scholarly journals Screening of Antimicrobial Activity of Siddha drug Kukkiladhi Choornam

2018 ◽  
Vol 10 (1) ◽  
pp. 40-42
Author(s):  
Marimuthu Revathi ◽  
Murugesan Karthikeyan ◽  
Ashok Gnanasekaran ◽  
Ranjith MS
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Streptococcus Pyogenes ◽  
Shigella Flexneri ◽  
Salmonella Typhi ◽  
Antibacterial And Antifungal Activity ◽  
Proteus Vulgaris ◽  
Solid Media ◽  
Antibacterial And Antifungal

Plan: Kukkiladhi choornam is one of the Siddha drugs, which has been indicated for its anti-microbial properties. The aim of the present study was to validate the antibacterial and antifungal activity of Kukkiladhi choornam extract against various microorganisms. Preface: The present study examined the in-vitro screening of antimicrobial activity of Siddha drug Kukkiladhi choornam. Methodology: The extracts were tested for antimicrobial activity using agar well diffusion on solid media. The microorganisms used in the present study include Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Shigella flexneri, Proteus vulgaris, and Candida albicans. Outcome: The study revealed that 50µl extract of Kukkiladhichoornam had significant inhibiting activity against Shigellaflexneri (17mm), Streptococcus pyogenes (17mm) and Candida albicans (18mm).

Substituted 4-Formyl-2H-chromen-2-ones: Their Reaction with N-(2,3,4,6-Tetra-Oacetyl- β-D-galactopyranosyl)thiosemicarbazide, Antibacterial and Antifungal Activity of Their Thiosemicarbazone Products

2020 ◽  
Vol 24 (19) ◽  
pp. 2272-2282
Author(s):  
Vu Ngoc Toan ◽  
Nguyen Minh Tri ◽  
Nguyen Dinh Thanh
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Selenium Dioxide ◽  
Antibacterial And Antifungal Activity ◽  
E Coli ◽  
Antibacterial And Antifungal Activities ◽  
Alkyl Ethers ◽  
Antibacterial And Antifungal

Several 6- and 7-alkoxy-2-oxo-2H-chromene-4-carbaldehydes were prepared from corresponding alkyl ethers of 6- and 7-hydroxy-4-methyl-2-oxo-2H-chromen-2-ones by oxidation using selenium dioxide. 6- and 7-Alkoxy-4-methyl-2H-chromenes were obtained with yields of 57-85%. Corresponding 4-carbaldehyde derivatives were prepared with yields of 41-67%. Thiosemicarbazones of these aldehydes with D-galactose moiety were synthesized by reaction of these aldehydes with N-(2,3,4,6-tetra-O-acetyl-β-Dgalactopyranosyl) thiosemicarbazide with yields of 62-74%. These thiosemicarbazones were screened for their antibacterial and antifungal activities in vitro against bacteria, such as Staphylococcus aureus, Escherichia coli, and fungi, such as Aspergillus niger, Candida albicans. Several compounds exhibited strong inhibitory activity with MIC values of 0.78- 1.56 μM, including 8a (against S. aureus, E. coli, and C. albicans), 8d (against E. coli and A. niger), 9a (against S. aureus), and 9c (against S. aureus and C. albicans).

scholarly journals Medicina Tradicional en el Perú: Actividad Antimicrobiana in vitro de los Aceites Esenciales Extraídos de Algunas Plantas Aromáticas

2014 ◽  
Vol 62 (2) ◽  
pp. 156 ◽  
Author(s):  
Libertad Alzamora ◽  
Liliana Morales ◽  
Lourdes Armas ◽  
Gilma Fernández
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Candida Albicans ◽  
Vibrio Cholerae ◽  
Eucalyptus Globulus ◽  
Shigella Flexneri ◽  
Salmonella Typhi ◽  
Cymbopogon Citratus ◽  
Investigación Cualitativa

