scholarly journals A 2-year longitudinal follow-up of quantitative assessment neck tics in Tourette’s syndrome

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261560
Author(s):  
Yosuke Eriguchi ◽  
Xiaoxue Gu ◽  
Naoto Aoki ◽  
Maiko Nonaka ◽  
Ryunosuke Goto ◽  
...  
Keyword(s):  
Clinical Course ◽  
Angular Acceleration ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Single Measure ◽  
Individual Level ◽  
Severity Scores ◽  
Motor Tics ◽  
The Individual

Background Neck motor tics in Tourette’s syndrome can cause severe neck complications. Although addressed in a few longitudinal studies, the clinical course of Tourette’s syndrome has not been quantitatively assessed. We had previously developed a method for quantifying the angular movements of neck tics using a compact gyroscope. Here, we present a follow-up study aimed at elucidating the clinical course of neck tics at both the group and individual levels. Methods Eleven patients with Tourette’s syndrome from our previous study participated in the present study, and their neck tics were recorded during a 5-min observation period. The severity of neck symptoms was assessed using the Yale Global Tic Severity Scale. The peak angular velocities and accelerations, tic counts, and severity scores in our previous study (baseline) and the present study (2-year follow-up) were compared at the group and individual levels. The individual level consistency between baseline and follow-up were calculated using intra-class correlation coefficients (ICCs, one-way random, single measure). Results At the group level, no significant change was observed between baseline and follow-up. At the individual level, angular velocity (ICC 0.73) and YGTSS scores (ICC 0.75) had substantial consistency over the two time points, and angular acceleration (ICC 0.59) and tic counts (ICC 0.69) had moderate consistency. Conclusions The intensity and frequency of neck tics did not change over time. Therefore, quantification of angular neck motor tics will aid in identifying patients with neck tics at high risk for severe neck complications.

scholarly journals Drug Use Changes at the Individual Level: Results from a Longitudinal, Multisite Survey in Young Europeans Frequenting the Nightlife Scene

2021 ◽  
pp. 1-6
Author(s):  
Meryem Grabski ◽  
Jon Waldron ◽  
Tom P. Freeman ◽  
Claire Mokrysz ◽  
Ruben J.J. van Beek ◽  
...  
Keyword(s):  
Drug Use ◽  
Online Survey ◽  
Prescription Opioids ◽  
Alkyl Nitrates ◽  
Cross Sectional ◽  
Individual Level ◽  
The Past ◽  
Frequency Of Use ◽  
The Individual

<b><i>Background:</i></b> Monitoring emerging trends in the increasingly dynamic European drug market is vital; however, information on change at the individual level is scarce. In the current study, we investigated changes in drug use over 12 months in European nightlife attendees. <b><i>Method:</i></b> In this longitudinal online survey, changes in substances used, use frequency in continued users, and relative initiation of use at follow-up were assessed for 20 different substances. To take part, participants had to be aged 18–34 years; be from Belgium, Italy, the Netherlands, Sweden, or the UK; and have attended at least 6 electronic music events in the past 12 months at baseline. Of 8,045 volunteers at baseline, 2,897 completed the survey at both time points (36% follow-up rate), in 2017 and 2018. <b><i>Results:</i></b> The number of people using ketamine increased by 21% (<i>p</i> &#x3c; 0.001), and logarithmized frequency of use in those continuing use increased by 15% (<i>p</i> &#x3c; 0.001; 95% CI: 0.07–0.23). 4-Fluoroamphetamine use decreased by 27% (<i>p</i> &#x3c; 0.001), and logarithmized frequency of use in continuing users decreased by 15% (<i>p</i> &#x3c; 0.001, 95% CI: −0.48 to −0.23). The drugs with the greatest proportion of relative initiation at follow-up were synthetic cannabinoids (73%, <i>N</i> = 30), mephedrone (44%, <i>N</i> = 18), alkyl nitrites (42%, <i>N</i> = 147), synthetic dissociatives (41%, <i>N</i> = 15), and prescription opioids (40%, <i>N</i> = 48). <b><i>Conclusions:</i></b> In this European nightlife sample, ketamine was found to have the biggest increase in the past 12 months, which occurred alongside an increase in frequency of use in continuing users. The patterns of uptake and discontinuation of alkyl nitrates, novel psychoactive substances, and prescription opioids provide new information that has not been captured by existing cross-sectional surveys. These findings demonstrate the importance of longitudinal assessments of drug use and highlight the dynamic nature of the European drug landscape.

