free latanoprost. Assessments were made on days 15, 45, and 90 (D15, D45, and D90) and included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, and subjective estimation of tolerability. Results: Mean best-corrected visual acuity remained unchanged during the study. Mean intraocular pressure compared with baseline (D0) remained stable throughout the study (D0, 15.9 mmHg (standard deviation = 2.6); D90, 15.3 mmHg (standard deviation = 2.4); p < 0.006). Tear film break-up time improved or remained unchanged relative to baseline in 92% of patients at D45 and in 93% at D90. Moderate-to-severe conjunctival hyperemia was seen in 56.8% of patients at D0, but this figure decreased to 13.7%, 2.2%, and 1.6% at D15, D45, and D90, respectively. Subjective assessment of tolerability (0–10 scale) indicated improvement with change of therapy (mean score: 5.3 (standard deviation = 2.2) at D0 versus 1.9 (standard deviation = 1.7) at D90; p < 0.0001). Conclusion: Preservative-free latanoprost has at least the same intraocular pressure-lowering efficacy as benzalkonium chloride–latanoprost, with a better tolerability profile. This may translate into greater control of treatment and improved quality of life.

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