scholarly journals A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Covid?

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259533
Author(s):  
Sally Fowler-Davis ◽  
Katharine Platts ◽  
Michael Thelwell ◽  
Amie Woodward ◽  
Deborah Harrop
Keyword(s):  
Data Extraction ◽  
Complex Interventions ◽  
Behavioural Therapy ◽  
Medical Systems ◽  
Diverse Range ◽  
Fatigue Management ◽  
Home Based ◽  
Cognitive Behavioural ◽  
Fatigue Severity ◽  
Mean Differences

Objectives Fatigue syndromes have been widely observed following post-viral infection and are being recognised because of Covid19. Interventions used to treat and manage fatigue have been widely researched and this study aims to synthesise the literature associated with fatigue interventions to investigate the outcomes that may be applicable to ‘long Covid’. Method The study was registered with PROSPERO (CRD42020214209) in October 2020 and five electronic databases were searched. Papers were screened, critically appraised and data extracted from studies that reported outcomes of fatigue interventions for post-viral syndromes. The narrative synthesis includes statistical analysis associated with effectiveness and then identifies the characteristics of the interventions, including identification of transferable learning for the treatment of fatigue in long Covid. An expert panel supported critical appraisal and data synthesis. Results Over 7,000 research papers revealed a diverse range of interventions and fatigue outcome measures. Forty papers were selected for data extraction after final screening. The effectiveness of all interventions was assessed according to mean differences (MD) in measured fatigue severity between each experimental group and a control following the intervention, as well as standardised mean differences as an overall measure of effect size. Analyses identified a range of effects–from most effective MD -39.0 [95% CI -51.8 to -26.2] to least effective MD 42.28 [95% CI 33.23 to 51.34]–across a range of interventions implemented with people suffering varying levels of fatigue severity. Interventions were multimodal with a range of supportive therapeutic methods and varied in intensity and requirements of the participants. Those in western medical systems tended to be based on self- management and education principles (i.e., group cognitive behavioural therapy (CBT). Conclusion Findings suggest that the research is highly focussed on a narrow participant demographic and relatively few methods are effective in managing fatigue symptoms. Selected literature reported complex interventions using self-rating fatigue scales that report effect. Synthesis suggests that long Covid fatigue management may be beneficial when a) physical and psychological support, is delivered in groups where people can plan their functional response to fatigue; and b) where strengthening rather than endurance is used to prevent deconditioning; and c) where fatigue is regarded in the context of an individual’s lifestyle and home-based activities are used.

scholarly journals Effectiveness of cognitive behavioural therapy on quality of life in patients with prostate cancer after androgen deprivation therapy: a protocol for systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e049314
Author(s):  
Fan Yuan ◽  
Degui Chang ◽  
Mingyi Jing ◽  
Baohua Zhu ◽  
Yaodong You
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Side Effects ◽  
Cognitive Behavioural Therapy ◽  
Meta Analysis ◽  
Behavioural Therapy ◽  
Data Synthesis ◽  
Cognitive Behavioural ◽  
Mean Differences

IntroductionProstate cancer (PCa), as a malignant tumour with rapid development in recent years, significantly affects men’s health, work, life and economy. Androgen deprivation therapy (ADT) plays an important role in the treatment of PCa and can be used as a complementary therapy in the late stage of castration-resistant prostate cancer. Though ADT targeting PCa shows an effective therapeutic effect, the underlying side effects (cognitive disorder, hot flashes, a decrease in sexuality) cannot be ignored. At present, cognitive behavioural therapy (CBT) has been widely used for patients with PCa after ADT due to its confirmed efficacy, fewer side effects and lower economic burden. However, the effectiveness of CBT for patients with PCa after ADT is still controversial. Therefore, we will conduct a systematic review and meta-analysis of the effectiveness of CBT for patients with PCa after ADT.Methods and analysisLiteratures will be searched from establishment of the database to 31 May 2021 with the language restrictions of English and Chinese in eight online databases (PubMed, Embase, the Web of Science, Cochrane Library, VIP, CNKI, CBM, and WAN FANG). This study will include RCTs that performed CBT as the main method of the experimental group for patients with PCa after ADT. Two or more reviewers will independently conduct the selection of studies, data extraction and data analysis. The risk ratios with 95% CIs will be used to present the data synthesis result of dichotomous data, while weighted mean differences or standardised mean differences with 95% CIs will be used to present the data synthesis result of continuous data. Meanwhile, evidence quality of outcome will be assessed by using the Grading of Recommendations Assessment, Development and Evaluation method. Stata V.13.0 and Review Manager software V.5.3 will be used for analysis and synthesis.Ethics and disseminationThis protocol is a second study based on a completed randomised controlled study. Thus, ethical approval is not required, and no additional data are available.OSF registration numberDOI 10.17605/OSF.IO/FUVEA

