scholarly journals Identification and characterization of phytoconstituents of ethanolic root extract of Clitoria ternatea L. utilizing HR-LCMS analysis

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
K N Jiji ◽  
P Muralidharan
Keyword(s):  
Nervous System ◽  
Medicinal Plants ◽  
The Body ◽  
Major Constituent ◽  
Root Extract ◽  
Active Metabolites ◽  
Clitoria Ternatea ◽  
Intellectual Capacity ◽  
Identification And Characterization

Medicinal plants act as a vital source in improving health and overcoming the side effects of modern-day medicine. Many evidence-based reports are present in the literature about the benefits of medicinal plants. Clitoria ternatea L. belongs to the family Fabaceae and is known to be one of the important Ayurvedic medicinal plant whose uses are specified mainly for the modification of nervous system activities. ‘Medhyarasayana’ is one of the Ayurvedic formulations which is used to promote the intellectual capacity, revive the body and nervous tissue, Clitoria ternatea serves as a major constituent of ‘Medhyarasayana.’ Identification and characterization of active metabolites of C. ternatea will help to isolate the important phytoconstituents responsible for the central nervous system effects, isolated components can be utilized in future for the formulation of new medicine for various neurodegenerative disorders. In the present study, the phytochemical evaluation of the ethanolic root extract of C. ternatea (EECT) was performed using the HR-LCMS technique. Preliminary qualitative phytoconstituents analysis showed the presence of tannins, alkaloids, saponins, steroids, carbohydrate, protein, flavonoids and triterpenoids in the ethanolic root extract. Almost 42 compounds were identified when the EECT subjected to HR-LCMS analysis.

Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates

Biochimie ◽  
2004 ◽  
Vol 86 (8) ◽  
pp. 523-531 ◽  
Author(s):  
Eishun Muto ◽  
Yoko Tabata ◽  
Takafumi Taneda ◽  
Yutaka Aoki ◽  
Akihiko Muto ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ph Domain ◽  
Gene Encoding ◽  
Novel Gene ◽  
Identification And Characterization

Abstract 4020: Identification and characterization of Novel MYC and p53 target molecules from medicinal plants of North East India

2017 ◽  
Author(s):  
Sora Sandhya ◽  
Joyeeta Talukdar ◽  
Bidisha Pal ◽  
Seema Bhuyan ◽  
Debabrat Baishya ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
North East India ◽  
North East ◽  
Target Molecules ◽  
Identification And Characterization

Linfoistiocitosi eritrofagocitica

2003 ◽  
Vol 16 (3) ◽  
pp. 365-372 ◽  
Author(s):  
F. Caranci ◽  
A. D'Amico ◽  
F. Briganti ◽  
R. Migliorati ◽  
C. De Fusco ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
White Matter ◽  
White Matter Abnormalities ◽  
Diffuse White Matter ◽  
Multisystem Involvement ◽  
Identification And Characterization

Erithrophagocytic lymphohistiocytosis is a rare disease characterized by exaggerated histiocytic proliferation and activation12 and multisystem involvement including visceral organs, lymph nodes, bone marrow and central nervous system4. Magnetic Resonance (MR) examination was performed in 10 patients with previously diagnosed Erithrophagocytic lymphohistiocytosis. This study was aimed at assessing MR accuracy in the identification and characterization of central nervous system lesions. MR findings show a good correlation with areas of parenchymal and meningeal lymphohistiocytic infiltration5, demonstrating diffuse white matter abnormalities in the early stages and necrotic areas with parenchymal volume loss as terminal findings4. In addition, MR allows the follow-up after chemotherapy and bone marrow transplantation2,3. Although rare, EL should be differentiated from other pediatric patchy white matter abnormalities5.

scholarly journals Identification of Patulin from Penicillium coprobium as a Toxin for Enteric Neurons

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2776 ◽  
Author(s):  
Brand ◽  
Stoye ◽  
Guilherme ◽  
Nguyen ◽  
Baumgaertner ◽  
...  
Keyword(s):  
Nervous System ◽  
Neuronal Cell ◽  
Enteric Neurons ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Gut Microorganisms ◽  
Identification And Characterization ◽  
Effective Compound ◽  
Specific Impact

