scholarly journals Independent effect of gestational weight gain and prepregnancy obesity on pregnancy outcomes among Saudi women: A sub-cohort analysis from Riyadh mother and baby cohort study (RAHMA)

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262437
Author(s):  
Amel Fayed ◽  
Hayfaa A. Wahabi ◽  
Samia Esmaeil ◽  
Roaa Elkouny ◽  
Hala Elmorshedy ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Pregnancy Outcomes ◽  
Cohort Analysis ◽  
Adverse Outcomes ◽  
Independent Effect ◽  
Gestational Weight ◽  
Increased Risk ◽  
Prepregnancy Obesity

Background Gestational weight gain (GWG) and prepregnancy obesity are garnering more attention as determining factors of pregnancy outcomes when it comes to the wellbeing of both the mother and her baby. This study was conducted to describe the pattern of GWG among participants of Riyadh Mother and Baby Multicenter Cohort Study (RAHMA) and to investigate the detrimental effects of excessive GWG and prepregnancy obesity on pregnancy outcomes. Methods RAHMA is a multicentre cohort study conducted in three hospitals in Riyadh, Saudi Arabia. Participants were categorized according to the Institute of Medicine into inadequate, adequate, and excessive GWG, and stratified by body mass index (BMI) into under/normal weight, overweight, and obese. To examine the independent effect of maternal prepregnancy obesity and GWG, a multivariate regression model was used and adjusted odds ratio (AOR) and 95% Confidence Interval (CI) for each outcome were calculated. Results A total of 7029 participants were included in this study; 31.8% had adequate GWG, 25.9% had excessive GWG and 42.3% had inadequate GWG, while 29.7% had normal BMI, 33.3% were overweight, 34.8% were obese, and 2.2% were underweight. Excessive GWG was independently associated with increased risk of hypertensive events, (AOR = 1.77, 95% CI 1.20–2.63). Obesity was associated with higher risk of gestational diabetes (AOR 2.11, 95% CI 1.76–2.53), hypertensive events (AOR 2.06, 95% CI 1.48–3.01), and delivery by emergency caesarean section (AOR = 1.63, 95% CI 1.35–1.97). Infants of obese women had increased odds of macrosomia (AOR 3.11, 95% CI 1.94–4.99) and lower odds of low birth weight (AOR = 0.68, 95% CI 0.53–0.88). Conclusion In comparison to excessive GWG, which increases the risk of hypertensive events during pregnancy, prepregnancy obesity is associated with more adverse outcomes including GDM, hypertensive events in pregnancy and emergency CS.

Obesity as a Predictor of Delayed Lactogenesis II

2017 ◽  
Vol 33 (4) ◽  
pp. 684-691 ◽  
Author(s):  
Irma Preusting ◽  
Jessica Brumley ◽  
Linda Odibo ◽  
Diane L. Spatz ◽  
Judette M. Louis
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Singleton Pregnancy ◽  
Targeted Interventions ◽  
Gestational Weight ◽  
Prepregnancy Bmi ◽  
Increased Risk ◽  
Prepregnancy Obesity ◽  
Observational Cohort ◽  
Breastfeeding Cessation

Background: Lactogenesis II is the onset of copious milk production. A delay in this has been associated with an increased risk of formula supplementation and early cessation of breastfeeding. Prepregnancy obesity has also been associated with decreased breastfeeding rates and early cessation. Research aim: This study aimed to evaluate the effect of prepregnancy obesity on self-reported delayed lactogenesis II. Methods: We conducted a prospective observational cohort study of 216 women with a singleton pregnancy and who planned to breastfeed. We compared the onset of lactogenesis II between women with a body mass index (BMI) < 30 kg/m2 and women with a BMI ≥ 30 kg/m2. Using multivariate logistic regression analyses, we assessed the relationship between maternal BMI and delay of lactogenesis II. Results: The prevalence of delayed lactogenesis II among women with prepregnancy BMI < 30 kg/m2 and BMI ≥ 30 kg/m2 was 46.4% and 57.9%, respectively. Delayed lactogenesis II occurred more frequently among women who were obese at the time of delivery ( p < .05). After controlling for the covariates, age, prepregnancy BMI, and gestational weight gain were positively associated with delayed lactogenesis II. Conclusion: Prepregnancy obesity and excessive gestational weight gain are associated with an increased risk of delayed lactogenesis II. Women who are at risk for delay in lactogenesis II and early breastfeeding cessation will need targeted interventions and support for them to achieve their personal breastfeeding goals.

