scholarly journals The utility of measures of anterior segment parameters of a Pentacam Scheimpflug tomographer in discriminating high myopic astigmatism from keratoconus

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260648
Author(s):  
Ebenezer Zaabaar ◽  
Samuel Kyei ◽  
Maame Ama Amamoah Parkson Brew ◽  
Samuel Bert Boadi-Kusi ◽  
Frank Assiamah ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Anterior Chamber ◽  
Operating Characteristic ◽  
Anterior Segment ◽  
Topographic Map ◽  
Significant Difference ◽  
Anterior Segment Parameters ◽  
Myopic Astigmatism ◽  
High Myopic Astigmatism ◽  
Receiver Operating

The study aimed to evaluate and compare anterior segment parameters between keratoconic eyes and eyes with high myopic astigmatism using Pentacam Scheimpflug tomography. This was a retrospective cross-sectional study that included sixty keratoconic eyes (thirty-two persons) and seventy-three eyes (forty-six persons) with high myopic astigmatism with mean ages 24.72 ± 11.65years and 26.60 ± 10.69years, respectively. Twenty-three parameters from the topographic map and fifteen parameters from the Belin-Ambrosió enhanced ectasia display map of the printouts of a Scheimpflug principle-based Pentacam tomographer were evaluated for their diagnostic accuracy using Receiver Operating Characteristic (ROC) curve. All parameters except cornea volume, anterior chamber volume, and anterior chamber angle indicated a significant difference between high myopic astigmatism and keratoconic eyes. The area under the receiver operating characteristic (AUROC) of eighteen Pentacam parameters was excellent (0.9–1.0) in discriminating keratoconus from high myopic astigmatism, out of which four {anterior minimum sagittal curvature (ant. Rmin), posterior minimum sagittal curvature (post. Rmin), maximum Ambrosió relational thickness (ART max) and total deviation value (D)} indicated excellent (>90%) sensitivity and specificity in addition to the excellent AUROC values. Topographic and Belin-Ambrosió enhanced ectasia display (BAD) maps of a Scheimpflug principle-based Pentacam tomographer are useful in enhancing the diagnosis of keratoconus and may also provide valuable information in effectively screening for keratoconus cases among refractive surgery candidates with high myopic astigmatism.

Predictive Performance and Variability of the Cardiac Anesthesia Risk Evaluation Score

2004 ◽  
Vol 100 (6) ◽  
pp. 1405-1410 ◽  
Author(s):  
Alexandre Ouattara ◽  
Michaëla Niculescu ◽  
Sarra Ghazouani ◽  
Ario Babolian ◽  
Marc Landi ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Risk Evaluation ◽  
Goodness Of Fit ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Predictive Performance ◽  
Cardiac Anesthesia ◽  
Goodness Of Fit Test ◽  
Significant Difference ◽  
Receiver Operating

Background The Cardiac Anesthesia Risk Evaluation (CARE) score, a simple Canadian classification for predicting outcome after cardiac surgery, was evaluated in 556 consecutive patients in Paris, France. The authors compared its performance to those of two multifactorial risk indexes (European System for Cardiac Operative Risk Evaluation [EuroSCORE] and Tu score) and tested its variability between groups of physicians (anesthesiologists, surgeons, and cardiologists). Methods Each patient was simultaneously assessed using the three scores by an attending anesthesiologist in the immediate preoperative period. In a blinded study, the CARE score category was also determined by a cardiologist the day before surgery, by a surgeon in the operating room, and by a second anesthesiologist at arrival in intensive care unit. Calibration and discrimination for predicting outcomes were assessed by goodness-of-fit test and area under the receiver operating characteristic curve, respectively. The level of agreement of the CARE scoring between the three physicians was then assessed. Results The calibration analysis revealed no significant difference between expected and observed outcomes for the three classifications. The areas under the receiver operating characteristic curves for mortality were 0.77 with the CARE score, 0.78 with the EuroSCORE, and 0.73 with the Tu score (not significant). The agreement rate of the CARE scoring between two anesthesiologists, between anesthesiologists and surgeons, and between anesthesiologists and cardiologists were 90%, 83%, and 77%, respectively. Conclusions Despite its simplicity, the CARE score predicts mortality and major morbidity as well the EuroSCORE. In addition, it remains devoid of significant variability when used by groups of physicians of different specialties.

scholarly journals Predicting 30-Day and 180-Day Mortality in Elderly Proximal Hip Fracture Patients: Evaluation of 4 Risk Prediction Scores at a Level I Trauma Center