Assessment, treatment and the importance of early intervention of childhood hoarding

2020 ◽  
Vol 45 (3) ◽  
pp. 145-152
Author(s):  
Davíð R. M. A. Højgaard ◽  
Gudmundur Skarphedinsson
Keyword(s):  
Behavioral Therapy ◽  
Contingency Management ◽  
Treatment Strategies ◽  
Behavioural Therapy ◽  
Assessment Tools ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Home Based ◽  
Cognitive Behavioural ◽  
General Data

Abstract Hoarding disorder (HD) is characterised by difficulties in discharging or parting with possessions irrespective of their actual value, urges to save and acquire new items and excessive clutter in living areas. There is an urgent need to advance the understanding of HD in child and adolescent populations. The aim of this paper is to cover the assessment, treatment strategies and tools currently available. In general, data on assessment of paediatric HD are scant. Only one psychometrically sound scale, the Child Savings Inventory, which is a parent-rated scale used to assess the severity of hoarding symptoms, was found. However, this scale is not sufficient to produce a diagnosis of HD. Regarding treatment, there was only a limited number of case studies suggesting the effectiveness of cognitive behavioural therapy that includes exposure to discarding and not collecting new items, using contingency management for exposure and oppositional behaviour, cognitive training and instructing parents to assist with home-based exposures. In conclusion, there is an urgent need for properly validated Diagnostic and Statistical Manual of Mental Disorders assessment tools, and we encourage practitioners and researchers to develop and test a Cognitive behavioral therapy (CBT) protocol for paediatric HD based on the aforementioned components.

scholarly journals A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
T. A. Kuut ◽  
F. Müller ◽  
A. Aldenkamp ◽  
E. Assmann-Schuilwerve ◽  
A. Braamse ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Behavioural Therapy ◽  
Cognitive Behavioural ◽  
Severe Fatigue ◽  
Trial Testing ◽  
Fatigue Severity ◽  
T1 And T2 ◽  
Randomised Controlled

Abstract Background Coronavirus disease 2019 (COVID-19) results in debilitating long-term symptoms, often referred to as Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), in a substantial subgroup of patients. One of the most prevalent symptoms following COVID-19 is severe fatigue. Prompt delivery of cognitive behavioural therapy (CBT), an evidence-based treatment that has shown benefit in reducing severe fatigue in other conditions, may reduce post-COVID-19 fatigue. Based on an existing CBT protocol, a blended intervention of 17 weeks, Fit after COVID, was developed to treat severe fatigue after the acute phase of infection with SARS-CoV-2. Method The ReCOVer study is a multicentre 2-arm randomised controlled trial (RCT) to test the efficacy of Fit after COVID on severe post-infectious fatigue. Participants are eligible if they report severe fatigue 3 up to and including 12 months following COVID-19. One hundred and fourteen participants will be randomised to either Fit after COVID or care as usual (ratio 1:1). The primary outcome, the fatigue severity subscale of the Checklist Individual Strength (CIS-fatigue), is assessed in both groups before randomisation (T0), directly post CBT or following care as usual (T1), and at follow-up 6 months after the second assessment (T2). In addition, a long-term follow-up (T3), 12 months after the second assessment, is performed in the CBT group only. The primary objective is to investigate whether CBT will lead to a significantly lower mean fatigue severity score measured with the CIS-fatigue across the first two follow-up assessments (T1 and T2) as compared to care as usual. Secondary objectives are to determine the proportion of participants no longer being severely fatigued (operationalised in different ways) at T1 and T2 and to investigate changes in physical and social functioning, in the number and severity of somatic symptoms and in problems concentrating across T1 and T2. Discussion This is the first trial testing a cognitive behavioural intervention targeting severe fatigue after COVID-19. If Fit after COVID is effective in reducing fatigue severity following COVID-19, this intervention could contribute to alleviating the long-term health consequences of COVID-19 by relieving one of its most prevalent and distressing long-term symptoms. Trial registration Netherlands Trial Register NL8947. Registered on 14 October 2020.