scholarly journals Interaction Between Pre-pregnancy Body Mass Index and Gestational Weight Gain to Newborn Outcomes: Results From the VDPM Cohort Study in Indonesia

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 770-770
Author(s):  
Dyah Ayu Larasati Kisworo Putri ◽  
Nur Indrawaty Lipoeto ◽  
Arif Sabta Aji
Keyword(s):  
Body Mass Index ◽  
Cohort Study ◽  
Weight Gain ◽  
Birth Weight ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Head Circumference ◽  
Pregnancy Outcomes ◽  
Gestational Weight ◽  
Newborn Outcomes

Abstract Objectives The aim of this study was to analyze the interaction between pre-pregnancy body mass index (PP BMI), gestational weight gain (GWG), and newborn outcomes among pregnant mothers in West Sumatera, Indonesia. Methods This VDPM cohort study was conducted from September 2017 to March 2018 in West Sumatra, Indonesia. We obtained 195 healthy mother-infant pairs. GWG status created by comparing PP BMI and GWG guidelines based on the World Health Organization (WHO). Newborn birth weight, birth length, and head circumference were taken immediately after delivery as pregnancy outcomes. SPSS version 20.0 was used to analyze bivariate and multivariate analysis to assess the interaction between PP BMI and gestational weight gain in pregnancy outcomes with adjusting potential confounders. A P-value less than 0.05 was considered as a significant association. Results Of the 195 mother-infant pairs (Mean 29.66 years) included in the main sample, Most of the mothers had 46.7% normal PP BMI with most of them had an inadequate GWG status during pregnancy with 53.3%. Adequate and excessive GWG statuses were 34.4% and 12.3%, respectively. There was a significant association between PP BMI and GWG (p &lt; 0.01). This study had no interaction between PP BMI and GWG to the newborn outcomes (p &gt; 0.05). Adverse newborn outcomes were not statistically significant among groups. However, mothers who had inadequate GWG status may have significant lower birth weight and head circumference compared to normal and excessive GWG status (p &lt; 0.05). Conclusions This study had no interaction between PP BMI and GWG status to newborn outcomes. However, the GWG status associated with newborn outcomes in birth weight and head circumference level. Further prospective studies with a larger number are required to confirm this finding. Funding Sources Indonesian Danone Institute Foundation.

Association between Gestational Weight Gain Adequacy and Adverse Maternal and Neonatal Outcomes

2018 ◽  
Vol 36 (06) ◽  
pp. 615-623 ◽  
Author(s):  
Han-Yang Chen ◽  
Suneet Chauhan
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Neonatal Morbidity ◽  
Error Variance ◽  
Normal Weight ◽  
Adverse Outcomes ◽  
Live Births ◽  
Gestational Weight ◽  
Increased Risk ◽  
Regression Adjustment

Objectives To estimate the prevalence of gestational weight gain (GWG) adequacy according to the 2009 guidelines, and to examine the association between GWG adequacy and the adverse outcomes, stratified by prepregnancy body mass index (BMI). Study Design A retrospective cohort study, using the 2011 to 2013 U.S. linked birth/infant death datasets, restricted to nonanomalous singleton live births at 37 to 41 weeks. The adverse outcomes included composite maternal morbidity (CMM), composite neonatal morbidity (CNM), and neonatal and infant mortalities. We used multivariable Poisson's regression models with robust error variance to examine the association between GWG adequacy and adverse outcomes. Results Of 8,656,791 singleton live births, 20, 32, and 48% had inadequate, adequate, and excessive GWG, respectively. After multivariable regression adjustment, compared with adequate GWG, excessive GWG had 1.10 (1.08–1.13) and 1.12 (1.10–1.14) times higher risk of CMM and CNM, respectively; similar findings were observed in BMI subgroups. Compared with adequate GWG, inadequate GWG had 1.14 (1.03–1.26) and 1.12 (1.07–1.18) times higher risk of neonatal and infant mortalities, respectively. Similar results were noted among women with normal weight. Conclusion Excessive GWG was associated with an increased risk of CMM and CNM, while inadequate GWG was associated with a higher risk of neonatal and infant mortalities.

