scholarly journals Тhe prevalence of metabolically healthy obesity: data from the epidemiological survey in of Novosibirsk

2019 ◽  
Vol 15 (4) ◽  
pp. 31-37 ◽  
Author(s):  
Svetlana V. Mustafina ◽  
Liliya V. Shcherbakova ◽  
Darya A. Kozupeeva ◽  
Sofiya K. Malyutina ◽  
Yulia I. Ragino ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Systolic Arterial Pressure ◽  
Hdl Cholesterol ◽  
Epidemiological Survey ◽  
Metabolically Healthy Obesity ◽  
Metabolic Complications ◽  
Men And Women ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Background: Obesity is associated with numerous metabolic complications, such as type 2 diabetes mellitus (DM2), dyslipidemia, arterial hypertension (AH), cardiovascular diseases and some forms of cancer. Nevertheless, the literature describes a group of obese individuals who are more resistant to the development of metabolic disorders. At present, this phenomenon is known as "Metabolically healthy obesity", "metabolically healthy obesity" (MZO). Despite the presence of excess weight or obesity, a favorable metabolic profile can be observed in this cohort of patients, characterized by preserved insulin sensitivity, absence of arterial hypertension, normal lipid, hormonal profile, absence of inflammation and unchanged hepatic transaminases. Aims: To study the prevalence of metabolically healthy obesity (MHO) and its characteristics in men and women at the age of 4569 years in Novosibirsk. Materials and methods: To study covered 3197 persons from the base of the international project HAPPIE. They had a body mass index (BMI 30 kg/m). Metabolically healthy obesity was determined as obesity (BMI 30 kg/m, with 2 and fewer components of metabolic syndrome (MS) by criteria NCEP ATP III, 2001. Statistical analisys SPSS-13. Results: The prevalence of metabolic healthy obesity (MHO) was 42% (38% for men and 43% for women). The examined people with MHO have reliably more favorable average level of TG, HDL-cholesterol, indicators of blood glucose, systolic arterial pressure and diastolic arterial pressure and less waist circumference. In the groups withMHO and MS abdominal obesity is common in men at 95 and 71%, in women at 99 and 90%; hyperTG in men at 74 and 9%, in women at 72 and 5,5%; lower level HDL-cholesterol in 16 and 1% for men, and in 44,5% and 3% for women; AP in 96 and 77% and 94 and 71% in men and women respectively, the frequency fasting of hyperglycaemia 77 and 21% in men and 60 and 5% in women was markedly different. According to the data obtained by us, the frequency in the sample is high and amounted to 42%. In the subgroup the most commonly found is the MHO phenotype 53%, than in the men -38%, р 0,001 Conclusions: According to our data, the frequency of metabolic healthy obesity in the sample is high and amounted to 42%. In the female subgroup, a metabolically healthy phenotype is more common 43% than in the male 38%, p 0.001. Metabolically healthy obese individuals are characterized by a significantly lower incidence of fasting hyperglycaemia and dyslipidemia.

scholarly journals Sex differences in blood pressure responsiveness to spontaneous K-complexes during stage II sleep

2020 ◽  
Author(s):  
Ian Mark Greenlund ◽  
Carl A. Smoot ◽  
Jason R. Carter
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Pressure ◽  
Cardiac Cycle ◽  
Pressor Response ◽  
Systolic Arterial Pressure ◽  
Stage Ii ◽  
Men And Women ◽  
Blood Pressures ◽  
Blood Pressure Responses

K-complexes are a key marker of non-rapid eye movement sleep (NREM), specifically during stages II sleep. Recent evidence suggests the heart rate responses to a K-complexes may differ between men and women. The purpose of this study was to compare beat-to-beat blood pressure responses to K-complexes in men and women. We hypothesized that the pressor response following a spontaneous K-complex would be augmented in men compared to women. Ten men (Age: 23 ± 2 years, BMI: 28 ± 4 kg/m2) and ten women (Age: 23 ± 5 years, BMI: 25 ± 4 kg/m2) were equipped with overnight finger plethysmography and standard 10-lead polysomnography. Hemodynamic responses to a spontaneous K-complex during stable stage II sleep were quantified for 10 consecutive cardiac cycles, and measurements included systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and heart rate. K-complex elicited greater pressor responses in men when blood pressures were expressed as SAP (cardiac cycle × sex: p = 0.007) and DAP (cardiac cycle × sex: p = 0.004). Heart rate trended to be different between men and women (cardiac cycle × sex: p = 0.078). These findings suggest a divergent pressor response between men and women following a spontaneous K-complex during normal stage II sleep. These findings could contribute to sex-specific differences in cardiovascular risk that exist between men and women.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Are metabolically healthy obese individuals really healthy?

