scholarly journals New approach for characterising a breakage event as a multi-stage process

2017 ◽  
Author(s):  
Seyedeh Fatemeh Saeidi
Keyword(s):  
New Approach ◽  
Multi Stage ◽  
Stage Process

Applied Pragmatism and Interaction Design

2009 ◽  
pp. 352-366
Author(s):  
Anders I. Mørch
Keyword(s):  
User Interfaces ◽  
Interaction Design ◽  
Interactive Systems ◽  
Furniture Design ◽  
Cultural Perspective ◽  
New Approach ◽  
Multi Stage ◽  
Cultural Domain ◽  
Stage Process ◽  
Translational Approach

This chapter presents a translational approach to socio-technical design, as a new approach to the theorybased design of user interfaces, supported by a multi-stage process. A survey of the early work on theorybased design in HCI identifies the strengths and limitations of this approach. This new approach extends HCI with a socio-cultural perspective, and adopts creative practices from the fields of architecture and furniture design. The process consists of three stages: selection, appropriation, and translation that “map” elements from the socio-cultural domain to the HCI domain. Two interactive systems are used to illustrate the process, informed by ideas of American pragmatism. The chapter ends by discussing the strengths and limitations of the translational approach, and points out directions for further work.

scholarly journals Insights into the Cellular and Molecular Mechanisms That Govern the Fracture-Healing Process: A Narrative Review

2021 ◽  
Vol 10 (16) ◽  
pp. 3554
Author(s):  
Dionysios J. Papachristou ◽  
Stavros Georgopoulos ◽  
Peter V. Giannoudis ◽  
Elias Panagiotopoulos
Keyword(s):  
Fracture Healing ◽  
Bone Repair ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Healing Process ◽  
Bone Architecture ◽  
Multi Stage ◽  
Stage Process ◽  
And Function ◽  
The Impact

Fracture-healing is a complex multi-stage process that usually progresses flawlessly, resulting in restoration of bone architecture and function. Regrettably, however, a considerable number of fractures fail to heal, resulting in delayed unions or non-unions. This may significantly impact several aspects of a patient’s life. Not surprisingly, in the past few years, a substantial amount of research and number of clinical studies have been designed, aiming at shedding light into the cellular and molecular mechanisms that regulate fracture-healing. Herein, we present the current knowledge on the pathobiology of the fracture-healing process. In addition, the role of skeletal cells and the impact of marrow adipose tissue on bone repair is discussed. Unveiling the pathogenetic mechanisms that govern the fracture-healing process may lead to the development of novel, smarter, and more effective therapeutic strategies for the treatment of fractures, especially of those with large bone defects.

scholarly journals Epigenetic and transcriptional regulation of osteoclastogenesis in the pathogenesis of skeletal diseases: a protocol for a systematic review

2020 ◽  
Author(s):  
Dr Siddhartha Sharma ◽  
Dr Anupam Mittal ◽  
Aditi Mahajan ◽  
Riddhi Gohil
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Genetic Material ◽  
Transcriptional Regulators ◽  
Osteoclast Formation ◽  
Micro Rna ◽  
Epigenetic Changes ◽  
Multi Stage ◽  
Stage Process ◽  
Skeletal Disorders

Osteoclastogenesis (OCG) is a multi-stage process that involves formation of activated osteoclasts from bone marrow macrophages. The progression of each stage of OCG is governed by a set of transcription factors and gene regulators, which are genetically and epigenetically regulated at both transcription and post-transcription levels. Epigenetic changes are used to denote interactions between genetic material and environment leading to phenotypic alterations that can be inherited, without any variations in DNA sequence. Epigenetic and transcription regulatory events have profound effects on osteoclast formation and activation; these have been implicated in numerous disorders including osteoporosis, osteopetrosis, rheumatoid arthritis, spondyloarthritis, gout and bone metastasis. We aim to conduct a systematic review to assess possible relationship between key epigenetic and transcriptional regulators of osteoclastogenesis, and their role in specific bone disorders. This is a protocol for the proposed review. Keywords: osteoclasts; osteoclastogenesis; epigenetics; transcription; bone; skeletal disorders; methylation; histone proteins; micro RNA

Paleomagnetic results from the western Himalaya indicate multi-stage India-Eurasia collision

2021 ◽  
Author(s):  
Craig R Martin ◽  
Oliver Jagoutz ◽  
Rajeev Upadhyay ◽  
Leigh H Royden ◽  
Michael P Eddy ◽  
...  
Keyword(s):  
Subduction Zone ◽  
Classical Model ◽  
Western Himalaya ◽  
Paleomagnetic Data ◽  
Northwestern Part ◽  
Himalayan Orogeny ◽  
The North ◽  
Multi Stage ◽  
Early Paleocene ◽  
Stage Process