The identification and characterization of fungal commensals of the human gut (the mycobiota) is ongoing, and the effects of their various secondary metabolites on the health and disease of the host is a matter of current research. While the neurons of the central nervous system might be affected indirectly by compounds from gut microorganisms, the largest peripheral neuronal network (the enteric nervous system) is located within the gut and is exposed directly to such metabolites. We analyzed 320 fungal extracts and their effect on the viability of a human neuronal cell line (SH-SY5Y), as well as their effects on the viability and functionality of the most effective compound on primary enteric neurons of murine origin. An extract from P. coprobium was identified to decrease viability with an EC50 of 0.23 ng/µL in SH-SY5Y cells and an EC50 of 1 ng/µL in enteric neurons. Further spectral analysis revealed that the effective compound was patulin, and that this polyketide lactone is not only capable of evoking ROS production in SH-SY5Y cells, but also diverse functional disabilities in primary enteric neurons such as altered calcium signaling. As patulin can be found as a common contaminant on fruit and vegetables and causes intestinal injury, deciphering its specific impact on enteric neurons might help in the elaboration of preventive strategies.

scholarly journals Targeting Angiogenesis

2014 ◽  
Vol 5 (2) ◽  
pp. 78-86
Author(s):  
Mandeep Kaur
Keyword(s):  
Wound Healing ◽  
Blood Vessels ◽  
Growth And Development ◽  
Angiogenesis Inhibitors ◽  
Capillary Blood ◽  
The Body ◽  
Blood Vessel Formation ◽  
Identification And Characterization ◽  
Head Neck

ABSTRACT Blood vessels constitute the first organ in the embryo and form the largest network in the body, but sadly are often deadly. Angiogenesis is the process of generating new capillary blood vessels. Vasculogenesis is the term used for spontaneous bloodvessel formation, and intussusception is the term for new blood vessel formation by splitting off existing ones. Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in granulation tissue. It is also a fundamental step in the transition of tumors from a dormant state to a malignant one, leading to the use of angiogenesis inhibitors. Angiogenesis may be a target for combating diseases characterized by either poor vascularization or abnormal vasculature. Application of specific compounds that may inhibit or induce the creation of new blood vessels in the body may help combat such diseases. In this review, we will present an overview of the knowledge gained in studies related to the identification and characterization of different inhibitors and regulators of angiogenesis and also to highlight briefly the pathological and physiological angiogenesis. How to cite this article Kaur M. Targeting Angiogenesis. Int J Head Neck Surg 2014;5(2):78-86.

scholarly journals Purification, identification, and characterization of two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities

2019 ◽  
Author(s):  
Jinhua Li ◽  
Ziqi Yan ◽  
Hongmei Li ◽  
Qiong Shi ◽  
Linfang Huang ◽  
...  
Keyword(s):  
Cell Division ◽  
Medicinal Plants ◽  
Crude Extract ◽  
Benzophenanthridine Alkaloids ◽  
Checkpoint Response ◽  
Antimitotic Activity ◽  
Chromosome Congression ◽  
Phenotypic Screen ◽  
Identification And Characterization

ABSTRACTMitosis has long been a therapeutic target for the treatment of cancer. After conducting a phenotypic screen for anti-mitotic activity in a crude extract library of more than 2000 medicinal plants, we identified the rhizomes of Corydalis longicalcarata. Guided by the bioactivity-based assay, two benzophenanthridine alkaloids were purified and subsequently identified as corynoline and its close analog acetylcorynoline. This study uncovers a previously unknown antimitotic activity for these two phytochemicals, discovers their potential to be developed as anticancer drugs, and highlights their pleiotropic effects on cell division, including prevention of chromosome congression, compromise of spindle checkpoint response, and blockage of cytokinesis.

scholarly journals Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system

2009 ◽  
Vol 147 (4) ◽  
pp. 565-579 ◽  
Author(s):  
C. Shimono ◽  
R. i. Manabe ◽  
T. Yamada ◽  
S. Fukuda ◽  
J. Kawai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Family Protein ◽  
The Central Nervous System ◽  
Identification And Characterization
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