scholarly journals Evaluation of anthelmintic efficacy of triclabendazole, nitroxynil and albendazole against naturally acquired fascioliasis in cattle of Bangladesh with special reference to its residual effect

2015 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Md. Aktaruzzaman ◽  
Zahurin Mohamed ◽  
Naim -Ul-Alam ◽  
Md. Siddiqu Islam ◽  
Md. Matiar Rahman Howlader
Keyword(s):  
Body Weight ◽  
Management Practices ◽  
Residual Effect ◽  
The Body ◽  
Current Status ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Blood Samples ◽  
Group A ◽  
Group D

<p>This study aimed to evaluate the efficacy of triclabendazole, nitroxynil and albendazole against fascioliasis in naturally infected cattle of government dairy farm, Sylhet, Bangladesh. The study included 50 cattle breed of which 30 were naturally infected and randomly selected 20 based on their weight and egg count. Twenty cattle of 2-3 years old irrespective of sex infested with fascioliasis were selected for this experiment and randomly divided into four equal groups (group A, B, C and D) where each group consisted of 5 cattle and cattle of group D were kept as control group. One injectable nitroxynil (10 mgkg-1 body weight, S/C) preparations (Renata Ltd. Bangladesh) and two solid triclabendazole, albendazole (12 mgkg-1, 15 mgkg-1 body weight, orally) preparations (Novartis Ltd. and Square Pharmaceuticals Ltd. Bangladesh) were used for positive control of fascioliasis as group A, B and C. Cattle of group D was kept as control without giving any treatment. Before trials (day 0), total egg count, blood samples and initial body weight were recorded. During the study period the fecal and blood samples were collected directly from rectum and examined on 7<sup>th</sup>, 14<sup>th</sup>, 21<sup>st</sup> and 28<sup>th</sup> day using McMaster fecal egg counting method. Body weight was recorded on day 28 following the treatments. The therapeutic efficacy was evaluated through determination of parasitic prevalence, body weight gain/loss and hematological findings. Pre and post-treatment EPG (eggs per gram) values were recorded, and efficacies compared. The results showed that the efficacy of nitroxynil was 92.57%, followed by triclabendazole 91.55% and albendazole 84.53%, which were significant (p&lt;0.01). The observed differences in efficacy between these three brands of anthelmintics were most likely due to variations either in quality or the administered doses. The body weight of the treated animals was increased, which were significant (p&lt;0.01). After treatment triclabendazole, nitroxynil and albendazole, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p&lt;0.01 and p&gt;0.05) in cattle but Erythrocyte Sedimentation Rate (ESR) and Total Leukocyte Count (TLC) were decreased significantly (p&lt;0.05 and p&gt;0.01) in all treated cattle and body weight was increased significantly (p&lt;0.01) on day 28.  The farm management practices along with results of the present study revealed the efficacy of multiple anthelmintics against fascioliasis in cattle. Additional detailed studies are required to clarify the current status of the efficacy of the anthelmintics widely used in different agro ecologies, animal species, and livestock management systems in Bangladesh.</p>

scholarly journals Therapeutic efficacy of ivermectin, fenbendazole and albendazole against naturally occuring gastrointestinal nematodiasis infection in Black Bengal Goat of Bangladesh

2015 ◽  
Vol 3 (1) ◽  
pp. 42 ◽  
Author(s):  
Md. Aktaruzzaman ◽  
Md. Mirazul Islam ◽  
Zahurin Mohamed ◽  
Md. Siddiqul Islam ◽  
Md. Matiar Rahman Howlader
Keyword(s):  
Body Weight ◽  
Therapeutic Efficacy ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Current Status ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Blood Samples ◽  
Group A ◽  
Group D

