Risk Factors of Infantile Diarrhea (A Case-Control Study)

From March thru April 1990 an unmatched case-control study had been conducted at the pediatric out-patient Clinic of Dr. Pirngadi Hospital Medan to assess risk factors of infantile diarrhea. The study population were infants, aged younger than 21 months. The mothers of the infants were interviewed, using structured questionnaires. Sample size, calculated by means of formula, with 95 % level of confidence, 90 % power of study, 50% estimated proportion of exposure in the control-group and 2.0 estimated odds ratio, was 121. All infants with diarrhea were included in the case-group until a total number of 124 infants were reached. One control, an infant without diarrhea, was taken for each case from the nearest sequence of attendance after the case. A total of 20 risk factors were tested. Exposure was indicated from the last day before illness. Computerized statistical analysis was performed to calculate odds ratio, 95 % confidence interval and two tailed significance testing for qualitative dichotomic data by means of Chi square test. A total of nine factors were confirmed as risk factors of infantile diarrhea i.e mothers age than 20 years, working mother, not cleaning nipple before suckling the baby bottle feeding, having only one nursing botlle/teat, not ready for use nursing bottle/teat, giving left over supplementary food without reheating, no band-washing before giving supplementary food and malnutrition. The result of this study can be emphasized in health education, especially in diarrheal disease control of infancy; Further well-designed studies are needed.

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Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Neonatology ◽

10.1159/000512020 ◽

2020 ◽

pp. 1-7

Author(s):

Tobias Hengartner ◽

Mark Adams ◽

Riccardo E. Pfister ◽

Diane Snyers ◽

Jane McDougall ◽

...

Keyword(s):

Retinopathy Of Prematurity ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Same Sex ◽

Live Births ◽

Adjusted Logistic Regression ◽

Control Study

Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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Analisis Faktor Fetus dan Tali Pusat terhadap Risiko Asphyxia Perinatal di Surakarta

Jurnal Ilmu Keperawatan Anak ◽

10.32584/jika.v3i1.521 ◽

2020 ◽

Vol 3 (1) ◽

pp. 16

Author(s):

Siti Lestari ◽

Dyah Dwi Astuti ◽

Fachriza Malika Ramadhani

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Perinatal Asphyxia ◽

Case Control ◽

Control Group ◽

Case Group ◽

Retrospective Case ◽

Chi Square ◽

Fetal Position ◽

Control Study

Asfiksia perinatal merujuk pada kekurangan oksigen selama persalinan, sehingga berpotensi menyebabkan kematian dan kecacatan. WHO memperkirakan 4 juta anak terlahir dengan asfiksia setiap tahun, dimana 1 juta di antaranya meninggal dan 1 juta anak bertahan hidup dengan gejala sisa neurologis yang parah. Penelitian ini bertujuan untuk menganalisis faktor risiko fetal dan tali pusat pada asfiksia neonatal.Penelitian dilakukan di lakukan di RS Dr Moewardi Surakarta dengan pendekatan quantitative retrospective case control study. Data diambil dari rekam medis antara tahun 2013-2018. Penelitan ini melibatkan 264 neonatal yang terdiri dari 88 kelompok kasus dan 176 kelompok control. Kelompok kasus adalah bayi dengan diagnosa asfiksia yang dilakukan analisis terhadap faktor risiko fetal, sedangkan bayi yang tidak mengalami asfiksia dijadikan kelompok kontrol. Hasil analisis statistik uji Chi-Square dan Fisher Exact ditemukan bahwa kelahiran prematur (OR 2,07 CI 95% P 0,02), persalinan dengan tindakan (OR 3,61 CI 95% P 0,00), berat bayi (OR 2,85 CI 95% P 0,00), posisi janin (OR 2,37 CI 95% P 0,05), tali pusat ( QR 3,071 CI 95% P 0,01) berisiko terhadap insiden asfiksia perinatal. Air ketuban yang bercampur meconium (OR 1,51 CI 95% P 0,16) tidak memiliki risiko dengan Asfiksia perinatal. Kesimpulan: Risiko terhadap insiden asfiksia perinatal meliputi kelahiran prematur, persalinan dengan tindakan, berat bayi, posisi janin, dan tali pusat.Perinatal asphyxia refers to a lack of oxygen during labor, which has the potential to cause death and disability. WHO estimates 4 million children born with asphyxia each year, in which 1 million dies and 1 million survive with severe neurological sequelae. This study aims to analyze fetal and umbilical risk factors in neonatal asphyxia.This research is a quantitative retrospective case-control study, which was conducted at The Dr. Moewardi hospital, Surakarta. Data was taken from medical records from 2013-2018. The case group was patients diagnosed asphyxia, while those who did not experience asphyxia were treated as a control group. A total of 264 samples, consisting of 88 case group respondents and 176 control group respondents. Statistical analysis Chi- Square and Fisher Exact found that preterm birth (OR 2.07 CI 95% P 0.02), labor with instrument or complication (OR 3.61 CI 95% P 0.00), infant weight (OR 2.85 CI 95% P 0, 00), fetal position (OR 2.37 CI 95% P 0.05), umbilical cord (QR 3.071 CI 95% P 0.01) are at risk for the incidence of perinatal Asphyxia. The amniotic fluid mixed with meconium (OR 1.51 CI 95% P 0.16) has no risk with perinatal asphyxia.The risk factors of incidences of perinatal asphyxia were preterm birth, labor with instrument or complication, baby weight, fetal position and umbilical cord.

