scholarly journals A Study of Clinicopathological Association in Chronic Liver Disease - A Cross Sectional Study from a Tertiary Referral Hospital of South India

2021 ◽  
Vol 10 (37) ◽  
pp. 3257-3261
Author(s):  
Adapa Ramakrishnam Naidu ◽  
Manchu Venkata Viswanadh Gandhi ◽  
Lotheti Sivakumar ◽  
Sreepada Venkata Ramana Murthy
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Clinical Diagnosis ◽  
South India ◽  
Cross Sectional Study ◽  
Chronic Liver ◽  
Histopathological Diagnosis ◽  
Age Group ◽  
Cross Sectional

BACKGROUND Chronic liver disease is a liver disorder of varying causes and severity with variable clinical, biochemical and histological findings with severity lasting for 6 months or more. The spectrum of chronic inflammatory diseases of the liver extends from acute hepatitis to chronic hepatitis and finally to cirrhosis. Whatever the aetiology, the same basic underlying histological changes may be seen in the liver. The objective of the study was to see the association of clinical diagnosis with the histopathological diagnosis among chronic liver disease patients. METHODS It is a cross-sectional study that included analysis of clinicopathological data of 40 patients with clinically suspected chronic liver disease who were admitted to the medical wards of government general hospital, Kakinada between March 2003 and May 2005. RESULTS Total number of patients (N = 40) of suspected chronic liver disease were included in the study in which 25 were males (62.5 %) and 15 were females (37.5 %). Most of the cases (36) were found in the age group of 30 - 69 years, a majority of 12 was in the age group of 50 - 59 years. The most common symptoms in this study were abdominal distension and loss of appetite in 28 (70 %) patients, followed by pain in abdomen 22 (55 %), jaundice 17 (42.5 %), loss of weight 16 (40 %), pedal oedema 11 (27.5 %). A total of 7 cases (41.7 %) of cirrhosis were seen in the age group of 40 - 49 years, 5 cases (45.45 %) with chronic hepatitis were in the age group of 50 - 59 years, 5 (45.45 %) hepatocellular carcinoma cases were in the age group of 60 - 69 years, hepatoblastoma was seen in a 60-year-old female. Clinical diagnosis was strongly associated with histopathology (Pearson chi-square value = 19.583, P = 0.021) and also showed fair agreement between clinical diagnosis and histopathology (P = 0.002). CONCLUSIONS Chronic liver disease is more in males, most commonly seen in the age group of 30 - 69 years and the majority of them are in the age group of 50 - 59 years. Cirrhosis is the most common chronic liver disease seen in North and Coastal Andhra, part of South India, followed by chronic hepatitis, hepatocellular carcinoma. The most common etiological factor is alcoholic abuse (35 %) followed by HBsAg positivity (15 %), native medicine in 5 % and unknown in 45 %. Clinical diagnosis of chronic liver disease should be confirmed with histopathological examination. In appropriate clinical settings, the clinical diagnosis of chronic liver disease made by experts is fairly associated with histopathological diagnosis. KEY WORDS Chronic Liver Disease, Clinical Diagnosis of Liver Disease, Histopathological Association

scholarly journals Nonalcoholic Steatohepatitis Challenges Hepatitis B Virus as the Leading Cause of Chronic Hepatitis in Bangladesh

2017 ◽  
Vol 28 (1) ◽  
pp. 24-27
Author(s):  
Mamun Al Mahtab ◽  
Dulal Chandra Das ◽  
Mohammad Abdur Rahim ◽  
Rokshana Begum ◽  
Sheikh Mohammad Noor e Alam ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Chronic Liver ◽  
Hbv Infection ◽  
Control Measures ◽  
Effective Control ◽  
Age Group ◽  
Cross Sectional