scholarly journals Associations Between Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Preterm Birth: a Cohort Study in Wuhan, China

2020 ◽  
Author(s):  
Yiyang Guo ◽  
Chao Xiong ◽  
Aifen Zhou ◽  
Ronghua Hu ◽  
Rong Yang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Preterm Birth ◽  
Gestational Weight Gain ◽  
Early Pregnancy ◽  
Tracking System ◽  
Normal Weight ◽  
Elevated Risk ◽  
Gestational Weight ◽  
Increased Risk

Abstract Background Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity worldwide. Methods This cohort study was designed to investigate the associations between pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy with PTB utilizing data of 83,096 Chinese women from the Maternal and Children Healthcare Information Tracking System of Wuhan, China. Results Women who were underweight, overweight or obese prior to pregnancy had an overall elevated risk of PTB, compared to their normal weight counterparts. Women with total GWG below the IOM recommendation had an increased risk of PTB compared to women who had GWG within the recommendation, whereas an increasing risk of PTB was observed asweekly early pregnancy GWGincreased. When stratified by subtypes of PTB, pre-pregnancy underweight was associated with higher risk of spontaneous PTB, and pre-pregnancy overweight /obese increased the risk of both spontaneous PTB and medically indicated PTB. Women with total GWG below the IOM recommendation had elevated risk for spontaneous PTB and PROM, and women with GWG above the recommendation had decreased risk for all three subtypes of PTB, whereas risk for the three subtypes of PTB increased along with increasing weekly GWG of early pregnancy. Conclusions Maternal underweight, overweight/obesity, total GWG, and GWG during early pregnancy should be considered in combination to reduce the risk of PTB, women should modify their weight gains during pregnancy according to the results.

scholarly journals Maternal thyroid function, prepregnancy obesity and gestational weight gain-The Generation R Study: A prospective cohort study

2017 ◽  
Vol 87 (6) ◽  
pp. 799-806 ◽  
Author(s):  
Fernanda M. Collares ◽  
Tim I.M. Korevaar ◽  
Albert Hofman ◽  
Eric A.P. Steegers ◽  
Robin P. Peeters ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Thyroid Function ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Gestational Weight ◽  
Prepregnancy Obesity ◽  
Maternal Thyroid

scholarly journals The Association between Pre-Pregnancy BMI, Gestational Weight Gain and Pregnancy Outcomes: A Retrospective Cohort Study in Ahvaz, Iran

2020 ◽  
Author(s):  
Kambiz Ahmadi Angali ◽  
Maryam Azhdari ◽  
Maria Cheraghi ◽  
parvin shahri ◽  
shokrolah salmanzadeh ◽  
...  
Keyword(s):  
Health Care ◽  
Body Mass Index ◽  
Cohort Study ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Gestational Age ◽  
Retrospective Cohort ◽  
Large For Gestational Age ◽  
Gestational Weight ◽  
Increased Risk

Abstract Background: Maternal body mass index and maternal gestational weight gain can have positive effects on birth and maternal outcomes. We aimed to identify the effect of pre-pregnancy weight and gestational weight gain on birth outcomes.Methods: Data of this retrospective cohort study were extracted using the 1457 out of 1800 pair health records belonged to the pregnant mother and infant at Ahvaz health care centers, from 2010 to 2018.Result: The 3.18-fold increased risk for large for gestational age in overweight mothers, and a 2.9 fold increased risk for small for gestational age in those mothers with gestational weight gain below the guidelines. An increased risk of large for gestational age, low birth weight, and macrosomia were observed in overweight mothers with gestational weight gain out of the guidelines. The increased association was found between the maternal pre-body mass index and fasting blood sugar (p = 0.0001). Hence, hyperglycemia is related to a 3.58-fold incidence of macrosomia. Conclusion: Therefore, conducting more educational programs of lifestyle intervention with respect to reproductive health care is required for all women in childbearing age (before and during pregnancy), with the purpose of reducing the adverse pregnancy outcome.