El objetivo fue la investigación cualitativa de la actividad antimicrobiana de los aceites esenciales de cinco plantas empleadas en Medicina Tradicional en el Perú: Eucalyptus globulus, Labill "eucalipto"; Cymbopogon citratus, (D.C.) Staff "hierba luisa"; Tagetes pusilla Lag. "Anís serrano"; Senecio tephrosioides, Turcz "huamanrripa" y Lepechinia meyenii, (Walp) Epling "salvia". Los aceites esenciales obtenidos por destilación por arrastre de vapor, se enfrentaron a Salmonella typhi ATCC 6539, S. typhimurium ATCC 14028, S. enteritidis INS, Vibrio cholerae ATCC E-7946 OGAWA, Pseudomonas aeruginosa GT 28, Shigella flexneri INS, Staphylococcus aureus INS, S. aureus ATCC 6538P y Candida albicans ATCC 10231. Se empleó discos de antibióticos como controles. Los aceites esenciales mostraron efecto variado sobre Gram positivos y Gram negativos; ninguno inhibió a Pseudomonas aeruginosa.

scholarly journals In vitro antimicrobial activity of Caesalpinia coriaria (Jacq.) Willd extracts on Streptococcus pyogenes and Candida albicans

Revista Vitae ◽  
2021 ◽  
Vol 28 (2) ◽  
Author(s):  
Silvio Alejandro Lopez-Pazos ◽  
Leanis Pitre-Ruiz ◽  
Deycis Galván-Ayala ◽  
Kelly Johanna Ávila Mendez ◽  
Omar Castro-Uriana
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Streptococcus Pyogenes ◽  
Ethanolic Extract ◽  
Antimicrobial Effect ◽  
Inhibitory Effect ◽  
Bioactive Metabolites ◽  
Soxhlet Method ◽  
Bacteria And Fungi

Background: “Dividivi” Caesalpinia coriaria (Jacq.) Willd fruits are traditionally used by the Wayuú community in La Guajira (Colombia) to treat oral and skin cavity diseases caused by bacteria and fungi. Streptococcus pyogenes is a gram-positive cocci of group A (beta-hemolytic) that is the cause of pharyngeal disease, scarlet fever, cellulitis, erysipelas, or toxic shock-like syndrome. Alternatively, Candida albicans is a yeast-like fungus that is a normal flora of the digestive tract, vagina, or skin folds; it has been known to be the root cause of opportunistic diseases such as diaper rash, oral and esophagus thrush, or vulvovaginitis. Objective: This study evaluated the antimicrobial activity of methanolic and ethanolic extracts of C. coriaria (Jacq.) Willd dry fruits on S. pyogenes ATCC 12384 and C. albicans ATTC 14053. Method: C. coriaria extracts were obtained from the Soxhlet method using two solvents (methanol and ethanol 98%) prepared from pulverized fruits. A phytochemical test and an antimicrobial activity assay were performed using the obtained extracts and tested using S. pyogenes ATCC 12384 and C. albicans ATTC 14053 strains. Results: A phytochemical profile was performed, examining the presence of bioactive metabolites (tannins, alkaloids, glycosides, saponins, and anthraquinones) from each extract. Antimicrobial susceptibility tests showed that the ethanolic extract inhibited S. pyogenes ATCC 12384, causing inhibition halos of 14.1 ± 0.1 mm and a Minimum Inhibitory Concentration (MIC) of 172 mg/ml, and C. albicans test shows inhibition halos of 16.1 ± 0.2 mm and MIC of 212 mg/ml. Additionally, the methanolic extract inhibited S. pyogenes with inhibition halos of 15.2 ± 0.2 mm and MIC of 152 mg/ml; no inhibitory effect was observed on C. albicans. Conclusion: This study revealed that C. coriaria has an antimicrobial effect on the tested species opening the field of its possible use as a therapeutic agent.

