Adult body height and age-related macular degeneration in healthy individuals: A nationwide population-based survey from Korea

Lutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated the associations of plasma lutein and zeaxanthin with the incidence of advanced AMD in the Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). The present study included 609 participants with complete ophthalmologic and plasma carotenoids data. Examinations were performed every two years over an eight-year period (2006 to 2017). Plasma lutein and zeaxanthin were determined at baseline from fasting blood samples using high-performance liquid chromatography. Cox proportional hazard models were used to assess associations between plasma lutein, zeaxanthin, and their (total cholesterol (TC) + triglycerides (TG)) ratios with AMD. Among the 609 included participants, 54 developed advanced incident AMD during a median follow-up time of 7.6 years (range 0.7 to 10.4). Participants with higher plasma lutein had a reduced risk for incident advanced AMD in the fully adjusted model (HR = 0.63 per 1-SD increase (95% CI, 0.41–0.97), p = 0.03). A similar association was observed using the lutein/(TC + TG) ratio (HR = 0.59 (95% CI, 0.39–0.90), p = 0.01). No associations were evidenced for other carotenoids. Higher plasma lutein was associated with a 37% reduced risk of incident advanced AMD.

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Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration

Scientific Reports ◽

10.1038/s41598-021-89677-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Manjot Kaur Grewal ◽

Shruti Chandra ◽

Alan Bird ◽

Glen Jeffery ◽

Sobha Sivaprasad

Keyword(s):

Macular Degeneration ◽

Healthy Aging ◽

Intraclass Correlation ◽

Age Related Macular Degeneration ◽

Healthy Individuals ◽

Age Related ◽

Rod Function ◽

The Mean ◽

Highly Correlated ◽

Effect Of Age

AbstractTo evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman rs = 0.75–0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.

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A Population-based Study on the Prevalence and Associated Factors of Age-related Macular Degeneration in Northern Iran the Gilan Eye Study

Ophthalmic Epidemiology ◽

10.1080/09286586.2020.1716379 ◽

2020 ◽

Vol 27 (3) ◽

pp. 209-218

Author(s):

Hassan Behboudi ◽

Homayoun Nikkhah ◽

Yousef Alizadeh ◽

Marzieh Katibeh ◽

Mojgan Pakbin ◽

...

Keyword(s):

Macular Degeneration ◽

Associated Factors ◽

Population Based ◽

Age Related Macular Degeneration ◽

Northern Iran ◽

Population Based Study ◽

Age Related

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Comparison of Retinal and Choriocapillaris Thicknesses Following Sitting to Supine Transition in Healthy Individuals and Patients With Age-Related Macular Degeneration

JAMA Ophthalmology ◽

10.1001/jamaophthalmol.2014.5168 ◽

2015 ◽

Vol 133 (3) ◽

pp. 297 ◽

Cited By ~ 14

Author(s):

David R. P. Almeida ◽

Li Zhang ◽

Eric K. Chin ◽

Robert F. Mullins ◽

Murat Kucukevcilioglu ◽

...

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Healthy Individuals ◽

Age Related

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Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

BMC Medicine ◽

10.1186/s12916-015-0329-0 ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 25

Author(s):

Layal Chaker ◽

Gabriëlle HS Buitendijk ◽

Abbas Dehghan ◽

Marco Medici ◽

Albert Hofman ◽

...

Keyword(s):

Cohort Study ◽

Macular Degeneration ◽

Thyroid Function ◽

Population Based ◽

Age Related Macular Degeneration ◽

Rotterdam Study ◽

Age Related

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Association Between Age‐Related Macular Degeneration and Risk of Heart Failure: A Population‐Based Nested Case‐Control Study

Journal of the American Heart Association ◽

10.1161/jaha.120.020071 ◽

2021 ◽

Author(s):

Chao‐Chien Chang ◽

Chi‐Hung Huang ◽

Yu‐Ching Chou ◽

Jin‐Yin Chang ◽

Chien‐An Sun

Keyword(s):

Heart Failure ◽

Macular Degeneration ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Age Related Macular Degeneration ◽

Age Related ◽

Increased Risk ◽

Nested Case Control ◽

Control Study

Background Heart failure (HF) is a major health problem worldwide because of its high morbidity and mortality. Recently, the role of the microvasculature in HF has gained more attention. Age‐related macular degeneration (AMD) is manifested through geographic atrophy or the development of neovascularization. However, there are limited data on investigations about the association between AMD and HF. The purpose of this study was to examine the association of AMD with the risk of HF in a large population‐based cohort of men and women. Methods and Results A nested case‐control study using Taiwan’s National Health Insurance Research Database was conducted between 2000 and 2012. Newly diagnosed heart failure cases (n=13 721) and matched controls (n=54 884) in the database were recruited. Patients who had ≥2 clinical visits with a diagnosis of AMD at least 1 year before the diagnosis of HF were identified as patients with AMD. Conditional logistic regressions were performed to calculate odds ratios and 95% CIs to assess the association between AMD and risk of HF. AMD was associated with a 1.58‐fold increased risk of HF (95% CI, 1.16–1.87) ( P <0.001) after adjustment for potential confounders. This significant association was evident in both nonexudative and exudative AMD subgroups. Conclusions Our study provides evidence that AMD was associated with an increased risk of HF. Further molecular and pathophysiological studies are needed to clarify the underlying pathophysiological mechanisms behind the association of AMD with HF.