Background: Chronic hepatitis is inflammation of the liver that lasts at least 6 months. Knowledge of aetiology and pattern of development of complications of chronic liver disease will help in designing optimal and cost effective control measures of the disease. Methods: The present study was performed to find out the aetiological factors in patients of chronic liver disease. This was a retrospective, cross-sectional study. Patients attending Hepatology Green Unit, Bangabandhu Sheikh Mujib Medical University, Dhaka in 2014 with chronic hepatitis were included. Results: Total 3250 patients were studied, 2310(71.08%) males and 940(28.92 %) females. Most of the patients 1547 (47.6%) belong to age group of 18 to 30 years followed by 922 (28.37%) who were between the age group of 31-40 years. Majority of patients 2012(61.91%) had HBV infection, 1095(33.69%) had nonalcoholic steatohepatitis ( NASH), 81(2.49%) had HCV infection, 7(0.22%) had alcohol abuse, 28(0.86%) had Wilson’s disease, 19(0.58%) had autoimmune hepatitis and no aetiological factors were recorded in 8(0.25%) patients. However in case of females 52.55 % (494/940) due to NASH, while 40.21 % (378/940) due to HBV. Conclusion: HBV infection is the major risk factor for chronic liver disease and NASH challenges HBV in our patients.Bangladesh J Medicine Jan 2017; 28(1) : 24-27

scholarly journals ANALISIS FERITIN DAN AST TO PLATELET RATIO INDEX SEBAGAI PETANDA DERAJAT FIBROSIS PENYAKIT HATI KRONIS (Analysis Ferritin and AST to Platelet Ratio Index as a Marker Degree of Fibrosis Chronic Liver Disease)

2018 ◽  
Vol 22 (1) ◽  
pp. 72
Author(s):  
Yulianti Yasin ◽  
Uleng Bahrun ◽  
Ibrahim Abdul Samad
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Cell Damage ◽  
Clinical Chemistry ◽  
Cross Sectional Study ◽  
Chronic Liver ◽  
Impedance Method ◽  
Iron Deposit ◽  
Cross Sectional ◽  
Modified Method

Chronic liver disease is an endemic disease in Indonesia which is still a global health problem and detected when it’s developinginto fibrosis. The determination of fibrosis is important for the treatment and prognosis of chronic liver disease. AST to Platelet RatioIndex (APRI) score is the most common used to assess the degree of liver fibrosis. Ferritin is an iron deposit that found in the liver andthe levels depend on the degree of the cell damage. The aim of this study was to analyze ferritin levels as a marker of the fibrosis degreein the chronic liver disease. This cross-sectional study of 47 patients with chronic liver disease performed at Dr. Wahidin SudirohusodoGeneral Hospital between May–June 2012. The subjects are grouped into cirrhotic and noncirrhotic, based on the theory that in cirrhoticliver fibrosis was considered as an irreversible condition. AST to platelet ratio index score based on the Wai CT formulation, includingthe examination of AST by optimizing UV-test according to International Federation of Clinical Chemistry (IFCC) modified method onthe ABX Pentra 400, examination of platelet by impedance method on Sysmex XT 2000i and ferritin levels were measured by ECLIAmethod using Elecsys 2010 Analyzer. The Spearman correlation tests showed no association between ferritin levels and APRI in cirrhoticand non cirrhotic patients (p=0.704 and r=–0.057). In conclusion, ferritin can not be used as the marker in determining the degreeof fibrosis patients suffering chronic liver disease. Further studies are expected using a more valid method for determining the degree offibrosis such as liver biopsy or fibro scan.

scholarly journals A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

2020 ◽  
Vol 7 (6) ◽  
pp. 1013
Author(s):  
Mohammed Jaleel P. ◽  
S. Bhagyabati Devi ◽  
Ningthoukhongjam Reema ◽  
Thangjam Gautam Singh ◽  
Dhileeban Maharajan P.
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Cross Sectional Study ◽  
Bone Diseases ◽  
Chronic Liver ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Metabolic Bone Diseases ◽  
Hepatic Osteodystrophy

