scholarly journals Rapid Brain Natriuretic Peptide Test and Doppler Echocardiography for Early Diagnosis of Mild Heart Failure

2006 ◽  
Vol 52 (9) ◽  
pp. 1802-1808 ◽  
Author(s):  
Nadia Aspromonte ◽  
Vincenzo Ceci ◽  
Antonella Chiera ◽  
Claudio Coletta ◽  
Alessandra D’Eri ◽  
...  
Keyword(s):  
Heart Failure ◽  
Early Diagnosis ◽  
Brain Natriuretic Peptide ◽  
Diastolic Dysfunction ◽  
Natriuretic Peptide ◽  
Systolic Dysfunction ◽  
Cost Effective ◽  
Risk Groups ◽  
Patients At Risk ◽  
Study Population

Abstract Background: The early identification of patients at risk for the development of clinical heart failure (HF) is a new challenge in an effort to improve outcomes. Methods: We prospectively evaluated whether the combination of brain natriuretic peptide (BNP) measurements (Triage BNP test, Biosite Diagnostics) and echocardiography would effectively stratify patients with new symptoms in a cost-effective HF program aimed at early diagnosis of mild HF. A total of 252 patients were referred by 100 general practitioners. Results: Among the study population, the median BNP value was 78 ng/L (range, 5–1491 ng/L). BNP concentrations were lower among patients without heart disease [median 15 ng/L (range, 5–167 ng/L); n = 96] than among patients with confirmed HF [median, 165 ng/L (22–1491 ng/L); n = 157; Mann–Whitney U-test, 12.3; P <0.001]. Patients were grouped into diastolic dysfunction [BNP, 195 (223) ng/L], systolic dysfunction [BNP, 290 (394) ng/L], and both systolic and diastolic dysfunction [BNP, 776 (506) ng/L]. In this model, a cutoff value of 50 ng/L BNP increases the diagnostic accuracy in predicting mild HF, avoiding 41 echocardiograms per 100 patients studied, with a net saving of 14% of total costs. Conclusions: Blood BNP concentrations, in a costeffective targeted screening, can play an important role in diagnosing mild HF and stratifying patients into risk groups of cardiac dysfunction.

scholarly journals The importance of NT proBNP in hypertensive patients management for preventing heart failure

2021 ◽  
Vol 68 (1) ◽  
pp. 71-76
Author(s):  
Irina Cuciureanu ◽  
◽  
Anamaria-Georgiana Avram ◽  
Maria Suzana Guberna ◽  
Cătălina Liliana Andrei ◽  
...  
Keyword(s):  
Heart Failure ◽  
At Risk ◽  
Diastolic Dysfunction ◽  
Medical Management ◽  
Systolic Dysfunction ◽  
Intervention Group ◽  
Control Group ◽  
Cardiovascular Pathology ◽  
Hypertensive Patients ◽  
Patients At Risk

Purpose. NT proBNP is routinely used in the diagnosis and prognosis of HF. The study aimed to determine whether the value of NT proBNP can be used in hypertensive patients to detect patients at risk of developing HF and whether in these patients medical management guided by NT proBNP can prevent the development of HF. Material and methods. We included 275 hypertensive patients who presented to the Bagdasar-Arseni Emergency Hospital for cardiological consultation for a period of 3 years. Patients diagnosed with heart failure or left ventricular systolic dysfunction and patients with symptoms of heart failure at enrollment were excluded. We divided the patients into 2 groups, a control group and an intervention group. Patients in the intervention group were managed according to the NT proBNP value, and patients in the control group received standard treatment. Results. The objectives pursued at 3 years were: diagnosis of heart failure, systolic or diastolic dysfunction of the left ventricle and hospitalization for cardiovascular pathology. After 3 years, in the control group there were 34 patients (25.4%) who developed HF, compared to 24 patients (17.0%) in the intervention group. In the control group, 51 patients (38.1%) were diagnosed with LV systolic dysfunction compared to 37 patients (26.2%) in the intervention group. Regarding diastolic LV dysfunction, in the control group there were 83 patients (61.9%), and in the intervention group there were 73 patients (51.8%). Also, the rate of hospitalizations for cardiovascular pathology was higher in the control group 47 patients (35.1%) compared to 27 patients (19.1%) in the intervention group. Discussions. Hypertensive patients in the intervention group, who were managed according to the NT proBNP value, had a lower incidence rate of heart failure, LV systolic or diastolic dysfunction, or hospitalizations for cardiovascular events than in the control group. Conclusions. The value of NT proBNP may be useful for detecting hypertensive patients at risk of developing HF, and NT proBNP-guided medical management may prevent or delay the onset of HF.

Concentrations of N-terminal pro-brain natriuretic peptide and troponin T in plasma of 75-year-old apparently healthy persons

2004 ◽  
Vol 42 (12) ◽  
Author(s):  
Klaus Roland Huber ◽  
Nazanin Mostafaie ◽  
Kurt Bauer ◽  
Brigitte Worofka ◽  
Eva Kittl ◽  
...  
Keyword(s):  
Heart Failure ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
Systolic Dysfunction ◽  
Myocardial Damage ◽  
Decompensated Heart Failure ◽  
Men And Women ◽  
Protein Assay ◽  
Apparently Healthy