scholarly journals Testing non-inferiority of blended versus face-to-face Cognitive Behavioural Therapy for severe fatigue in patients with Multiple Sclerosis and the effectiveness of blended booster sessions aimed at improving long term outcome following both therapies: – study protocol for two observer-blinded randomized clinical trials

2019 ◽  
Author(s):  
Marieke Houniet- de Gier ◽  
Heleen Beckerman ◽  
Kimberley van Vliet ◽  
Hans Knoop ◽  
Vincent de Groot
Keyword(s):  
Clinical Trials ◽  
Behavioural Therapy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Face To Face ◽  
Cognitive Behavioural ◽  
End Of Treatment ◽  
Booster Sessions ◽  
Fatigue Severity

Abstract Background: Cognitive behavioural therapy (CBT) has been found effective in reducing fatigue severity in MS patients directly following treatment. However, long-term effects are inconsistent leaving room for improvement. In addition, individual face-to-face CBT draws heavily on limited treatment capacity, and the travel distance to the treatment centre can be burdensome for patients. Therefore, we developed “MS Fit”, a blended CBT for MS-related fatigue, based on a face-to-face CBT protocol found effective in a previous study, and “MS Stay Fit”, internet-based booster sessions to improve long term effectiveness of CBT for MS-related fatigue. This paper presents the protocol of two Randomised Clinical Trials (RCTs) conducted within one study investigating 1) the non-inferiority of MS Fit compared to evidence-based face-to-face CBT for MS-related fatigue, and 2) the effectiveness of MS Stay Fit on the long-term outcome of fatigue compared to no booster sessions. Methods/design: The first part of this study is an observer-blinded non-inferiority multicentre RCT, in which 166 severely fatigued MS patients will be randomized (1:1 ratio, computer-generated sequence) to either face-to-face CBT or blended CBT (MS Fit) for fatigue. The primary endpoint is at 20 weeks after baseline. After this post-treatment assessment, patients will be randomized again (1:1 ratio, computer generated sequence) to either MS Stay Fit consisting of 2 booster sessions at 2 and 4 months after end of treatment, or no booster sessions. The primary endpoint of the second study is 52 weeks after baseline. Primary outcome measure in both studies is fatigue severity assessed with the fatigue severity subscale of the Checklist Individual Strength (CIS20r). Outcomes will be assessed at baseline (T0), end of treatment (T20), after 39 and 52 weeks (T39 and T52). Discussion: If MS Fit is found to be non-inferior to face-to-face CBT it will improve the accessibility of this treatment. In addition, the study aims to test if it is possible to improve long-term effectiveness of CBT for MS-related fatigue with MS Stay Fit.

scholarly journals Effectiveness of cognitive–behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e025761 ◽  
Author(s):  
Beth Fordham ◽  
Thavapriya Sugavanam ◽  
Sally Hopewell ◽  
Karla Hemming ◽  
Jeremy Howick ◽  
...  
Keyword(s):  
Cognitive Behavioural Therapy ◽  
Systematic Reviews ◽  
Data Extraction ◽  
Well Being ◽  
Behavioural Therapy ◽  
Cochrane Library ◽  
Cognitive Behavioural ◽  
The Individual ◽  
Meta Analyses

