scholarly journals Effect of Atropine and the Oxime HI-6 on Low-Level Sarin-Induced Alteration of Performance of Rats in a T-Maze

2002 ◽  
Vol 45 (3) ◽  
pp. 107-110 ◽  
Author(s):  
Gabriela Krejčová ◽  
Jiří Kassa ◽  
Josef Vachek
Keyword(s):  
Spatial Memory ◽  
Spatial Orientation ◽  
Cognitive Functions ◽  
Inhalation Exposure ◽  
Repeated Exposure ◽  
Single Exposure ◽  
Low Level ◽  
Hi 6 ◽  
Low Concentrations ◽  
Level 2

1. To study the influence of antidotes on low-level sarin-induced alteration of cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin for 60 minutes in the inhalation chamber. One minute following sarin exposure, the rats were i.m. treated with the oxime HI-6 in combination with atropine. Control rats were treated with antidotes as experimental rats but exposed to the pure air instead of sarin. Cognitive functions of the rats were tested using a T-maze where spatial memory and spatial orientation were evaluated. The performance of sarin-exposed and treated rats in the T-maze was tested several times within six weeks (single exposure) or five weeks (repeated exposure) following inhalation exposure to evaluate cognitive impairments. 2. In the case of single exposure to sarin, no statistically significant differencies between the performances of the control and the experimental groups in the alteration of spatial memory and spatial orientation were observed. The repeated exposure of treated rats to clinically asymptomatic dose of sarin (LEVEL 2) did not change the effect of low-level sarin exposure on spatial memory of the experimental rats compared to the single exposure to the same dose of sarin. 3. The decrease in the T-maze performance of the control rats was caused by the impairments of rat’s mobility due to the features of a solution of antidotes.

scholarly journals The Impairment of Spatial Memory Following Low-Level Sarin Inhalation Exposure and Antidotal Treatment in Rats

2002 ◽  
Vol 45 (4) ◽  
pp. 149-153 ◽  
Author(s):  
Jiří Kassa ◽  
Gabriela Krejčová ◽  
Josef Vachek
Keyword(s):  
Spatial Memory ◽  
Cognitive Functions ◽  
Inhalation Exposure ◽  
Maze Performance ◽  
Memory Impairments ◽  
Low Level ◽  
Y Maze ◽  
Level 1 ◽  
And Control ◽  
Level 2

1. To study the influence of antidotes on low-level sarin-induced impairment of cognitive functions, the rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber. In addition, one group of rats was exposed to LEVEL 2 of sarin repeatedly. 2. Testing of cognitive functions was carried out using the Y-maze evaluating learning and spatial memory. The correct averse behavior of sarin-exposed rats in the Y-maze was tested several times within four weeks following sarin inhalation exposure and antidotal treatment to look for any cognitive impairments. 3. The results were compared to the Y-maze performance of sarin-exposed rats without antidotal treatment and control rats exposed to pure air instead of sarin with or without antidotal treatment. While antidotal treatment was able to eliminate a short-term deficiency in the Y-maze performance in rats exposed to the LEVEL 1 of sarin, a significant decrease in the Y-maze performance in rats exposed to sarin at the LEVEL 2 and 3 was only shortened. Sarin-induced spatial memory impairments in rats exposed repeatedly to sarin at the LEVEL 2 was also shortened when rats were treated following each sarin inhalation exposure. 4. The findings confirm that antidotes currently used for nerve agent poisonings are beneficial for the treatment of rats singly or repeatedly exposed to non-convulsive symptomatic or even clinically asymptomatic concentrations of sarin.

scholarly journals Long Term Effects of Low-Level Sarin Inhalation Exposure on the Spatial Memory of Rats in a T-Maze

2001 ◽  
Vol 44 (3) ◽  
pp. 93-96 ◽  
Author(s):  
Jiří Kassa ◽  
Marie Koupilová ◽  
Josef Vachek
Keyword(s):  
Spatial Memory ◽  
Cognitive Functions ◽  
Inhalation Exposure ◽  
Long Term Effects ◽  
Low Level ◽  
Appetitive Motivation ◽  
Low Concentrations ◽  
Level 3 ◽  
Short Time

