scholarly journals A deep hybrid learning pipeline for accurate diagnosis of ovarian cancer based on nuclear morphology

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0261181
Author(s):  
Duhita Sengupta ◽  
Sk Nishan Ali ◽  
Aditya Bhattacharya ◽  
Joy Mustafi ◽  
Asima Mukhopadhyay ◽  
...  
Keyword(s):  
Machine Learning ◽  
Ovarian Cancer ◽  
Deep Learning ◽  
Cancer Cells ◽  
Hybrid Learning ◽  
Machine Learning Algorithms ◽  
Nuclear Shape ◽  
Machine Learning Techniques ◽  
Serous Carcinoma ◽  
Learning Techniques

Nuclear morphological features are potent determining factors for clinical diagnostic approaches adopted by pathologists to analyze the malignant potential of cancer cells. Considering the structural alteration of the nucleus in cancer cells, various groups have developed machine learning techniques based on variation in nuclear morphometric information like nuclear shape, size, nucleus-cytoplasm ratio and various non-parametric methods like deep learning have also been tested for analyzing immunohistochemistry images of tissue samples for diagnosing various cancers. We aim to correlate the morphometric features of the nucleus along with the distribution of nuclear lamin proteins with classical machine learning to differentiate between normal and ovarian cancer tissues. It has already been elucidated that in ovarian cancer, the extent of alteration in nuclear shape and morphology can modulate genetic changes and thus can be utilized to predict the outcome of low to a high form of serous carcinoma. In this work, we have performed exhaustive imaging of ovarian cancer versus normal tissue and developed a dual pipeline architecture that combines the matrices of morphometric parameters with deep learning techniques of auto feature extraction from pre-processed images. This novel Deep Hybrid Learning model, though derived from classical machine learning algorithms and standard CNN, showed a training and validation AUC score of 0.99 whereas the test AUC score turned out to be 1.00. The improved feature engineering enabled us to differentiate between cancerous and non-cancerous samples successfully from this pilot study.

scholarly journals Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL) For Accurate Diagnosis and Prognosis of Ovarian Cancer

2021 ◽  
Author(s):  
Duhita Sengupta ◽  
Sk Nishan Ali ◽  
Aditya Bhattacharya ◽  
Joy Mustafi ◽  
Asima Mukhopadhyay ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Morphological Changes ◽  
Hybrid Learning ◽  
Nuclear Shape ◽  
Machine Learning Techniques ◽  
Serous Carcinoma ◽  
Altered Expression ◽  
Diagnosis And Prognosis ◽  
Wide Range

Abstract Nuclear morphological features are potent determining factors for clinical diagnostic approaches adopted by pathologists to analyse the malignant potential of cancer cells. Considering the structural alteration of nucleus in cancer cells, various groups have developed machine learning techniques based on variation in nuclear morphometric information like nuclear shape, size, nucleus-cytoplasm ratio and various non-parametric methods like deep learning have also been tested for analysing immunohistochemistry images of tissue samples for diagnosing various cancers. Our aim is to study the morphometric distribution of nuclear lamin proteins as a specific parameter in ovarian cancer tissues. Besides being the principal mechanical component of the nucleus, lamins also present a platform for binding of proteins and chromatin thereby serving a wide range of nuclear functions like maintenance of genome stability, chromatin regulation. Altered expression of lamins in different subtypes of cancer is now evident from data across the world. It has already been elucidated that in ovarian cancer, extent of alteration in nuclear shape and morphology can determine degree of genetic changes and thus can be utilized to predict the outcome of low to high form of serous carcinoma. In this work, we have performed exhaustive imaging of ovarian cancer versus normal tissue and introduced a novel Deep Hybrid Learning approach on the basis of the distribution of lamin proteins. Although developed with ovarian cancer datasets in view, this architecture would be of immense importance in accurate and fast diagnosis and prognosis of all types of cancer associated with lamin induced morphological changes and would perform across small/medium to large datasets with equal efficiency.

scholarly journals Deep learning and model personalization in sensor-based human activity recognition

2022 ◽  
Author(s):  
Anna Ferrari ◽  
Daniela Micucci ◽  
Marco Mobilio ◽  
Paolo Napoletano
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Activity Recognition ◽  
Human Activity ◽  
Wearable Sensors ◽  
Human Activity Recognition ◽  
Population Diversity ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Learning Techniques