<p>The classical model for the collision between India and Eurasia, which resulted in the formation of the Himalayan orogeny, is a single-stage continent-continent collision event at around 55 – 50 Ma. However, it has also been proposed that the India-Eurasia collision was a multi-stage process involving an intra-oceanic Trans-Tethyan subduction zone south of the Eurasian margin. We present paleomagnetic data constraining the location the Kohistan-Ladakh arc, a remnant of this intra-oceanic subduction zone, to a paleolatitude of 8.1 ± 5.6 °N between 66 – 62 Ma. Comparing this result with new paleomagnetic data from the Eurasian Karakoram terrane, and previous paleomagnetic reconstructions of the Lhasa terrane reveals that the Trans-Tethyan Subduction zone was situated 600 – 2,300 km south of the contemporaneous Eurasian margin at the same time as the first ophiolite obduction event onto the northern Indian margin. Our results confirm that the collision was a multistage process involving at least two subduction systems. Collision began with docking between India and the Trans-Tethyan subduction zone in the Late Cretaceous and Early Paleocene, followed by the India-Eurasia collision in the mid-Eocene. The final stage of India-Eurasia collision occurred along the Shyok-Tsangpo suture zone, rather than the Indus-Tsangpo. The addition of the Kshiroda oceanic plate, north of India after the Paleocene reconciles the amount of convergence between India and Eurasia with the observed shortening across the India–Eurasia collision system. Our results constrain the total post-collisional convergence accommodated by crustal deformation in the Himalaya to 1,350 – 2,150 km, and the north-south extent of the northwestern part of Greater India to < 900 km.</p>

Collaborative Technologies and Innovation in SMEs

2010 ◽  
pp. 204-217
Author(s):  
Angel L. Meroño-Cerdan ◽  
Pedro Soto-Acosta ◽  
Carolina Lopez-Nicolas
Keyword(s):  
The Other ◽  
Research Model ◽  
Firm Level ◽  
Collaborative Technologies ◽  
Other Hand ◽  
Multi Stage ◽  
Stage Process ◽  
The One ◽  
The Impact ◽  
The Relationship

This study seeks to assess the impact of collaborative technologies on innovation at the firm level. Collaborative technologies’ influence on innovation is considered here as a multi-stage process that starts at adoption and extends to use. Thus, the effect of collaborative technologies on innovation is examined not only directly, the simple presence of collaborative technologies, but also based on actual collaborative technologies’ use. Given the fact that firms can use this technology for different purposes, collaborative technologies’ use is measured according to three orientations: e-information, e-communication and e-workflow. To achieve these objectives, a research model is developed for assessing, on the one hand, the impact of the adoption and use of collaborative technologies on innovation and, on the other hand, the relationship between adoption and use of collaborative technologies. The research model is tested using a dataset of 310 Spanish SMEs. The results showed that collaborative technologies’ adoption is positively related to innovation. Also, as hypothesized, distinct collaborative technologies were found to be associated to different uses. In addition, the study found that while e-information had a positive and significant impact on innovation, e-communication and e-workflow did not.

scholarly journals Geochemical Evidence for the Control of Fire by Middle Palaeolithic Hominins

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alex Brittingham ◽  
Michael T. Hren ◽  
Gideon Hartman ◽  
Keith N. Wilkinson ◽  
Carolina Mallol ◽  
...  
Keyword(s):  
Aromatic Hydrocarbons ◽  
Technological Development ◽  
Particulate Emissions ◽  
Middle Palaeolithic ◽  
Natural Fires ◽  
Fire Use ◽  
Multi Stage ◽  
The Social ◽  
Polycyclic Aromatic ◽  
Stage Process

Abstract The use of fire played an important role in the social and technological development of the genus Homo. Most archaeologists agree that this was a multi-stage process, beginning with the exploitation of natural fires and ending with the ability to create fire from scratch. Some have argued that in the Middle Palaeolithic (MP) hominin fire use was limited by the availability of fire in the landscape. Here, we present a record of the abundance of polycyclic aromatic hydrocarbons (PAHs), organic compounds that are produced during the combustion of organic material, from Lusakert Cave, a MP site in Armenia. We find no correlation between the abundance of light PAHs (3–4 rings), which are a major component of wildfire PAH emissions and are shown to disperse widely during fire events, and heavy PAHs (5–6 rings), which are a major component of particulate emissions of burned wood. Instead, we find heavy PAHs correlate with MP artifact density at the site. Given that hPAH abundance correlates with occupation intensity rather than lPAH abundance, we argue that MP hominins were able to control fire and utilize it regardless of the variability of fires in the environment. Together with other studies on MP fire use, these results suggest that the ability of hominins to manipulate fire independent of exploitation of wildfires was spatially variable in the MP and may have developed multiple times in the genus Homo.

An Anaerobic Process for Treatment of CTMP Effluent

1988 ◽  
Vol 20 (1) ◽  
pp. 143-147 ◽  
Author(s):  
T. Welander
Keyword(s):  
Volatile Fatty Acids ◽  
Anaerobic Bacteria ◽  
Methanogenic Bacteria ◽  
Second Stage ◽  
The Third ◽  
Multi Stage ◽  
Third Stage ◽  
Aluminum Iron ◽  
Stage Process ◽  
Iron And Calcium

A multi-stage process for treatment of CTMP effluent has been developed. It comprises primary settling and four biological stages. The concentration of hydrogen peroxide, a compound which is toxic to anaerobic bacteria, is reduced in the first biological stage by means of the biocatalytic action of biomass that is recycled from the following acidogenic and/or aerobic stages. The second stage is an acidogenic stage, in which volatile fatty acids are formed and remaining peroxide is decomposed. A mixture of aluminum, iron and calcium salts is added to the effluent in order to detoxify compounds which are toxic to methanogenic bacteria. The main part of the COD and BOD removal takes place in the third stage, the methanogenic stage, after which follows an aerobic stage for polishing and removal of bad-smelling compounds. The COD and BOD7 removals in the anaerobic part of the process are 60 and 90 %, respectively, and the methane yield is 0.20-0.25 Nm3/kg COD removed.

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