Synthesis and Molecular Docking Studies of Coumarinyl
Thiazole as Cell Division Protein Kinase 2 Inhibitor
Keyword(s):
A series of 2-alkylamino-4-(3-coumarinyl)thiazoles were synthesized, characterized and evaluated their anticancer activity through molecular docking studies. Cell division protein kinase 2 (PDB code: 1KE9) is selected as a target and the compounds which obeys Lipinski rule of five is selected as a ligand. Molecular docking study is carried out using AutoDock Vina in PyRx virtual screening tool. This study revealed that all the compounds are active against the molecular target and compounds 5a and 5c have the highest docking score.
2010 ◽
Vol 11
(9)
◽
pp. 3357-3374
◽
2021 ◽
Vol 12
(2)
◽
pp. 1385-1396
2021 ◽
Vol 59
(4)
◽
pp. 441