The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood

AbstractPrior research has shown that person-level characteristics (e.g., temperament, personality) correlate and interact with social-contextual factors (e.g., parent–child relationship quality, antisocial peer affiliation) to predict adolescent substance use, but less research has examined similar processes for adult substance use problems. We addressed this gap by testing for personality × romantic partner context interplay in relation to symptoms of alcohol use disorder (AUD) at ages 24 and 29. Participants were twins in the longitudinal Minnesota Twin Family Study (N = 2,769; 52% female). Results support the corresponsive principle of personality in that we found that key personality traits in late adolescence (low constraint, negative emotionality) predicted subsequent “selection” into key social contexts in early adulthood (poorer quality romantic relationships and greater romantic partner alcohol use), which subsequently reinforced those traits and associated outcomes (including correlated AUD symptoms) through late young adulthood. There were few meaningful gender differences in these associations. There was also no support for the personality × romantic partner context interaction as a significant predictor of AUD symptoms at ages 24 or 29. Taken together with prior studies, these results suggest that such interactions may be less relevant to the development of young adult AUD compared to adolescent substance use problems.

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Correlates of self-reported history of mental health help-seeking: a cross-sectional study among individuals with symptoms of a mental or substance use disorder initiating care for HIV in Cameroon

BMC Psychiatry ◽

10.1186/s12888-021-03306-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Lindsey M. Filiatreau ◽

Peter Vanes Ebasone ◽

Anastase Dzudie ◽

Rogers Ajeh ◽

Brian Pence ◽

...

Keyword(s):

Mental Health ◽

Health Care ◽

Substance Use ◽

Alcohol Use ◽

Mental Health Care ◽

Help Seeking ◽

Alcohol Use Disorder ◽

Hiv Care ◽

Informal Networks ◽

History Of

Abstract Background Mental health and substance use disorders (MSDs) increase the risk of poor human immunodeficiency virus (HIV) care outcomes among people living with HIV (PLWH). Receipt of mental health care may improve these adverse outcomes. We aimed to identify correlates of prior mental health help-seeking among PLWH with symptoms of an MSD in Cameroon. Methods We characterize prior mental health help-seeking from formal (mental health specialist/general medical provider) and informal (traditional healer/religious leader) sources among 161 people with symptoms of depression (Patient Health Questionnaire-9 scores> 9), anxiety (General Anxiety Disorder-7 scores> 9), probable post-traumatic stress disorder (PTSD Checklist for DSM-5 scores> 30), or possible alcohol use disorder (Alcohol Use Disorders Identification Test scores≥16) who were newly entering HIV care at three healthcare facilities in Cameroon between June 2019 and March 2020. Help-seeking was defined as ever speaking to a formal or informal source about emotional problems, sadness, or the way they were feeling or behaving. We estimated the association between sociodemographic and psychosocial measures and lifetime mental health help-seeking from each type of source using log-binomial regression. Results Overall, 55.3% of 161 PLWH with MSD symptoms reported prior mental health help-seeking, with 24.2% and 46.0% seeking help from formal and informal sources, respectively. Religious leaders were the most common source of help (40.4%), followed by general medical professionals (22.4%), traditional healers (16.8%), and mental health specialists (7.4%). Individuals with higher depressive, anxiety, and trauma symptom severity scores were more likely to have sought help than those with lower scores. Individuals with possible alcohol use disorder were the least likely to have sought help. Prior help-seeking was more common among those reporting a higher number of lifetime traumatic events (prevalence ratio [PR]: 1.06; 95% confidence interval [CI]: 1.01, 1.11) and those with a history of emotional intimate partner violence (PR: 1.34; 95% CI: 1.01, 1.80). Conclusions Prior mental health help-seeking was associated with psychosocial stressors. Help-seeking from informal networks was more common than formal help-seeking. Training in the provision of evidence-based mental health support for informal networks could improve access to mental health care for PLWH with MSDs in Cameroon.