To study the influence of low-level sarin exposure on cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber. Testing of cognitive functions was carried out using the T-maze evaluating learning and spatial memory. The behavior of sarin-exposed rats in the T-maze was tested several times within five weeks following sarin inhalation exposure to look for any cognitive impairments. The alteration of cognition was evaluated by using a method studying memory elicitation in response to appetitive motivation in a multiple T-maze. 2. Statistically significant, short-term deficiency in the T-maze performance was observed in rats exposed to symptomatic (LEVEL 3) as well as clinically asymptomatic concentration (LEVEL 2) of sarin. The repeated exposure of rats to clinically asymptomatic dose of sarin (LEVEL 2R) did not change the effect of lowlevel sarin exposure on spatial memory compared to the single exposure to the same dose of sarin. 3. Thus, sarin is able to influence the cognitive functions (e.g. spatial memory) even at low doses that do not cause clinically manifested intoxication following the inhalation exposure. Nevetheless, the alteration of spatial memory lasts for a short time only, in contrast with the severe sarin poisoning.

Evaluating Performance Effects of Low-Level Inhalation Exposure to Nerve Agents in Rats

2004 ◽  
Author(s):  
Raymond F. Genovese ◽  
◽  
Sara J. Shippee ◽  
Jessica Bonnell ◽  
Bernard J. Benton ◽  
...  
Keyword(s):  
Inhalation Exposure ◽  
Nerve Agents ◽  
Low Level ◽  
Performance Effects

Toxic Effects of Sarin in Rats at Three Months Following Single or Repeated Low-Level Inhalation Exposure

2008 ◽  
Vol 88 (4) ◽  
pp. 209-212 ◽  
Author(s):  
Jiří Kassa ◽  
Miroslav Pecka ◽  
Miloš Tichý ◽  
Jiří Bajgar ◽  
Marie Koupilová ◽  
...  
Keyword(s):  
Inhalation Exposure ◽  
Toxic Effects ◽  
Low Level

scholarly journals Indonesia's Interference in Translating Texts into English Texts

2020 ◽  
Vol 7 (1) ◽  
pp. 26
Author(s):  
Etika Ariyani
Keyword(s):  
Mother Tongue ◽  
Sampling Technique ◽  
Target Language ◽  
Past Tense ◽  
Source Language ◽  
Low Level ◽  
Class A ◽  
High Level ◽  
Level 2 ◽  
Bahasa Indonesia

This research is aimed: (1) to reveal that interference of bahasa Indonesia interrupt when the students at the sixth semester of FKIP in Muhammadiyah University of Mataram translate the English narrative past tense text; (2) to know the kinds of factors interupted the students’ in translating English narrative the text. The population of study were students in FKIP Muhammadiyah University of Mataram. They consist of three classes from class A to C. The number of population were 64 students so, the writer took only the 17 students to be sample, by using purposive sampling technique. The results of research showed that: (1) among 17 students in class A do some intereferences, they have less ability to construct the translation target text into the accuracy, acceptable and understandable/readable sentences by the reader. Moreover, there are two main Indonesian interference found by the researcher, they were morphological interference by misunderstand of using past tense sentences and sintactical interference by unstructural sentence in the target text, (2) The students’ only could get the range from 4 score to 8 score, where 5 students get very poor, 4 students get poor, 2 students get fair, 3 students get fairly good, 3 students get good. The students’ translation percentage for each standard such as accuracy is 16,5%, acceptable is 10,11%, readability is 5,47% and for total all of students’ mean score is 51,9%, where it took on poor score of translation (3) There are 4 factors made the students difficult to translate the target text, they were 1. Disloyalty of the speakers and receiver 2 Insufficient of vocabulary in translating the source language into target language, 3. The prestige of the source language and style, 4. Daily habits in the mother tongue influence target text, (4) The students’ translations result are 6 students got score of 0-3 namely very low level, 6 students got score of 5,5-6,5, who categorized as the low level, 2 students got the range score of 6,6-7,5, who categorized “sufficient level”, there are 3 students got this “high level” with the range score of 7,6-9,5, and no one getting the “highest level” score in the range of 9,6-10. 

