scholarly journals Synthesis, Characterization and in vitro Antimicrobial, Antioxidant and Anticancer Activity of Random Copolyester Using 1,4-Dithiane-2,5-diol

2019 ◽  
Vol 31 (10) ◽  
pp. 2341-2344
Author(s):  
B. Kalpana ◽  
R. Nanthini
Keyword(s):  
Chemical Structure ◽  
Sebacic Acid ◽  
Wide Angle ◽  
Anticancer Activities ◽  
Melt Polycondensation ◽  
Titanium Tetra Isopropoxide ◽  
Direct Melt Polycondensation ◽  
Ft Ir ◽  
Scanning Spectroscopy

A random copolyester was prepared by direct melt polycondensation method using 1,4-dithiane-2,5-diol, 1,4-cyclohexane diol and Sebacic acid in the mole ratio 1:1:2 using titanium tetra isopropoxide as catalyst. The synthesized copolyester poly(1,4-dithiane-2,5-diol sebacate–co–1,4-cyclohexane diol sebacate) (PDCSe) was characterized by FT-IR, 1H NMR and 13C NMR to determine the chemical structure, while wide angle XRD, differential scanning spectroscopy and Inherent viscosity were determined to study its physical properties. Further the antioxidant, antimicrobial and anticancer activities of the synthesized copolyester were determined to study its biological property.

scholarly journals Synthesis and Characterization of 2-Pyrazoline Derivatives and their in silico and in vitro Studies on Antimicrobial and Anticancer Activities

2019 ◽  
Vol 31 (10) ◽  
pp. 2191-2196 ◽  
Author(s):  
S. Rathinamanivannan ◽  
K. Megha ◽  
Raja Chinnamanayakar ◽  
Ashok Kumar ◽  
M.R. Ezhilarasi
Keyword(s):  
Breast Cancer ◽  
Synthesis And Characterization ◽  
Anticancer Activities ◽  
1H And 13C Nmr ◽  
Chemical Structures ◽  
Ft Ir ◽  
Affinity Score ◽  
High Binding Affinity

The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives chemical structures were confirmed from spectral data such as FT-IR, 1H and 13C NMR. 2-Pyrazoline derivatives were docked with bacterial (1UAG) and breast cancer (1OQA) protein. Based on high binding affinity score, the best compound was subjected to in vitro anticancer activity by MTT assay. Also, antimicrobial activity were studied for synthesized 2-pyrazoline derivatives.

scholarly journals Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening

2019 ◽  
Vol 15 (4) ◽  
pp. 613-616
Author(s):  
Shahrul Nizam Ahmad ◽  
Hadariah Bahron ◽  
Amalina Mohd Tajuddin ◽  
Kalavathy Ramasamy
Keyword(s):  
Schiff Base ◽  
Human Colon ◽  
Aromatic Diamine ◽  
Anticancer Activities ◽  
Schiff Base Ligands ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines ◽  
Ft Ir ◽  
Anticancer Compound

Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanyl-ylidene))bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis-(methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UV-Visible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 mg/ml.

Incorporation of Fluorinated Pyridine in the Side Chain of 4-Aminoquinolines: Synthesis, Characterization and Antibacterial Activity

Drug Research ◽  
2017 ◽  
Vol 68 (01) ◽  
pp. 17-22 ◽  
Author(s):  
Reza Ranjbar-Karimi ◽  
Alireza Poorfreidoni
Keyword(s):  
Antibacterial Activity ◽  
Chemical Structure ◽  
Side Chain ◽  
Gram Negative Bacteria ◽  
Pyridine Derivatives ◽  
Positive Bacterium ◽  
Gram Positive ◽  
In Vitro Antibacterial Activity ◽  
Ft Ir

AbstractA series of hybrid of 4-aminoquinoline and fluorinated pyridine derivatives were synthesized and their chemical structure were confirmed by 19F-NMR, 1H-NMR, 13C-NMR and FT-IR. All compounds were tested against one Gram-positive and one Gram-negative bacteria to assess their in vitro antibacterial activity. Compounds 10a, 10b, 11a and 12b showed moderate antibacterial activity against Gram-positive bacterium, Staphylococcus aureus.

Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

2008 ◽  
Vol 61 (10) ◽  
pp. 762 ◽  
Author(s):  
Yousef M. Hamdan ◽  
Shitao Fu ◽  
Xiangmei Jiang ◽  
Yinhua Cheng ◽  
Kaixun Huang ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Sebacic Acid ◽  
Gel Permeation Chromatography ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
Scanning Calorimetry ◽  
First Order ◽  
Melt Polycondensation ◽  
Model Drug

2-Octylsuccinic acid and its copolyanhydrides with sebacic acid have been synthesized by melt polycondensation, and were characterized by Fourier transform infrared spectroscopy, 1H NMR, gel permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. In vitro studies showed that all copolymers are degradable in phosphate buffer at 37°C. The release profiles of the hydrophilic model drug ciprofloxacin hydrochloride follow first-order release kinetics.

scholarly journals 1, 4 Dithiane 2, 5 Diol : An Versatile Monomer to Synthesis Aliphatic Random Copolyester with Biomedical Application

2019 ◽  
Vol 35 (2) ◽  
pp. 885-891
Author(s):  
Kalpana Balachandran ◽  
Nanthini Raveendiran ◽  
Margaret Marie John
Keyword(s):  
Biomedical Applications ◽  
Biomedical Application ◽  
Biological Properties ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Suitable Candidate ◽  
Melt Polycondensation ◽  
Direct Melt Polycondensation ◽  
Ft Ir ◽  
Antioxidant And Antimicrobial Activity

This article uses 1, 4-dithiane-2, 5-diol as a monomer to synthesize aliphatic random copolyester (PDDD).PDDD was synthesized by direct melt polycondensation method and characterized by FT-IR and 1H- NMR. The physical properties of PDDD were characterized by X-ray diffraction, differential scanning calorimetry, as well as viscosity and solubility measurements. The anticancer, antioxidant, and antimicrobial activity of PDDD were evaluated to investigate its potential biomedical applications. Generally, good results were obtained. It is evident that the copolyester exhibits favorable and tunable physical, thermal and biological properties and so is a suitable candidate for biomedical applications.