AbstractHuman activity recognition (HAR) is a line of research whose goal is to design and develop automatic techniques for recognizing activities of daily living (ADLs) using signals from sensors. HAR is an active research filed in response to the ever-increasing need to collect information remotely related to ADLs for diagnostic and therapeutic purposes. Traditionally, HAR used environmental or wearable sensors to acquire signals and relied on traditional machine-learning techniques to classify ADLs. In recent years, HAR is moving towards the use of both wearable devices (such as smartphones or fitness trackers, since they are daily used by people and they include reliable inertial sensors), and deep learning techniques (given the encouraging results obtained in the area of computer vision). One of the major challenges related to HAR is population diversity, which makes difficult traditional machine-learning algorithms to generalize. Recently, researchers successfully attempted to address the problem by proposing techniques based on personalization combined with traditional machine learning. To date, no effort has been directed at investigating the benefits that personalization can bring in deep learning techniques in the HAR domain. The goal of our research is to verify if personalization applied to both traditional and deep learning techniques can lead to better performance than classical approaches (i.e., without personalization). The experiments were conducted on three datasets that are extensively used in the literature and that contain metadata related to the subjects. AdaBoost is the technique chosen for traditional machine learning, while convolutional neural network is the one chosen for deep learning. These techniques have shown to offer good performance. Personalization considers both the physical characteristics of the subjects and the inertial signals generated by the subjects. Results suggest that personalization is most effective when applied to traditional machine-learning techniques rather than to deep learning ones. Moreover, results show that deep learning without personalization performs better than any other methods experimented in the paper in those cases where the number of training samples is high and samples are heterogeneous (i.e., they represent a wider spectrum of the population). This suggests that traditional deep learning can be more effective, provided you have a large and heterogeneous dataset, intrinsically modeling the population diversity in the training process.

scholarly journals Analysis On Deep Learning Approaches For Timely Detection Of Osteoarthritis

2021 ◽  
Vol 12 (3) ◽  
pp. 4396-4405
Author(s):  
R Kanthavel Et.al
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Elastic Tissue ◽  
Learning Approaches ◽  
X Rays ◽  
Imaging Analysis ◽  
Bone Injury ◽  
Learning Techniques

Osteoarthritis is mainly a familiar kind of arthritis when an elastic tissue named Cartilage that softens the tops of the bones, cracks down. The Person with osteoarthritis can encompass joint pain, inflexibility, or inflammation and there is no particular examination for osteoarthritis and physicians take the amalgamation of both medical cum clinical record and X-rays imaging analysis to make a diagnosis of the state. Osteoarthritis is generally only detected following ache and bone scratch and in advance, analysis could permit for ultimate involvement to avoid cartilage worsening and bone injury. Through machine-learning algorithms, the system can be trained to automatically distinguish among people who would develop osteoarthritis and persons who would not with the detection of exact biochemical variances in the midpoint of the knee’s cartilage. The outcome of the Machine learning Techniques will give the persons who are pre-symptomatic by the occasion of the baseline imaging and also the reduction in liquid concentration. In this study, we present the analysis of various deep learning techniques for timely detection of osteoarthritis disease. Several subsets of machine learning called deep learning techniques have been in use for the timely detection of osteoarthritis disease; and therefore analysis is needed highly to choose the best as far as accuracy and reliability are concerned.

Review on Various Machine Learning and Deep Learning Techniques for Prediction and Classification of Quotidian Datasets

2020 ◽  
pp. 296-323
Author(s):  
Anisha M. Lal ◽  
B. Koushik Reddy ◽  
Aju D.
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Learning Techniques ◽  
Supervised Methods ◽  
Regression Techniques

Machine learning can be defined as the ability of a computer to learn and solve a problem without being explicitly coded. The efficiency of the program increases with experience through the task specified. In traditional programming, the program and the input are specified to get the output, but in the case of machine learning, the targets and predictors are provided to the algorithm make the process trained. This chapter focuses on various machine learning techniques and their performance with commonly used datasets. A supervised learning algorithm consists of a target variable that is to be predicted from a given set of predictors. Using these established targets is a function that plots targets to a given set of predictors. The training process allows the system to train the unknown data and continues until the model achieves a desired level of accuracy on the training data. The supervised methods can be usually categorized as classification and regression. This chapter discourses some of the popular supervised machine learning algorithms and their performances using quotidian datasets. This chapter also discusses some of the non-linear regression techniques and some insights on deep learning with respect to object recognition.

