scholarly journals Magnitude, outcome, and associated factors of anti-tuberculosis drug-induced hepatitis among tuberculosis patients in a tertiary hospital in North Ethiopia: A cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241346
Author(s):  
Liwam Kidane Gezahegn ◽  
Ermias Argaw ◽  
Belete Assefa ◽  
Azeb Geberesilassie ◽  
Mengistu Hagazi
Keyword(s):  
Liver Disease ◽  
Serum Albumin ◽  
Associated Factors ◽  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Regression Analyses ◽  
Sectional Study ◽  
Drug Induced ◽  
Cross Sectional

Background Short-course chemotherapy comprising isoniazid, rifampicin, ethambutol, and pyrazinamide has proved to be highly effective in the treatment of tuberculosis (TB). However, the most common adverse effect of this regimen leading to interruption of therapy is hepatotoxicity. There is a paucity of evidence in Tigray region on anti-tuberculosis drug-induced hepatitis. Therefore, this study aims to determine the magnitude, outcomes, and associated factors of drug-induced hepatitis in Ayder specialized comprehensive hospital tuberculosis clinic. Methods An institution-based cross-sectional study was done on 188 cases of patients who took anti-tuberculosis drugs from August 4, 2015 to June 30, 2018 in tuberculosis clinic, Ayder Comprehensive Specialized Hospital, Northern Ethiopia. Data on socio-demography, clinical characteristics and magnitude of the incidence and outcome of anti-tuberculosis drugs-induced hepatitis were collected using structured checklist from patients’ records using census method. Then, we entered and analyzed the data using statistical packages for social sciences (SPSS) statistical software version 21. Descriptive statistics were done in tables, counts, proportions, median and range. Bivariate and multivariable regression analyses were done to identify factors that are associated with drug-induced hepatitis. Confidence interval was taken at 95% and p-value of less than 0.05 was used to denote significance. Results We approached a total of 226 patients’ records, and we collected data from188 records (83.2%response rate). Anti-tuberculosis drug-induced hepatitis was found in 26 (13.8%) of the patients, of which 3 (11.54%) have died. Using multivariable logistic regression analyses, preexisting liver disease (AOR: 42.01, 95% CI: 4.22–417.49), taking other hepatotoxic drugs (AOR: 23.66, 95% CI: 1.77–314.79), and having lower serum albumin (AOR: 10.55, 95% CI: 2.57–43.32) were found to be significantly associated with the development of anti-tuberculosis drug-induced hepatitis. Conclusion and recommendation The incidence of anti-tuberculosis drug-induced hepatitis was high. Patients with low baseline serum albumin, taking other hepatotoxic drugs and having preexisting liver disease should be followed with serial liver enzymes after initiation of anti-tuberculosis medications. These patients should be followed with frequent measurement of liver enzymes to assess for the development of drug-induced hepatitis.

scholarly journals Magnitude of preterm hospital neonatal mortality and associated factors in northern Ethiopia: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e051161
Author(s):  
Bekahegn Girma ◽  
Jemberu Nigussie
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Neonatal Mortality ◽  
Associated Factors ◽  
Distress Syndrome ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated

ObjectiveThis study aimed to assess the magnitude of preterm neonatal mortality in hospitals and associated factors in northern Ethiopia.DesignInstitutional-based cross-sectional study.SettingComprehensive specialised hospitals in the Tigray region, northern Ethiopia.ParticipantsPreterm neonates admitted in Ayder and Aksum comprehensive specialised hospitalsPrimary outcomeMagnitude of preterm neonatal mortality.Secondary outcomeFactors associated with preterm neonatal mortalityResultThis study was conducted from 1 April 2019 to 15 May 2019 among 336 participants with a response rate of 96.8%. The magnitude of preterm neonatal mortality was 28.6% (95% CI: 24.0 to 33.7). In multivariable logistic regression, respiratory distress syndrome (adjusted odd ratio (AOR)=2.85; 95% CI: 1.35 to 6.00), apnoea of prematurity (AOR=5.45; 95% CI: 1.32 to 22.5), nulli parity (AOR=3.63; 95% CI: 1.59 to 8.24) and grand parity (AOR=3.21; 95% CI: 1.04 to 9.94) were significant factors associated with preterm neonatal mortality. However, receiving Kangaroo mother care (AOR=0.08; 95% CI: 0.03 to 0.20) and feeding initiated during hospitalisation (AOR=0.07; 95% CI: 0.03 to 0.15) were protective against preterm neonatal mortality.ConclusionsThe magnitude of preterm neonatal mortality in hospitals was still high. Interventions geared towards curbing preterm in-hospital neonatal mortality should strengthen early diagnosis and treatment of preterm newborns with respiratory distress syndrome and apnoea of prematurity; while concomitantly reinforcing the implementation of kangaroo care and early feeding initiation is important.

scholarly journals Clinical practice competencies and associated factors among graduating nursing students attending at universities in Northern Ethiopia: institution-based cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e044119
Author(s):  
Addisu Getie ◽  
Yosief Tsige ◽  
Emebet Birhanie ◽  
Kenean Getaneh Tlaye ◽  
Asmamaw Demis
Keyword(s):  
Clinical Practice ◽  
Nursing Students ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Student Interaction ◽  
Clinical Instructor ◽  
Northern Ethiopia ◽  
Sectional Study ◽  
Amhara Region ◽  
Cross Sectional