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Risk Factors for Ectopic Pregnancy: A Multi-center Case Control Study

10.21203/rs.3.rs-136639/v1 ◽

2021 ◽

Author(s):

Nooria Atta ◽

Fahima Aram ◽

Nafisa Naseri ◽

Mahbooba Sahak

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Ectopic Pregnancy ◽

Case Control Study ◽

Case Control ◽

Pelvic Surgery ◽

Control Group ◽

Case Group ◽

History Of ◽

Control Study

Abstract Background: Ectopic pregnancy (EP) is defined as a pregnancy in which fertilized oocyte implants outside the endometrial cavity. Although there is no known etiology for ectopic pregnancy, some risk factors of EP have been determined. It has been evident that ectopic pregnancy can be of multifactorial origin. This multicenter research aims to study risk factors associated with increased risk of ectopic pregnancy in women living in Kabul. Methods: A multicenter case control study was conducted in five tertiary maternity hospitals located in Kabul, Afghanistan. A total of 457 pregnant women were included in this study. In the case group, women with diagnosed ectopic pregnancy, while in control group women with intrauterine pregnancy were included. For each case in this study, two controls were enrolled. Results: The mean (SD) age of women in case group was 27.9 (6) years while in control group it was 26.4 (5.5) years. This difference was not statistically significant. We found a significant association between history of abortion and EP (Adj. OR=1.57; 95%CI: 1.02, 2.42). Having history of abdominal/pelvic surgery was a risk factor for EP with adjusted OR 1.94 (95%CI: 1.15, 3.30). In this study we found an increasing risk of EP in women of 35 years or older compared to younger women (Crude OR=2.26; p= 0.024). In women reporting prior EP, the chance of its recurrence was increased (Crude OR= 9.64; 95%CI: 1.1, 83.2). No association of gravidity and parity was found with EP incidence. Conclusions: In this study we found a statistically significant association between history of abdominal/pelvic surgery and EP. In addition, history of abortion was suggested as a risk factor for ectopic pregnancy. In case of having a previous EP probability of its recurrence will be increased. Women with advanced age having other potential risk factors will be facing higher risk of EP.

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Predictors of Preeclampsia Based on a 10-Year Case-Control Study

Journal of Family & Reproductive Health ◽

10.18502/jfrh.v13i1.1608 ◽

2019 ◽

Author(s):

Arezoo Shayan ◽

Hadis Sourinejad ◽

Mansoureh Refaei ◽

Seyedeh Zahra Masoumi ◽

Leili Tapak ◽

...

