scholarly journals Antibacterial and antifungal activity of zinc(II) complexes with some 2-methylbenzimidazole derivatives

2005 ◽  
pp. 231-238 ◽  
Author(s):  
Sanja Podunavac-Kuzmanovic ◽  
Dragoljub Cvetkovic ◽  
Gordana Cetkovic
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Complex Structure ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Yeast Growth ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Candida Pseudotropicalis

Zinc(II) chloride reacts with 2-methylbenzimidazole derivatives to give complexes of the formula ZnL2Cl2-nH2O, where L=2-methylbenzimidazole l-benzyl-2-methylbenzimida-zole and l-(4-methylbenzyl)-2-methylbenzimidazole n=0, 0.5 or 1. All the ligands and their zinc(II) complexes were evaluated for their in vitro antimicrobial activity against Pseudomonas aeruginosa Bacillus sp., Staphylococcus aureus, Sarcina lutea and Candida pseudotropicalis. It was found that the majority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms, except for the starting ligand, 2-methylbenzimidazole and its zinc(II) complex which were active only against gram-negative bacteria. None of the compounds was significantly effective against Candida pseudotropicalis, except for l-(4-methylbenzyl)-2-methylbenzimidazoleandits complex, which very slightly or slightly inhibited the yeast growth. The minimum inhibitory concentration (MIC) was determined for all the ligands and their complexes. The effect of ligand and complex structure on the antimicrobial activity was discussed.

scholarly journals Synthesis and antimicrobial activity of azepine and thiepine derivatives

2015 ◽  
Vol 80 (7) ◽  
pp. 839-852 ◽  
Author(s):  
Nina Bozinovic ◽  
Irena Novakovic ◽  
Sladjana Kostic-Rajacic ◽  
Igor Opsenica ◽  
Bogdan Solaja
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Weak Antibacterial Activity

A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.

scholarly journals In vitro antibacterial effect of Euterpe oleracea Mart. and Theobroma grandiflorum hydroalcoholic extracts

2016 ◽  
Vol 21 (2) ◽  
Author(s):  
Lew Kan Sprenger ◽  
Elane Guerreiro Giese ◽  
Jeannie Nascimento Dos Santos ◽  
Marcelo Beltrão Molento
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Antimicrobial Treatment ◽  
Significant Inhibition ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Euterpe Oleracea ◽  
Agar Disc ◽  
Euterpe Oleracea Mart

This study evaluated the in vitro antimicrobial activity of these species against strains of Gram-positive and Gram-negative bacteria. The hydroalcoholic extracts were prepared from dried leaves, pulp and seeds of E. oleracea Mart. and T. grandiflorum by continuous percolation with 70% ethyl alcohol. The antimicrobial activity was evaluated against four microorganisms by the agar disc diffusion method and the minimal inhibitory concentration (MIC) assay. The antimicrobial activity showed that the açai pulp and seeds possessed significant inhibition in Clostridium perfringens (320 and 640 MIC), Staphylococcus aureus (80 and 320 MIC) and Pseudomonas aeruginosa (640 and 2560 MIC). Cupuassu extracts showed no effect on any bacteria. The use of açai extract products can be a sustainable, viable and an accessible alternative for antimicrobial treatment. New studies should be conducted to determine better results for acai herbals and new formulations of cupuassu extracts.

scholarly journals In vitro leaves and twigs antimicrobial properties of Psidium guajava L. (Myrtaceae)

2015 ◽  
Vol 61 (3) ◽  
pp. 93-104
Author(s):  
Basel Saleh ◽  
Lila Al-Halab ◽  
Ayman Al-Mariri
Keyword(s):  
Antimicrobial Activity ◽  
Ethyl Acetate ◽  
Inhibitory Concentration ◽  
Activity Index ◽  
Antimicrobial Properties ◽  
Psidium Guajava ◽  
Hot Water ◽  
Antibacterial And Antifungal ◽  
Diffusion Assay

