multisystem involvement
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2022 ◽  
Vol 17 (3) ◽  
pp. 784-789
Author(s):  
Jing Liu ◽  
Limin Gao ◽  
Huaxia Pu ◽  
Wenzhang He ◽  
Liqing Peng

2022 ◽  
Vol 71 (6) ◽  
pp. 2194-2201
Author(s):  
Nida Noor ◽  
Rabia Muhammad Wali ◽  
Annis -Ur- Rehman ◽  
Muhammad Abu Bakar

Objective: To find out the clinical manifestations, treatment given and outcome of children with diagnosis of Langerhans cell histiocytosis. Study Design: Retrospective observational study. Place and Duration of Study: Shaukat Khanum Cancer Hospital, Lahore Pakistan, from Jan 2005 to Dec 2015. Methodology: Medical charts were reviewed in detail along with the available imaging for the patients. The data included age at the time of diagnosis, extent of the disease, involvement of risk organs, treatment given, response at 6th week of chemotherapy and at the end of the treatment, and outcome in terms of disease progression during the treatment, relapse of disease on follow up and cause of death either due to treatment related mortality or disease complications. Results: There were 29 patients, 12 patients (41%) had single system and 17 (58%) had multisystem involvement. 7 patients (41%) had risk organ involvement in the multisystem group. All the patients of multisystem and 6 patients of single system were treated according to the Langerhans cell histiocytosis III protocol. Commonest sites of involvement were bone in 22 (75%), followed by lymph nodes in 18 (62%) patients. Disease relapse was seen in 6 patients and all of them had multisystem disease. Mortality was observed only in multisystem Langerhans cell histiocytosis patients and more than 50% were risk organ positive. Conclusion: Langerhans cell histiocytosis is a highly heterogeneous disease. Some forms are curable without chemotherapy, while the multisystem disease requires aggressive treatment. However, despite intensive treatment, the multisystem disease and risk organs involved have poor...........


Cureus ◽  
2021 ◽  
Author(s):  
Rahul Navab ◽  
Visweswara Reddy Yeragudi Jangamareddy ◽  
Nagabushana V Midthala ◽  
Thinagaran Kamalakannan

2021 ◽  
Author(s):  
Peter Novak ◽  
Shibani S. Mukerji ◽  
Haitham S. Alabsi ◽  
David Systrom ◽  
Sadie P. Marciano ◽  
...  

2021 ◽  
Vol 10 (22) ◽  
pp. 5404
Author(s):  
Tiziana Cantile ◽  
Noemi Coppola ◽  
Vito Carlo Alberto Caponio ◽  
Daniela Russo ◽  
Paolo Bucci ◽  
...  

Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity and cutaneous organ system, including nails, share a close embryologic origin. Nail disorders can manifest with nail hypoplasia or nail hypertrophy. Clinical pictures of affected oral mucosa can be extremely heterogeneous, ranging from asymptomatic papules to painful blisters, leukokeratosis, oral papillomas and fibromas to oral potentially malignant disorders and cancerous lesions. Oral mucosa and nails pathological features may occur synchronously or not and are usually associated with other systemic and skin manifestations. In some cases, oral mucosa and nails diseases may be distinct and constitute the principal sign of the genetic disorder, in other cases they represent only a part of the puzzle for the confirmation of the diagnosis. Continued awareness of the correlation between oral mucosa and nails findings can help physicians to diagnose genodermatosis in a timely manner, allowing more effective clinical management and prevention and/or early detection of complications. This article provides an overview of all specific genodermatoses affecting both oral mucosa and nails. Moreover, the correlation between teeth and nails is summarized in tabular form.


2021 ◽  
Vol 11 (6) ◽  
pp. 31-36
Author(s):  
Komal K Nikumbh

Diabetes is a long-term endocrine disease that affects people all over the world and is getting increasingly common. Because of its multisystem involvement and life-threatening effects, diabetes has become a major health concern for people of all ages in recent years. In 2019, diabetes was directly responsible for around 1.5 million fatalities. It's the primary cause of blindness, kidney failure, heart attack, stroke, and lower-limb amputations. Despite advances in pharmacological research and therapy, effective diabetes management remains a problem. Many therapeutic plants have demonstrated promising outcomes in animals in studies, and these findings can be applied to humans. This review examines the antidiabetic activity of common medicinal herbs such as Gymnema sylvestre, Swertia chirata, Momordica charantia, and others in experimental animals


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3964
Author(s):  
Marine Gérard ◽  
Meliha Mahmutovic ◽  
Aurélie Malgras ◽  
Niasha Michot ◽  
Nicolas Scheyer ◽  
...  

