scholarly journals Effects of microbiota-driven therapy on inflammatory responses in elderly individuals: A systematic review and meta-analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211233 ◽  
Author(s):  
Hua Qu ◽  
Ying Zhang ◽  
Hua Chai ◽  
Zhu-ye Gao ◽  
Da-zhuo Shi
Keyword(s):  
Systematic Review ◽  
Inflammatory Responses ◽  
Meta Analysis ◽  
Elderly Individuals

scholarly journals Structural and functional changes related to memory deficit in non-demential elderly individuals

2016 ◽  
Vol 49 (6) ◽  
pp. 533
Author(s):  
Nísea De A. Corrêa ◽  
Maria P. Foss ◽  
Paula R. B. Diniz
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Digit Span ◽  
Meta Analysis ◽  
Memory Deficit ◽  
Trail Making Test ◽  
Elderly Individuals ◽  
Functional Changes ◽  
Wechsler Memory Scale ◽  
Trail Making

Objetivo: Verificar as alterações estruturais e funcionais, evidenciadas através da imagem por ressonância magnética, relacionadas aos déficits de memória identificados em idosos normais, quando comparados a adultos jovens. Metodologia: Procedeu-se à revisão sistemática, cujo protocolo obedeceu ao fluxograma do Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Foram investigadas as bases de dados PubMed, Scopus, EBSCO, utilizando o gerenciador de referências JabRef, na versão 2.10, e o Web of Science, pelo website. Foram incluídos artigos de estudos quase experimentais, transversais, em coorte ou tipo caso-controle, publicados entre 2005 e 2014, em periódicos indexados nacionais e internacionais, cuja amostra incluísse idosos a partir de 60 anos, não dementes, submetidos à investigação de alterações estruturais e funcionais do sistema nervoso central, por ressonância magnética e sua associação com déficits de memória avaliados por testes neuropsicológicos. Resultados: Quanto à técnica de imagem empregada, identificaram-se dois estudos com imagem por ressonância magnética estrutural, seis estudos com utilização de imagem por ressonância magnética funcional, e quatro estudos que empregaram ambas as técnicas. Nos 12 estudos foi identificado o emprego de 38 testes neuropsicológicos distintos, com uma média de cinco testes por estudo, com variação de um a 12 testes. Dentre os testes mais usados, estiveram o WAIS Digit Span Backwards (em sete estudos), o Trail Making Test A and B (em quatro estudos) e o Wechsler Memory Scale (em quatro estudos). Conclusão: Os estudos demonstraram que no envelhecimento normal, ocorre redução do volume de substância branca para-hipocampal, do volume do hipocampo e do córtex entorrinal com redução de memória verbal, possivelmente por desmielinização das fibras; redução das vias que ligam o lobo temporal e frontal, contribuindo para a redução da memória episódica, da memória de trabalho e da fluência verbal; redução da supressão de informações irrelevantes, o que contribui para menor registro de informação; alterações das áreas frontal e parietal que comprometem a memória de reconhecimento; modificações na atividade e na conectividade do default mode network; reorganização das funções cognitivas, bem como alentecimento de resposta por provável redução de ativação do córtex pré- frontal

scholarly journals A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

2022 ◽  
Vol 12 ◽  
Author(s):  
Xin Liu ◽  
Hui Li
Keyword(s):  
Systematic Review ◽  
Publication Bias ◽  
Gene Polymorphisms ◽  
Inflammatory Responses ◽  
Meta Analysis ◽  
Cytokine Gene ◽  
Protective Function ◽  
Tnf Α ◽  
Cytokine Gene Polymorphisms ◽  
Ifn Γ

AimPeriodontitis is an inflammatory disease that destroys both soft and hard periodontal tissues. However, a complex periodontal cytokine network remains unclear. This systematic review explored multiple cytokine gene polymorphisms in the pathogenesis of periodontitis.Material and MethodsA systematic search was performed using the databases from previous publications, which indicated the association between cytokine polymorphisms and periodontitis pathogenesis. Meta-analysis was conducted using fixed or randomized models to calculate the significance of multiple cytokine polymorphisms. A total of 147 articles were analyzed with polymorphisms in 12 interleukins [Th1 (IL-2, IFN-γ, and TNF-α), Th2 (IL-4 and IL-13), Th17 (IL-1α, IL-1β, IL-6, and IL-17), and Treg cytokines (IL-10 and TGF-β)]. Doi plot was used to probe the occurrence of publication bias.ResultsThe polymorphisms of IL-2 and TNF-α of Th1 cytokine family may be associated with the pathogenesis or the prevention of periodontitis risk, while the polymorphism of IFN-γ is not related to periodontitis risk. The polymorphisms for IL-4 and IL-13 of Th2 cytokine family are not found to be associated with the pathogenesis of periodontitis. For the polymorphisms of the members of Th17 cytokine family, different IL-1α polymorphisms may have inverse actions in the pathogenesis of periodontitis. IL-1β is a noteworthy cytokine biomarker in periodontitis development and progression. IL-6 may have a protective function in the inflammatory responses of periodontitis, and IL-17 has a weak relationship the inflammatory responses. The polymorphisms for the members of Treg cell cytokines may have a protective function against periodontitis risk. LFK indexes show the major asymmetry due to publication bias.ConclusionIL-1β is a notable cytokine biomarker in periodontitis risk. Treg cytokines favor an anti-inflammatory and protective environment. Further data are needed to confirm the present conclusion due to publication bias.