An Amphiphilic Chitosan-Polylactide Graft Copolymer and its Nanoparticles as Fungicide Carriers

2014 ◽  
Vol 1051 ◽  
pp. 21-28 ◽  
Author(s):  
Xiang Dong Mei ◽  
Yan Hui Liang ◽  
Tao Zhang ◽  
Jun Ning ◽  
Zhong Yue Wang
Keyword(s):  
Graft Copolymer ◽  
Chemical Structure ◽  
In Vitro Release ◽  
Release Profile ◽  
Water Soluble ◽  
Small Particle Size ◽  
Nanoprecipitation Method ◽  
Ft Ir ◽  
Vitro Release

In the present study, an amphiphilic chitosan-polylactide (CS-PLA) graft copolymer was synthesized through grafting polylactide (PLA) onto water-soluble chitosan (CS), and the chemical structure of this newly developed copolymer was confirmed by FT-IR, 1H NMR and thermogravimetric analysis (TGA). Stable flusilazole-loaded nanoparticles (NS), with a size near 280.3 nm and a loading content (LC) of 29.0%, were prepared for the fungicide delivery using a nanoprecipitation method. Moreover, size, size distribution and the flusilazole LC as well as the in vitro release profile of flusilazole-loaded NS were investigated. In conclusion, the NS could provide a controlled release of flusilazole and enhance the penetration of flusilazole in the plant compared with classical flusilazole emulsifiable concentrate (EC) formulation due to their small particle size. Therefore, the CS-PLA NS could be used as fungicide carriers for the flusilazole delivery system.

Characterization and Screening of a Novel Multiparticulate Pulsatile Delivery of Aceclofenac

2016 ◽  
Vol 9 (5) ◽  
pp. 3494-3501
Author(s):  
Bipul Nath ◽  
Santimoni Saikia
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Alginate Beads ◽  
In Vitro Drug Release ◽  
Dsc Studies ◽  
Ft Ir ◽  
Lag Period ◽  
Pulsatile Delivery ◽  
Ca Alginate

In the present investigation, sodium alginate based multiparticulate system overcoated with time and pH dependent polymer was studied in the form of oral pulsatile system to achieve pulsatile with sustained release of aceclofenac for chronotherapy of rheumatoid arthritis seven batches of micro beads with varying concentration of sodium alginate (2-5 %) were prepared by ionotropic-gelation method using CaCl2 as cross-linking agent. The prepared Ca-alginate beads were coated with 5% Eudragit L100 and filled into pulsatile capsule with varying proportion of plugging materials. Drug loaded microbeads were investigated for physicochemical properties and drug release characteristics. The mean particle sizes of drug-loaded microbeads were found to be in the range 596±1.1 to 860 ± 1.2 micron and %DEE in the range of 65-85%. FT-IR and DSC studies revealed the absence of drug polymer interactions. The release of aceclofenac from formulations F1 to F7 in buffer media (pH 6.8) at the end of 5h was 65.6, 60.7, 55.7, 41.2, 39.2, 27 and 25% respectively. Pulsatile system filled with eudragit coated Ca-alginate microbeads (F2) showed better drug content, particle size, surface topography, in-vitro drug release in a controlled manner. Different plugging materials like Sterculia gum, HPMC K4M and Carbopol were used in the design of pulsatile capsule. The pulsatile system remained intact in buffer pH 1.2 for 2 hours due to enteric coat of the system with HPMCP. The enteric coat dissolved when the pH of medium was changed to 7.4. The pulsatile system developed with Sterculia gum as plugging material showed satisfactory lag period when compared to HPMC and Carbopol.

Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach

2018 ◽  
Vol 11 (2) ◽  
pp. 4036-4042
Author(s):  
Prakash Goudanavar ◽  
Ankit Acharya ◽  
Vinay C.H
Keyword(s):  
Chemical Interaction ◽  
Research Work ◽  
Antiviral Drug ◽  
In Vitro Release ◽  
Oral Route ◽  
Water Soluble ◽  
Precipitation Method ◽  
Dsc Studies ◽  
Ft Ir

Administration of an antiviral drug, acyclovir via the oral route leads to low and variable bioavailability (15-30%). Therefore, this research work was aimed to enhance bioavailability of acyclovir by nanocrystallization technique. The drug nanocrystals were prepared by anti-solvent precipitation method in which different stabilizers were used. The formed nanocrystals are subjected to biopharmaceutical characterization including solubility, particle size and in-vitro release. SEM studies showed nano-crystals were crystalline nature with sharp peaks. The formulated drug nanocrystals were found to be in the range of 600-900nm and formulations NC7 and NC8 showed marked improvement in dissolution velocity when compared to pure drug, thus providing greater bioavailability. FT-IR and DSC studies revealed the absence of any chemical interaction between drug and polymers used. 

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