Comparison of sensitivity and specificity of three diagnostic tests to detect Schistosoma mansoni infections in school children in Mwanza region, Tanzania

Sensitivity and specificity are often used to assess the performance of a diagnostic test with binary outcomes. Wald-type test statistics have been proposed for testing sensitivity and specificity individually. In the presence of a gold standard, simultaneous comparison between two diagnostic tests for noninferiority of sensitivity and specificity based on an asymptotic approach has been studied by Chen et al. (2003). However, the asymptotic approach may suffer from unsatisfactory type I error control as observed from many studies, especially in small to medium sample settings. In this paper, we compare three unconditional approaches for simultaneously testing sensitivity and specificity. They are approaches based on estimation, maximization, and a combination of estimation and maximization. Although the estimation approach does not guarantee type I error, it has satisfactory performance with regard to type I error control. The other two unconditional approaches are exact. The approach based on estimation and maximization is generally more powerful than the approach based on maximization.

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Testing the Infection Prevalence of Schistosoma mansoni after Mass Drug Administration by Comparing Sensitivity and Specificity of Species-Specific Repeat Fragment Amplification by PCR and Loop-Mediated Isothermal Amplification

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.19-0121 ◽

2019 ◽

Vol 101 (1) ◽

pp. 78-83 ◽

Cited By ~ 1

Author(s):

Miriam Price ◽

Austin Cyrs ◽

Chummy S. Sikasunge ◽

James Mwansa ◽

Nilanjan Lodh

Keyword(s):

Schistosoma Mansoni ◽

Sensitivity And Specificity ◽

Drug Administration ◽

Mass Drug Administration ◽

Isothermal Amplification ◽

Infection Prevalence ◽

Loop Mediated Isothermal Amplification ◽

Species Specific

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Correction: Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School Children in Mbita District, Western Kenya

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0003190 ◽

2014 ◽

Vol 8 (8) ◽

pp. e3190 ◽

Cited By ~ 1

Author(s):

Keyword(s):

Risk Factors ◽

Spatial Distribution ◽

Primary School ◽

Schistosoma Mansoni ◽

School Children ◽

Primary School Children ◽

Western Kenya

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Comparison of Coombs Gel Test with ELISA and Standard Tube Agglutination Tests Used in Serological Diagnosis of Brucellosis

Infectious Diseases and Clinical Microbiology ◽

10.36519/idcm.2019.0024 ◽

2020 ◽

Vol 2 (1) ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Cigdem Akalan Kuyumcu ◽

Serpil Erol ◽

Rıza Adaleti ◽

Seniha Senbayrak ◽

Secil Deniz ◽

...

Keyword(s):

Sensitivity And Specificity ◽

Diagnostic Tests ◽

Serological Test ◽

High Sensitivity ◽

Serological Diagnosis ◽

Control Groups ◽

Serum Samples ◽

Serological Tests ◽

Reliable Test ◽

And Control

Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; however, each serological test has some drawbacks. In this study, we aimed to determine the value of the Brucella Coombs gel test (BCGT) in the serological diagnosis of brucellosis in comparison with Standard tube agglutination (STA) and ELISA tests. Materials and Methods: The study included 42 patients who were considered to have brucellosis as a preliminary diagnosis. BCGT, Brucella-IgM/IgG ELISA, and STA tests were performed from serum samples of the patients. The correlation of the diagnostic tests was analyzed using Cohen’s Kappa Analysis. Results: Twenty-seven (64.2%) of 42 patients were diagnosed with brucellosis according to their medical history and clinical and serological tests. The sensitivity and specificity of BCGT to diagnose brucellosis was 96.2%, and 100%, respectively. The sensitivity and specificity for the diagnosis of brucellosis 62.9% and 100% for STA, respectively; 33.3% and 66.6% for Brucella-IgM; and 66.6% and 100% for Brucella-IgG. BCGT was significantly correlated with STA (κ= 0.590) and Brucella-IgG (κ=0.539) Conclusion: BCGT can be utilized as a simple and reliable test in the diagnosis of brucellosis with high sensitivity and specificity. Nevertheless, the sensitivity and specificity of BCGT should be demonstrated by comprehensive studies, including culture-confirmed cases and control groups.

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Sensitivity and specificity of commercially available rapid diagnostic tests for viral hepatitis B and C screening in serum samples

PLoS ONE ◽

10.1371/journal.pone.0235036 ◽

2020 ◽

Vol 15 (7) ◽

pp. e0235036

Author(s):

Ganbolor Jargalsaikhan ◽

Miriam Eichner ◽

Delgerbat Boldbaatar ◽

Purevjargal Bat-Ulzii ◽

Oyungerel Lkhagva-Ochir ◽

...

Keyword(s):

Hepatitis B ◽

Viral Hepatitis ◽

Sensitivity And Specificity ◽

Diagnostic Tests ◽

Rapid Diagnostic Tests ◽

Serum Samples ◽

Viral Hepatitis B

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Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2017-0045 ◽

2018 ◽

Vol 7 (1) ◽

Author(s):

Putri Healthireza Novianesari ◽

Nuswil Bernolian ◽

Henni Maulani ◽

Afifa Ramadanti ◽

Theodorus

Keyword(s):

Pregnant Women ◽

Sensitivity And Specificity ◽

Gestational Age ◽

Neonatal Sepsis ◽

Predictive Value ◽

Diagnostic Tests ◽

Esterase Activity ◽

Histopathological Examination ◽

Outcome Data ◽

Membrane Rupture

Abstract Objective To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age <37 weeks. The duration of membrane rupture was significantly associated with chorioamnionitis (P = 0.001 and P = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (P = 0.014 and P = 0.036). A LEA value with the cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.

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