scholarly journals GIZI UNTUK PROSES PENYEMBUHAN LUKA PADA PASIEN DENGAN DIABETIC FOOT ULCER (DFU): LITERATURE REVIEW

2021 ◽  
Vol 10 (1) ◽  
pp. 39-46
Author(s):  
Melani Puji Lestari ◽  
Niken Safitri Dyan Kusumaningrum
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Vitamin E ◽  
Literature Review ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Omega 3 ◽  
Randomized Controlled

Latar belakang: Asupan gizi merupakan salah satu faktor yang berperan penting dalam proses penyembuhan luka, khususnya Diabetic Foot Ulcer (DFU). Oleh karena itu, selain merawat kaki, pasien DFU sangat dianjurkan untuk memperhatikan diet dan gizi yang dikonsumsi.Tujuan: Penelitian ini bertujuan untuk mereview peran gizi pada proses penyembuhan DFU.Metode: Metode yang digunakan dalam penelitian ini adalah literature review yaitu mengkaji secara kritis temuan-temuan yang telah dipublikasikan sebelumnya. Artikel dari 3 database, yaitu SCOPUS, PubMed, dan Google Scholar yang sesuai dengan kriteria inklusi kemudian dianalisis untuk menjawab tujuan penelitian. Kriteria inklusi artikel yang disertakan dalan penelitian meliputi artikel yang telah dipublikasikan pada jurnal internasional dengan rentang publikasi dari Januari 2015 sampai Desember 2019, berupa Randomized Controlled Trial (RCT), dan  berbentuk full-text. Enam artikel dianalisis dan disintesis untuk mendapatkan hasil penelitian berdasarkan proses skrining, seleksi, dan pemilihan artikel.Hasil: Literature review ini menunjukkan bahwa gizi, baik dalam bentuk macronutrient (misalnya omega 3) maupun micronutrient (seng, magnesium, vitamin D, vitamin E, dan probiotik), berperan penting dalam proses penyembuhan luka DFU. Macro dan micronutrient ini berperan mulai dari proses modulasi proliferasi sel, metabolisme kolagen, serta sebagai biomarker fase inflamasi dan oksidasi. Asupan gizi yang tepat akan mengontrol dan menekan komplikasi DFU sehingga penyembuhan lukanya berjalan secara optimal. Omega-3, seng, magnesium, vitamin D, vitamin E, dan probiotik berperan besar dalam peningkatan produksi kolagen, sintesis protein, dan pembuangan bakteri serta sel - sel nekrotik.Simpulan: Baik macronutrient maupun micronutrient, keduanya dibutuhkan di dalam tubuh untuk mendukung proses penyembuhan luka DFU. Masing-masing komponen tersebut mempunyai peran penting dalam proses penyembuhan luka.

scholarly journals Beraprost Sodium for Chronic Diabetic Foot Ulcer: A Randomized Controlled Trial in Thammasat University Hospital

2014 ◽  
Vol 7 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Surajit Awsakulsutthi ◽  
Kwanjit Punpho ◽  
Jinpitcha Mamom ◽  
Pairat Baikrut ◽  
Patcharee Yingchoorod
Keyword(s):  
Randomized Controlled Trial ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
University Hospital ◽  
Randomized Controlled ◽  
Beraprost Sodium

175-LB: Effect of a Telemedicine Diabetic Foot Ulcer Intervention on Health and Well-Being: A Cluster Randomized Controlled Trial

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 175-LB
Author(s):  
MARJOLEIN MEMELINK IVERSEN ◽  
JANNICKE IGLAND ◽  
HILDE SMITH-STRøM ◽  
TRULS OSTBYE ◽  
GRETHE S. TELL ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Well Being ◽  
Cluster Randomized Controlled Trial ◽  
Randomized Controlled ◽  
Cluster Randomized ◽  
Health And Well Being

scholarly journals One year randomized controlled trial to compare the effectiveness of honey dressing versus povidone iodine dressing for diabetic foot ulcer at Dr. Prabhakar Kore Hospital and MRC, Belagavi

2020 ◽  
Vol 7 (2) ◽  
pp. 506 ◽  
Author(s):  
Ramesh S. Koujalagi ◽  
V. M. Uppin ◽  
Soham Shah ◽  
Dron Sharma
Keyword(s):  
Randomized Controlled Trial ◽  
Diabetic Foot ◽  
Povidone Iodine ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Randomized Controlled ◽  
Wound Size ◽  
The Difference