scholarly journals Leveraging Deep Learning Techniques for Malaria Parasite Detection Using Mobile Application

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Mehedi Masud ◽  
Hesham Alhumyani ◽  
Sultan S. Alshamrani ◽  
Omar Cheikhrouhou ◽  
Saleh Ibrahim ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Mobile Application ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Stochastic Gradient Descent ◽  
Cognitive Computing ◽  
Human Errors ◽  
Learning Techniques

Malaria is a contagious disease that affects millions of lives every year. Traditional diagnosis of malaria in laboratory requires an experienced person and careful inspection to discriminate healthy and infected red blood cells (RBCs). It is also very time-consuming and may produce inaccurate reports due to human errors. Cognitive computing and deep learning algorithms simulate human intelligence to make better human decisions in applications like sentiment analysis, speech recognition, face detection, disease detection, and prediction. Due to the advancement of cognitive computing and machine learning techniques, they are now widely used to detect and predict early disease symptoms in healthcare field. With the early prediction results, healthcare professionals can provide better decisions for patient diagnosis and treatment. Machine learning algorithms also aid the humans to process huge and complex medical datasets and then analyze them into clinical insights. This paper looks for leveraging deep learning algorithms for detecting a deadly disease, malaria, for mobile healthcare solution of patients building an effective mobile system. The objective of this paper is to show how deep learning architecture such as convolutional neural network (CNN) which can be useful in real-time malaria detection effectively and accurately from input images and to reduce manual labor with a mobile application. To this end, we evaluate the performance of a custom CNN model using a cyclical stochastic gradient descent (SGD) optimizer with an automatic learning rate finder and obtain an accuracy of 97.30% in classifying healthy and infected cell images with a high degree of precision and sensitivity. This outcome of the paper will facilitate microscopy diagnosis of malaria to a mobile application so that reliability of the treatment and lack of medical expertise can be solved.

scholarly journals Music Signal Analysis: Regression Analysis

2021 ◽  
Author(s):  
V. N. Aditya Datta Chivukula ◽  
Sri Keshava Reddy Adupala
Keyword(s):  
Machine Learning ◽  
Regression Analysis ◽  
Deep Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Statistical Machine Learning ◽  
Ongoing Research ◽  
Music Signal ◽  
Learning Techniques

Machine learning techniques have become a vital part of every ongoing research in technical areas. In recent times the world has witnessed many beautiful applications of machine learning in a practical sense which amaze us in every aspect. This paper is all about whether we should always rely on deep learning techniques or is it really possible to overcome the performance of simple deep learning algorithms by simple statistical machine learning algorithms by understanding the application and processing the data so that it can help in increasing the performance of the algorithm by a notable amount. The paper mentions the importance of data pre-processing than that of the selection of the algorithm. It discusses the functions involving trigonometric, logarithmic, and exponential terms and also talks about functions that are purely trigonometric. Finally, we discuss regression analysis on music signals.

scholarly journals Automated Amharic News Categorization Using Deep Learning Models

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Demeke Endalie ◽  
Getamesay Haile
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Document Classification ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Language Resources ◽  
Data Set ◽  
Learning Techniques ◽  
Proposed Model

For decades, machine learning techniques have been used to process Amharic texts. The potential application of deep learning on Amharic document classification has not been exploited due to a lack of language resources. In this paper, we present a deep learning model for Amharic news document classification. The proposed model uses fastText to generate text vectors to represent semantic meaning of texts and solve the problem of traditional methods. The text vectors matrix is then fed into the embedding layer of a convolutional neural network (CNN), which automatically extracts features. We conduct experiments on a data set with six news categories, and our approach produced a classification accuracy of 93.79%. We compared our method to well-known machine learning algorithms such as support vector machine (SVM), multilayer perceptron (MLP), decision tree (DT), XGBoost (XGB), and random forest (RF) and achieved good results.

scholarly journals Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL): A novel architecture for accurate diagnosis/prognosis of Ovarian Cancer