IntroductionCognitive–behavioural therapy (CBT) is a psychological therapy that has been used to improve patient well-being across multiple mental and physical health problems. Its effectiveness has been examined in thousands of randomised control trials that have been synthesised into hundreds of systematic reviews. The aim of this overview is to map, synthesise and assess the reliability of evidence generated from these systematic reviews of the effectiveness of CBT across all health conditions, patient groups and settings.Methods and analysisWe will run our search strategy, to identify systematic reviews of CBT, within the Database of Abstracts of Reviews of Effects, the Cochrane Library of Systematic Reviews, MEDLINE, Embase, PsycInfo, CINAHL, Child Development and Adolescent Studies, and OpenGrey between January 1992 and 25 April 2018. Independent reviewers will sift, perform data extraction in duplicate and assess the quality of the reviews using the Assessing the Methodological Quality of Systematic Reviews (V.2) tool. The outcomes of interest include: health-related quality of life, depression, anxiety, psychosis and physical/physiological outcomes prioritised in the individual reviews. The evidence will be mapped and synthesised where appropriate by health problem, patient subgroups, intervention type, context and outcome.Ethics and disseminationEthical approval is not required as this is an overview of published systematic reviews. We plan to publish results in peer-reviewed journals and present at international and national academic, clinical and patient conferences.Trial registration numberCRD42017078690.

Brief Cognitive Behavioural Therapy with Male Adolescent Offenders in Open Custody or on Probation: An Evaluation of Management of Anger

1995 ◽  
Vol 76 (3) ◽  
pp. 1056-1058 ◽  
Author(s):  
Paul M. Valliant ◽  
Brent Jensen ◽  
Lynne Raven-Brook
Keyword(s):  
Cognitive Behavioural Therapy ◽  
Minnesota Multiphasic Personality Inventory ◽  
Self Esteem ◽  
Behavioural Therapy ◽  
Adolescent Male ◽  
Male Adolescent ◽  
Adolescent Offenders ◽  
Male Offenders ◽  
Cognitive Behavioural ◽  
Mean Differences

A 6-wk. cognitive behavioural program administered to 24 adolescent male offenders assigned to open custody and 5 to probation showed no mean differences on the Test of Nonverbal Intelligence, the Minnesota Multiphasic Personality Inventory, and the Coopersmith Self-esteem Inventory. Significant correlations were found for the personality measures with pretreatment and posttreatment scores on the Buss-Durkee Hostility Inventory.

Fatigue in Chronic Migraine Patients

Cephalalgia ◽  
2002 ◽  
Vol 22 (9) ◽  
pp. 720-724 ◽  
Author(s):  
MFP Peres ◽  
E Zukerman ◽  
WB Young ◽  
SD Silberstein
Keyword(s):  
Chronic Migraine ◽  
Exercise Program ◽  
Chronic Fatigue ◽  
Behavioural Therapy ◽  
Therapeutic Interventions ◽  
Common Symptom ◽  
Physical Fatigue ◽  
Fatigue Syndrome ◽  
Cognitive Behavioural ◽  
Fatigue Severity

Fatigue is a common symptom frequently reported in many disorders including headaches, but little is known about its nature. The objective was to determine the prevalence of fatigue in chronic migraine (CM) patients, to define its subtypes and its relationship with other conditions comorbid with CM. Sixty-three CM patients were analysed. The Fatigue Severity Scale (FSS), the Chalder fatigue scale and the CDC diagnostic criteria for chronic fatigue syndrome (CFS) were used. Fifty-three (84.1%) patients had FSS scores greater than 27. Forty-two (66.7%) patients met the CDC criteria for CFS. Thirty-two patients (50.8%) met the modified CDC criteria (without headache). Beck depression scores correlated with FSS, mental and physical fatigue scores. Trait anxiety scores also correlated with fatigue scales. Women had higher FSS scores than men, P < 0.05. Physical fatigue was associated with fibromyalgia, P < 0.05. Fatigue as a symptom and CFS as a disorder are both common in CM patients. Therapeutic interventions include a graded aerobic exercise program, cognitive behavioural therapy and antidepressants. Identification of fatigue and its subtypes in headache disorders and recognition of headaches in CFS patients has implications for the pathophysiology, diagnosis and treatment of these disorders.