Background: The objective of the study is to find out the effect of honey dressing versus povidone iodine dressing for reduction of wound size in diabetic foot ulcer.Methods: This randomized controlled trial was done in the Department of General Surgery, KLES Dr. Prabhakar Kore Hospital, Belagavi from January 2017 to December 2017. 64 patients were randomized into 32 group each undergoing unprocessed honey dressing and other group undergoing povidone iodine dressing.Results: The mean wound size in honey dressing was 23.16 cm2 and 23.03 cm2 in povidone dressings  at baseline, 23.16 cm2 and 22.94 cm2 at 1st day follow up, 23.16 cm2 and 22.94 cm2 at 3rd day follow up, 19.38 cm2 and  20.28 cm2 at 5th day follow up, 16.13 cm2 and 17.06 cm2 at 7th day follow up, 12.44 cm2 and  16.13 cm2 at 10th day follow up and the end of 15th day, it was 10.69 cm2 and 15.06 cm2 respectively in honey dressing group and povidone dressing group. The difference in the wound size in honey dressing group and povidone dressing group at 1st day, 3rd day, 5th day, 7th day, 10th day follow up period were statistically not significant (p>0.05). The difference in the wound size in honey dressing group at 15th day follow up period were statistically significant (p<0.05).Conclusions: This study shows more favorable results with honey dressing for reduction of wound size in diabetic foot ulcers.

Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial

2017 ◽  
Vol 32 (17) ◽  
pp. 2096-2099 ◽  
Author(s):  
Mozhgan Afkhamizadeh ◽  
Robab Aboutorabi ◽  
Hassan Ravari ◽  
Mohsen Fathi Najafi ◽  
Sajad Ataei Azimi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Randomized Controlled Trial ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Randomized Controlled

scholarly journals Omega-3 Fatty Acids plus Vitamin E Cosupplementation versus Vitamin E in Fibrocystic Breast Patient with Mastalgia: A Randomized Controlled Trial

2021 ◽  
Vol 9 (B) ◽  
pp. 116-121
Author(s):  
Marwa Mostafa Ahmed ◽  
Eman Ahmed Rushdy ◽  
Dalia Ahmed Aboul Azm ◽  
Rehab Mohamed Sabry ◽  
Heba Galal El Nahas
Keyword(s):  
Randomized Controlled Trial ◽  
Vitamin E ◽  
Pain Score ◽  
Controlled Trial ◽  
Control Group ◽  
Common Symptom ◽  
Omega 3 ◽  
Negative Effects ◽  
Randomized Controlled ◽  
Significant Difference

BACKGROUND: Fibrocystic changes (FCCs) of the breast are a common breast condition. Mastalgia is the most common symptom of FCC; it usually causes fear of breast cancer and has negative effects on the quality of life. AIM: The objective of the research was to establish the effect of cosupplementation of omega-3 plus Vitamin E on mastalgia in FCC patients, to evaluate its effect with that of Vitamin E only, and to determine the effect of omega-3 plus Vitamin E versus Vitamin E only on the radiological findings in FCC patients. METHODS: This randomized controlled trial was conducted on 120 FCC patients with mastalgia. The participants were randomly assigned into three groups: Omega-3 plus Vitamin E group, Vitamin E only group, and control group. The new breast pain chart was used to assess the severity of mastalgia in the three groups before, through, and after intervention. Radiological assessment was done before and after the intervention. RESULTS: After 3 months of the intervention, there was a statistically significant difference between the three groups regarding radiological results with p > 0.05 and, after the 3rd month of interventions, there was a statistically significant difference between the groups regarding the new pain score with p > 0.001. The median of the new pain score premenstrual was 4.8, 2, and 2.5 in control, omega-3 plus Vitamin E, and Vitamin E only, respectively, but this difference was insignificant between the last two groups (p < 0.996). CONCLUSION: This study showed that Vitamin E and Vitamin E plus omega-3 were effective in relieving mastalgia in FCC patients. However, the addition of omega-3 was ineffective.

scholarly journals Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2432 ◽  
Author(s):  
Maddalena Massari ◽  
Chiara Novielli ◽  
Chiara Mandò ◽  
Stefania Di Francesco ◽  
Matteo Della Porta ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Docosahexaenoic Acid ◽  
Controlled Trial ◽  
Visual Development ◽  
Controlled Study ◽  
Omega 3 ◽  
Anthropometric Parameters ◽  
Randomized Controlled ◽  
Vitamin D Levels

Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus are governed by the maternal diet. In this multicenter, parallel, randomized controlled trial, we evaluated once-daily supplementation with multiple micronutrients and DHA (i.e., multiple micronutrient supplementation, MMS) on maternal biomarkers and infant anthropometric parameters during the second and third trimesters of pregnancy compared with no supplementation. Primary efficacy endpoint: change in maternal red blood cell (RBC) DHA (wt% total fatty acids) during the study. Secondary variables: other biomarkers of fatty acid and oxidative status, vitamin D, and infant anthropometric parameters at delivery. Supplementation significantly increased RBC DHA levels, the omega-3 index, and vitamin D levels. Subscapular skinfold thickness was significantly greater with MMS in infants. Safety outcomes were comparable between groups. This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting—an important finding considering the essential roles of DHA and vitamin D.

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