scholarly journals The impact of fat distribution in obesity

1996 ◽  
Vol 42 (6) ◽  
pp. 30-34 ◽  
Author(s):  
M. M. Ginzburg ◽  
G. S. Kozupitsa
Keyword(s):  
Body Weight ◽  
Abdominal Cavity ◽  
Fat Distribution ◽  
Insulin Dependent Diabetes Mellitus ◽  
Developed Countries ◽  
Long Term Results ◽  
Dependent Diabetes Mellitus ◽  
Excess Body Weight ◽  
Common Disease ◽  
The Impact

Obesity remains the most common disease in the population of economically developed countries. 16-25% of the inhabitants of these countries have a body weight exceeding the norm by more than 15%. There has been an increase in the incidence of obesity over the past 20 years. The connection between overweight and such formidable diseases as hypertension, coronary heart disease, and non-insulin-dependent diabetes mellitus (NIDDM) is well known. The current state and especially long-term results of the treatment of obesity remain unsatisfactory. It is known that in more than 80% of patients the initial body weight is restored within the first 3-6 months after the end of the course of treatment. The mechanisms of the development of diseases associated with obesity have not been fully studied, and therefore pathogenetically substantiated treatment regimens have not been developed. After the classic work of J. Vague, performed more than 40 years ago, there are many studies showing that the risk of developing diseases associated with obesity depends not only on the degree of excess body weight, patient age, duration of the disease, but also on the distribution of fat. According to some reports, the dependence on the distribution of fat is more pronounced than the dependence on other factors, in particular on the degree of obesity. It turned out that complications are more characteristic for patients with a predominant accumulation of fat on the trunk and in the abdominal cavity (android, or abdominal, or visceral, or upper obesity) and are less typical for patients with a predominant deposition of fat on the buttocks and hips (gynoid, or gluteofemoral, or lower obesity).

Pregnancy After Simultaneous Pancreas-Kidney Transplantation in Treatment of End-Stage Diabetes Mellitus: a Review

2021 ◽  
Author(s):  
Zana Stanic ◽  
Marko Vulic ◽  
Zlatko Hrgovic ◽  
Rajko Fureš ◽  
Milvija Plazibat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Transplantation ◽  
Graft Function ◽  
Insulin Dependent Diabetes Mellitus ◽  
Organ Damage ◽  
Multiple Organ ◽  
Dependent Diabetes Mellitus ◽  
Increased Risk ◽  
Simultaneous Pancreas Kidney ◽  
The Impact

AbstractThe majority of patients with simultaneous pancreas and kidney transplant (SPKT) required transplantation owing to a long-standing history of insulin-dependent diabetes mellitus (IDDM). The disease causes multiple organ damage, impairs fertility, and affects quality of life. A successful kidney and pancreas transplant can improve health, ameliorate the consequences of pre-existent diabetes, and restore fertility. Good graft function, without any sign of rejection, and stable doses of immunosuppressant drugs are of utmost importance prior to the planned pregnancy. SPKT recipients who become pregnant may be at an increased risk for an adverse outcome and require meticulous multidisciplinary surveillance. We present experiences with SPKT pregnancies, traditional approaches, and recent considerations. In light of complex interactions between new anatomic relations and the impact of developing pregnancy and immunosuppressive medications, special stress is put on the risk of graft rejection, development of pregnancy complications, and potential harmful effects on fetal development. Recent recommendations in management of SPKT recipients who wish to commence pregnancy are presented as well. Key words: transplantation, pregnancy, pancreas, kidney, simultaneous pancreas and kidney transplantation (SPKT)

scholarly journals The first experience of stapled intestinal anastomoses application in children in Ukraine

2020 ◽  
pp. 15-20
Author(s):  
O. Sliepov ◽  
◽  
M. Migur ◽  
O. Ponomarenko ◽  
O. Gladyshko ◽  
...  
Keyword(s):  
Body Weight ◽  
Necrotizing Enterocolitis ◽  
Postoperative Period ◽  
Abdominal Cavity ◽  
Operation Time ◽  
Developed Countries ◽  
Premature Baby ◽  
Diffuse Peritonitis ◽  
Level Of Evidence ◽  
Intestinal Anastomoses