<p>This study aimed to evaluate the efficacy of ivermectin, fenbendazole and albendazole against gastrointestinal nematodes in naturally infected goats of government goat development farm, Sylhet, Bangladesh. The study included 50 black Bengal breed of which 30 were naturally infected and randomly selected 20 on the basis of their weight and egg count. Twenty black Bengal goats of 13-15 month old irrespective of sex infested with gastrointestinal nematodes were selected for this experiment and randomly divided into four equal groups (group A, B, C and D) where each group consisted of 5 goats and goats of group D were kept as control group. One injectable ivermectin (200 µgkg-1 body weight, S/C) preparations (Techno Drugs, Limited, Bangladesh) and two solid fenbendazole, albendazole (7.5 mgkg-1 body weight, orally) preparations (Techno Drugs, Limited and Square Pharmaceuticals Ltd, Bangladesh) were used for positive control of gastrointestinal nematodes as group A, B and C. Goats of group D was kept as control without giving any treatment. Before trials (day 0), total egg count, blood samples and initial body weight were recorded. During the study period the fecal and blood samples were collected directly from rectum and examined on 7<sup>th</sup>, 14<sup>th</sup>, 21<sup>st</sup> and 28<sup>th</sup> day using McMaster fecal egg counting method. Body weight was recorded on day 28 following the treatments. The therapeutic efficacy was evaluated through determination of parasitic prevalence, body weight gain/loss and hematological findings. Pre and post-treatment EPG (eggs per gram) values were recorded, and efficacies compared. The results showed that the efficacy of ivermectin was 100%, followed by fenbendazole 95.33% and albendazole 90.11%. The observed differences in efficacy between these three brands of anthelmintics were most likely due to variations either in quality or the administered doses. The body weight of the treated animals was slightly increased, which were significant (p&lt;0.05). After treatment with ivermectin, fenbendazole and albendazole, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p&lt;0.01 and p&gt;0.05) in goats but Erythrocyte Sedimentation Rate (ESR) and Total Leukocyte Count (TLC) were decreased significantly (p&lt;0.05 and p&gt;0.01) in all treated goat and body weight was increased significantly (p&lt;0.01) on day 28. The farm management practices along with results of the present study revealed the efficacy of multiple anthelmintics against gastrointestinal nematodiasis in goat. Additional detailed studies are required to clarify the current status of the efficacy of the anthelmintics widely used in different agro ecologies, animal species and livestock management systems in Bangladesh.</p>

scholarly journals Evaluation of Anthelmintic Efficacy of Ivermectin, Levamisole HCl and Albendazole Administered through Different Routes against Naturally Occuring Gastrointestinal Nematodiasis in Black Bengal Goat Inducing Hematological Parameters and Live Weight Indices

2016 ◽  
Vol 5 (1) ◽  
pp. 26-34 ◽  
Author(s):  
M Aktaruzzaman ◽  
MS Islam ◽  
MMI Hasan ◽  
MJU Bhuiyan ◽  
MM Hossain ◽  
...  
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Live Weight ◽  
Gastrointestinal Nematodes ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Counting Method ◽  
Blood Samples ◽  
Group A ◽  
Group D

This study aimed to evaluate the efficacy of ivermectin, levamisole HCl and albendazole against gastrointestinal nematodes in naturally infected goats of government goat development farm, Sylhet, Bangladesh. The study included 52 black Bengal breed of which 30 were naturally infected and randomly selected 20 on the basis of their weight and egg count. Twenty black Bengal goats of 12-13 month old irrespective of sex infested with gastrointestinal nematodes were selected for this experiment and randomly divided into four equal groups (group A, B, C and D) where each group consisted of 5 goats and goats of group D were kept as control group. One injectable ivermectin (200?gkg-1 body weight, S/C) preparations (Techno Drugs Ltd. Bangladesh) and two solid levamisole HCl, albendazole (7.5 mgkg-1 body weight, orally) preparations (The ACME Laboratories Ltd. and Square Pharmaceuticals Ltd. Bangladesh) were used for positive control of gastrointestinal nematodes as group A, B and C. Goats of group D was kept as control without giving any treatment. Before trials (day 0), total egg count, blood samples and initial body weight were recorded. During the study period the fecal and blood samples were collected directly from rectum and examined on 7th, 14th, 21st and 28th day using McMaster fecal egg counting method. Body weight was recorded on day 28 following the treatments. The results of the comparative efficacies of different anthelmintic of ivermectin was 86.75%, followed by levamisole HCl 85.07% and albendazole 92.81%. McMaster fecal egg counting method discloses the percentage of Haemonchus spp. (15.38%), with Trichostrongylus spp, Strongyloides spp., and Cooperia spp. also present. After treatment with ivermectin, levamisole HCl and albendazole, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p<0.01 and p>0.05) in goats but Erythrocyte Sedimentation Rate (ESR) and Total Leukocyte Count (TLC) were decreased significantly (p<0.05 and p>0.01) in all treated goat and body weight was increased significantly (p<0.01) on day 28.International Journal of Natural Sciences (2015), 5(1) 26-34