scholarly journals Motor, Behavioral and Pharmacologic Findings in Tourette's Syndrome

1987 ◽  
Vol 14 (S3) ◽  
pp. 541-546 ◽  
Author(s):  
Joseph Jankovic ◽  
Haydee Rohaidy
Keyword(s):  
Family Member ◽  
Sleep Disturbances ◽  
Age Of Onset ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Duration Of Symptoms ◽  
Female Ratio ◽  
Motor Tics ◽  
Vocal Tics

ABSTRACT:We studied 112 patients with Tourette's syndrome (TS); the male-to-female ratio was 3.8, the mean age of onset was 7.3 years, and the average duration of symptoms prior to the initial evaluation was 15.2 years. Seventy-nine percent of the patients had at least one family member with motor or vocal tics, and an additional 10 percent had a family member with marked obsessive-compulsive behavior. Simple motor tics occurred as the presenting symptom in about one-third of patients; one-third had multiple motor tics at the onset, and another third started with vocal tics. During the course of the illness all patients developed multifocal motor tics and 86 percent had vocal tics. Verbal and mental coprolalia was present in 44 percent of the patients. Copropraxia was seen in 19 percent of patients, and both coprolalia and copropraxia were more frequent among the males than expected. Attentional deficit disorder was diagnosed in 36 percent of the patients and 32 percent had obsessive-compulsive personality. Sleep disturbances were reported by 62 percent of the patients and polysomnography in 34 patients showed motor and vocal tics during all stages of sleep, sleep apnea, abnormal arousal pattern, and other sleep disturbances. Patients with mild symptoms improved with clonidine or clonazepam, but those with more advanced disorder required fluphenazine, pimozide, haloperidol or tetrabenazine.

Individual Components of Three Inequality Measures for Analyzing Shapes of Inequality

2019 ◽  
pp. 004912411987596
Author(s):  
Tim Futing Liao
Keyword(s):  
Sociological Research ◽  
Aggregate Level ◽  
Current Population Survey Data ◽  
Single Measure ◽  
Generalized Entropy ◽  
Individual Level ◽  
Inequality Measures ◽  
Entropy Measures ◽  
Individual Contributions ◽  
The Individual

In common sociological research, income inequality is measured only at the aggregate level. The main purpose of this article is to demonstrate that there is more than meets the eye when inequality is indicated by a single measure. In this article, I introduce an alternative method that evaluates individuals’ contributions to inequality as well as the between-group and within-group components of these individual contributions. I first highlight three common inequality measures, the Gini index and two generalized entropy measures—Theil’s T and Theil’s L indices—by presenting their individual components as a method for evaluating inequality. Five artificial data examples illustrate the use of these individual components first. An empirical analysis of the 2007 and 2017 Current Population Survey data then focuses on the differences in inequality revealed by such individual inequality components between the 2007 and 2017. The individual-level inequality measures can reveal patterns of inequality concealed by single measures at the aggregate level. In particular, the Gini individual measures differentiate cases better than the generalized entropy measures and tend to have smaller standard errors in a regression analysis.

scholarly journals Cognition, Emotion and Behavior in Children with Tourette’s Syndrome and Children with ADHD-Combined Subtype—A Two-Year Follow-Up Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144874 ◽  
Author(s):  
Kjell Tore Hovik ◽  
Kerstin J. Plessen ◽  
Andrea E. Cavanna ◽  
Erik Winther Skogli ◽  
Per Normann Andersen ◽  
...  
Keyword(s):  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Children With Adhd ◽  
Follow Up Study ◽  
Subtype A ◽  
And Behavior ◽  
Combined Subtype