Keyword(s):

Risk Factors ◽

Blood Group ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Retrospective Case ◽

Low Education ◽

High Age ◽

Control Study

Objective: To investigate the predictors of preeclampsia based on a 10-years case-control study. Materials and methods: The present retrospective, case-control study was carried out in a referral Hospital in Hamadan, Iran, during 2005-2015. Using a hospital information system (HIS), all the available information on hospitalized preeclamptic patients during 10-years period was collected and all preeclamptic women were qualified for the study as the case group (729 subjects) and the same number of non-preeclamptic women were assigned to the control group. The required data were collected using the researcher-made questionnaire and analyzed using descriptive statistics, chi-square test, independent t-test and logistic regression. Results: The results show that high age (OR = 1.04), low education (diploma compared to illiterate OR = 0.51 and middle school education compared to illiterate OR = 0.55), blood group O (AB: OR = 0.32; B: OR = 0.36; A: OR = 0.26) and fertilization during autumn (spring: OR = 0.41; summer: OR = 0.26; autumn: OR = 1.13) could raise the risk of preeclampsia. Conclusion: High age, low education, blood group O and fertilization in cold seasons could be the risk factors of preeclampsia. Recognizing the risk factors of preeclampsia could help the determination of high risk cases and designing of effective interventions.

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Epidemiological characteristics and risk factors of biliary atresia: a case–control study

BMJ Open ◽

10.1136/bmjopen-2021-049354 ◽

2021 ◽

Vol 11 (12) ◽

pp. e049354

Author(s):

Jingying Jiang ◽

Rou Wan ◽

Shiwei He ◽

Ying Wu ◽

Zhen Shen ◽

...

Keyword(s):

Risk Factors ◽

Biliary Atresia ◽

Case Control Study ◽

Case Control ◽

Secondary Outcome ◽

Control Group ◽

Case Group ◽

Increased Risk ◽

Epidemiological Characteristics ◽

Control Study

ObjectivesBiliary atresia (BA) is regarded as a serious neonatal hepatobiliary disease, and its aetiology and pathogenesis remain unclear. Epidemiological studies are limited, especially for the data from China. This study aims to explore risk factors of BA and provide new evidence to improve understanding of its aetiology.DesignThis is a case–control study from 1 January 2015 to 31 December 2016.SettingCases were consecutively recruited from an urban tertiary care academic children’s hospital in Shanghai, China, while the controls were recruited from a community hospital in Shanghai through a random sampling system.Participants721 patients suspected for BA who planned to take the diagnostic surgery were enrolled preoperatively. 613 were diagnosed with BA and recruited into the case group. Meanwhile, 688 infants without any observed major congenital anomalies or jaundice were enrolled. Finally, 594 valid questionnaires from the case group and 681 from the control group were obtained.Primary and secondary outcome measuresStandardised questionnaires were used for data collection. Multivariate logistic regression analysis was performed to evaluate associations reported as ORs and precision, by adjusting covariates.ResultsAnxiety or stress during pregnancy was strongly associated with increased risk of BA (OR 8.36 (95% CI: 4.08 to 17.15); p<0.001), respectively. Lower birth weight, fathers from ethnic minorities of China, older age of fathers, lower income of parents, and exposure to infection, diseases and medication during pregnancy all made differences.ConclusionsSocial factors including the educational and economic background and its related anxiety and stress during pregnancy might be noticed in the occurrence of BA. Maternal infections during pregnancy in the prevalence of BA were demonstrated.Trial registration numberChiCTR-IPR-15005885.

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Behavioral, health- related and demographic risk factors of death in floods: A case-control study

PLoS ONE ◽

10.1371/journal.pone.0262005 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0262005

Author(s):

Arezoo Yari ◽

Homa Yousefi Khoshsabegheh ◽

Yadolah Zarezadeh ◽

Ali Ardalan ◽

Mohsen Soufi Boubakran ◽

...

Keyword(s):

Risk Factors ◽

Behavioral Health ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Health Related ◽

Demographic Risk ◽

Demographic Risk Factors ◽

Control Study

During the first half of 2019, many provinces of Iran were affected by floods, which claimed the lives of 82 people. The present study aimed to investigate the behavioral, health related and demographic risk factors associated with deaths due to floods. We measured the odds ratio and investigated the contribution and significance of the factors in relation to mortality. This case-control study was conducted in the cities affected by flood in Iran. Data were collected on the flood victims using a questionnaire. Survivors, a member of the flood victim’s family, were interviewed. In total, 77 subjects completed the survey in the case group, and 310 subjects completed the survey in the control group. The findings indicated that factors such as the age of less than 18 years, low literacy, being trapped in buildings/cars, and risky behaviors increased the risk of flood deaths. Regarding the behavioral factors, perceived/real swimming skills increased the risk of flood deaths although it may seem paradoxical. This increment is due to increased self confidence in time of flood. On the other hand, skills and abilities such as evacuation, requesting help, and escape decreased the risk of flood deaths. According to the results, the adoption of support strategies, protecting vulnerable groups, and improving the socioeconomic status of flood-prone areas could prevent and reduce the risk of flood deaths.