The Main Receptors Involved with COVID-19: a Systematic Review and Meta-analysis

2021 ◽  
Vol 28 ◽  
Author(s):  
Alice Barros Câmara ◽  
Igor Augusto Brandão
Keyword(s):  
Systematic Review ◽  
G Protein ◽  
Inflammatory Responses ◽  
Meta Analysis ◽  
The United States ◽  
R Programming Language ◽  
Regulatory Effects ◽  
R Programming ◽  
G Protein Coupled ◽  
The Brain

Objective: This review aims to study the receptor's family and functions most related to COVID-19 infection, also suggesting the tissue and cell location that the majority of COVID-19 receptors are mainly expressed. Methods: This systematic review (PROSPERO: CRD42020210643) is according to PRISMA guidelines. PubMed, Cochrane, SciELO, Lilacs, Web of Science, and DOAJ databases were used. Clinical trials and research articles studying receptors related to COVID-19 were included in this review. R programming language was used to elaborate charts and receptors network and SPSS(26v) software was used to perform statistical analyses. Results: The majority of studies regarding the involvement of receptors in COVID-19 included plasma receptors and G protein-coupled receptor families (p<0.05). These receptors are highly expressed in the brain (24%) and 80% of them can interact with each other in a protein network, exerting some regulatory effects in various tissues. The main influential receptor on the network of receptors involved in COVID-19 was the EGFR and the majority of receptors were associated with pathological processes in the disease (p<0.05), including the amplification of inflammatory responses in COVID-19, which may be related to neurological disorders in some cases. Humans from the United States, Spain, and Brazil were the most used model in studies adressing receptors involved in COVID-19 (p<0.05). Conclusions: Plasma receptors and G protein-coupled receptors, especially the EGFR, and involved with pathological effects on the COVID-19 inflammatory process in the brain have shown significant importance in this review.

scholarly journals Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Anna Hwee Sing Heng ◽  
Yee-How Say ◽  
Yang Yie Sio ◽  
Yu Ting Ng ◽  
Fook Tim Chew
Keyword(s):  
Systematic Review ◽  
Skin Diseases ◽  
Inflammatory Responses ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Random Effect ◽  
Gene Families ◽  
Significant Heterogeneity ◽  
Gene Variants ◽  
Increased Risk

Abstract Background Multiple factors have been attributed to acne vulgaris predisposition and individual variations in the severity of skin symptoms, and genetics stood out as one of the major factors. Methods We performed a systematic review on the genes and their variants that have been investigated for association with acne presentation and severity. A random-effect meta-analysis using the allele model (minor allele vs. major allele) was also conducted to provide an overall estimation of risk effects of frequently reported gene variants. This included a subset data of 982 acne cases and 846 controls extracted from our existing GWAS database on various allergic and skin diseases among Singapore Chinese. Results Systematic review of 51 articles covering Asians and Caucasians found 60 genes/loci and their 100 variants implicated in acne; majority of them were in the intron, coding region/missense, and promoter regions. The commonly studied candidate genes/gene families include tumor necrosis factor (TNF), and the interleukin (IL) and cytochrome P450 (CYP) gene families. Our meta-analysis showed that most of the analyzed gene variants exhibited insignificant pooled odds ratio (pOR) and significant heterogeneity between studies. Nevertheless, we found that TNF rs1800629 A allele carriers and CYP17A1 rs743572 T allele carriers had significantly reduced mild acne risk [pOR: 0.60; 95% Confidence Interval (CI): 0.33–0.86] and severe acne risk (pOR: 0.59; 95% CI: 0.40–0.79), respectively, across populations. Overall, FST (follistatin) rs629725 A allele poses a significantly modest increased risk for acne presentation (pOR: 1.19, 95% CI: 1.14, 1.23), but neither TIMP2 (TIMP metallopeptidase inhibitor 2) rs8179090 nor CYP1A1 rs4646903 (pOR: 0.96, 95% CI: 0.80–1.12; pOR: 0.95, 95% CI: 0.83, 1.08), respectively. We discovered 15 novel SNPs in the 3′ UTR region of the Toll-like Receptor 4 gene (TLR4) associated with acne presentation. Conclusions This systematic review and meta-analysis suggest that genes influencing inflammatory responses, specifically TNF, and genes influencing the function and activity of sebaceous glands, specifically CYP17A1 and FST, have potential risk variants for acne presentation and severity across populations. Understanding the genetic susceptibility factors and biological pathways involved in the pathogenesis of acne will help us to gain insights into developing effective acne treatments.

Sign in / Sign up

Export Citation Format

Share Document