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 497
Author(s):  
Arastoo Nia ◽  
Domenik Popp ◽  
Georg Thalmann ◽  
Fabian Greiner ◽  
Natasa Jeremic ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Risk Prediction ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Acs Nsqip ◽  
Significant Difference ◽  
Operating Characteristic Curve ◽  
Receiver Operating

This study evaluated the use of risk prediction models in estimating short- and mid-term mortality following proximal hip fracture in an elderly Austrian population. Data from 1101 patients who sustained a proximal hip fracture were retrospectively analyzed and applied to four models of interest: Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), Charlson Comorbidity Index, Portsmouth-POSSUM and the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP®) Risk Score. The performance of these models according to the risk prediction of short- and mid-term mortality was assessed with a receiver operating characteristic curve (ROC). The median age of participants was 83 years, and 69% were women. Six point one percent of patients were deceased by 30 days and 15.2% by 180 days postoperatively. There was no significant difference between the models; the ACS-NSQIP had the largest area under the receiver operating characteristic curve for within 30-day and 180-day mortality. Age, male gender, and hemoglobin (Hb) levels at admission <12.0 g/dL were identified as significant risk factors associated with a shorter time to death at 30 and 180 days postoperative (p < 0.001). Among the four scores, the ACS-NSQIP score could be best-suited clinically and showed the highest discriminative performance, although it was not specifically designed for the hip fracture population.

Scheimpflug Image-Based Changes in Anterior Segment Parameters during Accommodation Induced by Short-Term Reading

2016 ◽  
Vol 27 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Agnes Lipecz ◽  
Alexis Tsorbatzoglou ◽  
Ziad Hassan ◽  
Andras Berta ◽  
Laszlo Modis ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Anterior Segment ◽  
Short Term ◽  
Significant Difference ◽  
Corneal Volume ◽  
Before And After ◽  
Accommodation Process ◽  
Anterior Segment Parameters ◽  
Short Time ◽  
Segment Data

Purpose To analyze the effect of the accommodation on the anterior segment data (corneal and anterior chamber parameters) induced by short-time reading in a healthy, nonpresbyopic adult patient group. Methods Images of both eyes of nonpresbyopic volunteers were captured with a Scheimpflug device (Pentacam HR) in a nonaccommodative state. Fifteen minutes of reading followed and through fixation of the built-in target of Pentacam HR further accommodation was achieved and new images were captured by the device. Anterior segment parameters were observed and the differences were analyzed. Results Fifty-two healthy eyes of 26 subjects (range 20.04-28.58 years) were analyzed. No significant differences were observed in the keratometric values before and after the accommodative task (p = 0.35). A statistically significant difference was measured in the 5.0-mm-diameter and the 7.0-mm-diameter corneal volume (p = 0.01 and p = 0.03) between accommodation states. Corneal aberrometric data did not change significantly during short-term accommodation. Significant differences were observed between nonaccommodative and accommodative states of the eyes for all measured anterior chamber parameters. Conclusions Among the parameters of the cornea, only corneal volume changed during the short-term accommodation process, showing some fine changes with accommodation of the cornea in young, emmetropic patients. The position of the pupil and the anterior chamber parameters were observed to change with accommodation as captured by a Scheimpflug device.

Receiver Operating Characteristic Curve Analysis of Screening Tools for Bipolar Disorder Comorbid With ADHD in Schoolchildren

2015 ◽  
Vol 24 (10) ◽  
pp. 1403-1412 ◽  
Author(s):  
Mara L. Cordeiro ◽  
Antonio C. Farias ◽  
Peter C. Whybrow ◽  
Erico P. G. Felden ◽  
Alexandre Cunha ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Aggressive Behavior ◽  
Receiver Operating Characteristic ◽  
Child Behavior Checklist ◽  
Operating Characteristic ◽  
Rating Scale ◽  
Attention Problems ◽  
Screening Tools ◽  
Significant Difference ◽  
Receiver Operating

Objective: We compared Child Behavior Checklist (CBCL)-AAA (Attention Problems, Aggressive Behavior, and Anxious/Depressed) and Parent–Young Mania Rating Scale (P-YMRS) profiles in Brazilian children with ADHD, pediatric-onset bipolar disorder (PBD), and PBD + ADHD. Method: Following analyses of variance or Kruskal–Wallis tests with multiple-comparison Least Significant Difference (LSD) or Dunn’s Tests, thresholds were determined by Mann–Whitney U Tests and receiver operating characteristic (ROC) plots. Results: Relative to ADHD, PBD and PBD + ADHD groups scored higher on the Anxious/Depressed, Thought Problems, Rule-Breaking, and Aggressive Behavior subscales and Conduct/Delinquency Diagnostic Scale of the CBCL; all three had similar attention problems. The PBD and PBD + ADHD groups scored higher than the ADHD and healthy control (HC) groups on all CBCL problem scales. The AAA-profile ROC had good diagnostic prediction of PBD + ADHD. PBD and PBD-ADHD were associated with (similarly) elevated P-YMRS scores. Conclusion: The CBCL-PBD and P-YMRS can be used to screen for manic behavior and assist in differential diagnosis.

