scholarly journals Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257752
Author(s):  
Jordi Aligué ◽  
Mireia Vicente ◽  
Anna Arnau ◽  
Jaume Trapé ◽  
Eva Martínez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Small Samples ◽  
Main Diagnosis ◽  
X Rays ◽  
Vital Status ◽  
Diagnostic Unit ◽  
Specific Symptoms ◽  
Involuntary Weight Loss ◽  
Tomography Scan ◽  
Overall Mortality

Background Numerous studies on involuntary weight loss (IWL) have been published since the 1980s, although most of them have included small samples of patients with specific symptoms. The aim of the present study was to determine the causes, demographic and clinical characteristics and mortality at 12 months in patients attended at a rapid diagnostic unit (RDU) for isolated IWL. Methods A single-center retrospective observational study including all patients presenting to the RDU for isolated IWL between 2005 and 2013. The following data were recorded: demographic and clinical variables, results of complementary tests (blood tests, x-rays, computed tomography scan and digestive endoscopy), main diagnosis and vital status at 12 months. Results Seven hundred and ninety-one patients met the criteria for IWL. Mean age was 67.9 years (SD 4.7), 50.4% were male and mean weight loss was 8.3 kg (SD 4.7). The cause for IWL was malignant disease in 23.6% of patients, non-malignant organic disease in 44.5%, psychiatric disorder in 29.0% and unknown in 3.2%. Overall mortality at 12 months was 18.6% (95%CI: 16.1–21.6). The mortality rate was highest in the group with malignancy (61.1%; 95%CI: 54.2–68.2). Conclusions Almost a quarter of all patients attended at the RDU for IWL were diagnosed with cancer. Mortality at 12 months was higher in this group than in the other three. Malignancy should therefore be ruled out during the first visit for patients attended for IWL.

Clinical evaluation for cancer in patients with involuntary weight loss without specific symptoms

2003 ◽  
Vol 114 (8) ◽  
pp. 631-637 ◽  
Author(s):  
José L Hernández ◽  
José A Riancho ◽  
Pedro Matorras ◽  
Jesús González-Macías
Keyword(s):  
Weight Loss ◽  
Clinical Evaluation ◽  
Specific Symptoms ◽  
Involuntary Weight Loss

scholarly journals Involuntary weight loss without specific symptoms: a clinical prediction score for malignant neoplasm

QJM ◽  
2003 ◽  
Vol 96 (9) ◽  
pp. 649-655 ◽  
Author(s):  
J.L. Hernandez ◽  
P. Matorras ◽  
J.A. Riancho ◽  
J. Gonzalez-Macias
Keyword(s):  
Weight Loss ◽  
Malignant Neoplasm ◽  
Prediction Score ◽  
Clinical Prediction ◽  
Specific Symptoms ◽  
Involuntary Weight Loss

scholarly journals Endograft connector technique to treat popliteal artery aneurysm in a morbid obese patient

Vascular ◽  
2014 ◽  
Vol 23 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Felice Pecoraro ◽  
Guido Bajardi ◽  
Ettore Dinoto ◽  
Gaetano Vitale ◽  
Mario Bellisi ◽  
...  
Keyword(s):  
Obese Patient ◽  
Popliteal Artery ◽  
Surgical Repair ◽  
Artery Aneurysm ◽  
X Rays ◽  
Dacron Graft ◽  
Popliteal Artery Aneurysm ◽  
Bypass Patency ◽  
Morbid Obese ◽  
Tomography Scan

Surgical repair of popliteal artery aneurysm in morbid obese patients poses additional challenges. We report a morbid obese patient who had a 59 mm right popliteal artery aneurysm which was successfully treated with the endograft connector technique. This technique was used to perform the distal anastomosis of the below-knee femoro-popliteal bypass. A 10 mm Dacron graft was used as a main graft bypass and an 11 mm/10 cm stentgraft as endograft connector. Following the respective tunnel of the Dacron graft, an end-to-side proximal anastomosis was performed at distal femoral artery. The aneurysm exclusion was obtained through a proximal and a distal ligation. Postoperative duplex showed adequate bypass patency. Knee x-rays demonstrated no signs of stent kinking/fractures. The postoperative course was uneventful and the patient was discharged home on fourth day post operative. The six-month computed tomography scan and the 12-month duplex control showed a patent bypass with no signs of stenosis.

scholarly journals Primary Pancreatic Echinococcosis: A Rare Cause of Pancreatic Cyst

2019 ◽  
pp. 1-8
Author(s):  
Rahul Khullar ◽  
Hirdaya Nag ◽  
Sundeep Saluja
Keyword(s):  
Hydatid Cyst ◽  
Pancreatic Cyst ◽  
Postgraduate Medical Education ◽  
Imaging Studies ◽  
Pain Abdomen ◽  
Post Operative Period ◽  
Primary Hydatid Cyst ◽  
Surgery Department ◽  
Specific Symptoms ◽  
Tomography Scan

Introduction: Primary Hydatid cyst of pancreas is a rare entity even in endemic countries. These cases usually present with non specific symptoms such as pain abdomen, vomiting or feeling of vague lump in abdomen. Presentation of Case: A 55 year old lady presented to GI surgery department, GB Pant institute of Postgraduate Medical Education and Research (GIPMER), India with complaints of lump in abdomen and pain abdomen which was evaluated with imaging studies (Computed tomography scan Abdomen and Magnetic resonance imaging Abdomen). Initially considered as cystic lesion pancreas, Endoscopic ultrasound (EUS) confirmed diagnosis of Hydatid cyst and patient underwent open deroofing and drainage of cyst with uneventful post operative period.

