scholarly journals Expression of CK-19 in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors - A Cross-Sectional Study

2021 ◽  
Vol 10 (11) ◽  
pp. 813-818
Author(s):  
Revathy V.J. ◽  
Sarath Kumar A
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Tumour Size ◽  
Cross Sectional Study ◽  
Papillary Thyroid ◽  
Sectional Study ◽  
Cross Sectional ◽  
Node Metastasis

BACKGROUND Papillary thyroid carcinomas (PTC) are the most common carcinomas of the thyroid. Diagnosis of PTC is with its distinct nuclear features. Prognosis of PTC is favourable but can also be aggressive as demonstrated by its recurrence. So, we wanted to improve the present diagnostic tools to identify cases with aggressive course. Immunohistochemistry (IHC) markers which are thought to be useful are CK-19 and CD56. METHODS This is a cross sectional study, done in the Department of Pathology, Government Medical College, Thiruvananthapuram from January 2018 to May 2019. Histopathology slides were prepared from 80 samples, IHCs performed, and the data was analysed using statistical software SPSS version 23.0. RESULTS The classic variant was the most common. In the study, predominant population was below 45 years. There was a female predominance and majority of cases had a tumour size of more than 1 cm. 23.8 % of the cases showed lymph node metastasis. On evaluating CK-19 expression in PTC, 98.75 % showed a positive expression, but there was no association between CK-19 expression and factors like age, gender, tumour size, and lymph node metastasis. 96.3 % of cases showed a loss of expression of CD56. CONCLUSIONS Both CK-19 and CD56 can be used together as markers for PTC including all their variants but CK-19 cannot be used to assess the prognosis of PTC as no association was identified in the study between the expression of CK-19 and prognostic factors. KEY WORDS Papillary Thyroid Carcinoma, Immunohistochemistry

scholarly journals PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: A cross-sectional study

2021 ◽  
Vol 65 ◽  
pp. 102303
Author(s):  
Mayara Mota de Oliveira ◽  
Gabriela Tonini Peterle ◽  
Cinthia Vidal Monteiro da Silva Couto ◽  
Lucas de Lima Maia ◽  
Andre Kühl ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cancer ◽  
Inflammatory Infiltrate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Node Metastasis ◽  
Pai 1

Sentinel lymph node metastasis in primary cutaneous basosquamous carcinoma. A cross-sectional study

2018 ◽  
Vol 117 (8) ◽  
pp. 1752-1758 ◽  
Author(s):  
Despoina D. Kakagia ◽  
Polyxeni Zapandioti ◽  
Grigoris Trypsiannis ◽  
Alexandra N. Grekou ◽  
Dimosthenis Tsoutsos
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Cross Sectional Study ◽  
Sentinel Lymph Node Metastasis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Node Metastasis

scholarly journals Association of Clinicopathological Features with Lymph Node Metastasis: A Cross Sectional Study of Oral Squamous Cell Carcinoma Patients

2020 ◽  
pp. 46-53
Author(s):  
Fizza Abidi ◽  
Mervyn Hosein ◽  
Saima Akram Butt ◽  
Abeeha Batool Zaidi ◽  
Angbeen Anjum ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Node Metastasis ◽  
The Mean

Aims: The aim of this study is to determine association between lymph node metastasis and various clinico-pathological parameters in order to predict their future prognosis of cancer patients. Study Design: Cross sectional study design. Place and Duration of Study: Ziauddin Hospital, North Nazimabad campus, Karachi. Methodology: November 2018 to September 2019. Results: The present study enrolled 140 OSCC patients visiting Ziauddin University of which 30 (21.4%) were females and 110 (78.6%) were male patients. The mean age of patients was 46.99 ± 12.26. The buccal mucosa was the most common site observed 93 (66.4%). The mean size of tumour was 4.05 ± 2.261 mm, mean thickness was 1.70 ±1.32 mm. It was found that lymph node metastasis was not present in 66 (47.1%) of OSCC cases, 22 (15.7%) cases were found N1, 9(6.4%) N2a, 27(19.3%) N2b, 3 (2.1%) and 13(9.3%) N3. Significant association was found between age and lymph node metastasis: (P 0.02); however, gender showed no significant association. (P 0.149). Thickness of tumor, site of tumor, peri-neural invasion, lympho-vascular invasion and bone penetration showed significant association with lymph node metastasis with (P 0.040, 0.021, 0.016, 0.00 and 0.001) respectively. Conclusion: Our study showed significant association of lymph node involvement with tumour staging, tumour thickness, lymphovascular involvement, perineural invasion and bone penetration. Our suggestion is to incorporate these clinic-pathological variables while determining the treatment and prognosis of Oral squamous cell Carcinoma (OSCC). Given the very high incidence and prevalence of Oral Cancer in our country and the region further multi-centered researches should be carried out and with larger sample sizes. Early diagnosis and restrictions on smokeless tobacco products can limit the occurrence and progression of OSCC.

scholarly journals Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuanchao Liu ◽  
Yizeng Wang ◽  
Ke Zhao ◽  
Dongyang Li ◽  
Zuoyu Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Middle Aged ◽  
Node Metastasis
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