scholarly journals Comparative Efficacy of Tobacco, Jute and Levavet® Against Gastrointestinal Nematodes in Cattle

2013 ◽  
Vol 19 (1) ◽  
pp. 61-68
Author(s):  
MR Amin ◽  
M Mostofa ◽  
MA Awal ◽  
SMA Hakim
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Water Extract ◽  
Gastrointestinal Nematode ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Group D

The effect of tobacco (Nicotiana tabacum, Linn., @100mg/kg bwt.), jute (Corchorus capsularis, Linn., @100 mg/kg bwt.) and Levavet® (levamisole, @ 7.5 mg/kg bwt.) against natural gastrointestinal nematodes were studied in cattle. Their effect on hematological parameters (TEC, Hb, PCV and TLC), biochemical parameters (ALT and AST) and clinical parameter (body weight) were also observed. Twenty four (24) naturally parasitized cattle of BAU Dairy Farm, Mymensingh were randomly divided into four groups, each consisting of six (6) cattle. Water extract of leaves of tobacco and jute were administered orally to the cattle of group A and B, respectively. Cattle of group C were treated with Levavet® orally. Cattle of group D was kept as infected control group. Fecal samples, body weight, hematological and biochemical parameters were examined before treatment and on 3rd, 10th, 17th and 28th day. A significant (p<0.01) reduction of EPG count was found following administration of tobacco (34.32-51.26%), jute (8.80-27.76%) and Levavet®(89.31-100%) in cattle. The EPG count of the control group (D) were significantly (p<0.01) increased up to the last day of experimental period. After treatment with tobacco, jute and Levavet®, total erythrocyte count (TEC), hemoglobin (Hb) content and packed cell volume (PCV) were gradually increased significantly (p<0.01 and p<0.05) in cattle. Conversely, the total leukocyte count (TLC) were decreased significantly (p<0.01 and p<0.05) in treated cattle. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level were not significantly changed in the cattle. The body weight was increased significantly (p<0.01 and p<0.05) in tobacco, jute and Levavet® treated cattle whereas decreased in control group. It is found that water extracts of tobacco leaves were moderately effective and jute leaves were relatively less effective against mixed gastrointestinal nematode infections in cattle.DOI: http://dx.doi.org/10.3329/pa.v19i1.17108 Progress. Agric. 19(1): 61 - 68, 2008 

scholarly journals Effects of aqueous leaf extract of Corchorus olitorius on the testis and blood testosterone level of adult Wistar rats

2021 ◽  
Vol 10 (2) ◽  
pp. 024-030
Author(s):  
Godwin Chinedu Uloneme ◽  
Demian Nnabuihe Ezejindu ◽  
Darlington Cyprian Akukwu ◽  
Amadi Chibundu Chiekezie
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Day Treatment ◽  
Control Group ◽  
Corchorus Olitorius ◽  
Group A ◽  
Normal Rat ◽  
Group B ◽  
Calcium Iron ◽  
Group D