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Risk factors for difficult peripheral venous cannulation in hospitalised patients. Protocol for a multicentre case–control study in 48 units of eight public hospitals in Spain

BMJ Open ◽

10.1136/bmjopen-2017-020420 ◽

2018 ◽

Vol 8 (2) ◽

pp. e020420 ◽

Cited By ~ 6

Author(s):

Miguel Angel Rodriguez-Calero ◽

Ismael Fernandez-Fernandez ◽

Luis Javier Molero-Ballester ◽

Catalina Matamalas-Massanet ◽

Luis Moreno-Mejias ◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Public Hospitals ◽

Hospital Treatment ◽

Control Group ◽

Case Group ◽

Venous Cannulation ◽

Hospitalised Patients ◽

Control Study

IntroductionPatients with difficult venous access experience undesirable effects during healthcare, such as delayed diagnosis and initiation of treatment, stress and pain related to the technique and reduced satisfaction. This study aims to identify risk factors with which to model the appearance of difficulty in achieving peripheral venous puncture in hospital treatment.Methods and analysisCase–control study. We will include adult patients requiring peripheral venous cannulation in eight public hospitals, excluding those in emergency situations and women in childbirth or during puerperium. The nurse who performs the technique will record in an anonymised register variables related to the intervention. Subsequently, a researcher will extract the health variables from the patient’s medical history. Patients who present one of the following conditions will be assigned to the case group: two or more failed punctures, need for puncture support, need for central access after failure to achieve peripheral access, or decision to reject the technique. The control group will be obtained from records of patients who do not meet the above conditions. It has been stated a minimum sample size of 2070 patients, 207 cases and 1863 controls.A descriptive analysis will be made of the distribution of the phenomenon. The variables hypothesised to be risk factors for the appearance of difficult venous cannulation will be studied using a logistic regression model.Ethics and disseminationThe study was funded in January 2017 and obtained ethical approval from the Research Ethics Committee of the Balearic Islands. Informed consent will be obtained prior to data collection. Results will be published in a peer-reviewed scientific journal.

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Case-control study to identify risk factors for bovine cysticercosis on farms in Switzerland

Parasitology ◽

10.1017/s0031182008004228 ◽

2008 ◽

Vol 135 (5) ◽

pp. 641-646 ◽

Cited By ~ 25

Author(s):

F. FLÜTSCH ◽

D. HEINZMANN ◽

A. MATHIS ◽

H. HERTZBERG ◽

R. STEPHAN ◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Control Strategies ◽

Case Control ◽

Human Infection ◽

Control Group ◽

Case Group ◽

Structured Interviews ◽

Bovine Cysticercosis ◽

Control Study

SUMMARYTaenia saginatacysticercosis causes financial losses to the beef industry and farmers, and represents a significant source for human infection in many countries. A case-control study was conducted to identify risk factors for bovine cysticercosis on farms in Switzerland. The case group (n=119) consisted of farms with infected cattle identified at slaughter in 2005 and 2006. Infections were confirmed by morphological or molecular diagnosis. The control group (n=66) comprised randomly selected farms with cattle slaughtered in the same period but with no evidence or history of infection. In personal structured interviews with the farmers, information regarding local surroundings and farm management was collected. Logistic regression revealed the following 5 factors as being positively associated with the occurrence of bovine cysticercosis: the presence of a railway line or a car park close to areas grazed by cattle, leisure activities around these areas, use of purchased roughage and organized public activities on farms attracting visitors. This information is considered useful for government authorities to direct control strategies as well as for farmers to take measures tailored to local situations.