scholarly journals Prognosis Associated with Sub-Types of Hyperglycaemia in Pregnancy

2021 ◽  
Vol 10 (17) ◽  
pp. 3904
Author(s):  
Emmanuel Cosson ◽  
Sid Ahmed Bentounes ◽  
Charlotte Nachetergaele ◽  
Narimane Berkane ◽  
Sara Pinto ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Gestational Age ◽  
Pregnancy Outcomes ◽  
Insulin Requirement ◽  
Large For Gestational Age ◽  
Gestational Weight ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
In Pregnancy

We aimed to compare pregnancy outcomes in 4665 women according to the following types of hyperglycaemia in pregnancy sub-types: (i) normoglycaemia, (ii) gestational diabetes mellitus (GDM), (iii) diabetes in pregnancy (DIP), (iv) early-diagnosed (i.e., <22 weeks of gestation) GDM (eGDM), and (v) early-diagnosed DIP (eDIP). The prevalence of normoglycaemia, eGDM, eDIP, GDM, and DIP was 76.4%, 10.8%, 0.6%, 11.7%, and 0.6%, respectively. With regard to pregnancy outcomes, gestational weight gain (11.5 ± 5.5, 9.0 ± 5.4, 8.3 ± 4.7, 10.4 ± 5.3, and 10.1 ± 5.0 kg, p < 0.0001) and insulin requirement (none, 46.0%, 88.5%, 25.5%, and 51.7%; p < 0.001) differed according to the glycaemic sub-types. eGDM and eDIP were associated with higher rates of infant malformation. After adjustment for confounders, with normoglycaemia as the reference, only GDM was associated with large-for-gestational-age infant (odds ratio 1.34 (95% interval confidence 1.01–1.78) and only DIP was associated with hypertensive disorders (OR 3.48 (1.26–9.57)). To conclude, early-diagnosed hyperglycaemia was associated with an increased risk of malformation, suggesting that it was sometimes present at conception. Women with GDM, but not those with eGDM, had an increased risk of having a large-for-gestational-age infant, possibly because those with eGDM were treated early and therefore had less gestational weight gain. Women with DIP might benefit from specific surveillance for hypertensive disorders.

scholarly journals Gestational Weight Gain—Re-Examining the Current Paradigm

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2314
Author(s):  
Jennie Louise ◽  
Andrea R. Deussen ◽  
Jodie M. Dodd
Keyword(s):  
Physical Activity ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Outcomes ◽  
Obese Women ◽  
Gestational Weight ◽  
Diet And Physical Activity ◽  
Adverse Pregnancy

Our aim was to investigate the underlying assumptions of the current gestational weight gain (GWG) paradigm, specifically that—(1) GWG is modifiable through diet and physical activity; (2) optimal GWG and risk of excess GWG, vary by pre-pregnancy body mass index (BMI) category and (3) the association between GWG and adverse pregnancy outcomes is causal. Using data from three large, harmonized randomized controlled trials (RCTs) of interventions to limit GWG and improve pregnancy outcomes and with appropriate regression models, we investigated the link between diet and physical activity and GWG; the relationships between pre-pregnancy BMI, GWG and birth weight z-score; and the evidence for a causal relationship between GWG and pregnancy outcomes. We found little evidence that diet and physical activity in pregnancy affected GWG and that the observed relationships between GWG and adverse pregnancy outcomes are causal in nature. Further, while there is evidence that optimal GWG may be lower for women with higher BMI, target ranges defined by BMI categories do not accurately reflect risk of adverse outcomes. Our findings cast doubt upon current advice regarding GWG, particularly for overweight and obese women and suggest that a change in focus is warranted.

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