The LLWR’s 2011 Environmental Safety Case

2011 ◽  
Author(s):  
Richard Cummings ◽  
Andrew J. Baker ◽  
Trevor Sumerling ◽  
John Shevelan ◽  
Amy Huntington
Keyword(s):  
Formal System ◽  
Environmental Safety ◽  
Management Control ◽  
Careful Examination ◽  
Supporting Evidence ◽  
Gas Generation ◽  
Low Level ◽  
The Future ◽  
Safety Case ◽  
Level 2

The UK’s Low Level Waste Repository Ltd submitted an Environmental Safety Case (ESC) for the disposal of low-level waste to the Environment Agency on the 1st of May 2011. The ESC is a major submission that will decide the future use of the Repository and has major implications for the success of the UK’s LLW Strategy and decommissioning programme. This paper provides an overview of the work that has been carried out to support the submission. Key aspects of this ESC include: • detailed investigations of existing disposals, based on careful examination of existing records and other investigations, including interviews with former operational staff; • analysis of uncertainties in future disposals; • modelling of the biogeochemical evolution of the disposal system, which provides understanding of the evolution of pH, Eh and gas generation and thence underpinning for radionuclide releases in groundwater and gas; • development of a 3-D groundwater flow model, calibrated against observed heads and with a detailed representation of the engineered features; • analysis of coastal erosion and its impacts; • a major focus on optimisation based on detailed technical studies; • a conclusion that existing disposals do not require remediation; • the choice of a concrete vault design with permeable side walls designed to avoid bathtubbing after the end of management control; • a comprehensive set of assessment calculations, including thorough analysis of uncertainties, which demonstrate consistency with the Environment Agency’s risk and dose guidance levels; • revision of the LLWR’s WAC, based in part on the use of the ‘sum of fractions’ approach; • the use of a safety case document structure that emphasises key safety arguments in a Level 1 document and provides supporting evidence in a series of Level 2 documents; • the provision of a Level 2 document that describes in detail how each aspect of the regulatory guidance has been addressed. In the future, the 2011 ESC will be maintained using a formal system of change control. It will be used as a tool for decision making concerning the future development of the LLWR and waste acceptance.

scholarly journals The propensity for re-triggered predation fear in a prey fish

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Adam L. Crane ◽  
Laurence E. A. Feyten ◽  
Indar W. Ramnarine ◽  
Grant E. Brown
Keyword(s):  
Traumatic Stress ◽  
Post Traumatic Stress ◽  
Prey Fish ◽  
Single Exposure ◽  
Predation Threat ◽  
Low Level ◽  
Multiple Exposures ◽  
Risk Period ◽  
Post Traumatic ◽  
High Level

Abstract Variation in predation risk can drive variation in fear intensity, the length of fear retention, and whether fear returns after waning. Using Trinidadian guppies, we assessed whether a low-level predation threat could easily re-trigger fear after waning. First, we show that background risk induced neophobia after either multiple exposures to a low-level threat or a single exposure to a high-level threat. However, a single exposure to the low-level threat had no such effect. The individuals that received multiple background exposures to the low-level threat retained their neophobic phenotype over an 8-day post-risk period, and this response was intensified by a single re-exposure to the low-level threat on day 7. In contrast, the neophobia following the single high-level threat waned over the 8-day period, but the single re-exposure to the low-level threat on day 7 re-triggered the neophobic phenotype. Thus, despite the single low-level exposure being insufficient to induce neophobia, it significantly elevated existing fear and re-triggered fear that had waned. We highlight how such patterns of fear acquisition, retention, and rapid re-triggering play an important role in animal ecology and evolution and outline parallels between the neophobic phenotype in fishes and dimensions of post-traumatic stress in humans.

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