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

2009 ◽  
Vol 2009 (10) ◽  
pp. 593-598 ◽  
Author(s):  
Fatma El Mariah
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Studies ◽  
Antibacterial And Antifungal Activity ◽  
Pyridazine Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis Reactions

The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

Synthesis of s-Triazine-Based Thiazolidinones as Antimicrobial Agents

2012 ◽  
Vol 67 (3-4) ◽  
pp. 108-122
Author(s):  
Divyesh Patel ◽  
Rahul Patel ◽  
Premlata Kumari ◽  
Navin B. Patel
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Shigella Flexneri ◽  
Salmonella Typhi ◽  
Proteus Vulgaris ◽  
Aspergillus Clavatus ◽  
Schiff Base Derivatives

5A novel series of thiazolidinone derivatives, namely 4-{4-dimethylamino-6-[4-oxo- 2-phenyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-thiazolidin-3-yl]-[1,3,5]-triazin-2-yloxy}- 1-methyl-1H-quinolin-2-ones, have been synthesized from the key intermediate 4-(4-amino- 6-dimethylamino-[1,3,5]-triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (). Compound 5 was condensed with various aldehydes to give Schiff base derivatives, which after cyclization gave thiazolidinones that were linked with 1-pyridin-2-yl-piperazine to obtain the target compounds. The newly synthesized compounds were evaluated for their antimicrobial activity against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneri) and four fungi (Aspergillus niger, Candida albicans, Aspergillus fumigatus, Aspergillus clavatus)

scholarly journals COMPONENT COMPOSITION OF THE EXTRACTS AND ESSENTIAL OILS FROM THE ALHAGI PERSARUM, GROWING IN UZBEKISTAN AND THEIR ANTIMICROBIAL ACTIVITY

2018 ◽  
pp. 125-132
Author(s):  
Сабир (Sabir) Зарипбаевич (Zaripbaevich) Нишанбаев (Nishanbaev) ◽  
Хайрулла (Khairulla) Мамадиевич (Mamadievich) Бобакулов (Bobakulov) ◽  
Баходир (Bakhodir) Сотволдиевич (Sotvoldievich) Охундедаев (Okhundedaev) ◽  
Собирджан (Sobirjan) Анарматович (Anarmatovich) Сасмаков (Sasmakov) ◽  
Насрулла (Nasrullah) Джалилович (Dzhalilovich) Абдуллаев (Abdullayev) ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Aerial Part ◽  
Component Composition ◽  
Flowering Period ◽  
Antibacterial And Antifungal Activity ◽  
Hexahydrofarnesyl Acetone ◽  
The Republic ◽  
Antibacterial And Antifungal

The volatile compounds of hexane and benzene extracts were studied by GC-MS analysis, as well as were investigated the composition of essential oils obtained by steam and hydrodistillation from the aerial part of Alhagi persarum Boiss. & Buhse, collected during the flowering period in the Fergana region of the Republic of Uzbekistan. As a result of the studies, 44 components were found in the hexane and benzene extracts, among them the neophytadiene (44.0%), hexahydrofarnesyl acetone (20.5%), phytol (17.1%), dihydroactinidiolide (2.0%), a-thujone (32.1%) and b-thujone (9.8%), camphor (30.5%) are dominated. In the composition of essential oils isolated by steam and hydrodistillation methods, were identified 69 and 56 compounds, respectively. The dominating components are eucalyptol (4.7% and 2.9%), a-thujone (44.0% and 35.3%) and b-thujone (17.1% and 14.3%), camphor (12.7% and 28.2%). In vitro screening for antibacterial and antifungal activity of extracts were carried out, as well as EО from Alhagi persarum. Among the samples studied, EO, obtained by steamdistillation, possesses the highest antimicrobial activity against Bacillus subtilis (15 mm), Staphylococcus aureus (13 mm), Escherichia coli (11 mm) and Candida albicans (8 mm).

scholarly journals The Study of Antimicrobial Activity of Citrullus colocynthis Seeds

2012 ◽  
Vol 6 (1) ◽  
pp. 56-60
Author(s):  
Sundus J. Al-Janabi ◽  
Ali O. Abed ◽  
Majda J. Durwish ◽  
Fitua M. GaAziztta
Keyword(s):  
Candida Albicans ◽  
Streptococcus Pyogenes ◽  
Methanolic Extract ◽  
Salmonella Typhi ◽  
Proteus Vulgaris ◽  
Citrullus Colocynthis ◽  
Antimicrobial Drugs ◽  
E Coli ◽  
Enterococcus Spp ◽  
Hexane Extracts