Summary The current study aimed to investigate antimicrobial activity of methanol, ethanol, acetone, ethyl acetate and hot water (leaves and twigs fractions) Psidium guajava L. crude extracts against three bacteria and two fungi pathogens. Antimicrobial activity expressed by disc-diffusion assay (zone of inhibitions - ZIs), activity index (AI) and minimum inhibitory concentration (MICs) that were measured as reported in many investigations. Based upon the estimated ZIs, AI and MICs values, hot water twigs <1 cm diameter extract was the most potent against all tested microorganisms. The MICs value ranged between 4 and 7.2 mg/ml for bacteria, while, it was between 14.5 and 37.3 mg/ml for fungi. Moreover, ethyl acetate had the lowest antimicrobial activity compared to the other tested solvents. From the results obtained herein, it could be concluded that P. guajava serve as antibacterial and antifungal agent.

scholarly journals Antimicrobial activity of cobalst(II) complexes with 2-aminobenzimidazole derivatives

2004 ◽  
pp. 231-238 ◽  
Author(s):  
Sanja Podunavac-Kuzmanovic ◽  
Dragoljub Cvetkovic ◽  
Gordana Cetkovic
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Complex Structure ◽  
Gram Negative Bacteria ◽  
Bacillus Sp ◽  
Yeast Saccharomyces Cerevisiae ◽  
Mic Value

Cobalt(II) chloride reacts with 2-aminobenzimidazole derivatives to give complexes of the formula [CoL2Cl2], where L=2-aminobenzimidazole 1-benzyl-2-aminobenzimidazole and 1-(4-methylbenzyl)-2-aminobenzimidazole. All the ligands and their cobalt(II) complexes were evaluated for their in vitro antimicrobial activity against Pseudomonas aeruginosa, Bacillus sp. Staphylococcus aureus, Sarcina lutea and Saccharomyces cerevisiae. The minimum inhibitory concentration (MIC) was determined for all ligands and their complexes. It was found that tested compounds were more active against gram-positive than gram-negative bacteria. None of the compounds were significantly effective against yeast Saccharomyces cerevisiae, except 2-aminobenzimidazole complex, which moderately inhibited the growth of yeast. 1-(4-methylbenzil)-2-aminobenzimidazole was found to be slightly active against Saccharomyces cerevisiae. The same ligand showed the lowest MIC value of 60 (g/ml against Pseudomonas aeruginosa, as well as 125 (g/ml, against Bacillus sp. and Sarcina lutea. The MIC value of its cobalt(II) complex was 60 (g/ml against Pseudomonas aeruginosa. Cobalt(II) complex with 1-benzyl-2-aminobenzimidazole showed the lowest MIC value of 60 (g/ml against Staphylococcus aureus. The effect of ligand and complex structure on the antimicrobial activity was discussed.

scholarly journals Synthesis, Characterization of Biologically Potent Novel Chalcones Bearing Urea, Thiourea and Acetamide Linkages

2014 ◽  
Vol 36 ◽  
pp. 281-294
Author(s):  
Nirali S. Mewada ◽  
Dhruvin R. Shah ◽  
Kishor H. Chikhalia
Keyword(s):  
Antifungal Activity ◽  
Dilution Method ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antibacterial And Antifungal ◽  
Antimicrobial And Antifungal Activities

Three series of some novel chalcone based urea, thiourea and acetamide derivatives were designed, synthesized and screened for their antimicrobial and antifungal activities. All the synthesized compounds are first reported. The structures of the compounds were elucidated with the aid of elemental analysis and spectral methods including IR, 1H-NMR spectral data. The prepared compounds were evaluated for antibacterial activity against two Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus), two Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also investigated for their antifungal activity using the broth micro dilution method. The bioassay results showed that compounds a few compounds showed good to superior in vitro antibacterial and antifungal activity.

scholarly journals Composition and in vitro antimicrobial activity of the essential oil of Dorema ammoniacum D. Don. fruit from Iran

2011 ◽  
Vol 76 (6) ◽  
pp. 857-863 ◽  
Author(s):  
Morteza Yousefzadi ◽  
Hossein Mirjalili ◽  
Naba Alnajar ◽  
Amineh Zeinali ◽  
Mitra Parsa
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Staphylococcus Epidermidis ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
In Vitro Antimicrobial Activity ◽  
Main Components ◽  
Total Oil ◽  
Antimicrobial Assay

The genus Dorema (Apiaceae) is represented in the flora of Iran with seven species of which two, D. ammoniacum D. Don. and D. aucheri Boiss. are endemic. Ripe fruits of D. ammoniacum collected just in the deciduous time were subjected to hydrodistillation to yield the essential oil, which was subsequently analyzed by GC and GC-MS. Twenty-nine compounds were identified and quantified, representing 95.1 % of the total oil. (Z)-Ocimenone (22.3 %) and (E)-ocimenone (18.1 %) were the main components of the oil. In vitro antimicrobial activity of the oil was evaluated against seven Gram-positive and Gram-negative bacteria (Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) and three fungi (Candida albicans, Saccharomyces cerevisiae and Aspergillus niger). The results of the antimicrobial assay of the oil by the disc diffusion method and the MIC values indicated that the oil exhibited moderate to high antimicrobial activity, especially against B. subtilis and S. epidermidis with MIC value of 3.75 mg ml-1.

