scholarly journals Chlamydia pneumoniae and chronic asthma: Updated systematic review and meta-analysis of population attributable risk

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250034
Author(s):  
David L. Hahn
Keyword(s):  
Chlamydia Pneumoniae ◽  
Population Attributable Risk ◽  
Asthma Severity ◽  
Specific Ige ◽  
Attributable Risk ◽  
Respiratory Pathogen ◽  
Chronic Asthma ◽  
Case Control Studies ◽  
Specific Igg ◽  
Population Attributable Risks

Background Chlamydia pneumoniae (Cp) is an obligate intracellular human respiratory pathogen producing persisting lung infection with a plausible link to asthma pathogenesis. The population attributable risk of potentially treatable Cp infection in asthma has not been reported. Methods The author searched from 2000 to 2020 inclusive for previously un-reviewed and new cross sectional and prospective controlled studies of Cp biomarkers and chronic asthma in both children and adults. Qualitative descriptive results and quantitative estimates of population attributable risk for selected biomarkers (specific IgG, IgA and IgE) are presented. Findings No large, long-term prospective population-based studies of Cp infection and asthma were identified. About half of case-control studies reported one or more significant associations of Cp biomarkers and chronic asthma. Heterogeneity of results by age group (pediatric v adult asthma), severity category (severe/uncontrolled, moderate/partly controlled, mild/controlled) and antibody isotype (specific IgG, IgA, IgE) were suggested by the qualitative results and confirmed by meta-analyses. The population attributable risks for Cp-specific IgG and IgA were nul in children and were 6% (95% confidence interval 2%-10%, p = 0.002) and 13% (9%-18%, p<0.00001) respectively in adults. In contrast to the nul or small population attributable risks for Cp-specific IgG and IgA, the population attributable risk for C. pneumoniae-specific IgE (children and adults combined) was 47% (39%-55%, p<0.00001). In the subset of studies that reported on asthma severity categories, Cp biomarkers were positively and significantly (P<0.00001) associated with asthma severity. Interpretation C. pneumoniae-specific IgE is strongly associated with asthma and asthma severity, suggesting a possible mechanism linking chronic Cp infection with asthma in a subset of individuals with asthma. Infection biomarkers should be included in future macrolide treatment trials for severe and uncontrolled asthma.

Suicidal Ideation in a Random Community Sample: Attributable Risk Due to Depression and Psychosocial and Traumatic Events

2000 ◽  
Vol 34 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Robert D. Goldney ◽  
David Wilson ◽  
Eleonora Dal Grande ◽  
Laura J. Fisher ◽  
Alexander C. McFarlane
Keyword(s):  
Multivariate Analysis ◽  
Suicidal Ideation ◽  
Short Form ◽  
Community Sample ◽  
General Health Questionnaire ◽  
Traumatic Events ◽  
Population Attributable Risk ◽  
Attributable Risk ◽  
Clinical Depression ◽  
Population Attributable Risks

Objective: To determine the attributable risk for suicidal ideation of depression and psychosocial and traumatic events in a random and representative population. Method: Data were gathered from a random and representative sample of 2501 South Australians. Suicidal ideation and clinical depression were determined by the general health questionnaire (GHQ-28) and the short-form health survey (SF-12) respectively, and information regarding psychosocial stressors and traumatic events was collated. These data were subjected to univariate and multivariate analyses to determine the population-attributable risks for suicidal ideation. Results: Overall, 5.6% of men and 5.3% of women had suicidal ideation. Univariate analyses demonstrated a significant attributable risk for suicidal ideation for depression and the majority of the psychosocial and traumatic events. Multivariate analysis demonstrated that clinical depression remained significantly associated with suicidal ideation, with a population-attributable risk of 46.9%. Because of the small number of people in the population who experience both suicidal ideation and specific events, multivariate analysis could not be applied to individual events. However, even when the psychosocial events were summed, they no longer remained significantly associated with suicidal ideation, whereas the summation of traumatic events remained significant, with a population-attributable risk of 38.0%. Conclusions: These results confirm the importance of traumatic events as significant factors in contributing to suicidal ideation. However, of even greater importance is that they indicate, unequivocally, the magnitude of the contribution of clinical depression to suicidal ideation, with the population-attributable risk of depression indicating that elimination of mood disorders would reduce suicidal ideation by up to 46.9%.