Background: Hepatic osteodystrophy encompasses the spectrum of metabolic bone diseases in chronic liver disease (CLD) patients. CLD causing changes in BMD is well known. Although BMD evaluation in CLD cirrhosis are recommended by societies of British and American gastroenterology ,very less number of literature exist from India and none from the North-eastern region of India. Aim of the study to determine the association and severity of bone mineral density changes in patients with CLD and to correlate it with different aetiologies and severity of CLD.Methods: This cross-sectional study which included 79 patients with CLD was conducted in RIMS, Manipur from September 2017 to August 2019. All CLD patients of age 18-60 years were included. DEXA scan and other related blood investigations were performed.Results: Chronic alcohol intake (56.9%), viral infection (20.3%) and mixed (17.7%) were the main aetiology of CLD in our study. Seventy three (92.4%) of the total 79 patients had low BMD (Osteopenia in 29 (36.7%) and osteoporosis in 44 (55.7%) patients). Osteoporosis was detected in 53.4% of alcohol related Cirrhosis, 25%of viral liver disease. Majority of the severe CLD patients (Child class C) had osteoporosis (70.6%) as compared to less severe groups (23.5% and 36.4% in class B and A respectively).Conclusions: CLD patients have high prevalence of osteoporosis. Severity of liver disease, alcoholic liver disease, serum calcium and vitamin D deficiency predisposes to osteoporosis in these patients. Hence early screening of BMD is necessary in CLD patients.

scholarly journals Correlation of lipid profile in patients with severity of liver disease: a cross sectional study in a tertiary care hospital

2016 ◽  
Vol 5 (1) ◽  
pp. 326
Author(s):  
Hashik P. Muhammed ◽  
Kezhakkut Jayaraj
Keyword(s):  
Liver Disease ◽  
Lipid Profile ◽  
Chronic Liver Disease ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Chronic Liver ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lipid Parameters

Background: Many previous studies concluded variation in the lipid parameters such as total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) with severity of liver disease. Hence, this study was conducted to find out the correlation of lipid profile in patients with severe liver disease.Methods: A cross sectional study which included 170 patients admitted with chronic liver disease. Severity of liver disease according to Child Pugh Turcotte Score. The patients were subjected to routine investigation and fasting lipid profile test. Correlation was studied using the Pearson correlation coefficient and the comparison of lipid parameters was also done.Results: Total of 170 consecutive chronic liver disease patients were analysed over a period of one year. Majority of the patients were of the age 51 to 60 years (39.8%). Among the total, 24 patients were in Child Pugh Turcotte Score class A, 47 patients were in class B and 52 were patients in class C. We could observe a significant (p<0.001) negative correlation of all the lipid profile parameters with the severity of liver disease.Conclusions: Serum TC, LDL TG and HDL were decreased in patients with cirrhosis and they are inversely correlated to severity of disease.

scholarly journals Catastrophic Health Expenditure, Distress Financing and Impoverishment due to Out-of-Pocket Expenses for Healthcare among Patients with Chronic Liver Disease: A Cross-sectional Study among Hospitalized Patients in Bangladesh

2021 ◽  
Author(s):  
Mohammad Farhadul Haque ◽  
ANM Shamsul Islam ◽  
Samina Pervin ◽  
Emily Akter ◽  
Mahmudul Hasan
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Health Expenditure ◽  
Cross Sectional Study ◽  
Catastrophic Health Expenditure ◽  
Hospitalized Patients ◽  
Chronic Liver ◽  
Sectional Study ◽  
Cross Sectional ◽  
Distress Financing