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The Gender Risk–Severity Paradox for Alcohol Use Disorder From Adolescence Through Young Adulthood

Emerging Adulthood ◽

10.1177/2167696817740453 ◽

2017 ◽

Vol 6 (6) ◽

pp. 375-386 ◽

Cited By ~ 1

Author(s):

Katherine T. Foster ◽

Brian M. Hicks ◽

C. Emily Durbin ◽

William G. Iacono ◽

Matt McGue

Keyword(s):

Alcohol Use ◽

Young Adulthood ◽

Alcohol Use Disorder ◽

Risk Exposure ◽

Depression Symptoms ◽

Alcohol And Drug Use ◽

The Public ◽

Age Related ◽

History Of ◽

Chronic Course

A large proportion of the public health costs of alcohol use disorder (AUD) can be accounted for by a small percentage of severe cases with a chronic course starting in adolescence and persisting into adulthood. However, chronicity may be a less effective marker of AUD severity in women than men due to a gender risk–severity paradox, wherein comparable levels of risk exposure yield more co-occurring problems for women than men with AUD. To model this paradox, we compared trajectories of alcohol and drug use problems, depression symptoms, and antisocial behavior from ages 17 to 29 in men and women with a persistent, desistent, or no history of AUD. Problems followed a quadratic trajectory (i.e., increases followed by decreases), with gender and AUD chronicity moderating age-related change. Specifically, persistent and desistent courses differentiated the severity of problems more effectively in men while chronicity had less utility for differentiating AUD severity in women.

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Polygenic Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young Adulthood

10.31234/osf.io/axkqb ◽

2020 ◽

Cited By ~ 1

Author(s):

Joseph D. Deak ◽

D. Angus Clark ◽

Mengzhen Liu ◽

C. Emily Durbin ◽

William G. Iacono ◽

...

Keyword(s):

Substance Use ◽

Alcohol Use ◽

Young Adulthood ◽

Externalizing Behavior ◽

Molecular Genetic ◽

Early Adulthood ◽

Predictive Utility ◽

Problematic Use ◽

Discovery Sample ◽

Polygenic Scores

Objective: Molecular genetic studies of alcohol and nicotine have identified many genome-wide loci. We examined the predictive utility of drinking and smoking polygenic scores (PGS) for alcohol and nicotine use from late childhood to early adulthood, substance-specific versus broader-liability PGS effects, and if PGS performance varied between consumption versus pathological use. Methods: Latent growth curve models with structured residuals were used to assess the predictive utility of drinks per week and regular smoking PGS for measures of alcohol and nicotine consumption and problematic use from age 14 to 34. PGSs were generated from the largest discovery sample for alcohol and nicotine use to date (i.e., GSCAN), and examined for associations with alcohol and nicotine use in the Minnesota Twin Family Study (N=3225).Results: The drinking PGS was a significant predictor of age 14 problematic alcohol use and increases in problematic use during young adulthood. The smoking PGS was a significant predictor for all nicotine use outcomes. After adjusting for the effects of both PGSs, the smoking PGS demonstrated incremental predictive utility for most alcohol use outcomes and remained a significant predictor of nicotine use trajectories. Conclusions: Higher PGS for drinking and smoking were associated with more problematic levels of substance use longitudinally. The smoking PGS seems to capture both nicotine-specific and non-specific genetic liability for substance use, and may index genetic risk for broader externalizing behavior. Validation of PGS within longitudinal designs may have important clinical implications should future studies support the clinical utility of PGS for substance use disorders.

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Content Analysis of Health Concerns among Housing First Residents with a History of Alcohol Use Disorder

Journal of Health Care for the Poor and Underserved ◽

10.1353/hpu.2021.0035 ◽

2021 ◽

Vol 32 (1) ◽

pp. 463-486

Author(s):

Jessica L. Mackelprang ◽

Seema L. Clifasefi ◽

Véronique S. Grazioli ◽

Susan E. Collins

Keyword(s):

Content Analysis ◽

Alcohol Use ◽

Alcohol Use Disorder ◽

Housing First ◽

Health Concerns ◽

History Of

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Assessment of alcohol use disorder and its associated factors among alcohol users of medical and surgical outpatients attending a specialized hospital in Gondar, Ethiopia: a cross-sectional study

