Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

AbstractAlcohol use disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as gender differences, age, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants (31 women) with AUD and 63 healthy control (NC) participants (30 women) without AUD. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into mixed models to examine the relationships of brain volume with AUD group, gender, age, drinking history, and memory. The AUD group had approximately 5% smaller CA1, hippocampal tail, and molecular layer regions than the NC group. Age was negatively associated with volumes for the AUD group in the hippocampal tail, subiculum, and presubiculum. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.02% per year) and increasing volume size in men (0.03% per year). These findings confirm and extend evidence that AUD, gender, age, and abstinence differentially impact volumes of component parts of the hippocampus. The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subregional volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail.

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The trajectory of psychiatric problems following an adolescent vs. young adult onset of alcohol use disorder

10.31234/osf.io/eq2vd ◽

2021 ◽

Author(s):

Katherine T. Foster ◽

Marilyn Piccirillo ◽

William G. Iacono ◽

Matt McGue ◽

...

Keyword(s):

Young Adult ◽

Alcohol Use ◽

Alcohol Use Disorder ◽

Alcohol Problems ◽

Adolescent And Young Adult ◽

Men And Women ◽

Onset Timing ◽

History Of ◽

Psychiatric Problems

BACKGROUND: Alcohol use disorder (AUD) most often onsets in young adulthood (YAO), but prospective studies are needed to determine whether an onset in adolescence (AO) confers a more severe trajectory of psychiatric problems (e.g., depression, antisocial behavior, and other substance use) alongside AUD in men and women.METHODS: Using a prospective approach, we compared the trajectories of psychiatric problems for men and women with an AO, a YAO, and no history of AUD from ages 17 to 29 years old. RESULTS: Both gender and AUD onset moderated linear and non-linear changes in problems from adolescence to adulthood. AO conferred the poorest adolescent and young adult adjustment relative to the same-gender control and YAO groups. Critically, onset groups were more distinct among men (i.e., AO > YAO > no AUD) than women (i.e., AO = YAO > no AUD).CONCLUSIONS: Adolescent onset of alcohol problems portends severe, broad spread problems for both men and women into adulthood. Critically, adolescent onset yields the worst psychiatric problems among men (vs. YAO) while women experience severe, persistent problems across domains irrespective of onset timing. For both genders, mitigating the long-term, cascade of problems that accompany AUD will require special attention to heterogeneity in the timing of its onset and acceleration of psychiatric problems thereafter.

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The role of pubertal timing in the link between family history of alcohol use disorder and late adolescent substance use

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2020.107955 ◽

2020 ◽

Vol 210 ◽

pp. 107955

Author(s):

Alexander S. Weigard ◽

Jillian E. Hardee ◽

Robert A. Zucker ◽

Mary M. Heitzeg ◽

Adriene M. Beltz

Keyword(s):

Substance Use ◽

Family History ◽

Alcohol Use ◽

Alcohol Use Disorder ◽

Pubertal Timing ◽

Adolescent Substance Use ◽

Late Adolescent ◽

Adolescent Substance ◽

History Of

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Content Analysis of Health Concerns among Housing First Residents with a History of Alcohol Use Disorder

Journal of Health Care for the Poor and Underserved ◽

10.1353/hpu.2021.0035 ◽

2021 ◽

Vol 32 (1) ◽

pp. 463-486

Author(s):

Jessica L. Mackelprang ◽

Seema L. Clifasefi ◽

Véronique S. Grazioli ◽

Susan E. Collins

Keyword(s):

Content Analysis ◽

Alcohol Use ◽

Alcohol Use Disorder ◽

Housing First ◽

Health Concerns ◽

History Of

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Assessment of alcohol use disorder and its associated factors among alcohol users of medical and surgical outpatients attending a specialized hospital in Gondar, Ethiopia: a cross-sectional study

International Journal of Mental Health Systems ◽

10.1186/s13033-021-00454-2 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Demeke Demilew ◽

Berhanu Boru ◽

Getachew Tesfaw ◽

Habtamu Kerebih ◽

Endalamaw Salelew

Keyword(s):