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Risk Factors of Gout in MDR-TB Patients in Eritrea: A Case-Control Study

Tuberculosis Research and Treatment ◽

10.1155/2019/9429213 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Mulugeta Russom ◽

Hager Tesfaselassie ◽

Rozina Goitom ◽

Tadese Ghirmai ◽

Freweini Weldedhawariat ◽

...

Keyword(s):

Risk Factors ◽

Drug Exposure ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Increased Risk ◽

Mdr Tb ◽

Control Study ◽

Gastrointestinal Upset

Though the incidence of gout in general population is less than 5% (globally), a study conducted in Eritrea among patients with multidrug resistant tuberculosis (MDR-TB) revealed a higher incidence (25%). Other similar studies conducted elsewhere, however, did not report gout as an adverse effect. It is unknown why a higher incidence of gout is being reported in Eritrea compared to similar studies from other countries. The objective of this study is therefore to explore risk factors for the increased risk of incident gout among MDR-TB patients in Eritrea. A case-control study was conducted in Merhano MDR-TB National Referral Hospital in Eritrea. All MDR-TB patients diagnosed with gout between June 2011 and June 2018 were considered as cases. Controls matched by age, sex, and cumulative drug exposure time were selected from the same study population (1:1 ratio). A total of 84 MDR-TB patients, 42 cases and 42 controls, were included in this study. No patient from the control group has comorbidities, while six patients from the case group have diabetes (χ2 = 6.46, df=1, p=0.026). Patients having tachycardia (OR=3.26, 95% CI=1.28, 8.27), alopecia (OR=3.11, 95% CI=1.00, 9.67), and gastrointestinal upset (OR=3.17, 95% CI=1.26, 7.96) as adverse effects and being on prolonged use of propranolol (OR=3.26, 95% CI=1.28, 8.27) were found to be more likely to develop incident gout compared to their controls. In conclusion, MDR-TB patients with diabetes mellitus, tachycardia, alopecia, and gastrointestinal upset and on prolonged use of propranolol tablet had increased risk of incident gout.

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Associations of TGFBR1 and TGFBR2 gene polymorphisms with the risk of hypospadias: a case–control study in a Chinese population

Bioscience Reports ◽

10.1042/bsr20170713 ◽

2017 ◽

Vol 37 (5) ◽

Author(s):

Xin-Rui Han ◽

Xin Wen ◽

Shan Wang ◽

Xiao-Wu Hong ◽

Shao-Hua Fan ◽

...

Keyword(s):

Risk Factors ◽

Gene Polymorphisms ◽

Chinese Population ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Abnormal Pregnancy ◽

Control Study ◽

Genotype And Allele Frequencies

This case–control study investigated the association of transforming growth factor-β (TGF-β) receptor type I and II (TGFBR1 and TGFBR2) gene polymorphisms with the risk of hypospadias in a Chinese population. One hundred and sixty two patients suffering from hypospadias were enrolled as case group and 165 children who underwent circumcision were recruited as control group. Single nucleotide polymorphisms (SNPs) in TGFBR1 and TGFBR2 genes were selected on the basis of genetic data obtained from HapMap. PCR-restriction fragment length polymorphism (PCR-RFLP) was performed to identify TGFBR1 and TGFBR2 gene polymorphisms and analyze genotype distribution and allele frequency. Logistic regression analysis was conducted to estimate the risk factors for hypospadias. No significant difference was found concerning the genotype and allele frequencies of TGFBR1 rs4743325 polymorphism between the case and control groups. However, genotype and allele frequencies of TGFBR2 rs6785358 in the case group were significantly different in contrast with those in the control group. Patients carrying the G allele of TGFBR2 rs6785358 polymorphism exhibited a higher risk of hypospadias compared with the patients carrying the A allele (P<0.05). The TGFBR2 rs6785358 genotype was found to be significantly related to abnormal pregnancy and preterm birth (both P<0.05). The frequency of TGFBR2 rs6785358 GG genotype exhibited significant differences amongst patients suffering from four different pathological types of hypospadias. Logistic regression analysis revealed that preterm birth, abnormal pregnancy, and TGFBR2 rs6785358 were the independent risk factors for hypospadias. Our study provides evidence that TGFBR2 rs6785358 polymorphism might be associated with the risk of hypospadias.

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