2014 ◽  
Vol 171 (6) ◽  
pp. R209-R219 ◽  
Author(s):  
Matthias Blüher
Keyword(s):  
Metabolic Complications ◽  
Fitness Level ◽  
Metabolically Healthy Obese ◽  
Open Questions ◽  
Increased Risk ◽  
Biological Determinants ◽  
Metabolically Healthy ◽  
Treatment Of Obesity ◽  
Weight Loss Interventions

Obesity has become one of the major public health concerns of the past decades, because it is a key risk factor for type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, and certain types of cancer, which may lead to increased mortality. Both treatment of obesity and prevention of obesity-related diseases are frequently not successful. Moreover, a subgroup of individuals with obesity does not seem to be at an increased risk for metabolic complications of obesity. In this literature, this obesity subphenotype is therefore referred to as metabolically healthy obesity (MHO). Importantly, individuals with MHO do not significantly improve their cardio-metabolic risk upon weight loss interventions and may therefore not benefit to the same extent as obese patients with metabolic comorbidities from early lifestyle, bariatric surgery, or pharmacological interventions. However, it can be debated whether MHO individuals are really healthy, especially since there is no general agreement on accepted criteria to define MHO. In addition, overall health of MHO individuals may be significantly impaired by several psycho-social factors, psychosomatic comorbidities, low fitness level, osteoarthritis, chronic pain, diseases of the respiratory system, the skin, and others. There are still open questions about predictors, biological determinants, and the mechanisms underlying MHO and whether MHO represents a transient phenotype changing with aging and behavioral and environmental factors. In this review, the prevalence, potential biological mechanisms, and the clinical relevance of MHO are discussed.

scholarly journals Emotional states of different obesity phenotypes: A sex-specific results in a west-Asian population

2020 ◽  
Author(s):  
Fahimeh Mehrabi ◽  
Parisa Amiri ◽  
Leila Cheraghi ◽  
Ali Kheradmand ◽  
Farhad Hosseinpanah ◽  
...  
Keyword(s):  
Asian Population ◽  
Diabetes Type 2 ◽  
Emotional States ◽  
Men And Women ◽  
Metabolically Healthy Obese ◽  
Adult Participants ◽  
Ordinal Logistic Regression Analysis ◽  
Metabolically Healthy ◽  
Relationship Of

Abstract Background The present study aimed to investigate the relationship of obesity phenotypes with depression, anxiety, and stress of the adult participants in Tehran Lipid and Glucose Study (TLGS). Methods Depression, anxiety, and stress levels of 2469 adult participants aged > 19 (1158 men and 1311 women) from Tehran Lipid and Glucose Study were examined among different obesity phenotypes in the current study. Weight, height, and waist circumferences of participants were measured by trained personnel. Obesity was defined as BMI ≥ 30 kg/m², and metabolically unhealthy status based on having metabolic syndrome (MetS) or diabetes type 2. Finally, four obesity phenotypes were defined: 1) Metabolically Healthy Non-Obese (MHNO), 2) Metabolically Healthy Obese (MHO) 3) Metabolically Unhealthy Non-Obese (MUNO), and 4) Metabolically Unhealthy Obese (MUO). Ordinal logistic regression analysis was used to compare sex-specific odds ratios. Results The mean age of 2469 men and women was 46.2 ± 15.9 and 45.6 ± 14.7, respectively. In total, women were more likely to experience different levels of depression (30.5%), anxiety (44.2%), and stress (43.5%). After adjusting for potential confounders, the odds of experiencing higher levels of anxiety were significantly greater in metabolically unhealthy men whether they were obese (OR: 1.78, 95% CI: 1.25–2.54; P = < 0.001) or non-obese (OR: 1.61, 95% CI: 1.17–2.21; P = < 0.001), and also in MUO women (OR: 1.73, 95% CI: 1.28–2.34; P = < 0.001) comparing to their MHNO counterparts. Moreover, the odds of experiencing higher levels of stress were significantly greater in MUNO men (OR: 1.40, 95% CI: 1.02–1.90; P = 0.04), and in MUO women (OR: 1.45, 95% CI: 1.07–1.96; P = 0.02) comparing to their MHNO counterparts. No difference in having higher levels of depression was observed in both genders. Conclusions Compared to MHNO individuals, MUO women and all metabolically unhealthy men reported higher levels of anxiety and stress. The obesity phenotypes were by no means associated with depression in men and women.

scholarly journals Association between HDL Cholesterol Levels and the Consumption of Vitamin A in Metabolically Healthy Obese Lebanese: A Cross-Sectional Study among Adults in Lebanon

Cholesterol ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
J. Zalaket ◽  
L. Hanna-Wakim ◽  
J. Matta
Keyword(s):  
Vitamin A ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Dietary Vitamin ◽  
Limited Information ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Cholesterol Levels ◽  
Healthy Obese ◽  
Metabolically Healthy