AbstractClinical chemical reference values for older persons are sparse and mostly intermixed with those for younger persons. We had a unique opportunity to obtain blood samples from volunteers who were 75years old and living in two districts of Vienna, Austria. Consequently, we utilized stored plasma samples to obtain reference intervals for 120 apparently healthy 75-year-old participants for pro-brain natriuretic peptide (proBNP), as well as for troponin T. The N-terminal (NT)-proBNP protein assay is currently used as a diagnostic and prognostic aid in patients with heart failure and as a prognostic marker in acute coronary syndromes. Specifically, the concentration of NT-proBNP in serum or plasma aids in the prognosis of ventricular systolic dysfunction and helps to differentiate between cardiac and non-cardiac causes. The median NT-proBNP plasma value for men and women in our cohort was calculated as 98pg/ml, comparing favorably with reported values, in that a NT-proBNP concentration less than 100pg/ml excludes acutely decompensated heart failure. Our calculated 97.5 percentile was slightly higher (359 pg/ml) than the 97.5 percentile in a group of 50–65-year-old persons (198 and 222pg/ml for men and women, respectively) revealing the influence of age on this parameter. Because of its high tissue-specificity, cardiac troponin T is a cardiospecific, highly sensitive marker for myocardial damage. However, the troponin T concentrations in the plasma specimens from this cohort were all below the detection limit of 0.01ng/ml, preventing any further data handling.

scholarly journals The Relationship Between Brain Natriuretic Peptide (NT-proBNP) Levels and Diastolic Heart Failure in Patients With COVID-19

2021 ◽  
Author(s):  
Naghmeh Ziaie ◽  
Khadijeh Ezoji ◽  
Seyedeh Golnaz Ziaei ◽  
Mohammad Chehrazi ◽  
Parviz Amri Maleh ◽  
...  
Keyword(s):  
Heart Failure ◽  
Brain Natriuretic Peptide ◽  
Diastolic Dysfunction ◽  
Natriuretic Peptide ◽  
Diastolic Heart Failure ◽  
Secondary Outcome ◽  
Predictive Role ◽  
Left And Right ◽  
The Relationship

Abstract Background: Diastolic dysfunction has been reported in patients with COVID-19. Due to the role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the diagnosis of heart failure, this study investigated the relationship between serum NT-proBNP levels and diastolic heart failure in COVID-19 patients.Methods: This descriptive-analytical study was performed at Ayatollah Rouhani Hospital in Babol. Fifty-four patients with confirmed COVID-19 diagnosis who were admitted to the ICU were included in the study. The primary outcome was the relationship and predictive role of NT-proBNP and diastolic heart failure in patients with severe SARS-COV-2 infection. Patients with pro BNP >125 pg/mL underwent echocardiography and the relationship between echocardiographic indices and NT-proBNP was assessed as a secondary outcome.Results: Our study showed that plasma NT-proBNP levels in patients with increased diastolic dysfunction were associated with disease severity. It was also found that the cut-off point of NT-proBNP = 799 pg/mL could be a predictor of diastolic dysfunction grades two and three. In this study, patients with a serum NT-proBNP level equal or above 799 had 37 times higher chance of having diastolic dysfunction than those with a serum NT-proBNP level below 799. Patients with NT-proBNP above 556 had RV_EA> 2 in echocardiography, indicating increased right-sided filling pressures.Conclusion: Despite the confounding factors in the interpretation of the pro BNP level in COVID-19, its level can be used to estimate the presence of high-grade diastolic heart failure on the left and right sides of the heart and the presence of high filling pressures. Lower levels of NT-proBNP are associated with right-sided diastolic failure.

scholarly journals Major increase in brain natriuretic peptide indicates right ventricular systolic dysfunction in patients with heart failure

2003 ◽  
Vol 5 (4) ◽  
pp. 481-488 ◽  
Author(s):  
Denis Mariano-Goulart ◽  
Marie-Claude Eberlé ◽  
Vincent Boudousq ◽  
Azadeh Hejazi-Moughari ◽  
Christophe Piot ◽  
...  
Keyword(s):  
Heart Failure ◽  
Brain Natriuretic Peptide ◽  
Right Ventricular ◽  
Natriuretic Peptide ◽  
Systolic Dysfunction ◽  
Ventricular Systolic Dysfunction ◽  
Patients With Heart Failure ◽  
Major Increase

scholarly journals Investigation of early signs of systolic and diastolic dysfunction among persons with type 1 diabetes

Open Heart ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. e001020
Author(s):  
Daniel Vestberg ◽  
Magnus Carl Johansson ◽  
Anette Letho ◽  
Aldina Pivodic ◽  
Sara Hallström ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Type 1 Diabetes ◽  
Diastolic Dysfunction ◽  
Systolic Dysfunction ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Early Signs ◽  
Study Population

BackgroundPersons with type 1 diabetes have a higher risk to develop heart failure than the general population, and the mechanism behind the increased risk is unclear. In epidemiological studies with hospitalisation for heart failure as endpoint HbA1c, body mass index and decreased kidney function are significant risk factors, but it is unclear how these risk factors influence the development of heart failure.MethodsIn this study, we investigated early signs of systolic and diastolic dysfunction with transthoracic echocardiography. Statistical analysis on correlation of risk factors and early signs of diastolic and systolic dysfunction was made.ResultsIn this study population of 287 persons with type 1 diabetes, 160 were men and 127 were women with a mean age of 53.8 (SD 11.6) years and a mean diabetes duration of 36.2 (SD 13.5) years. There were 23 (8.2%) persons who fulfilled the definition of systolic dysfunction (ejection fraction <50% or regional wall motion abnormalities) and 24 persons (9%) the definition for diastolic dysfunction. When comparing the groups with either systolic or diastolic dysfunction to the rest of the population, the only significant risk factor was age in both groups and previous myocardial infarction in the systolic group.ConclusionIn our study population with type 1 diabetes, we found signs of diastolic dysfunction in 9% and systolic dysfunction in 8.2%. Compared with published data from the general population, this rate is somewhat higher in a younger population. Only age was a significant risk factor in the study.

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