scholarly journals Optimization of a Portable Adenosine Triphosphate Bioluminescence Assay Coupled with a Receiver Operating Characteristic Model to Assess Bioaerosol Concentrations on Site

2020 ◽  
Vol 8 (7) ◽  
pp. 975
Author(s):  
Chun-Chieh Tseng ◽  
Yi-Chian Lu ◽  
Kai-Chih Chang ◽  
Chien-Che Hung
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Collection Efficiency ◽  
Characteristic Curve ◽  
Characteristic Model ◽  
Atp Assay ◽  
Significant Difference ◽  
Chamber Study ◽  
Bioluminescence Assay ◽  
Receiver Operating

Rapid monitoring of the microbial content in indoor air is an important issue. In this study, we develop a method for applying a Coriolis sampler coupled with a portable ATP luminometer for characterization of the collection efficiency of bioaerosol samplers and then test this approach in field applications. The biological collection efficiencies of the Coriolis sampler and a BioSampler for collecting four different types of bioaerosols, including Escherichia coli, Staphylococcus aureus, Candida famata and endospores of Bacillus subtilis, were compared in a chamber study. The results showed that the ATP assay may indicate the four microbes’ viability, and that their defined viabilities were positively correlated with their culturability. In addition, the optimal sampling conditions of the Coriolis sampler were a 200 L/min flow rate and a sampling time of 30 min. Under these conditions, there was no significant difference in sampling performance between the BioSampler and Coriolis sampler. In field applications, the best ATP benchmark that corresponded to culturable levels of < 500 CFU/m3 was 287 RLUs (sensitivity: 100%; specificity: 80%) for bacteria and 370 RLUs (sensitivity: 79%; specificity: 82%) for fungi according to receiver operating characteristic curve analysis. Consequently, an ATP criterion is recommended for indicating whether the corresponding airborne culturable concentrations of microbes meet those of published guidelines.

scholarly journals Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yuan Zong ◽  
Qian Xu ◽  
Chunhui Jiang ◽  
Haohao Zhu ◽  
Jian Yu ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Chinese Adults ◽  
Factors Associated ◽  
Chamber Volume ◽  
Significant Difference ◽  
Anterior Chamber Volume ◽  
Anterior Segment Parameters ◽  
Healthy Chinese

Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults.Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined.Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility. There was a significant difference between the horizontal and vertical anterior chamber widths (ACW) (P<0.05), with a mean difference of 390 μm. The ACV (mean153.83±32.42 mm3) was correlated with most of the anterior segment parameters, especially anterior chamber depth (ACD), which accounted for about 85% of the variation of ACV. Most of the anterior segment parameters were significantly correlated with age, and the relative changes in ACV and ACD were greatest in subjects aged 41–50 years.Conclusion. ACV was correlated with most of the anterior segment parameters measured in this study, particularly ACD. The relatively large difference between horizontal and vertical ACW suggests that the ACV could and should be measured using multiple OCT scans.

Ten highly sensitive thyrotropin assays compared by receiver-operating characteristic curves analysis: results of a prospective multicenter study.

1988 ◽  
Vol 34 (4) ◽  
pp. 691-695 ◽  
Author(s):  
B Thonnart ◽  
O Messian ◽  
N C Linhart ◽  
B Bok
Keyword(s):  
Receiver Operating Characteristic ◽  
Multicenter Study ◽  
Operating Characteristic ◽  
Free Triiodothyronine ◽  
Prospective Multicenter Study ◽  
Characteristic Curves ◽  
Receiver Operating Characteristic Curves ◽  
Highly Sensitive ◽  
Significant Difference ◽  
Receiver Operating

