scholarly journals Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice

2014 ◽  
Vol 61 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Shiva PD Senthil Kumar ◽  
Minqian Shen ◽  
Elizabeth G Spicer ◽  
Ashley J Goudjo-Ako ◽  
Justin D Stumph ◽  
...  
2009 ◽  
Vol 25 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Maiko Matsuura ◽  
Nadja Herbach ◽  
Ellen Kienzle ◽  
Marc Slawik ◽  
...  

Author(s):  
Jacaline K. Parkman ◽  
Kristiana Sklioutovskaya-Lopez ◽  
Kalhara R. Menikdiwela ◽  
Logan Freeman ◽  
Naima Moustaid-Moussa ◽  
...  

2008 ◽  
Vol 7 (6) ◽  
pp. 2388-2398 ◽  
Author(s):  
Anthony Fardet ◽  
Rafael Llorach ◽  
Jean-François Martin ◽  
Catherine Besson ◽  
Bernard Lyan ◽  
...  

Lipids ◽  
1985 ◽  
Vol 20 (10) ◽  
pp. 668-674 ◽  
Author(s):  
M. S. Thomassen ◽  
J. Norseth ◽  
E. N. Christiansen

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55603 ◽  
Author(s):  
Mirjam Luijten ◽  
Amar V. Singh ◽  
Caleb A. Bastian ◽  
Anja Westerman ◽  
M. Michele Pisano ◽  
...  

2019 ◽  
Author(s):  
Andrea A. Hill ◽  
Myunghoo Kim ◽  
Daniel F. Zegarra-Ruiz ◽  
Hyo Won Song ◽  
Michael C. Renfroe ◽  
...  

AbstractDefective tissue repair is a hallmark of many inflammatory disorders including, inflammatory bowel disease (IBD). While it is clear that high fat diets (HFD) can exacerbate inflammatory disease by increasing inflammation, the direct effect of lipids on tissue homeostasis and repair remains undefined. We show here that short term exposure to HFD directly impairs barrier repair after intestinal epithelial damage by interfering with recognition and uptake of apoptotic neutrophils by intestinal macrophages. Apoptotic neutrophil uptake induces macrophage IL-10 production, which is lacking after intestinal damage in the context of HFD. Overexpression of IL-10 rescues repair defects after HFD treatment, but not if epithelial cells lack the IL-10 receptor, highlighting the key role of IL-10 in barrier repair. These findings demonstrate a previously unidentified mechanism by which dietary lipids directly interfere with homeostatic processes required to maintain tissue integrity.


1995 ◽  
Vol 269 (1) ◽  
pp. R30-R37 ◽  
Author(s):  
Z. S. Warwick ◽  
H. P. Weingarten

High-fat diets often promote greater caloric intake and/or weight gain than high-carbohydrate diets in both laboratory animals and humans. Because altering the fat content of a diet simultaneously changes both its sensory properties and postingestive effects, it is unclear whether high-fat hyperphagia is due to the diet's palatability, its postingestive effects, or both. The present studies isolated the independent capacity of the orosensory and postingestive effects of a liquid high-fat diet (High-Fat) to produce overeating relative to an isocaloric liquid high-carbohydrate (High-CHO) diet. Rats fed High-Fat orally ate more calories and gained more weight over 16 days than rats fed High-CHO orally. One-bottle sham-feeding intake of High-Fat and High-CHO did not differ, but in two-bottle sham-feeding tests High-Fat was clearly preferred. When orosensory influences on intake were equated via chronic self-regulated intragastric feeding, High-Fat still promoted greater intake than High-CHO, although absolute intake across both diets was lower during intragastric feeding relative to oral feeding. An analysis of short-term intake revealed that rats accustomed to infusion of High-CHO increased meal size immediately when switched to High-Fat. The present results, coupled with previous findings, suggest that the postingestive effects of fat enhance daily caloric intake in two ways: 1) during a meal, fat produces less suppression of intake per calorie than carbohydrate; and 2) after a meal, fat produces less suppression of intake per calorie during the intermeal interval than carbohydrate.


Metabolism ◽  
2012 ◽  
Vol 61 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Valérie Guay ◽  
Benoît Lamarche ◽  
Amélie Charest ◽  
André J. Tremblay ◽  
Patrick Couture

2007 ◽  
Vol 54 (5) ◽  
pp. 229-232 ◽  
Author(s):  
Michiyuki Kojima ◽  
Shigenori Nishi ◽  
Yusuke Saito ◽  
Kazunori Hironaka ◽  
Hiroshi Koaze ◽  
...  

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