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Age-Related Macular Degeneration and Associated Risk Factors in the Population-Based Study of Health in Pomerania (SHIP-Trend)

Medical Science Monitor ◽

10.12659/msm.915493 ◽

2019 ◽

Vol 25 ◽

pp. 6383-6390 ◽

Cited By ~ 1

Author(s):

Lisa Lüdtke ◽

Clemens Jürgens ◽

Till Ittermann ◽

Henry Völzke ◽

Frank Tost

Keyword(s):

Risk Factors ◽

Macular Degeneration ◽

Population Based ◽

Age Related Macular Degeneration ◽

Population Based Study ◽

Age Related ◽

Associated Risk Factors

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Association Between Silymarin Use and Age-related Macular Degeneration in Patients With Chronic Hepatic Diseases: a Population-based Retrospective Cohort Study

10.21203/rs.3.rs-993679/v1 ◽

2021 ◽

Author(s):

Mu-Ming Chien ◽

Hsiu-Chen Lin ◽

Li-Fen Lee ◽

Joseph Jordan Keller ◽

Li-Hsuan Wang

Keyword(s):

Cohort Study ◽

Macular Degeneration ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Population Based ◽

Hazard Ratio ◽

Age Related Macular Degeneration ◽

Defined Daily Dose ◽

Hepatic Diseases ◽

Age Related

Abstract Silymarin is a bioflavonoid compound mostly used in patients with chronic hepatic diseases (CHDs). It has been shown to inhibit retinal angiogenesis in in vitro and in vivo animal studies. Age-related macular degeneration (AMD) is a leading cause of vision impairment worldwide, and no definite preventive measures for AMD exist at present. Through this study, we aimed to investigate whether the use of silymarin affects the risk of AMD in patients with CHDs. Cox proportional hazard models were used to assess the hazard ratio (HR) of AMD in this population-based retrospective cohort study. The CHDs was associated with a higher risk of AMD (adjusted hazard ratio (aHR): 1.33, 95% CI 1.22–1.46), and the use of silymarin reduced the risk of AMD among patients with CHDs (aHR: 0.76, 95% CI: 0.67–0.87). A higher accumulative dose (defined daily dose [DDD] < 631 mg) of silymarin was associated with a lower risk of AMD, but the difference was nonsignificant. In conclusion, CHDs were associated with a higher incidence of AMD, and the use of silymarin was associated with a reduced risk of AMD in patients with CHDs. However, a higher accumulative DDD of silymarin did not reduce the risk of AMD.

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Traffic-related air pollutants increase the risk for age-related macular degeneration

Journal of Investigative Medicine ◽

10.1136/jim-2019-001007 ◽

2019 ◽

Vol 67 (7) ◽

pp. 1076-1081 ◽

Cited By ~ 1

Author(s):

Kuang-Hsi Chang ◽

Po-Yuan Hsu ◽

Chun-Ju Lin ◽

Cheng-Li Lin ◽

Suh-Hang Hank Juo ◽

...

Keyword(s):

Macular Degeneration ◽

Population Based ◽

Air Pollutant ◽

Age Related Macular Degeneration ◽

Cox Proportional Hazard ◽

Age Related ◽

Increased Risk ◽

Taiwan National Health Insurance ◽

Cox Proportional Hazard Regression ◽

Year 2000

The aim of this study was to investigate whether ambient nitrogen dioxide (NO2) and carbon monoxide (CO) increase the risk for age-related macular degeneration (AMD). This is a longitudinal population-based study using the data on Taiwan National Health Insurance Program between year 2000 and 2010. From the nationwide dataset, we enrolled subjects aged 50 or older and the annually total NO2 and CO exposure was calculated from 1998 to 2010 for each subject. The Cox proportional hazard regression was used to estimate the HRs with adjustment for other variables. A total of 39,819 AMD-free residents were enrolled, and 1442 participants developed AMD during the 11 -year follow-up. Compared with the lowest exposure quartile, the highest quartile of each air pollutant was associated with an increased risk for AMD. The adjusted HR was 1.91 (95% CI 1.64 to 2.23, p<0.001) for the highest NO2 quartile, and was 1.84 (95% CI 1.5 to 2.15, p<0.001) for the highest CO quartile. In this study, chronic exposure to the highest quartile of ambient NO2 or CO significantly increases the risk for AMD.

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