Alcohol Use ◽

Associated Factors ◽

Alcohol Use Disorder ◽

Alcohol Use Disorders ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariate Logistic Regression ◽

Cross Sectional ◽

History Of ◽

Male Sex

Abstract Background Alcohol use disorder increase the risk of physical harm, mental or social consequences for patients and others in the community. Studies on alcohol use disorder and associated factors among medical and surgical outpatients in Ethiopia are limited. Therefore, this study is meant to provide essential data on alcohol use disorder and associated factors among alcohol user medical and surgical outpatients to intervene in the future. Methods An institution-based cross-sectional study was conducted by using the systematic random sampling technique. Alcohol use disorders were assessed using the World Health Organization’s 10-item Alcohol Use Disorder Identification Test (AUDIT) questionnaire. Bivariate and multivariate logistic regression analyses were performed, a P-value less than 0.05 were considered statistically significant in the multivariate analysis and the strength of association was measured at a 95% confidence interval. Results The prevalence of alcohol use disorder was 34.5% with a 95% CI (29.20, 39.80) among study participants. In the multivariate logistic regression analysis, male sex (AOR = 3.33, 95%CI: 1.40, 7.93), history of mental illness (AOR = 2.68, 95%CI: 1.12, 6.38), drinking for relaxation (AOR = 1.88, 95%CI: 1.02, 3.48) and history of lifetime tobacco use (AOR = 5.64, 95%CI: 1.95, 16.29) were factors significantly associated with alcohol use disorder. Conclusion The prevalence of alcohol use disorders among medical and surgical outpatients was found to be high. Male sex, history of mental illness, alcohol use for relaxation and lifetime cigarette smoking need more attention during the assessment of patients in the medical and surgical outpatient departments.

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The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood

Journal of Studies on Alcohol and Drugs ◽

10.15288/jsad.2017.78.426 ◽

2017 ◽

Vol 78 (3) ◽

pp. 426-434 ◽

Cited By ~ 1

Author(s):

Brooke E. Sadler ◽

Julia D. Grant ◽

Alexis E. Duncan ◽

Carolyn E. Sartor ◽

Mary Waldron ◽

...

Keyword(s):

Substance Use ◽

Alcohol Use ◽

Educational Attainment ◽

Young Adulthood ◽

Alcohol Use Disorder ◽

History Of ◽

Disorder Risk

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Genetic variation in alcohol dehydrogenase is associated with neurocognition in men with HIV and history of alcohol use disorder: preliminary findings

Journal of NeuroVirology ◽

10.1007/s13365-019-00825-z ◽

2020 ◽

Vol 26 (2) ◽

pp. 214-225 ◽

Cited By ~ 3

Author(s):

Rowan Saloner ◽

Emily W. Paolillo ◽

Maulika Kohli ◽

Sarah S. Murray ◽

David J. Moore ◽

...

Keyword(s):

Genetic Variation ◽

Alcohol Use ◽

Alcohol Dehydrogenase ◽

Alcohol Use Disorder ◽

History Of

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Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives

European Psychiatry ◽

10.1016/j.eurpsy.2019.08.003 ◽

2019 ◽

Vol 62 ◽

pp. 107-115 ◽

Cited By ~ 3

Author(s):

Irina Filippi ◽

Nicolas Hoertel ◽

Eric Artiges ◽

Guillaume Airagnes ◽

Christophe Guérin-Langlois ◽

...

Keyword(s):