Introduction. Conducting reconstructive surgery in children, especially those with low body weight, associated with an increase in the operation time and a worsening of the postoperative period. Therefore, to reduce the operation time, surgical clinics in developed countries of the world use linear staplers for anastomoses in children, especially young children. Case report. A premature newborn, with a birth weight of 1420 g, was diagnosed with necrotizing enterocolitis, with ileal perforation and diffuse peritonitis. According to vital indications, the operation was performed: laparotomy, revision of the abdominal cavity, Mikulich enterostomy. After complete stabilization of the general condition of the child, upon reaching 2550 g of body weight, at the age of 2 months, enterostomy closure was performed with the imposition of a stapled side-to-side functional end-to-end ileoileostomy. In 14 days after the operation, the child achieved full enteral autonomy. There were no postoperative surgical complications. In the late postoperative period, the child gains weight well, grows and develops according to age. Conclusion. The use of linear staplers in time of enteroanastomoses creation can significantly reduce operation time in children, in particular, premature babies with low body weight. Level of evidence. Level V. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of an participating institution.The informed consent of the child’s parents was obtained from the studies. No conflict of interest was declared by the authors. Key words: linear staplers, enteroanastomosis, necrotizing enterocolitis, perforation of the small intestine, newborn premature baby.

Blood Pressure Response to Physical Exercise in Healthy Adolescents and Adolescents with Insulin-Dependent Diabetes Mellitus

1994 ◽  
Vol 86 (4) ◽  
pp. 425-432 ◽  
Author(s):  
H. Nordgren ◽  
U. Freyschuss ◽  
B. Persson
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Body Weight ◽  
Metabolic Control ◽  
Blood Pressure Response ◽  
Insulin Dependent Diabetes Mellitus ◽  
Pressure Response ◽  
Pressure Increase ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

1. Reference values for systolic blood pressure during exercise are provided for 88 healthy adolescents (12–22 years of age) of both sexes. Data were related to oxygen uptake, heart rate, blood lactate concentration, rate of perceived exertion, age, sex, body size and physcial fitness. 2. The same variables were measured in 55 adolescents of both sexes with insulin-dependent diabetes mellitus of about 12 years duration and were analysed with respect to the healthy control group, to degree of metabolic control and to late diabetic complications. 3. In healthy adolescents the pressure response was not related to sex or age. When compared with control subjects diabetic patients had a higher diastolic blood pressure at rest and a more marked blood pressure increase, 23 versus 19 mmHg W−1 kg−1 body weight, during exercise with no sex difference. The blood pressure rise was not related to metabolic control, glomerular hyperfiltration or physical fitness. 4. Prolonged exercise tests were no more informative regarding the blood pressure response to exercise than the stepwise increased load test. Analysing the blood pressure increase versus relative work load (W/kg body weight) during exercise reveals blood pressure differences otherwise not noted. A diabetic patient with blood pressure above the 97.5% confidence limit during exercise seems to have a higher risk of developing incipient nephropathy 5 years later.

Cardiorespiratory Function as Assessed by Exercise Testing in Patients with Non-Insulin-Dependent Diabetes Mellitus

1996 ◽  
Vol 24 (2) ◽  
pp. 209-213 ◽  
Author(s):  
J Katoh ◽  
Y Hara ◽  
M Kmvsu ◽  
J Miyaji ◽  
K Nabutaki
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Weight ◽  
Oxygen Uptake ◽  
Body Mass ◽  
Exercise Testing ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Cardiorespiratory Function ◽  
Insulin Dependent