International Journal of Mental Health Systems ◽

10.1186/s13033-021-00454-2 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Demeke Demilew ◽

Berhanu Boru ◽

Getachew Tesfaw ◽

Habtamu Kerebih ◽

Endalamaw Salelew

Keyword(s):

Alcohol Use ◽

Associated Factors ◽

Alcohol Use Disorder ◽

Alcohol Use Disorders ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariate Logistic Regression ◽

Cross Sectional ◽

History Of ◽

Male Sex

Abstract Background Alcohol use disorder increase the risk of physical harm, mental or social consequences for patients and others in the community. Studies on alcohol use disorder and associated factors among medical and surgical outpatients in Ethiopia are limited. Therefore, this study is meant to provide essential data on alcohol use disorder and associated factors among alcohol user medical and surgical outpatients to intervene in the future. Methods An institution-based cross-sectional study was conducted by using the systematic random sampling technique. Alcohol use disorders were assessed using the World Health Organization’s 10-item Alcohol Use Disorder Identification Test (AUDIT) questionnaire. Bivariate and multivariate logistic regression analyses were performed, a P-value less than 0.05 were considered statistically significant in the multivariate analysis and the strength of association was measured at a 95% confidence interval. Results The prevalence of alcohol use disorder was 34.5% with a 95% CI (29.20, 39.80) among study participants. In the multivariate logistic regression analysis, male sex (AOR = 3.33, 95%CI: 1.40, 7.93), history of mental illness (AOR = 2.68, 95%CI: 1.12, 6.38), drinking for relaxation (AOR = 1.88, 95%CI: 1.02, 3.48) and history of lifetime tobacco use (AOR = 5.64, 95%CI: 1.95, 16.29) were factors significantly associated with alcohol use disorder. Conclusion The prevalence of alcohol use disorders among medical and surgical outpatients was found to be high. Male sex, history of mental illness, alcohol use for relaxation and lifetime cigarette smoking need more attention during the assessment of patients in the medical and surgical outpatient departments.

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Polygenic Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young Adulthood

10.1101/2020.07.29.227439 ◽

2020 ◽

Author(s):

Joseph D. Deak ◽

D. Angus Clark ◽

Mengzhen Liu ◽

C. Emily Durbin ◽

William G. Iacono ◽

...

Keyword(s):

Substance Use ◽

Alcohol Use ◽

Young Adulthood ◽

Externalizing Behavior ◽

Molecular Genetic ◽

Early Adulthood ◽

Predictive Utility ◽

Problematic Use ◽

Discovery Sample ◽

Polygenic Scores

AbstractObjectiveMolecular genetic studies of alcohol and nicotine have identified many genome-wide loci. We examined the predictive utility of drinking and smoking polygenic scores (PGS) for alcohol and nicotine use from late childhood to early adulthood, substance-specific versus broader-liability PGS effects, and if PGS performance varied between consumption versus pathological use.MethodsLatent growth curve models with structured residuals were used to assess the predictive utility of drinks per week and regular smoking PGS for measures of alcohol and nicotine consumption and problematic use from age 14 to 34. PGSs were generated from the largest discovery sample for alcohol and nicotine use to date (i.e., GSCAN), and examined for associations with alcohol and nicotine use in the Minnesota Twin Family Study (N=3225).ResultsThe drinking PGS was a significant predictor of age 14 problematic alcohol use and increases in problematic use during young adulthood. The smoking PGS was a significant predictor for all nicotine use outcomes. After adjusting for the effects of both PGSs, the smoking PGS demonstrated incremental predictive utility for most alcohol use outcomes and remained a significant predictor of nicotine use trajectories.ConclusionsHigher PGS for drinking and smoking were associated with more problematic levels of substance use longitudinally. The smoking PGS seems to capture both nicotine-specific and non-specific genetic liability for substance use, and may index genetic risk for broader externalizing behavior. Validation of PGS within longitudinal designs may have important clinical implications should future studies support the clinical utility of PGS for substance use disorders.

