scholarly journals Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for genetically-modified fibroblasts

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174860 ◽  
Author(s):  
Tatjana Perisic ◽  
Ziyang Zhang ◽  
Peter Foehr ◽  
Ursula Hopfner ◽  
Kathrin Klutz ◽  
...  
Polymer ◽  
2010 ◽  
Vol 51 (6) ◽  
pp. 1425-1431 ◽  
Author(s):  
Hongyun Tai ◽  
Clare E. Upton ◽  
Lisa J. White ◽  
Ronny Pini ◽  
Giuseppe Storti ◽  
...  

2015 ◽  
Vol 3 (41) ◽  
pp. 8143-8153 ◽  
Author(s):  
Ji Hoon Park ◽  
Hwi Ju Kang ◽  
Doo Yeon Kwon ◽  
Bo Keun Lee ◽  
Bong Lee ◽  
...  

To develop an appropriate drug carrier for drug delivery systems, we prepared random poly(lactide-co-glycolide-co-ε-caprolactone) (PLGC) copolymers in comparison to commercial poly(lactic acid-co-glycolic acid) (PLGA) grades.


Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 249
Author(s):  
Han-Seung Ko ◽  
Sangwoon Lee ◽  
Doyoung Lee ◽  
Jae Young Jho

To enhance the mechanical strength and bioactivity of poly(lactic acid) (PLA) to the level that can be used as a material for spinal implants, poly(glycolic acid) (PGA) fibers and hydroxyapatite (HA) were introduced as fillers to PLA composites. To improve the poor interface between HA and PLA, HA was grafted by PLA to form HA-g-PLA through coupling reactions, and mixed with PLA. The size of the HA particles in the PLA matrix was observed to be reduced from several micrometers to sub-micrometer by grafting PLA onto HA. The tensile and flexural strength of PLA/HA-g-PLA composites were increased compared with those of PLA/HA, apparently due to the better dispersion of HA and stronger interfacial adhesion between the HA and PLA matrix. We also examined the effects of the length and frequency of grafted PLA chains on the tensile strength of the composites. By the addition of unidirectionally aligned PGA fibers, the flexural strength of the composites was greatly improved to a level comparable with human compact bone. In the bioactivity tests, the growth of apatite on the surface was fastest and most uniform in the PLA/PGA fiber/HA-g-PLA composite.


LWT ◽  
2021 ◽  
pp. 112356
Author(s):  
Phatthranit Klinmalai ◽  
Atcharawan Srisa ◽  
Yeyen Laorenza ◽  
Wattinee Katekhong ◽  
Nathdanai Harnkarnsujarit

2018 ◽  
Vol 381 (1) ◽  
pp. 1800133 ◽  
Author(s):  
Elaine C. Lopes Pereira ◽  
Bluma G. Soares ◽  
Rayan B. Jesus ◽  
Alex S. Sirqueira

2021 ◽  
pp. 096739112110576
Author(s):  
Ying Zhou ◽  
Can Chen ◽  
Lan Xie ◽  
Xiaolang Chen ◽  
Guangqiang Xiao ◽  
...  

In this work, novel plasticizing biodegradable poly (lactic acid) (PLA) composites were prepared by melt blending of jute and tung oil anhydride (TOA), and the physical and mechanical properties of PLA/jute/TOA composites were tested and characterized. The impact strength of PLA/jute/TOA composites significantly increases with increasing the content of TOA. The SEM images of fracture surface of PLA/jute/TOA composites become rough after the incorporation of TOA. In addition, TOA changes the crystallization temperature and decomposition process of PLA/jute/TOA composites. With increasing the amount of TOA, the value of storage modulus (E′) of PLA/jute/TOA composites gradually increases. The complex viscosity (η*) values for all samples reduce obviously with increasing the frequency, which means that the pure PLA and PLA/jute/TOA composites is typical pseudoplastic fluid. This is attributed to the formation of crosslinking, which restricts the deformation of the composites.


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