scholarly journals Understanding eHealth Cognitive-Behavioural Therapy Targeting Sub-stance Use: A Realist Review (Preprint)

2020 ◽  
Author(s):  
Farhud Shams ◽  
James S.H. Wong ◽  
Mohammadali Nikoo ◽  
Ava Outadi ◽  
Ehsan Moazen-Zadeh ◽  
...  
Keyword(s):  
Substance Use ◽  
Cognitive Behavioural Therapy ◽  
Literature Search ◽  
Data Extraction ◽  
Realist Review ◽  
Behavioural Therapy ◽  
Future Research ◽  
Qualitative Evidence ◽  
Cognitive Behavioural ◽  
Growing Body

BACKGROUND There is a growing body of evidence on eHealth interventions that are targeting substance use disorders. Development and decision-making in eHealth has been challenging due to the lack of understanding of how programs work effectively. OBJECTIVE We conducted a realist review on literature of Electronic Health Cognitive-behavioural Therapy (eCBT) programs for substance use with the goal of answering the following realist question: “how do different eCBT interventions for substance use interact with different contexts to pro-duce certain outcomes?” METHODS A literature search of published and gray literature of all eHealth programs targeting substance use was conducted. After data extraction, the scope was refined to only include literature fo-cusing on eCBT programs targeting substance use. We synthesized the available qualitative evidence from the literature into Context-Mechanism-Outcome configurations in order to bet-ter understand when and how programs work. RESULTS A total of 54 papers studying 24 programs were reviewed. Our final results identified 8 Con-text-Mechanism-Outcome configurations from 5 unique programs that met criteria for rele-vance and rigor. CONCLUSIONS 5 strategies that may be applied in future eCBT programs for substance use are discussed and may contribute to a better understanding of mechanisms and ultimately help design more ef-fective solutions in the future. Future research on eHealth CBT programs should try and under-stand mechanisms of program strategies and how they lead to outcomes in different contexts.

scholarly journals Guidelines on treatment of perinatal depression with antidepressants: An international review

2018 ◽  
Vol 52 (4) ◽  
pp. 320-327 ◽  
Author(s):  
Nina M Molenaar ◽  
Astrid M Kamperman ◽  
Philip Boyce ◽  
Veerle Bergink
Keyword(s):  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Data Extraction ◽  
Severe Depression ◽  
Quality Criteria ◽  
Behavioural Therapy ◽  
Evaluation Instrument ◽  
Cognitive Behavioural ◽  
Perinatal Depressive Symptoms

Objective: Several countries have developed Clinical Practice Guidelines regarding treatment of perinatal depressive symptoms and perinatal use of antidepressant. We aimed to compare guidelines to guide clinicians in best clinical practice. Methods: An extensive search in guideline databases, MEDLINE and PsycINFO was performed. When no guidelines were (publicly) available online, we contacted psychiatric-, obstetric-, perinatal- and mood disorder societies of all first world countries and the five largest second world countries. Only Clinical Practice Guidelines adhering to quality criteria of the Appraisal of Guidelines for Research and Evaluation instrument and including a systematic review of evidence were included. Data extraction focussed on recommendations regarding continuation or withdrawal of antidepressants and preferred treatment in newly depressed patients. Results: Our initial search resulted in 1094 articles. After first screening, 40 full-text articles were screened. Of these, 24 were excluded for not being an official Clinical Practice Guidelines. In total, 16 Clinical Practice Guidelines were included originating from 12 countries. Eight guidelines were perinatal specific and eight were general guidelines. Conclusion: During pregnancy, four guidelines advise to continue antidepressants, while there is a lack of evidence supporting this recommendation. Five guidelines do not specifically advise or discourage continuation. For new episodes, guidelines agree on psychotherapy (especially cognitive behavioural therapy) as initial treatment for mild to moderate depression and antidepressants for severe depression, with a preference for sertraline. Paroxetine is not preferred treatment for new episodes but switching antidepressants for ongoing treatment is discouraged (three guidelines). If mothers use antidepressants, observation of the neonate is generally recommended and breastfeeding encouraged.

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