Background: The extract of Corchorus olitorius has a reasonable content of vitamins A and C, calcium, iron and fibre, and therefore enjoys a universal application in the treatment of some disease conditions, even as the whole leaf is a very important component of food in so many cultures. Purpose: The study was designed to investigate the effect of Corchorus olitorius extracts on the testis of adult Wistar rats. Method: A total number of thirty two adult Wistar rats weighing between 180 and 200 grammes separated into four groups labeled A,B,C and D respectively were used for the study. Animals in group A which served as the control group were fed with the normal rat chow and water only. The group B rats were administered 100mg/kg body weight of aqueous extract of Corchorus olitorus; while those in group C were administered 500mg/kg body weight of the extract. The group D rats received 1000mg/kg body weight of the extract. For a period of four weeks, the different experimental animal groups received the respective aforementioned treatments once daily, around nine- o’clock in the morning through oral intubation. At the end of the 28 day treatment, the animals were sacrificed and the testes harvested for histological, investigation, and through cardiac puncture, blood samples for some hormonal studies was also collected and investigated using standard laboratory standards. Results: Observations made showed that the extract produced no histological distortions, degenerative or defective effects on the testicular tissues. The testosterone levels of group B, C, and D rats were observed to be significantly higher (P<0.005) than that of the group A (control group).ound: The extract of Corchorus olitorius has a reasonable content of vitamins A and C, calcium, iron and fibre, and therefore enjoys a universal application in the treatment of some disease conditions, even as the whole leaf is a very important component of food in so many cultures. Purpose: The study was designed to investigate the effect of Corchorus olitorius extracts on the testis of adult Wistar rats. Method: A total number of thirty two adult Wistar rats weighing between 180 and 200 grammes separated into four groups labeled A,B,C and D respectively were used for the study. Animals in group A which served as the control group were fed with the normal rat chow and water only. The group B rats were administered 100mg/kg body weight of aqueous extract of Corchorus olitorus; while those in group C were administered 500mg/kg body weight of the extract. The group D rats received 1000mg/kg body weight of the extract. For a period of four weeks, the different experimental animal groups received the respective aforementioned treatments once daily, around nine- o’clock in the morning through oral intubation. At the end of the 28 day treatment, the animals were sacrificed and the testes harvested for histological, investigation, and through cardiac puncture, blood samples for some hormonal studies was also collected and investigated using standard laboratory standards. Results: Observations made showed that the extract produced no histological distortions, degenerative or defective effects on the testicular tissues. The testosterone levels of group B, C, and D rats were observed to be significantly higher (P<0.005) than that of the group A (control group).

scholarly journals Comparative Efficacy of Barbados Lilac, Pineapple And Benazol® Against Gastrointestinal Nematodes in Cattle

2013 ◽  
Vol 19 (1) ◽  
pp. 51-59
Author(s):  
MR Amin ◽  
M Mostofa ◽  
MA Awal ◽  
ML Sharmin
Keyword(s):  
Body Weight ◽  
Water Extract ◽  
Gastrointestinal Nematode ◽  
Experimental Period ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Ananas Comosus ◽  
Total Leukocyte Count ◽  
Melia Azedarach ◽  
Control Group

The effect of barbados lilac (Melia azedarach, Linn., @100 mg/kg bwt. ), pineapple (Ananas comosus, Merr., @100mg/kg bwt.) and Benazol® (albendazole, @7.5 mg/kg bwt.) against natural gastrointestinal nematodes were studied in cattle. Their effect of TEC, Hb, PCV, TLC, ALT, AST and body weight were observed. Twenty four (24) naturally parasitized cattle of BAU Dairy Farm, Mymensingh were randomly divided into four groups, each consisting of six (6) cattle. Water extract of leaves of barbados lilac and pineapple were administered orally to the cattle of group A and B, respectively. Cattle of group C were treated with Benazol® orally. Cattle of group D was kept as infected control group. Fecal samples, body weight, hematological and biochemical parameters were examined before treatment and on 3rd, 10th, 17th and 28th day. A significant (p<0.01) reduction of EPG count was found following administration of barbados lilac (39.11-60.07%), pineapple (29.50-45.36%) and Benazol® (62.19-90.44%) in cattle. Whereas EPG increased significantly (p<0.01) in control group throughout the experimental period. After treatment with barbados lilac, pineapple and Benazol®, total erythrocyte count (TEC), hemoglobin (Hb) content and packed cell volume (PCV) were gradually increased significantly (p<0.01 and p<0.05) in cattle. Conversely, the total leukocyte count (TLC) were decreased significantly (p<0.01 and p<0.05) in treated cattle. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level were not significantly changed in the cattle. The body weight was increased significantly (p<0.01 and p<0.05) in barbados lilac, pineapple and Benazol® treated cattle.In contrast, body weight was decreased in control group. The present study reveals that water extracts of barbados lilac leaves were moderately effective and pineapple leaves were relatively less effective against mixed gastrointestinal nematode infections in cattle.DOI: http://dx.doi.org/10.3329/pa.v19i1.17107 Progress. Agric. 19(1): 51 - 59, 2008 

scholarly journals Effects of neem, betel leaf, devil's tree, jute and turmeric against gastrointestinal nematodes in sheep