Population Level Contribution of Clonal Hematopoiesis of Indeterminate Potential to Myeloid Neoplasm Development: Pooled Analysis and Population Attributable Risk Percent Determination from Case-Control and Cohort Studies

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 16-17
Author(s):  
Abhay Singh
Keyword(s):  
Population Attributable Risk ◽  
Population Level ◽  
Pooled Analysis ◽  
Case Control ◽  
Attributable Risk ◽  
Population Exposure ◽  
Case Control Studies ◽  
Clonal Hematopoiesis ◽  
Myeloid Neoplasm ◽  
Negative Population

Background. Clonal hematopoiesis of indeterminate potential (CHIP) represents a precursor state of myeloid leukemogenesis. Several studies thus far have convincingly demonstrated that presence of CHIP is associated with increased risks of myeloid neoplasm (MN) development. These findings have important intrinsic utility; however, there has been lack of attempts to translate this knowledge into estimates of disease burden suitable for determining its potential at population level. Therefore, the aim of this analysis was to estimate the population attributable fraction (PAF) for MNs associated with CHIP using risk ratio estimates derived from pooled analysis of observational studies. Methods. Eligible studies were case-control (n=3) and cohort (n=3) studies with dichotomous outcome (MN or no MN) and the presence or absence of the risk factor (CHIP). Mantel-Haenszel method for calculating the weighted pooled odds ratio (OR) under the fixed effects model was used, using software RevMan 5.3. OR being the key statistic for case-control studies was the preferred risk estimate to measure association between CHIP and MN in the selected case-control studies. We used OR as risk estimate for cohort studies as well, since MN occurred in less than 10% of the CHIP negative population, and therefore, OR provided a reasonable approximation of the relative risk. From the pooled OR, estimate of population attributable risk% (PAR%) was calculated using the formula: 100*(Px*(OR-1))/(1+(Px*(OR-1))), where Px represented estimate of population exposure (proportion of CHIP positive cases in the population). Results. 23,983 participants with 345 MN cases in six studies were included in the pooled analyses (Figure 1). In the CHIP positive population, there were total 230 MN cases of the total 2304 participants. There were 115 MN cases in the CHIP negative population (n= 21,679). For all studies, the pooled OR for those with CHIP compared with those without was 5.45 (95% CI, 4.06-7.30) with low overall heterogeneity (I2=2%, Fig. 1). Estimate of population exposure (Px) was 0.088 (2074/23638). PAR% calculated using formula 100*(Px*(OR-1))/(1+(Px*(OR-1))), was 28.14%, suggesting that of all the MN cases, including those with or without CHIP, 28.14% could be attributed to CHIP. Conclusion. CHIP's strong association with myeloid neoplasm development was confirmed in this pooled analysis. Individuals with MN were 5.45 times more likely to be CHIP positive than those without MN. Further, in this analysis, we estimate population level contribution of CHIP to MN development. We estimate that 28% of MNs were attributable to positive CHIP status, thus representing 28% of the cases in the total population that can be prevented by intervening against the exposure- CHIP. Determining PAR% is an especially useful and often underutilized first step in designing public health interventions directed against harmful exposures. These findings also brings forth an important consideration, that CHIP though an important risk factor is not obligatory for MN development. Majority of MNs can not attributed to positive CHIP status. Therefore, importance of traditionally known risk factors such as smoking, chemotherapy and radiation exposure need appropriate quantification, especially as they can be entirely preventable and are established risk factors for CHIP positivity as well. Disclosures No relevant conflicts of interest to declare.

scholarly journals Secular trends of population attributable risk of overweight and obesity for hypertension among Chinese adults from 1991 to 2011

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jian Gou ◽  
Huiying Wu
Keyword(s):  
Population Attributable Risk ◽  
Attributable Risk ◽  
Secular Trends ◽  
Overweight And Obesity ◽  
Regression Coefficients ◽  
Chinese Adults ◽  
Intervention Effect ◽  
Obesity Epidemic ◽  
The Past ◽  
Increasing Trend

AbstractWe determined if the increasing trend in hypertension can be partly attributed to increasing prevalence of overweight/obesity in China over the past two decades. Data were collected from 1991 to 2011 and the population attributable risk (PAR), which is used to estimate the intervention effect on hypertension if overweight/obese, were eliminated. Linear regression was used to evaluate the secular trends. The age-standardized prevalence of overweight and obesity increased by 26.32% with an overall slope of 1.27% (95% CI: 1.12–1.43%) per year. Hypertension also increased by 12.37% with an overall slope of 0.65% (95% CI: 0.51–0.79%) per year. The adjusted ORs of overweight/obesity for hypertension across the survey years remained unchanged; however, the trend in PAR increased steadily from 27.1 to 44.6% with an overall slope of 0.81% (95% CI: 0.34–1.28%) per year (P = 0.006). There was no significant gender difference in the slopes of increasing PAR, as measured by regression coefficients (β = 0.95% vs. β = 0.63% per year, P = 0.36). Over the past two decades, the increase in the prevalence of hypertension in China was partly attributed to the overweight/obesity epidemic, which highlights the importance of controlling weight and further reducing the burden of hypertension.