Objectives. Previous studies show the association between vitamin A and elevation of plasma triglyceride concentrations. However, limited information exists on the association between vitamin A and plasma HDL cholesterol concentrations. The aim of this study is to investigate the association between plasma HDL cholesterol levels and vitamin A intake in 57 metabolically healthy obese (MHO) Lebanese. Methods. Out of the 112 adult obese participants who had completed anthropometric and biochemical data, 57 (22 males and 35 females) aged 18–62 years old are metabolically healthy and their data are included in this study. A valid semiquantitative food frequency questionnaire (SQFFQ) was used to test vitamin A intake among other antioxidants. The participants were recruited from the database of three dietary clinics across Lebanon. Results. Pearson’s correlation coefficient was used to measure the strength of the relationship between vitamin A and plasma HDL cholesterol levels. There was a significant positive correlation (P value = 0.0225) between vitamin A consumption and HDL cholesterol serum levels in obese participants; when vitamin A levels decrease, HDL levels decrease more in female than in male participants. Conclusion. The association between dietary vitamin A, a powerful antioxidant, and high HDL levels is shown in MHO but should be further exploited in future studies.

scholarly journals Association of Metabolically Healthy and Unhealthy Obesity Phenotype with Markers Related to Obesity, Diabetes among Young, Healthy Adult Men. Analysis of MAGNETIC Study

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1350
Author(s):  
Mateusz Lejawa ◽  
Kamila Osadnik ◽  
Zenon Czuba ◽  
Tadeusz Osadnik ◽  
Natalia Pawlas
Keyword(s):  
Plasminogen Activator Inhibitor ◽  
Normal Weight ◽  
Obese Patients ◽  
Metabolically Healthy Obesity ◽  
Plasminogen Activator Inhibitor 1 ◽  
Metabolic Markers ◽  
Adult Men ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Adipose tissue secretes many regulatory factors called adipokines. Adipokines affect the metabolism of lipids and carbohydrates. They also influence the regulation of the immune system and inflammation. The current study aimed to evaluate the association between markers related to obesity, diabesity and adipokines and metabolically healthy and unhealthy obesity in young men. The study included 98 healthy participants. We divided participants into three subgroups based on body mass index and metabolic health definition: 49 metabolically healthy normal-weight patients, 27 metabolically healthy obese patients and 22 metabolically unhealthy obese patients. The 14 metabolic markers selected were measured in serum or plasma. The analysis showed associations between markers related to obesity, diabesity and adipokines in metabolically healthy and unhealthy obese participants. The decreased level of adipsin (p < 0.05) was only associated with metabolically healthy obesity, not with metabolically unhealthy obesity. The decreased level of ghrelin (p < 0.001) and increased level of plasminogen activator inhibitor-1 (p < 0.01) were only associated with metabolically unhealthy obesity, not with metabolically healthy obesity. The decreased level of adiponectin and increased levels of leptin, c-peptide, insulin and angiopoietin-like 3 protein were associated with metabolically healthy and unhealthy obesity. In conclusion, our data show that metabolically healthy obesity was more similar to metabolically unhealthy obesity in terms of the analyzed markers related to obesity and diabesity.

scholarly journals Emotional states of different obesity phenotypes: A sex-specific study in a west-Asian population

2020 ◽  
Author(s):  
Fahimeh Mehrabi ◽  
Parisa Amiri ◽  
Leila Cheraghi ◽  
Ali Kheradmand ◽  
Farhad Hosseinpanah ◽  
...  
Keyword(s):  
Asian Population ◽  
Cross Sectional Study ◽  
Emotional States ◽  
Psychological Consequences ◽  
Cross Sectional ◽  
Men And Women ◽  
Metabolically Healthy Obese ◽  
Ordinal Logistic Regression Analysis ◽  
Stress Levels ◽  
Metabolically Healthy