1970 ◽  
Vol 8 (2) ◽  
pp. 259-263 ◽  
Author(s):  
MR Amin ◽  
M Mostofa ◽  
MN Islam ◽  
MA Asgar
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Water Extract ◽  
Gastrointestinal Nematode ◽  
Experimental Period ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Control Group ◽  
Betel Leaf ◽  
Group A

Effects of neem, betel leaf, devil’s tree, jute and turmeric against natural gastrointestinal nematodes in sheep and on some hematological parameters (TEC, Hb and PCV) and body weight were studied. Thirty (30) naturally parasitized sheep were randomly divided into six groups(A, B, C, D, E and F), each consisting of five sheep. Ten percent water extract of leaves of neem, betel leaf, devil’s tree and jute were administered orally to the sheep of group A, B, C and D, respectively. Sheep of group E was treated orally with 10% water extract of rhizome of turmeric. Sheep of group F was kept as infected control group. Fecal samples, hematological parameters and body weight were examined before treatment and on 7th, 14th, 21st and 28th day. A significant (p<0.01) reduction of EPG count was found following administration of neem (37.60-47.03%), betel leaf (6.43-14.00%), devil’s tree (3.04-11.04%), jute (0.50-5.26%) and turmeric (0.46-8.30) in sheep. The EPG count of the control group (F) were significantly (p<0.01) increased up to the last day of experimental period. After treatment with neem, betel leaf, devil’s tree, jute and turmeric total erythrocyte count (TEC), hemoglobin (Hb) content and packed cell volume (PCV) were increased significantly (p<0.01 and p<0.05) in sheep. The body weight was increased significantly (p<0.01 and p<0.05) in neem, betel leaf, devil’s tree, jute and turmeric treated sheep. On the other hand, body weight was decreased in untreated control group. The present study reveal that 10% water extract of neem was moderately effective and betel leaf, devil’s tree, jute and turmeric were relatively less effective against gastrointestinal nematodes in sheep. Keywords: Neem; Betel leaf; Devil’s tree; Jute; Turmeric; Gastrointestinal nematode DOI: 10.3329/jbau.v8i2.7935 J. Bangladesh Agril. Univ. 8(2): 259-263, 2010  

Hippocampal size did not differ between epileptic and non-epileptic dogs using volumetric and subjective methods

2021 ◽  
Author(s):  
Borbála A. Lőrincz ◽  
Agustina Anson ◽  
Stephan Handschuh ◽  
Alexander Tichy ◽  
Conor Rowan ◽  
...  
Keyword(s):  
Body Weight ◽  
Human Study ◽  
Positive Association ◽  
Brain Structures ◽  
Hippocampal Volume ◽  
The Body ◽  
Control Group ◽  
Volumetric Assessment ◽  
Significant Difference ◽  
Group A

AbstractHippocampal changes in epilepsy may manifest as hippocampal atrophy/sclerosis. A recent human study suggests that the demonstration of hippocampal volume loss is more reliable using quantitative evaluation methods. The aim of the present study was to obtain volumetric data in both epileptic and healthy dogs, to compare hippocampal volumes in both groups, and to compare subjective and volumetric assessment. Volumetric measurements of the hippocampi, lateral ventricles and hemispheria were performed in 31 epileptic and 15 control dogs. There was a positive association between the body weight and the hemispheric volume, as well as between the hemispheric volume and the ipsilateral hippocampal volume. There was no significant correlation between age and the volume of any measured brain structures. There was no statistically significant difference between the hippocampal volumes of the control group and the epileptic group. A statistically significant difference between the two groups for hippocampus/hemispherium ratio or hippocampal asymmetric ratio was not identified. An extrapolated hippocampal volume based on body weight was not possible in this study population.