Tics and Gilles de la Tourette's Syndrome: A Follow-up Study and Critical Review

1969 ◽  
Vol 115 (528) ◽  
pp. 1229-1241 ◽  
Author(s):  
J. A. Corbett ◽  
A. M. Mathews ◽  
P. H. Connell ◽  
D. A. Shapiro
Keyword(s):  
Emotional Disturbance ◽  
Critical Review ◽  
Adult Life ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Child Psychiatrist ◽  
Follow Up Study ◽  
History Of ◽  
Accompanying Symptoms

Tics or habit spasms have been described in various ways, but perhaps the most useful definition is that of Kanner (1937) that they are “quick, sudden and frequently repeated movements of circumscribed groups of muscles, serving no apparent purpose”. Children with this symptom not infrequently present to the paediatrician or child psychiatrist with accompanying symptoms of emotional disturbance, and by the age of seven years approximately five per cent of children have a history of such movements (Kellmer Pringle et al., 1967). Less commonly, adolescents who have suffered with tics from an earlier age develop vocal tics and coprolalia (compulsive swearing) symptomatic of Gilles de la Tourette's syndrome. Tiqueurs are rarely seen for treatment in adult life, except in a few well-documented cases where Gilles de la Tourette's syndrome persists (Fernando 1967).

Progression-free survival (PFS) as surrogate endpoint for overall survival (OS) in clinical trials of HER2-targeted agents in HER2-positive metastatic breast cancer (MBC): An individual patient data (IPD) analysis.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 610-610 ◽  
Author(s):  
Stefan Michiels ◽  
Lina Pugliano ◽  
Delphine Grun ◽  
Jana Barinoff ◽  
David A. Cameron ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Effects ◽  
Randomized Clinical Trials ◽  
Metastatic Breast ◽  
Targeted Agents ◽  
First Line ◽  
Her2 Positive ◽  
Individual Level ◽  
The Individual

610 Background: The gold standard endpoint in randomized clinical trials (RCTs) in MBC is OS, which has the disadvantage of requiring extended follow-up and being confounded by subsequent anti-cancer therapies. Although therapeutics have been approved based on PFS, its use as a primary endpoint is controversial. This study, the first IPD meta-analysis of targeted agents in MBC, aimed to collect data from RCTs of HER2-targeted agents in HER2+ MBC, assessing to what extent PFS correlates with, and may be used as, a surrogate for OS. Methods: A search was conducted in April 2011. Eligible RCTs accrued HER2+ MBC patients (pts) in 1992-2008. Collaboration was obtained from industrial partners (Roche, GSK) for industry-led studies. Investigator-assessed PFS was defined as the time from randomization to clinical or radiological progression, or death. A correlation approach was used: at the individual level, to estimate the association between PFS and OS using a bivariate survival model and at the trial level, to estimate the association between treatment effects on PFS and OS. Squared correlation values close to 1.0 would indicate strong surrogacy. Results: The search strategy resulted in 2137 eligible pts in 13 RCTs testing trastuzumab or lapatinib. We collected IPD data from 1963 pts in 9 RCTs. One phase II RCT did not have sufficient follow-up data so that 1839 pts in 8 RCTs were retained (5 evaluating trastuzumab, 3 lapatinib); 6 out of 8 RCTs were first-line. At the individual level, the Spearman rank correlation using Hougaard copula was equal to r=0.66 (95% CI 0.65 to 0.66) corresponding to an r2 of 0.42. At the trial level, the squared correlation between treatment effects on PFS and OS was provided by R2=0.33 (95% CI -0.22 to 0.86) using Hougaard copula and R2=0.53 (95% CI 0.22 to 0.83) using log hazard ratios from Cox models. Conclusions: In RCTs of HER2-targeted agents in HER2+ MBC, PFS is moderately correlated with OS and treatment effects on PFS are modestly correlated with treatment effects on OS, similarly to first-line chemotherapy in MBC (Burzykowski et al JCO 2008). PFS does not completely substitute for OS.