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

2009 ◽  
Vol 2009 (10) ◽  
pp. 593-598 ◽  
Author(s):  
Fatma El Mariah
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Studies ◽  
Antibacterial And Antifungal Activity ◽  
Pyridazine Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis Reactions

The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

Oxidation studies on β-lactam antibiotics: In-vitro antimicrobial activity of the oxidized products of 3-heteroarylthiomethyl-ceph-3-ems

1991 ◽  
Vol 56 (11) ◽  
pp. 2362-2372 ◽  
Author(s):  
Rajeshwar Singh ◽  
Maya P. Singh ◽  
Ronald G. Micetich
Keyword(s):  
Hydrogen Peroxide ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acetic Acid ◽  
Side Chain ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
In Vitro Antimicrobial Activity ◽  
Oxidized Products

Various products from the oxidation of 3-heteroarylthiomethyl-ceph-3-ems using m-chloroperbenzoic acid (m-CPBA) and hydrogen peroxide in acetic acid in varying stoichiometric ratios have been isolated, identified and their in vitro antimicrobial activity determined. The oxidized compounds with the 2-aminothiazol-4-yl-(Z)-2-methoxyiminoacetamido side chain showed better antibacterial activity against various Gram negative bacteria compared to the unoxidized compounds.

scholarly journals COMPONENT COMPOSITION OF THE EXTRACTS AND ESSENTIAL OILS FROM THE ALHAGI PERSARUM, GROWING IN UZBEKISTAN AND THEIR ANTIMICROBIAL ACTIVITY

2018 ◽  
pp. 125-132
Author(s):  
Сабир (Sabir) Зарипбаевич (Zaripbaevich) Нишанбаев (Nishanbaev) ◽  
Хайрулла (Khairulla) Мамадиевич (Mamadievich) Бобакулов (Bobakulov) ◽  
Баходир (Bakhodir) Сотволдиевич (Sotvoldievich) Охундедаев (Okhundedaev) ◽  
Собирджан (Sobirjan) Анарматович (Anarmatovich) Сасмаков (Sasmakov) ◽  
Насрулла (Nasrullah) Джалилович (Dzhalilovich) Абдуллаев (Abdullayev) ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Aerial Part ◽  
Component Composition ◽  
Flowering Period ◽  
Antibacterial And Antifungal Activity ◽  
Hexahydrofarnesyl Acetone ◽  
The Republic ◽  
Antibacterial And Antifungal

The volatile compounds of hexane and benzene extracts were studied by GC-MS analysis, as well as were investigated the composition of essential oils obtained by steam and hydrodistillation from the aerial part of Alhagi persarum Boiss. & Buhse, collected during the flowering period in the Fergana region of the Republic of Uzbekistan. As a result of the studies, 44 components were found in the hexane and benzene extracts, among them the neophytadiene (44.0%), hexahydrofarnesyl acetone (20.5%), phytol (17.1%), dihydroactinidiolide (2.0%), a-thujone (32.1%) and b-thujone (9.8%), camphor (30.5%) are dominated. In the composition of essential oils isolated by steam and hydrodistillation methods, were identified 69 and 56 compounds, respectively. The dominating components are eucalyptol (4.7% and 2.9%), a-thujone (44.0% and 35.3%) and b-thujone (17.1% and 14.3%), camphor (12.7% and 28.2%). In vitro screening for antibacterial and antifungal activity of extracts were carried out, as well as EО from Alhagi persarum. Among the samples studied, EO, obtained by steamdistillation, possesses the highest antimicrobial activity against Bacillus subtilis (15 mm), Staphylococcus aureus (13 mm), Escherichia coli (11 mm) and Candida albicans (8 mm).

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