scholarly journals Diagnostic accuracy of single-voided urine protein/ creatinine ratio for proteinuria assessment in children with nephrotic syndrome

2009 ◽  
Vol 49 (6) ◽  
pp. 355
Author(s):  
Devie Kristiani ◽  
Pungky Ardani Kusuma ◽  
Purnomo Suryantoro
Keyword(s):  
Nephrotic Syndrome ◽  
Sensitivity And Specificity ◽  
Good Accuracy ◽  
Urinary Protein ◽  
Diagnostic Purpose ◽  
Creatinine Ratio ◽  
Protein Excretion ◽  
Background Measurement ◽  
The Common ◽  
Urine Specimens

Background Measurement of protein excretion is not onlyused for diagnostic purpose but also to monitor disease severityand prognosis in children with nephrotic syndrome (NS).The common method to measure proteinuria is 24-hour urinecollection. However, 24-hour urine collection is cumbersome,time consuming, and tedious. An alternative simplified methodis the measurement of protein/creatinine ratio in single-voidedurine specimens.Objective The aim of this study was to determine whether urineprotein/creatinine ratio is accurate to predict pathologic (> 100mg/m2/day) and massive proteinuria (> 1 g/m2/day).Methods Seventy single voided and 24-hour urine specimenswere collected from children aged 3-18 years. The relationshipbetween urinary protein/creatinine ratio and total daily proteinexcretion was calculated using correlation and linear regressionanalysis. Diagnostic test was conducted to estimate the accuracyof protein/creatinine ratio for the diagnosis of pathologic andmassive proteinuria in NS.Results Correlation coefficient between quantity of protein in24-hour urine specimens and protein/creatinine ratio in singlevoided urine specimens was 0.96 (R2=0.93). Both sensitivity and specificity of urinary protein/creatinine ratio were 87% in diagnosing pathologic proteinuria, whereas the sensitivity and specificity of the ratio to predict massive proteinuria were 88% and 91%, respectively.Conclusion The urinary protein/creatinine ratio in single voidedurine specimen has a good accuracy to predict pathologic andmassive proteinuria in children with NS aged 3-18 years.

scholarly journals Comparative study of 24-hour urinary protein and spot urine protein creatinine ratio in pre-eclamptic women

2021 ◽  
Vol 10 (7) ◽  
pp. 2734
Author(s):  
Rupakala B. M. ◽  
Akshata S. Hiremath
Keyword(s):  
Predictive Value ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Spearman Correlation ◽  
Urine Protein ◽  
Spot Urine ◽  
Medical College ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
Urine Specimens

Background: The aim of the study was to evaluate the ability of the random urine P/C ratio to predict significant proteinuria, as well as to introduce a diagnostic test for pre-eclampsia which will avoid the inconvenience and time consumption of 24-hour urine protein collection. The objective of this study was to compare spot urine protein- creatinine ratio with 24-hour urine protein for estimation of proteinuria in pre-eclampsia.Methods: A total of 50 pregnant women with pre-eclampsia were prospectively studied for proteinuria in Rajarajeswari medical college and Hospital Bangalore for a period of 9 months from September 2018 to May 2019. Spot urine specimens for measuring P/C ratio were obtained immediately before 24-hour urine collection. The correlation between the spot urine P/C ratio and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test.Results: PCR at a cut off value 0.15 g/mmol had sensitivity and specificity of 96.6% and 55% respectively. In prediction of proteinuria of 300 mg/24 hr positive predictive value and negative predictive value 76.3% and 91.6% respectively.Conclusions: We found that there was a strong correlation between 24-hour urine protein excretion and spot urine protein creatinine ratio in pre-eclamptic women. Spot PCR can be used as a reasonable alternative to 24-hour urine protein test which is a cumbersome.

scholarly journals Assessment of Proteinuria in Nephrotic Syndrome in Children by Using Spot Urinary Protein/Creatinine Ratio

2018 ◽  
Vol 42 (3) ◽  
pp. 108-111
Author(s):  
Delowar Hossain ◽  
Zahiruddin ◽  
Monimul Hoque
Keyword(s):  
Nephrotic Syndrome ◽  
Total Protein ◽  
Mean Value ◽  
Urinary Protein ◽  
Urine Collection ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Spot Urine ◽  
Protein Excretion ◽  
The Mean