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Prevalence and associations of psychoactive substance use among male supportive staff members in a tertiary care hospital of Sri Lanka

BJPsych Open ◽

10.1192/bjo.2021.778 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S293-S293

Author(s):

Chathurie Suraweera ◽

Iresha Perera ◽

Priyanka Rupasinghe ◽

Janith Galhenage

Keyword(s):

Substance Use ◽

Sri Lanka ◽

Alcohol Use ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Psychoactive Substance ◽

Staff Members ◽

History Of ◽

Psychoactive Substance Use

AimsThe study describes the prevalence and associated socio-demographic variables of psychoactive substance use among male supportive staff members at a tertiary care hospital in Sri Lanka.MethodA cross-sectional descriptive study was carried out among male supportive staff members of a tertiary care hospital in Colombo District, Sri Lanka by using a self-administered anonymous questionnaire. Participants were recruited using stratified cluster sampling in thirteen overseer divisions of the hospital. Anonymous questionnaires were collected into a sealed box and analysed using Statistical Package for Social Sciences 20.ResultThe mean age of the 404 male staff members who participated in the study was 38.78(SD = 10.90) years and 71.5% were married. Among them 202 (49.1%) were educated up to grade 6-11 and 30 of them has had encounters with law in the past. Thirty of participants had history of psychoactive substance use in the family. Alcohol was used more than once a month by 127(30.9%) and more than once a week by 19(4.6%) individuals. Among other substances, tobacco, beetle and beedi were used by 104(25.3%), 78(19.0%) and 18(4.4%) respectively at least once a month. Further, 22(5.3%), 20(4.8%), 7(1.7%) and 7(1.7%) participants used Mava, Cannabis, Methamphetamine and Thool respectively at least less than once a month. Heroin, Tramadol and Morphine were used by two individuals at least less than once a month. Among substance using participants, 132 wished to cut down their habit. Most commonly identified (14.1%) adverse consequence was financial issues secondary to psychoactive substance use. Eleven (4.5%) staff members used the substance at hospital. Alcohol use was associated with age more than 35 years (p = 0.039) and history of forensic involvement (p = 0.038). Tobacco(p = 0.000), beetle (p = 0.056), Cannabis (p = 0.000) and mava (p = 0.015) use were significantly associated with positive forensic history. Supportive staff members’ alcohol and cannabis use was associated with tobacco (p = 0.000, p = 0.000) and beetle use (p = 0.001, p = 0.049). Mava use was associated with alcohol (p = 0.060) use in addition to tobacco (p = 0.020) and beetle use (p = 0.008).Binomial logistic regression revealed alcohol use and beetle use were associated with the number of children in family and above associations.ConclusionCommonest psychoactive substance consumed by supportive staff members were alcohol, tobacco, beetle, Cannabis and Mava in descending order of frequency. Forensic history was significantly associated with substance use. True prevalence of substance use can be higher than these values.

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An adolescent with binge drinking

Child and Adolescent Psychiatry ◽

10.1093/med/9780197577479.003.0027 ◽

2021 ◽

pp. 213-220

Author(s):

Eun Kyung Ellen Kim ◽

David L. Beckmann

Keyword(s):

Parent Involvement ◽

Substance Use ◽

Family Therapy ◽

Alcohol Use ◽

Motivational Interviewing ◽

Binge Drinking ◽

Alcohol Use Disorder ◽

Treatment Medication ◽

Problematic Alcohol Use ◽

Risk Taking Behaviors

Alcohol use disorder (AUD) occurs in approximately 5% of adolescents. The diagnosis of AUD requires the presence of at least two signs or symptoms of problematic alcohol use. Adolescent AUD differs from adult AUD in several ways. Adolescents are more likely to engage in binge drinking rather than daily drinking. They are also less likely to experience tolerance or withdrawal and are more likely to engage in risk-taking behaviors related to substance use. All adolescents should be screened for alcohol and other substance use. A motivational interviewing approach should be used. Treatment includes individual and family therapy; parent involvement is an essential component of treatment. Medication options include naltrexone, acamprosate, and disulfiram.

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