scholarly journals Population attributable risk of aflatoxin-related liver cancer: Systematic review and meta-analysis

2012 ◽  
Vol 48 (14) ◽  
pp. 2125-2136 ◽  
Author(s):  
Yan Liu ◽  
Chung-Chou H. Chang ◽  
Gary M. Marsh ◽  
Felicia Wu
Keyword(s):  
Systematic Review ◽  
Liver Cancer ◽  
Meta Analysis ◽  
Population Attributable Risk ◽  
Attributable Risk

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PEMILIHAN DUKUN BERANAK SEBAGAI PENOLONG PERSALINAN PADA PESERTA JAMINAN KESEHATAN

2019 ◽  
Vol 10 (2) ◽  
pp. 211-219
Author(s):  
Imelda Diana Marsilia
Keyword(s):  
Population Attributable Risk ◽  
Case Control ◽  
Attributable Risk ◽  
Chi Square

Program Jaminan Kesehatan  merupakan salah satu upaya dalam penurunan Angka Kematian Ibu (AKI)  di Indonesia. Cakupan persalinan oleh tenaga kesehatan di Indonesia masih di bawah target yang diharapkan, termasuk di Kecamatan Babakan Madang Kabupaten Bogor yang hanya mencapai 66,4 % tahun 2011.  Cakupan persalinan oleh dukun beranak peserta jaminan kesehatan di Puskesmas Babakan Madang  adalah 40% pada tahun 2011. Tujuan  penelitian ini untuk menganalisis faktor-faktor yang berhubungan dengan pemilihan dukun beranak sebagai penolong persalinan pada peserta jaminan kesehatan di wilayah kerja Puskesmas Babakan Madang Kabupaten Bogor. Metode  Penelitian ini merupakan penelitian analitik dengan pendekatan Case Control. Penelitian dilakukan terhadap 122 orang ibu bersalin pada periode Juli sampai dengan Desember  2012 dibagi dalam 2 kelompok 61 orang kelompok kasus (dukun beranak) dan 61 orang kelompok kontrol (bidan). Analisis data menggunakan uji  chi square  dan uji regresi logistik ganda dengan tingkat kemaknaan (p0,05), dan analisis PAR (population attributable risk).  Hasil penelitian menunjukkan faktor yang berhubungan  dengan pemilihan dukun beranak sebagai penolong persalinan  secara signifikan adalah pengetahuan ibu p=0,003, sikap p= 0,007, pendidikan ibu p= 0,001, Sosial Budaya p= 0,001, penghasilan keluarga p=0,001, dukungan suami p=0,018 sedangkan keterjangkauan layanan, umur, paritas, pekerjaan tidak berhubungan (p0,05). Faktor dominan yang berhubungan dengan keputusan memilih penolong persalinan berdasarkan analisis multivariabel adalah  sosial budaya (OR= 5,644  ;95%CI=  2,016-15,797).  Penelitian ini memberikan kesimpulan bahwa pengetahuan,  Sikap,  pendidikan ibu, sosial budaya penghasilan keluarga dan dukungan suami yang tidak mendukung memilih dukun beranak sebagai  penolong persalinan pada peserta jaminan kesehatan. Perlu dilakukan upaya peningkatan pengetahuan, pendidikan, dukungan suami dan sosial budaya yang mendukung serta pendidikan bidan gratis bagi anak dukun beranak.  Kata Kunci : Pemilihan penolong persalinan, Dukun beranak, Jaminan kesehatan

scholarly journals Population-Attributable Risk Estimates forCampylobacterInfection, Australia

2009 ◽  
Vol 15 (5) ◽  
pp. 851-852
Author(s):  
Russell J. Stafford ◽  
Philip J. Schluter ◽  
Martyn D. Kirk ◽  
Andrew J. Wilson
Keyword(s):  
Population Attributable Risk ◽  
Attributable Risk ◽  
Risk Estimates
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