Background: Quantification of proteinuria is usually predicted upon 24-hour urine collection. Multiple factors influence urine collection and the rate of protein and creatinine excretion. A spot urine protein-creatinine (P-C) ratio has been shown over the years to be a reliable alternative to the 24-hour collection for detection and follow up of proteinuria. The objective of the study was to evaluate the accuracy of urine protein creatinine ratio (UP/UC) in a spot sample for quantitative measurement of proteinuria in comparison with 24 hours urinary protein excretion in children of nephrotic syndrome having normal Glomerular Filtration Rate (GFR). Methodology: This was a prospective study conducted in the department of paediatrics, Sir Salimullah Medical College & Mitford Hospital Dhaka over a period of six months from January 2003. Fifty cases of Nephrotic syndrome were included who were on initial attack and relapse cases noted down into the proforma with respect to history, examination and investigation. All the patients were advised regarding 24 hours urine collection. They were asked to give a 24 hours urine sample starting at 9.00 am for total protein excretion rate. A spot urine sample was obtained and urine protein/creatinine ratio was calculated. The data was analyzed by linear regression and by calculating the correlation coefficient between urinary protein/ creatinine ratio and 24-hour urinary protein. Results: Sample size was fifty. Urine total protein in a timed 24-hour sample of nephrotic syndrome patients was in the range of 300-3150mg/m2/hour with the mean value of 1725 mg/m2/hour. While as U(Pr/Cr) ratio ranged from 3.1-27.5 with the mean value of 15.2. A significant correlation was found between timed 24-hour urinary protein and UP/UC ratio (r=0.622, p=<.001.) Conclusions: Spot urine protein-creatinine ratio is highly reliable and rapid test for quantification of proteinuria in children with nephrotic syndrome. Bangladesh J Child Health 2018; VOL 42 (3) :108-111

scholarly journals Comparison of single spot urinary albumin-creatinine ratio with 24-hour urinary protein excretion in women with preeclampsia

2018 ◽  
Vol 7 (5) ◽  
pp. 1929
Author(s):  
Indu Kaul ◽  
Bawa Ram Bhagat ◽  
Deepika Sharma ◽  
Gagan Singh
Keyword(s):  
Urine Sample ◽  
Predictive Value ◽  
Solute Concentration ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Single Spot ◽  
Spot Urine ◽  
Protein Excretion

Background: The measurement of albumin: creatinine ratio (ACR) in a spot urine sample avoids the influence of variation in urinary solute concentration and provides a more convenient and rapid method to assess protein excretion. The aim of this study was to evaluate urinary spot ACR as a new marker for proteinuria and to study its correlation and accuracy in comparison with 24-hour urinary protein.Methods: The prospective one-year study was conducted on 100 pregnant women, 18-40 years, >20 weeks gestation with a diagnosis of preeclampsia. A spot midstream urine sample was taken for detection of albuminuria by dipstick method. Another spot sample was taken for detection and calculation of spot ACR. The 24-hour urine collection was taken immediately afterward to evaluate 24-hour urinary protein excretion.Results: A positive linear relation exists between ACR and 24-hour urinary protein excretion The ROC revealed cut-off of 20.4 with 88.5% sensitivity, 75% specificity, 98.8% positive predictive value and 21.4% negative predictive value. Spot urinary ACR >20.4 correctly identified women having 24-hour urinary protein excretion in excess of 0.3 gm/DL.Conclusions: A strong correlation exists between single spot urinary ACR with 24-hour urinary protein excretion in women with preeclampsia.

Acute Effects of Ciclosporin on Renal Hemodynamics and Urinary Protein Excretion in Patients with the Nephrotic Syndrome

Nephron ◽  
1991 ◽  
Vol 59 (3) ◽  
pp. 369-374 ◽  
Author(s):  
Giorgio Fuiano ◽  
Giuseppe Conte ◽  
Vincenzo Sepe ◽  
Mario Balletta ◽  
Paola Cianfrone ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Hemodynamics ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Acute Effects ◽  
Protein Excretion

scholarly journals A study of the relationship between albuminuria, proteinuria and urinary reagent strips

2009 ◽  
Vol 46 (3) ◽  
pp. 247-249 ◽  
Author(s):  
Geraldine Collier ◽  
Marie Clare Greenan ◽  
Jennifer J Brady ◽  
Barbara Murray ◽  
Sean K Cunningham
Keyword(s):  
Sensitivity And Specificity ◽  
Total Protein ◽  
Clinical Excellence ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Protein Loss ◽  
Discordant Result ◽  
Nice Guidance ◽  
Reagent Strips ◽  
The Relationship