Abstract Background: The present study aimed to investigate the relationship of obesity phenotypes with depression, anxiety, and stress among adults in the Tehran Lipid and Glucose Study (TLGS)."Methods: Depression, anxiety, and stress levels of participants from the TLGS were examined among different obesity phenotypes in this cross-sectional study. Weight, height, and waist circumferences of participants were measured. Obesity was defined as body mass index (BMI) ≥30 kg/m², and metabolically unhealthy status based on having metabolic syndrome (MetS) or type 2 diabetes. Four obesity phenotypes were defined: 1) Metabolically Healthy Non-Obese (MHNO), 2) Metabolically Healthy Obese (MHO) 3) Metabolically Unhealthy Non-Obese (MUNO), and 4) Metabolically Unhealthy Obese (MUO). Emotional states of different obesity phenotypes were assessed by the Persian version of depression, anxiety, and stress scale-21 items (DASS-21). Ordinal logistic regression analysis was used to compare sex-specific odds ratios of depression, anxiety, and stress in different obesity phenotypes. Results: The mean age of 2469 men and women was 46.2±15.9 and 45.6±14.7, respectively. In total, women were more likely to experience higher levels of depression (30.5%), anxiety (44.2%), and stress (43.5%) symptoms compared to men. After adjusting for potential confounders, compared to MHNO men, the odds of experiencing higher anxiety levels were significantly greater in metabolically unhealthy men whether they were obese (OR: 1.78, 95% CI: 1.25-2.54; P=<0.001) or non-obese (OR: 1.61, 95% CI: 1.17-2.21; P= <0.001), and also in MUO women (OR: 1.73, 95% CI: 1.28-2.34; P=<0.001) compared to MHNO women. Moreover, the odds of experiencing higher stress levels were significantly greater in MUNO men (OR: 1.40, 95% CI: 1.02-1.90; P=0.04) compared to MHNO men, and in MUO women (OR: 1.45, 95% CI: 1.07-1.96; P=0.02) compared to MHNO women. No difference in having higher levels of depression was observed in either sex. Conclusions: Our results showed that men and women with various obesity phenotypes experience different anxiety and stress levels. While MUO women and all metabolically unhealthy men experienced more anxiety and stress levels than MHNO individuals, none of the obesity phenotypes were associated with depression. These findings provide insight into recognizing the psychological consequences of different phenotypes of obesity.

scholarly journals Metabolically Healthy Obesity and Physical Fitness in Military Males in the CHIEF Study

2020 ◽  
Author(s):  
Sheng-Huei Wang ◽  
Pei-Shou Chung ◽  
Yen-Po Lin ◽  
Kun-Zhe Tsai ◽  
Ssu-Chin Lin ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Analysis Of Covariance ◽  
Metabolically Healthy Obesity ◽  
Physically Active ◽  
P Values ◽  
Metabolically Healthy Obese ◽  
Male Cohort ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
The Difference

Abstract The metabolically healthy obese (MHO) characterized by the absence of abdominal obesity have been reported to have superior cardiorespiratory fitness (CRF) than the metabolically unhealthy obese (MUO). However, this finding might be biased by the baseline sedentary behavior in the general population.This study utilized 3,669 physically active military males aged 18-50 years in Taiwan. Obesity and metabolically unhealthy were respectively defined as body mass index ≥27.5 kg/m2 and waist circumference ≥90 cm, specifically for Asian male adults. Four groups were accordingly classified as the metabolically healthy lean (MHL, n=2,607), metabolically unhealthy lean (MUL, n=234), MHO (n=208) and MUO (n=620). CRF was evaluated by time for a 3-kilometer run, and muscular strengths were separately assessed by numbers of push-up and sit-up within 2 minutes. Analysis of covariance was utilized to compare the difference in each exercise performance between groups adjusting for age, service specialty, smoking, alcohol intake, and physical activity.The prevalence of metabolic syndrome in MUO, MHO, MUL and MHL was 45.3% 13.0%, 29.1% and 3.7%, respectively. The performance of CRF did not differ between MHO and MUO (895.3±5.1 sec and 891.5±3.1 sec, p=0.68) which were both inferior to MUL and MHL (877.5±4.8 sec and 849.5±1.4 sec, all p-values <0.05). The performance of muscular strengths evaluated by 2-minute push-ups did not differ between MUL and MUO (44.8±0.2 and 45.2±0.5, p=0.40) which were both less than MHO and MHL (48.1±0.8 and 50.5±0.2, all p-values <0.05). However, the performance of 2-minute sit- ups were only superior in MHL (48.0±0.2) as compared with MUL, MHO and MUO (46.0±0.5, 46.7±0.5 and 46.2±0.3, respectively, all p-values <0.05).Our findings suggested that in a physically active male cohort, the MHO might have greater muscle strengths, but have similar CRF level compared with the MUO.

scholarly journals Metabolically healthy obesity: Is it really benign?

2021 ◽  
pp. 24-26
Author(s):  
Nikolaos Kourris ◽  
Konstantinos Tziomalos
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Abnormalities ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy Obese ◽  
Increased Risk ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Recently, a subgroup of patients with obesity but without cardiometabolic abnormalities has attracted considerable attention and has been characterized as metabolically healthy obese (MHO) patients. MHO is quite prevalent among patients with obesity. Even though these subjects have less pronounced metabolic abnormalities compared with patients with metabolically unhealthy obesity (MUO), they are at increased risk for progressing to MUO and for developing cardiovascular disease. Accordingly, diet, exercise and appropriate pharmacotherapy should be recommended to patients with MHO as strongly as in those with MUO.

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