ObjectiveTo assess clinical practice competencies and associated factors among graduating nursing students attending public universities found in the Amhara Region, EthiopiaDesignInstitution-based cross-sectional study designSettingThe study was conducted in six universities found in the Amhara Region from February to April 2018.Participants307 graduating nursing students participated. Of these, 173 were male and 134 were females from different ethnic groups; Amhara 145, Oromo 84, Tigris 44 and Gurage 17. Graduating nursing students attending regular degree programmes were included.Outcome measurementsClinical instructor (good vs not good), clinical environment (conducive vs not conducive), assessment method (measurable vs not measurable), clinical staff-student interaction (good vs not good), clinical practice competency (competent vs incompetent).ResultThe study revealed that 33.6% (95% CI 26.3% to 39.41%) of students were clinically competent. Orientation about the objective of clinical practice (adjusted OR, AOR 2.387; 95% CI 1.011 to 5.635), enough time for mentoring during clinical practice (AOR 2.247; 95% CI 1.100 to 4.593). Students followed by instructors during conducting a procedure (AOR 2.655; 95% CI 1.294 to 5.449), assessment checklist during clinical practice (AOR 2.663; 95% CI 1.324 to 5.358), students who were allowed by clinical staffs to perform tasks (AOR 5.858; 95% CI 2.657 to 12.916), clinical instructor factors (AOR 3.051; 95% CI 1.717 to 5.421) and student–staff interaction factors (AOR 2.348; 95% CI (1.337 to 4.124) were statistically significant variables with the level of competency.ConclusionAround one-third of the students were clinically competent. Clinical instructor and staff–student interaction were significantly associated with clinical practice competencies among graduating nursing students. Therefore, designing an appropriate clinical practice protocol that includes improving the supervision of a clinical instructor is important to enhance the clinical practice competency of students.

scholarly journals Low Back Pain and Associated Factors among Hairdressers in Northern Ethiopia: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Gebrerufael Tsegay Solomon ◽  
Berihu Gebremeskel Fisseha ◽  
Selam Gezahegn Desalegn ◽  
Desalegn Teklemichael Massa
Keyword(s):  
Job Satisfaction ◽  
Low Back Pain ◽  
Back Pain ◽  
Job Stress ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Low Back ◽  
Sectional Study ◽  
Cross Sectional

Low back pain is one of the major occupational health problems ranked the highest in terms of years lived with disability, and it has an economic burden on individuals and society in general. Hairdressers are high-risk professionals, but they are usually getting less attention in research and policy actions. The objective of this study is to assess the magnitude and associated factors of low back pain among hairdressers working in female beauty salons of Mekelle, Northern Ethiopia. A cross-sectional study was employed from January up to March 2018. A simple random sampling was applied to select 344 participants. Interviewer-administered, pretested, and structured questionnaire was used. Bivariate and multivariate binary logistic regression analyses were performed using SPSS version 23. A p value of <0.05 was used to declare statistical significance. A total of 314 hairdressers participated, with a 91.3% response rate. The study found that the prevalence of low back pain was 47.5% with 95% CI (41.8–53.1). Marital status (AOR: 0.40, 95% CI (0.23–0.71)), awkward posture (AOR: 2.59, 95%CI (1.45–4.63)), working greater than 4 days in a week (AOR: 5.12, 95% CI (1.94–13.70)), the task of washing the client’s hair (AOR: 4.45, 95% CI (1.93–10.26)), having adjustable washing basin (AOR: 0.35, 95% CI (0.18–0.69)), job stress (AOR: 0.45, 95% CI (0.27–0.77)), and job satisfaction (AOR: 0.58, 95% CI (0.34–0.98)) were factors that show a statistically significant association with low back pain. This study found that low back pain is a major health problem among hairdressers. Marital status, awkward postures, working days per week, the task of washing the client’s hair, adjustable washing basin, job stress, and job satisfaction show a strong association with low back pain. The result suggests that effective intervention strategies for low back pain need to include ergonomic improvements and psychosocial and behavioral aspects of the participants.

scholarly journals Days away from Work Injury and Associated Factors among Waste Collectors in Mekelle City, Northern Ethiopia: A Cross Sectional Study

2020 ◽  
Author(s):  
Mesele Bahre Abrha ◽  
Yisak Arbise Messelle ◽  
Akeza Awealom Asgedom ◽  
Beyene Meressa
Keyword(s):  
Associated Factors ◽  
Study Participant ◽  
Well Being ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Sectional Study ◽  
Work Injury ◽  
Cross Sectional ◽  
Work Injuries ◽  
Mekelle City

Abstract Background: In its nature, solid waste management is a labour intensive industry, which exposes workers to numerous occupational hazards. This study was aimed to investigate the magnitude of days away from work injuries and associated factors among organized waste collectors in Mekelle city, Northern Ethiopia. Method: A questionnaire and observation checklist based cross-sectional study design was employed from June 1 to 30, 2017. Data was analysed using SPSS for windows 20.0. Descriptive statistics and logistic regression methods were used to describe the study population and assess the association between dependent and independent variables, respectively. Result: From the total of 279 waste collectors involved as a study participant, ten percent(10%) of them reported at least one day away from work injuries during the last twelve months. Female were 96% less likely to be injured as compared to male (AOR = 0.04, 95%CI: 0.008 -0.204). Being married is 87% less likely to be injured as compared to being a single (AOR = 0.130 95% CI: 0.027-0.621). The odds of injury were 4.5 times higher among those who do not use personal protective equipment as compared to their counterparts (AOR = 4.514 95%CI: 1.684-12.095). Waste collectors, who had less than 1000 Birr income, were 3 times more likely to be injured than waste collectors who had greater than 1001 Birr per month income (AOR = 3.008 95%CI: 1.081 - 8.371.Conclusion: Days away from work injury among waste collectors is a public health problem and has an impact on the economic and social well-being of workers. Therefore, strengthening the provision of personal protective devices and insuring its utilization is highly recommended.

Sign in / Sign up

Export Citation Format

Share Document