Family History ◽

Alcohol Use ◽

Childhood Maltreatment ◽

Alcohol Use Disorder ◽

Grey Matter ◽

Brain Regions ◽

Whole Brain ◽

Childhood Trauma Questionnaire ◽

Functional Changes ◽

History Of

Abstract Background: Neuroimaging studies of vulnerability to Alcohol Use Disorder (AUD) have identified structural and functional variations which might reflect inheritable features in alcohol-naïve relatives of AUD individuals (FH+) compared to controls having no such family history (FH-). However, prior research did not simultaneously account for childhood maltreatment, any clinically significant disorder and maternal AUD. Therefore, we mainly aimed to investigate the brain structure and reward-related neural activations (fMRI), using whole-brain analysis in FH+ young adults with no prevalent confounders. Methods: 46 FH+ and 45 FH- male and female participants had no severe childhood maltreatment exposure, neither any psychiatric disorder or AUD, nor a prenatal exposure to maternal AUD. We used a 3 T MRI coupled with a whole brain voxel-based method to compare between groups the grey matter volumes and activations in response to big versus small wins during a Monetary Incentive Delay task. The Childhood Trauma Questionnaire score was used as confounding variable in the analyses to account for the remaining variance between groups. Results: Compared to FH- controls, FH+ participants had smaller grey matter volumes in the frontal and cingulate regions as well as in the bilateral nucleus accumbens and right insula. The FH+ participants’ fMRI datasets denoted a blunted activation in the middle cingulum with respect to FH- controls’ during the processing of reward magnitude, and a greater activation in the anterior cingulum in response to anticipation of a small win. Conclusions: Family history of alcohol use disorder is linked to structural and functional variations including brain regions involved in reward processes.

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Alcohol use disorder and its determinant factors among patients with schizophrenia attending treatment at mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study

SAGE Open Medicine ◽

10.1177/20503121211048748 ◽

2021 ◽

Vol 9 ◽

pp. 205031212110487

Author(s):

Habtamu Tadesse ◽

Yohannes Mirkana ◽

Tadesse Misgana

Keyword(s):

Alcohol Use ◽

Alcohol Use Disorder ◽

Addis Ababa ◽

Previous History ◽

Cross Sectional Study ◽

Cross Sectional ◽

Duration Of Illness ◽

Specialized Hospital ◽

Audit Score ◽

History Of

Background: Alcohol use disorder is one of the primary causes of avoidable death, illness, and injury in many societies throughout the world. Although alcohol use disorder can influence the natural history of a disease, disease recurrence, quality of life, and treatment adherence in psychiatric patients, the data on its magnitude is scarce. Objectives: This study was aimed to determine the magnitude of alcohol use disorder and its determinants among patients with schizophrenia attending a mental specialized hospital in Addis Ababa, Ethiopia. Methods: An institutional-based cross-sectional study was conducted from May 15 to June 15, 2018. An alcohol use disorder identification test was employed among a sample of 414 randomly selected patients with schizophrenia. Alcohol use disorder was categorized as hazardous drinking (Alcohol Use Disorders Identification Test (AUDIT) score of 8–15), harmful drinking (AUDIT score of 16–19), and alcohol dependence (AUDIT score of 20 or above). The data were entered into Epi-Data 3.1 and exported to SPSS 20 for analysis. Logistic regression was fitted to identify factors associated with alcohol use disorder. Results: The prevalence of alcohol use disorder was 38.4% (95% confidence interval (CI) 33.7, 42.9). Of this, 22.4% of the patients had hazardous drinking, 8.4% harmful drinking, and 7.6% alcohol dependence. Factors associated with alcohol use disorder were male sex (adjusted odds ratio (AOR) = 5.8, 95% CI 2.55, 13.19), being single (AOR = 3.0, 95% CI 1.63, 5.51), divorced (AOR = 4.3, 95% CI 1.95, 9.47) and widowed (AOR = 3.5, 95% CI 1.39, 8.81), having family history of alcoholism (AOR = 3.8, 95% CI 1.98, 7.19), longer duration of illness (AOR = 3.9, 95% CI 1.83, 8.36), previous history of psychiatric diagnosis (AOR = 2.2, 95% CI 1.1, 4.34), and concomitant use of non-alcoholic substances (AOR = 3.7, 95% CI 2.06, 6.74). Conclusions: Almost four in ten patients with schizophrenia had alcohol use disorder. Male sex, single, divorced, and widowed, family history of alcohol use, long duration of illness, previous history of psychiatric diagnosis, and concomitant use of non-alcoholic substances were significantly associated with alcohol use disorder. Continuous counseling of at risk populations about alcohol consumption should be strengthened.

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