Exercise testing was used to examine 19 cardiorespiratory diabetes mellitus patients, aged 32 – 68 years (body mass index, 27.8 ± 4.8 kg/m2), and 16 healthy volunteers, aged 23 – 57 years (body mass index, 22.7 ± 2.5 kg/m2). A graded cycling exercise test was done, monitoring gas exchange, ventilation and heart rate. Values were significantly higher in the non-insulin-dependent diabetes mellitus (NIDDM) patients than in the controls for fasting blood glucose ( P < 0.01), glycosylated haemoglobin ( P < 0.01), body weight ( P < 0.05) and body mass index ( P < 0.05). The exercise testing produced values that were significantly lower in the patients with NIDDM than in the controls for percentage oxygen uptake ( P < 0.05), maximum load ( P < 0.05), maximum metabolic equivalent ( P < 0.01) and maximum oxygen uptake per unit body weight ( P < 0.01). Ventilatory capacity and forced expiratory volume at 1 sec did not differ significantly in the two groups. These results suggest that general fitness is diminished due to reduced cardiorespiratory function in patients with NIDDM.

scholarly journals Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects

1998 ◽  
Vol 80 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Arefaine Abraha ◽  
Sandy M. Humphreys ◽  
Mo L. Clark ◽  
David R. Matthews ◽  
Keith N. Frayn
Keyword(s):  
Body Weight ◽  
Insulin Dependent Diabetes Mellitus ◽  
Acute Effect ◽  
Dependent Diabetes Mellitus ◽  
Plasma Insulin Concentration ◽  
Postprandial Lipaemia ◽  
Insulin Resistant ◽  
Triacylglycerol Metabolism ◽  
Heparin Plasma ◽  
Insulin Dependent

We investigated whether the potentiation of postprandial lipaemia by fructose occurs in both non-diabetic subjects and those with non-insulin-dependent diabetes mellitus. Six non-diabetic and six diabetic subjects were studied on two occasions. They were given a meal containing 1 g fat/kg body weight with, on one occasion, 0.75 g fructose/kg body weight, on the other occasion 0.75 g starch/kg body weight. In both groups, plasma glucose and insulin concentrations rose more after starch than after fructose. At 1–2 h after the meal, plasma non-esterified fatty acid concentrations were suppressed more after fructose than after starch, but later they rose more after fructose than after starch. Plasma triacylglycerol concentrations rose more slowly after fructose, but were considerably higher than those after starch from 4–6 h after the meal. There were no differences in post-heparin plasma lipoprotein lipase (EC 3.1.1.34) activity at the end of the test. The potentiation of postprandial lipaemia by fructose was positively related to the fasting plasma insulin concentration, suggesting that insulin-resistant subjects are more prone to this effect. We conclude that the potentiation of postprandial lipaemia by fructose is seen in both diabetic and non-diabetic subjects. Our results suggest that alterations in the dynamics of plasma non-esterified fatty acids might underlie the effects of fructose on triacylglycerol metabolism.

scholarly journals Physical Activity and Obesity: Biomechanical and Physiological Key Concepts

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Julie Nantel ◽  
Marie-Eve Mathieu ◽  
François Prince
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Gait Pattern ◽  
Relative Energy ◽  
Excess Body Weight ◽  
Energy Expenditures ◽  
Structure Changes ◽  
Musculoskeletal Structure ◽  
Low Levels ◽  
The Impact

Overweight (OW) and obesity (OB) are often associated with low levels of physical activity. Physical activity is recommended to reduce excess body weight, prevent body weight regain, and decrease the subsequent risks of developing metabolic and orthopedic conditions. However, the impact of OW and OB on motor function and daily living activities must be taken into account. OW and OB are associated with musculoskeletal structure changes, decreased mobility, modification of the gait pattern, and changes in the absolute and relative energy expenditures for a given activity. While changes in the gait pattern have been reported at the ankle, knee, and hip, modifications at the knee level might be the most challenging for articular integrity. This review of the literature combines concepts and aims to provide insights into the prescription of physical activity for this population. Topics covered include the repercussions of OW and OB on biomechanical and physiological responses associated with the musculoskeletal system and daily physical activity. Special attention is given to the effect of OW and OB in youth during postural (standing) and various locomotor (walking, running, and cycling) activities.

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