Out-of-pocket (OOP) expenses for hospitalized patients with chronic liver disease (CLD) poses an economic challenge on affected household in the form of catastrophic health expenditure (CHE), distress financing and impoverishment. OOP Expenses data for hospitalized CLD patients from Bangladesh is scarce. This study aimed to estimate the OOP expenses and resulting CHE, distress financing and impoverishment among hospitalized patients with CLD. This cross-sectional study was conducted among conveniently selected 107 diagnosed CLD patients admitted at Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH) aged 18 years and above. Data were collected from the respondents using a semi-structured questionnaire through face to face interview during discharge from hospital. Out of pocket expenditure for chronic liver disease in selected hospitals was Bangladeshi Taka (BDT) 19,262. Direct medical, direct non-medical and indirect cost was BDT 16,240; 2,165 and 1,510, respectively. Investigation cost and medicine cost contributed to 48.48% and 31.81% of the total OOP expenses, respectively. At 10% threshold level, 29% of the respondents were affected by CHE. 64.5% of the respondents were facing distress financing due to OOP expenses. Among the respondents, 1.9% slipped below the international poverty line of $1.90 (BDT 161.10, in 2019).There was statistically significant (p &lt; 0.05) difference among the mean OOP expenses for different etiological types of chronic liver disease. The study concluded that it requires establishing a more accessible and affordable decentralized health care system for CLD treatment along with the implementation of financial risk protection.

A Cross Sectional Study of Chronic Liver Disease with Reference to Portal Hypertension and Endoscopic Finding at Down Town Hospital, Guwahati, Assam

2021 ◽  
Vol 8 (27) ◽  
pp. 2373-2380
Author(s):  
Manabendra Nayak ◽  
Ghodke Chinmoy Pradeep
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Cross Sectional Study ◽  
Chronic Liver ◽  
Sectional Study ◽  
Cross Sectional ◽  
Town Hospital ◽  
Pugh Class ◽  
Grade Iii

BACKGROUND Cirrhosis is a progressive clinical condition associated with considerable mortality and morbidity. It leads to a wide spectrum of characteristic clinical manifestations, mainly attributable to hepatic insufficiency and portal hypertension.1 In cirrhosis, primary diagnostic test for evaluation of upper-gastro-intestinal bleeding (UGIB) is endoscopy.2 The present study attempts to find out different clinical patterns of the chronic liver disease (CLD) with portal hypertension along with the endoscopic profile of the patients. METHODS It was a cross sectional study conducted in Down Town Hospital, Guwahati, Assam. RESULTS A cross sectional study was conducted at Downtown Hospital, Guwahati, Assam on patients diagnosed with chronic liver disease from 01 January 2017 to 31 January 2018. Male predominance was observed in this study with 84 % males and 16 % females. Male to female ratio was 5.25 : 1. Maximum patients (58 %) were observed in the age group of 40 to 60 years followed by 30 % in the age group of 60 to 80 years. The average age was 53.6 years. Most common aetiological factor was alcohol (66 %) followed by non-alcoholic steatohepatitis (NASH) (16 %). Other aetiologies were hepatitis-B, hepatitis-C and cryptogenic. 88 % cases were recorded in model for end stage liver disease (MELD) score range of 10 to 29. Ascites was noted in 88 % cases, of which 20 % had grade-1 and grade-2, 48 % had grade-3. Splenomegaly was noted in 70 % cases. Child-Pugh class-C consisted of 26 % cases (13) with grade-III varices followed by 18 % cases (9) with grade-II varices while Child-Pugh Class-B had 24 % cases (12) and 8 % cases (4) with grade-III and grade-II varices respectively. Child-Pugh class-A had all the cases with grade-I varices. CONCLUSIONS Alcoholism was the leading cause for cirrhosis followed by hepatitis-B, hepatitis-C, NASH and cryptogenic. Class-C had maximum number of cases with grade-III varices followed by class-B. MELD score ranged between 10 - 29 in majority. Severe anaemia was noted in 10 % cases. Thrombocytopenia a non-invasive indicator of oesophageal varices was noted in 70 % with different grades of oesophageal varices. KEYWORDS Endoscopy, Portal Hypertension, Chronic Liver Disease

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