scholarly journals Analysis of co-authorship patterns at the individual level

2014 ◽  
Vol 26 (3) ◽  
pp. 229-238 ◽  
Author(s):  
Wolfgang Glänzel
Keyword(s):  
Research Collaboration ◽  
Citation Impact ◽  
Career Mobility ◽  
Individual Level ◽  
Utmost Care ◽  
Performance Profiles ◽  
And Performance ◽  
The Individual ◽  
New Applications

Publication activity, citation impact and communication patterns, in general, change in the course of a scientist's career. Mobility and radical changes in a scientist's research environment or profile are among the most spectacular factors that have effect on individual collaboration patterns. Although bibliometrics at this level should be applied with the utmost care, characteristic patterns of an individual scientist's research collaboration and changes in these in the course of a career can be well depicted using bibliometric methods. A wide variety of indicators and network tools are chosen to follow up the evolution and to visualise and to quantify collaboration and performance profiles of individual researchers. These methods are, however, designed to supplement expert-opinion based assessment and other qualitative assessments, and should not be used as stand-alone evaluation tools. This study presents part of the results published in an earlier study by Zhang and Glänzel (2012)4 as well as new applications of these methods.

scholarly journals A Bifactor Model of Subjective Well-Being at Personal, Community, and Country Levels: A Case With Three Latin-American Countries

2021 ◽  
Vol 12 ◽  
Author(s):  
Javier Torres-Vallejos ◽  
Joel Juarros-Basterretxea ◽  
Juan Carlos Oyanedel ◽  
Masatoshi Sato
Keyword(s):  
Latin American ◽  
Well Being ◽  
Bifactor Model ◽  
General Factor ◽  
Subjective Well Being ◽  
Specific Level ◽  
Single Measure ◽  
Individual Level ◽  
The Individual ◽  
Latin American Countries

Improving citizens' subjective well-being (SWB) has become an increasingly visible policy goal across industrialized countries. Although an increasing number of studies have investigated SWB at the individual level, little is known about subjective evaluation at social levels, such as the community and national levels. While the relationships between these levels have been analyzed in previous research, these assessments, which are part of the same unique construct of SWB, are under-investigated. The purpose of this study was to examine the dimensionality and reliability of a single measure of SWB, which contained individual, community, and national levels across three Latin-American countries (Argentina, Chile, and Venezuela), using a bifactor model analysis. Findings showed that the bifactor model exhibited a good fit to the data for the three countries. However, invariance testing between countries was not fully supported because of each item's specific contribution to both specific and general constructs. The analyses of each country showed that the SWB construct was in a gray area between unidimensionality and multidimensionality; some factors contributed more to the general factor and others to the specific level, depending on the country. These findings call for integrating more distant levels (community and country levels) into the understanding of SWB at the individual level, as they contribute not only to an overall construct, but they make unique contributions to SWB, which must be considered in public policy making.

Hereditary Agoraphobia and Obsessive-Compulsive Behaviour in Relatives of Patients with Gilles de la Tourette's Syndrome

1987 ◽  
Vol 151 (2) ◽  
pp. 195-199 ◽  
Author(s):  
D. E. Comings ◽  
B. G. Comings
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Panic Attacks ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genetic Subtypes ◽  
Compulsive Behaviour ◽  
Motor Tics ◽  
Vocal Tics

We present 11 pedigrees in which a propositus with Gilles de la Tourette's syndrome had first or second-degree relatives with obsessive-compulsive behaviour or agoraphobia with panic attacks, but only partially expressed the TS gene (i.e. had only motor tics or vocal tics, or neither). Of 90 females over the age of 18 presenting with TS, or with motor or vocal tics alone, nine had severe agoraphobia with panic attacks. There may be genetic subtypes of both obsessive-compulsive disorder and agoraphobia with panic attacks that are due to partial expression of the TS gene.

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