2020 ◽  
Author(s):  
Duhita Sengupta ◽  
Sk Nishan Ali ◽  
Aditya Bhattacharya ◽  
Joy Mustafi ◽  
Asima Mukhopadhyay ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Deep Learning ◽  
Cancer Cells ◽  
Hybrid Learning ◽  
Nuclear Morphology ◽  
Learning Approach ◽  
Diagnosis And Prognosis ◽  
Learning Techniques ◽  
Wide Range ◽  
Cancer Tissues

AbstractNuclear morphological features are potent determining factors for clinical diagnostic approaches adopted by pathologists to analyse the malignant potential of cancer cells. Considering the structural alteration of nucleus in cancer cells, various groups have developed machine learning techniques based on variation in nuclear morphometric information like nuclear shape, size, nucleus-cytoplasm ratio and various non-parametric methods like deep learning have also been tested for analysing immunohistochemistry images of tissue samples for diagnosing various cancers. Our aim is to study the morphometric distribution of nuclear lamin proteins as a specific parameter in ovarian cancer tissues. Besides being the principal mechanical component of the nucleus, lamins also present a platform for binding of proteins and chromatin thereby serving a wide range of nuclear functions like maintenance of genome stability, chromatin regulation. Altered expression of lamins in different subtypes of cancer is now evident from data across the world. It has already been elucidated that in ovarian cancer, extent of alteration in nuclear shape and morphology can determine degree of genetic changes and thus can be utilized to predict the outcome of low to high form of serous carcinoma. In this work, we have performed exhaustive imaging of ovarian cancer versus normal tissue and introduced a novel Deep Hybrid Learning approach on the basis of the distribution of lamin proteins. Although developed with ovarian cancer datasets in view, this architecture would be of immense importance in accurate and fast diagnosis and prognosis of all types of cancer associated with lamin induced morphological changes and would perform across small/medium to large datasets with equal efficiency.Significance StatementWe have developed a novel Deep Hybrid Learning approach based on nuclear morphology to classify normal and ovarian cancer tissues with highest possible accuracy and speed. Ovarian cancer cells can be easily distinguished from their enlarged nuclear morphology as is evident from lamin A & B distribution pattern. This is the first report to invoke specific nuclear markers like lamin A & B instead of classical haematoxylin-eosin staining in an effort to build parametric datasets. Our approach has been shown to outperform the existing deep learning techniques in training and validation of datasets over a wide range. Therefore this method could be used as a robust model to predict malignant transformations of benign nuclei and thus be implemented in the diagnosis and prognosis of ovarian cancer in future. Most importantly, this method can be perceived as a generalized approach in the diagnosis for all types of cancer.

Using Machine Learning Algorithms on Prediction of Stock Price

2020 ◽  
Vol 12 (2) ◽  
pp. 84-99
Author(s):  
Li-Pang Chen
Keyword(s):  
Machine Learning ◽  
Stock Price ◽  
Short Term Memory ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Short Term ◽  
Learning Techniques ◽  
Historical Database ◽  
Long Short Term Memory

In this paper, we investigate analysis and prediction of the time-dependent data. We focus our attention on four different stocks are selected from Yahoo Finance historical database. To build up models and predict the future stock price, we consider three different machine learning techniques including Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN) and Support Vector Regression (SVR). By treating close price, open price, daily low, daily high, adjusted close price, and volume of trades as predictors in machine learning methods, it can be shown that the prediction accuracy is improved.

A Comparative Study of Different Machine Learning Algorithms for Disease Prediction

2017 ◽  
Vol 7 (7) ◽  
pp. 172
Author(s):  
Anantvir Singh Romana
Keyword(s):  
Machine Learning ◽  
Subsequent Treatment ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Disease Prediction ◽  
Classification Problems ◽  
Learning Techniques ◽  
Neural Network Classifiers ◽  
Diagnostic Detection

Accurate diagnostic detection of the disease in a patient is critical and may alter the subsequent treatment and increase the chances of survival rate. Machine learning techniques have been instrumental in disease detection and are currently being used in various classification problems due to their accurate prediction performance. Various techniques may provide different desired accuracies and it is therefore imperative to use the most suitable method which provides the best desired results. This research seeks to provide comparative analysis of Support Vector Machine, Naïve bayes, J48 Decision Tree and neural network classifiers breast cancer and diabetes datsets.

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