Alterations In Macronutrient ­Metabolism In Starvation And Disease

2018 ◽  
Author(s):  
L John Hoffer
Keyword(s):  
Weight Loss ◽  
Muscle Atrophy ◽  
Systemic Inflammation ◽  
Protein Energy Malnutrition ◽  
Metabolic Adaptation ◽  
Clinical Approach ◽  
Protein Energy ◽  
Key Words Adaptation ◽  
Disuse Muscle Atrophy ◽  
Involuntary Weight Loss

This review explains starvation as both a physiologic process and a disease. It includes a detailed explanation of the modifying effects of metabolic adaptation and systemic inflammation, as interpreted in a clinical context. It navigates the reader through the difficult shoals of vague and conflicting terminology that burden this topic and provides current definitions and nuanced explanations of the important but frequently misunderstood terms related to starvation and its modifiers and consequences. It provides a succinct explanation of the physiology of total fasting and its clinical correlates. Finally, it explains the interactions among starvation, sarcopenia, frailty, involuntary weight loss, systemic inflammation, cachexia, and disuse muscle atrophy. The multiple and interacting causes of generalized muscle atrophy are pointed out. Inadequate appreciation of these interactions can result in failure to diagnose and treat starvation-induced diseases. A clinical approach to involuntary weight loss is outlined.   This review contains 6 figures, 2 tables and 56 references Key words: adaptation, cachexia, frailty, hypoalbuminemia, inflammation, ketosis, kwashiorkor, malnutrition, marasmus, muscle atrophy, protein-energy malnutrition, sarcopenia, starvation, systemic inflammation, weight loss

scholarly journals Incidental finding of aberrant subclavian artery during computed tomography scan

2015 ◽  
Vol 3 (4) ◽  
pp. 162-164
Author(s):  
Mubarak Mohd Yusof ◽  
Sharini Shamsudin
Keyword(s):  
Computed Tomography ◽  
Weight Loss ◽  
Aortic Arch ◽  
Subclavian Artery ◽  
Left Subclavian Artery ◽  
Incidental Finding ◽  
Right Aortic Arch ◽  
Aberrant Right Subclavian Artery ◽  
Computed Tomography Scan ◽  
Tomography Scan

Two cases of aberrant subclavian arteries were detected incidentally during computed tomography scan of the thorax for other medical conditions. The patients did not have weight loss or dysphagia lusoria. The origin and course of theaberrant subclavian arteries are related to the anomaly of the aortic arch. The variations of aberrant right subclavian artery with left aortic arch and aberrant left subclavian artery with right aortic arch on computed tomography are discussed.Journal of Kathmandu Medical CollegeVol. 3, No. 4, Oct.-Dec., 2014Page: 162-164

scholarly journals Future developments for macromolecular crystallography at the CLS

2014 ◽  
Vol 70 (a1) ◽  
pp. C1737-C1737
Author(s):  
Pawel Grochulski ◽  
Miroslaw Cygler ◽  
Michel Fodje ◽  
Shaunivan Labiuk ◽  
James Gorin ◽  
...  
Keyword(s):  
High Efficiency ◽  
Single Photon ◽  
Temporal Stability ◽  
Small Samples ◽  
X Rays ◽  
Macromolecular Crystallography ◽  
Optical Elements ◽  
X Ray ◽  
Small Crystals ◽  
Reported Data

The Canadian Macromolecular Crystallography Facility (CMCF) at the Canadian Light Source (CLS) is a suite of fully automated beamlines, 08ID-1 and 08B1-1 [1]. It serves over 60 Canadian groups plus academic and commercial users in the US. Besides remote data collection, we offer Mail-In service where data are collected by CMCF staff. Beamline 08B1-1 has been in operation since 2011 and beamline 08ID-1 since 2006. When beamline 08ID-1 was designed, over 10 years ago, small crystals were defined as having sizes of 50-100 μm. Today, the most challenging experiments require more intense X-ray beams that can be focused to accommodate much smaller crystal sizes of less than 5 μm with flux on the order of 10^11 photons/s. To reach these stringent parameters, a new more powerful source of X-rays will be required, which will be provided by a longer small-gap in-vacuum undulator (SGU). To accommodate the higher power levels and to focus X-rays to a smaller focal spot with a high degree of spatial and temporal stability, the existing X-ray optical elements need to be upgraded. The remaining components of the project include a 5-axis alignment table for improving alignment of small samples with the microbeam, a high-efficiency robotic sample-changer and a single-photon X-ray detector. Several options for the new design will be discussed. These developments are consistent with the current direction of structural biology research at the CLS [2]. Since 2006 over 225 (240) papers and 400 (444) PDB deposits reported data collected at beamline 08ID-1. Parentheses indicate the total number for the CMCF. Many of these have been published in very high impact journals such as N. Engl. J. Med., Nature, Cell, Science, PNAS, among others (http://cmcf.lightsource.ca/publications/).

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