Crude methanolic and hexane extracts of seeds of citrullus colocynthis were examined for antimicrobial effects of different concentrations ranging from (3.1- 50) mg/ml against Staphylococcus aureus, Streptococcus pyogenes, Listeria monocytogenes, Bacillus subtilis, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Psendomonas aeruginosa, Salmonella typhi, Entero coccus spp. and Candida albicans. The agar well diffusion methode was used in this study.The extract was found to be active against S.aureus, B.subtilis, P. vulgaris, K. pneumoniae, and PS. aeruginosa at concentrations of (50, 25, 12.5, 6.25) mg/ml.while S. pyogenes and L.monocytogenes were sensitie at (50, 25, 12.5) mg/ml. E. coli shown sensitivity at (50, 25)mg/ml. Enterococcus spp. and Salmonella typhi showed no response. Candida albicans was sensitive to all different concentrations. Hexane extract was less effective against the tested microorganisms than methanolic extract. The results support the notion that Citrullus colocynthis seeds extract may have a role in pharmacentical uses, like antimicrobial drugs.

scholarly journals Antimicrobial activity of Hypericum annulatum moris and Hypericum elegans stephan ex willd. essential oils from Serbia

2013 ◽  
Vol 19 (1) ◽  
pp. 7-11
Author(s):  
Aleksandra Djordjevic ◽  
Jelena Lazarevic ◽  
Violeta Mitic ◽  
Radosav Palic ◽  
Gordana Stojanovic
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Antibacterial And Antifungal Activity ◽  
Significant Difference ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Hypericum Species

The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils was evaluated against a panel of standardized bacteria and fungi using broth microdilution assay. Both essential oils showed antimicrobial activity against all the tested microorganisms. Hypericum annulatum essential oil showed better antibacterial than antifungal activity, being more effective against Pseudomonas aeruginosa and Escherichia coli while H. elegans essential oil showed no significant difference between antibacterial and antifungal activity. Antimicrobial testing of ?-pinene, ?-pinene and ?-myrcene compounds was also performed. All the compounds were active against all the tested microorganisms, however, based on the MIC, MBC and MFC values, none of these compounds could be thought of as the main bearer of the oils? antimicrobial activity. This is the first report regarding the antimicrobial activity of the essential oils of the two Hypericum species.

scholarly journals Antimicrobial activity of Eucalyptus globulus oil, xylitol and papain: a pilot study

2015 ◽  
Vol 49 (2) ◽  
pp. 0216-0220 ◽  
Author(s):  
Valéria de Siqueira Mota ◽  
Ruth Natalia Teresa Turrini ◽  
Vanessa de Brito Poveda
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Eucalyptus Globulus ◽  
Antimicrobial Effect ◽  
Inhibition Zone ◽  
Proteus Vulgaris ◽  
Test And Evaluation ◽  
Agar Diffusion Test

OBJECTIVE To evaluate the in vitro antimicrobial activity of the Eucalyptus globulus essential oil, and of the xylitol and papain substances against the following microorganisms: Pseudomonas aeruginosa; Samonella sp.; Staphylococus aureus; Proteus vulgaris; Escherichia coli and Candida albicans. METHOD The in vitro antimicrobial evaluation was used by means of the agar diffusion test and evaluation of the inhibition zone diameter of the tested substances. Chlorhexidine 0.5% was used as control. RESULTS The Eucalyptus globulus oil showed higher inhibition than chlorhexidine when applied to Staphylococcus aureus, and equal inhibition when applied to the following microorganisms: Escherichia coli, Proteus vulgaris and Candida albicans. Papain 10% showed lower antimicrobial effect than chlorhexidine in relation to Candida albicans. Xylitol showed no inhibition of the tested microorganisms. CONCLUSION The Eucalyptus globulus oil has antimicrobial activity against different microorganisms and appears to be a viable alternative as germicidal agent hence, further investigation is recommended.

Sign in / Sign up

Export Citation Format

Share Document