Background The aims of this study were to examine the relationship between proteinuria and albuminuria and to assess the equivalence between the albumin to creatinine ratio (ACR) and the protein to creatinine ratio (PCR) at the cut-offs recommended by the National Institute for Health and Clinical Excellence (NICE) guidance on chronic kidney disease. The sensitivity and specificity of the reagent strips used in our laboratory for the detection of clinical proteinuria was also assessed. Methods Urine samples ( n = 117) were screened for protein using the Bayer Multistix 10SG and read manually. Urinary total protein and creatinine was measured on the Roche P Modular by the benzethonium chloride and kinetic Jaffe methods, respectively. Urinary albumin was measured by immunoturbidimetry on the Roche Cobas Mira. Results The relationship between urinary protein and albumin loss was non-linear ( P < 0.05). As urinary protein loss increased the percentage of albumin to total protein increased. At the NICE guidance recommended cut-offs for clinical proteinuria (ACR ≥30 mg/mmol and PCR ≥50 mg/mmol) there was one discordant result between ACR and PCR (ACR <30 mg/mmol and PCR >50 mg/mmol). The Bayer Multistix 10SG had a sensitivity and specificity of 97% and 62%, respectively, for the detection of clinical proteinuria compared with ACR. Conclusions The proportion of urinary total protein attributable to albumin changes with concentration. There was only one discordant result between ACR and PCR: therefore either ratio may be used for the identification of clinical proteinuria. As a screening test for proteinuria, the Bayer Multistix 10SG had an acceptable sensitivity but poor specificity.

scholarly journals Spot urinary protein/osmolality ratio as a predictor for proteinuria of nephrotic range

1970 ◽  
Vol 33 (2) ◽  
pp. 65-68
Author(s):  
Salma Jahan ◽  
Md. Saiful Islam ◽  
Md. Moazzam Hossain
Keyword(s):  
Total Protein ◽  
Pediatric Patients ◽  
Urinary Protein ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Creatinine Ratio ◽  
Total Proteins ◽  
Spot Urine ◽  
Protein Excretion ◽  
A Prospective Study

A prospective study was carried out on 50 patients (age 1-15 years) with nephrotic range of proteinuria to determine the correlation of 24-hour urinary total protein with spot urinary protein/creatinine ratio and urinary protein/osmolality ratio. Another 50 patients having no proteinuria grouped as control. Twenty-four hours urine and spot urine were collected from each child and were analyzed for total volume, total protein, creatinine and osmolality level. The average 24-hour urinary total proteins in nephritic patient were 2148.6 ± 808.7 mg and the spot urinary protein/creatinine and spot urinary protein/osmolality were 3.2332 ± 0.4293 mg/mg and 3.2418 ± 0.4393 mg/mOsm respectively. There was a strong positive correlation of the 24-hour urinary total protein with spot urinary protein/creatinine and protein/osmolality ratios (r=0.9846 and 0.9870, p= <0.001). But in control group, these ratios did not show any correlation with 24-hour urinary total protein. These results suggest that in pediatric patients with nephrotic range of proteinuria, the spot urinary protein/osmolality ratio can predict the 24-hour  urinary total protein excretion like that of spot urinary protein/creatinine ratios. Keywords: Kidney; Proteinuria; UrinaryDOI: 10.3329/bmrcb.v33i2.1207Bangladesh Med Res Counc Bull 2007; 33: 65-68

THYROID PROFILE IN CHILDREN WITH NEPHROTIC SYNDROME

2021 ◽  
pp. 75-77
Author(s):  
Meiyappan Kavitha ◽  
Mallaiyan Manonmani
Keyword(s):  
Nephrotic Syndrome ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
The Body ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Free Triiodothyronine ◽  
Free T4 ◽  
Renal Disorder

Objectives: Nephrotic syndrome is a common renal disorder seen in children, with proteinuria as the hallmark. Growth retardation is a known feature of nephrotic syndrome, either due to the disease or treatment with steroids. Thyroid hormone strongly inuences growth of the body. So, the present study was undertaken with the objective to assess the thyroid prole in children with nephrotic syndrome Methods: The study involved 41 cases of nephrotic syndrome and 41 age and sex matched controls. Serum total triiodothyronine (T3), total thyroxine (T4), free triiodothyronine (T3), free thyroxine (T4) and thyroid stimulating hormone (TSH) were assessed in these subjects. The thyroid hormones were correlated with urinary protein creatinine ratio. The cases were followed up after one month and the levels of thyroid hormones were reassessed. Results: Total T3, total T4, free T3 and free T4 are signicantly decreased and TSH signicantly increased among cases when compared to controls. TSH is positively correlating with urinary protein creatinine ratio in cases. After one month of treatment, total T3 and total T4 are signicantly increased in cases. Conclusions: The thyroid hormone levels are altered in children with nephrotic syndrome during the episode. A state of subclinical hypothyroidism exists during the nephrotic stage. The alteration is normalized with remission and does not require treatment.

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