scholarly journals Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252646
Author(s):  
Margot Geens ◽  
Sofie Stappers ◽  
Heleen Konings ◽  
Benedicte Y. De Winter ◽  
Pol Specenier ◽  
...  
Keyword(s):  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Epidermal Growth Factor ◽  
Healthy Volunteers ◽  
Control Group ◽  
Node Metastasis ◽  
Oncological Patients ◽  
Platinum Based Chemotherapy ◽  
Epidermal Growth

In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for treatment response to platinum-based chemotherapy. A total of 59 oncological patients and a control group of age- and sex-matched healthy volunteers were included in this study. Pre-treatment serum EGF from both groups was determined. Patient’s and tumour characteristics and mortality were recorded during a 5-year follow up period. Baseline serum EGF significantly differed between the oncological patients and the healthy volunteers (p<0.001). Serum EGF was associated with lymph node metastasis (p = 0.004) but not with sex (p = 0.753), age (p = 1.00), TNM stage (p = 0.191) or tumour size (p = 0.077). Neither serum EGF (p = 0.81) nor age (p = 0.55) showed an effect on the patient’s survival. Tumour location was significantly associated with overall 5-year survival (p = 0.003). The predictive capacity of serum EGF of response to chemotherapy was limited (AUC = 0.606), a sensitivity of 80% and a specificity of 56% was observed resulting in a likelihood ratio of a positive and negative test equal to 1.81 and 0.36, respectively. In conclusion, serum EGF levels are 5.5 times higher in an oncological population compared to a control group. Within the oncological population, low serum EGF values are associated with the presence of lymph node metastasis. Further investigation is necessary to determine if the serum EGF levels could serve as a diagnostic biomarker.

scholarly journals Epidermal Growth Factor Facilitates Melanoma Lymph Node Metastasis by Influencing Tumor Lymphangiogenesis

2013 ◽  
Vol 133 (1) ◽  
pp. 230-238 ◽  
Author(s):  
Andreas Bracher ◽  
Ana Soler Cardona ◽  
Stefanie Tauber ◽  
Astrid M. Fink ◽  
Andreas Steiner ◽  
...  
Keyword(s):  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Epidermal Growth Factor ◽  
Node Metastasis ◽  
Tumor Lymphangiogenesis ◽  
Epidermal Growth

Epidermal growth factor 61 A/G polymorphism and uterine cervical cancer

2007 ◽  
Vol 17 (2) ◽  
pp. 492-496 ◽  
Author(s):  
S. Kang ◽  
J. W. Kim ◽  
N.-H. Park ◽  
Y.-S. Song ◽  
S.-Y. Park ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Epidermal Growth Factor ◽  
Cervical Carcinogenesis ◽  
Node Metastasis ◽  
Homozygous Genotype ◽  
Increasing Trend ◽  
Epidermal Growth

Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). However, although many women are infected with high-risk types of HPV, only a subset of infected women will ever develop cervical cancer. Therefore, host genetic factor may play a role in cervical carcinogenesis. Alterations in epidermal growth factor receptor (EGFR) are common events in cervical cancer. Therefore, we hypothesized that a functional polymorphism in the 5′ untranslated region of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the cervical carcinogenesis and tumor invasiveness. We assessed the possible association between EGF +61 A/G polymorphism and cervical cancer risk in a hospital-based case–control study among 337 Korean women (168 cases, 169 age-matched controls). The frequencies of EGF +61 allele and genotype were not different between cases and controls. We observed increasing trend of lymph node metastasis from A/A homozygous genotype toward G/G homozygous genotype. We did not find any evidence that EGF +61 A/G polymorphism was associated with individual susceptibility of cervical cancer. However, although it was not statistically significant, the increasing trend of lymph node metastasis according to EGF genotype suggests the possibility that individual variance of EGF expression may be associated with cervical cancer invasiveness. We also confirmed that there exists striking ethnic heterogeneity of EGF genotype between Caucasian and East Asian population

scholarly journals Expression of HIF-2αand VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Lixia Zhang ◽  
Qiang Chen ◽  
Jing Hu ◽  
Yue Chen ◽  
Chenglong Liu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Significance ◽  
Systemic Disease ◽  
Cervical Squamous Cell Carcinoma ◽  
Control Group ◽  
Vegf Mrna ◽  
Node Metastasis ◽  
Figo Staging ◽  
Vegf Mrna Expression

CSCC is a systemic disease involving polygenic alteration and multiple steps, and HIF and VEGF are closely associated with tumorigenesis. Specimens surgically resected from 64 cases of CSCC and 22 cases of normal cervical tissue were selected randomly to detect the expression of HIF-2αand VEGF in CSCC for exploring their clinical significance; information regarding the age, lymph node metastasis, and FIGO staging were collected as well; expression of HIF-2αand VEGF was detected by qPCR and immunohistochemistry. We found that the expression of HIF-2αand VEGF mRNA in CSCC was significantly higher than that of normal cervical tissues and showed a positive correlation between them. The positive rates of HIF-2αand VEGF protein expression in CSCC and normal cervical tissues were 93.8% and 18.2%, respectively, with correlation between them. The expression of both HIF-2αand VEGF mRNA did not relate closely to age but the FIGO staging and lymph node metastasis. Compared with the counterpart control group, CSCC tissues with high FIGO staging and lymph node metastasis had a higher level of HIF-2αand VEGF mRNA expression. So, HIF-2αand VEGF were overexpressed in CSCC, which has a great clinical significance for its diagnosis.

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