scholarly journals Effects of oxyclozanide (Tremacid®) preparation against fascioliasis on clinical and haematological parameters in cattle of Bangladesh

2015 ◽  
Vol 3 (1) ◽  
pp. 46 ◽  
Author(s):  
Naim Alam ◽  
Md Islam ◽  
Matiar Howlader ◽  
Nasrin Lucky
Keyword(s):  
Body Weight ◽  
Untreated Control ◽  
Hematological Parameters ◽  
Experimental Period ◽  
The Body ◽  
Haematological Parameters ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Untreated Control Group ◽  
Group B

<p>The effects of Oxyclozanide (Tremacid®) on some clinical (body weight) and haematological parameters (TEC, Hb, PCV, ESR and TLC) were determined in this study. Among 55 cattle, 10 were selected, which were suffering from fascioliasis and divided randomly into two groups. Each group was consisting of five cattle. One was treated with Tremacid® @ (15 mg/kg body weight). Other was kept as an infected control group. Before trials with Tremacid® initial body weight, EPG of liver fluke and hematological parameters were examined. During the experimental period the faecal samples, clinical and hematological parameters were examined on 7th, 14th, 21st and 28th days for the determination of effects of Tremacid®. A significant reduction of EPG count was found on 7th, 14th, 21st and 28th day of Tremacid® (61.87%, 71.22%, 76.98% and 84.53%) in a treated cattle group. The EPG of an untreated control group was significantly (p&lt;0.01) increased about 3.97%, 7.64%, 11.04% and 64.89% respectively. Total TEC was increased after treatment with Tremacid® and decreased in an untreated control group significantly (p&lt;0.01), Likewise, after treatment with Tremacid® Hb content and PCV were increased, and ESR was decreased. Total leukocyte count (TLC) was decreased and the body weight was increased after Tremacid® treatment in the group A. On the other hand, Hb content PCV and body weight was decreased significantly (p&lt;0.01) in the group B.</p>

Effects of Ganoderma Lucidum and Krestin on Subset T-cell in Spleen of γ-irradiated Mice

1995 ◽  
Vol 23 (03n04) ◽  
pp. 289-298 ◽  
Author(s):  
Wang-Chi Chen ◽  
Dou-Mong Hau ◽  
Chih-Chung Wang ◽  
I-Hsin Lin ◽  
Shiuh-Sheng Lee
Keyword(s):  
Body Weight ◽  
Ganoderma Lucidum ◽  
Radiation Treatment ◽  
Whole Body ◽  
Control Group ◽  
Γ Irradiation ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Better Than

Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in γ-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy γ-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after γ-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of γ-irradiated mice.

scholarly journals CELECOXIB

2018 ◽  
Vol 25 (01) ◽  
pp. 50-57
Author(s):  
Sadia Sundus ◽  
Nazia Qamar ◽  
Raheela Adil ◽  
Muhammad Faisal Fahim
Keyword(s):  
Body Weight ◽  
Relative Weight ◽  
Treated Group ◽  
Renal Tissue ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Group A ◽  
Group B ◽  
General Architecture

Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on celecoxib induced kidney with protection by lycopene. Study Design:Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomydepartment), JPMC, Karachi, from 4th May 2015 to 3rd June 2015. Materials and Methods: Fortyhealthy adult, male Albino rats, 90-120 days old, weighing 200-220gm was taken for the study.The rats were divided into 4 groups, Group A was control group, Group B receive Celecoxib 50mg/kg body weight orally, Group C receive Celecoxib 50 mg/kg body weight orally along withlycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weightorally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stainedwith hematoxylin and eosin. Results: Markedly decreased weight was observed in rats takingcelecoxib. Slides which were stained with hematoxylin and eosinshowed general architecture ofrenal parenchyma, shape and arrangement of epithelial cells. Apoptosis, hemorrhage, necrosisand vacuolation seen in Celecoxib group, whereas renal architecture were ameliorated andreverted back in celecoxib along with lycopene receiving group. Conclusion: This studyconcludes that lycopene restored the body weight, absolute and relative kidney weight incelecoxib treated group.

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