Abstract We report a prospective multicenter study, undertaken to compare the efficacy of 10 highly sensitive thyrotropin assay kits for the diagnosis of hyperthyroidism. Performances of the kits were compared with a reference diagnosis based on clinical examination, pertinent biological tests, and determination by an independent laboratory of the concentrations in serum of free triiodothyronine and free thyroxin. No thyrotropin determination was used in establishing this reference diagnosis. Receiver-operating characteristic curves were obtained for results from 600 patients (217 hyperthyroid and 383 euthyroid) by each kit. Even though analyses were performed out of the working range of most kits, the clinical correlation was nevertheless excellent. The best results corresponded to a sensitivity of 97.5% associated with a specificity of 96.1% and were significantly better than those obtained with all other kits. Results of this comparison depended greatly on the heterogeneity of the "normal"/"abnormal" categories. When only diffuse hyperthyroidism was considered, sensitivity and specificity were improved for all kits, and there was no significant difference among the five best kits.

scholarly journals Comparative Analysis of Anterior Segment Parameters in Normal and Keratoconus Eyes Generated by Scheimpflug Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Faik Orucoglu ◽  
Ebru Toker
Keyword(s):  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Sensitivity And Specificity ◽  
Operating Characteristic ◽  
Predictive Accuracy ◽  
Characteristic Curve ◽  
Anterior Segment ◽  
Area Under The Curve ◽  
Operating Characteristic Curve ◽  
Receiver Operating

Purpose. To assess and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconic and normal corneas with the Pentacam Scheimpflug corneal tomography and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes.Methods. The study included 656 keratoconus eyes and 515 healthy eyes with a mean age of30.95±9.25and32.90±14.78years, respectively. Forty parameters obtained from the Pentacam tomography were assessed by the receiver operating characteristic curve analysis for their efficiency.Results. Receiver operating characteristic curve analyses showed excellent predictive accuracy (area under the curve, ranging from 0.914 to 0.972) for 21 of the 40 parameters evaluated. Among all parameters indices of vertical asymmetry, keratoconus index, front elevation at thinnest location, back elevation at thinnest location, Ambrósio Relational Thickness (ARTmax), deviation of average pachymetric progression, deviation of ARTmax, and total deviation showed excellent (>90%) sensitivity and specificity in addition to excellent area under the receiver operating characteristic curve (AUROC).Conclusions. Parameters derived from the topometric and Belin-Ambrósio enhanced ectasia display maps very effectively discriminate keratoconus from normal corneas with excellent sensitivity and specificity.

Übereinstimmung von klinischer Diagnose, strukturierten Interviews und Selbstbeurteilungsfragebögen bei Depression im Kindes- und Jugendalter

2012 ◽  
Vol 40 (6) ◽  
pp. 405-414 ◽  
Author(s):  
Kathrin Dolle ◽  
Gerd Schulte-Körne ◽  
Nikolaus von Hofacker ◽  
Yonca Izat ◽  
Antje-Kathrin Allgaier
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Kinder Und Jugendliche ◽  
Prädiktive Werte ◽  
Receiver Operating

Fragestellung: Die vorliegende Studie untersucht die Übereinstimmung von strukturierten Kind- und Elterninterviews sowie dem klinischen Urteil bei der Diagnostik depressiver Episoden im Kindes- und Jugendalter. Zudem prüft sie, ob sich die Treffsicherheit und die optimalen Cut-off-Werte von Selbstbeurteilungsfragebögen in Referenz zu diesen verschiedenen Beurteilerperspektiven unterscheiden. Methodik: Mit 81 Kindern (9–12 Jahre) und 88 Jugendlichen (13–16 Jahre), die sich in kinder- und jugendpsychiatrischen Kliniken oder Praxen vorstellten, und ihren Eltern wurden strukturierte Kinder-DIPS-Interviews durchgeführt. Die Kinder füllten das Depressions-Inventar für Kinder und Jugendliche (DIKJ) aus, die Jugendlichen die Allgemeine Depressions-Skala in der Kurzform (ADS-K). Übereinstimmungen wurden mittels Kappa-Koeffizienten ermittelt. Optimale Cut-off-Werte, Sensitivität, Spezifität sowie positive und negative prädiktive Werte wurden anhand von Receiver operating characteristic (ROC) Kurven bestimmt. Ergebnisse: Die Interviews stimmten untereinander sowie mit dem klinischen Urteil niedrig bis mäßig überein. Depressive Episoden wurden häufiger nach klinischem Urteil als in den Interviews festgestellt. Cut-off-Werte und Validitätsmaße der Selbstbeurteilungsfragebögen variierten je nach Referenzstandard mit den schlechtesten Ergebnissen für das klinische Urteil. Schlussfolgerungen: Klinische Beurteiler könnten durch den Einsatz von strukturierten Interviews profitieren. Strategien für den Umgang mit diskrepanten Kind- und Elternangaben sollten empirisch geprüft und detailliert beschrieben werden.

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