Post-acute consequences of COVID-19, also termed long COVID, include signs and symptoms persisting for more than 12 weeks with prolonged multisystem involvement; most often, however, malnutrition is ignored. Method: The objective was to analyze persistent symptoms, nutritional status, the evolution of muscle strength and performance status (PS) at 6 months post-discharge in a cohort of COVID-19 survivors. Results: Of 549 consecutive patients hospitalized for COVID-19 between 1 March and 29 April 2020, 23.7% died and 288 patients were at home at D30 post-discharge. At this date, 136 of them (47.2%) presented persistent malnutrition, a significant decrease in muscle strength or a PS ≥ 2. These patients received dietary counseling, nutritional supplementation, adapted physical activity guidance or physiotherapy assistance, or were admitted to post-care facilities. At 6 months post-discharge, 91.0% of the 136 patients (n = 119) were evaluated and 36.0% had persistent malnutrition, 14.3% complained of a significant decrease in muscle strength and 14.9% had a performance status > 2. Obesity was more frequent in patients with impairment than in those without (52.8% vs. 31.0%; p = 0.0071), with these patients being admitted more frequently to ICUs (50.9% vs. 31.3%; p = 0.010). Among those with persistent symptoms, 10% had psychiatric co-morbidities (mood disorders, anxiety, or post-traumatic stress syndrome), 7.6% had prolonged pneumological symptoms and 4.2% had neurological symptoms. Conclusions: Obese subjects as well as patients who have stayed in intensive care have a higher risk of functional loss or undernutrition 6 months after a severe COVID infection. Malnutrition and loss of muscle strength should be considered in the clinical assessment of these patients.


2021 ◽  
Vol 43 ◽  
pp. S20
Author(s):  
Özden ÖZLÜK ◽  
Metban GÜZEL MASTANZADE ◽  
Beyza ŞEN OLUK ◽  
Sevgi KALAYOĞLU BEŞIŞIK ◽  
Bezirgen BALLYYEV

2021 ◽  
pp. 388-390
Author(s):  
Suparna Guha ◽  
Debabrata Manna ◽  
Papai Khetrapal ◽  
Sumita Basu

Pediatric inflammatory multisystem syndrome due to severe acute respiratory syndrome coronavirus-2 infection is not very common. It may vary from a simple febrile inflammatory response to a severe multisystem involvement including myocarditis and shock. Here, we report the case of a 10-year-old female child with fever, rash, and mucositis who presented with shock and complete heart block along with encephalopathy and convulsions. The primary investigations revealed raised inflammatory markers along with a high titer of COVID antibodies. She was given full inotrope support along with immunomodulators. She underwent temporary pacing but ultimately needed a dual-chamber pacemaker. The novel coronavirus in children can present with a myriad of manifestations affecting almost every organ. In these pandemic times, one must always keep in mind the possibility of COVID-19 infection in a child that presents with shock, carditis, and arrhythmias. These children need intense immunosuppression and must be managed very aggressively


2021 ◽  
Vol 11 (20) ◽  
pp. 9505
Author(s):  
Alexandra Enache ◽  
Veronica Ciocan ◽  
Camelia Oana Muresan ◽  
Talida Georgiana Cut ◽  
Dorin Novacescu ◽  
...  

The physiopathology of SARS-CoV-2 infection, during pregnancy and in early childhood, is poorly understood. Unfavorable maternal outcomes, the risk of vertical/postpartum transmission, and severe, multisystem involvement in infants and children highlight the importance of developing a cohesive treatment and nuanced prophylaxis strategy. In this study, we evaluate autopsy reports, pathological findings, and SARS-CoV-2 genome expression in three distinct clinical scenarios: maternal death due to severe COVID-19 with in utero fetal demise (27 weeks); mother with moderate COVID-19 and in utero fetal demise (29 weeks); and 2-month-old infant death with confirmed COVID-19 caregivers. We report the presence of the SARS-CoV-2 genome in amniotic fluid and placental tissue in the context of in utero transmission of SARS-CoV-2, but also in postmortem infant pulmonary tissue samples in a case of late postpartum SARS-CoV-2 transmission with asymptomatic, rapidly progressive disease, resulting in infant death. Key pathological findings offer a descriptive portrayal of maternal, in utero, and infantile COVID-19 pathogenesis. Further investigations are necessary to fully comprehend the clinical implications of SARS-CoV-2 infection during pregnancy, a prerequisite for adequate therapeutic management and harm reduction.


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