scholarly journals Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats

2009 ◽  
Vol 25 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Maiko Matsuura ◽  
Nadja Herbach ◽  
Ellen Kienzle ◽  
Marc Slawik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mineral ◽  
High Fat ◽  
Mineral Density ◽  
Short Term ◽  
Short Term Exposure ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Consequences of high‐fat diets on body growth and bone mineral density, in growing rats

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Silvia Maria Friedman ◽  
Elisa Vanesa Macri ◽  
Patricia Noemi Rodriguez ◽  
Natalia Juiz ◽  
Cristina Graciela Suarez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Body Growth ◽  
High Fat ◽  
Mineral Density ◽  
Growing Rats ◽  
High Fat Diets ◽  
Fat Diets

Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats

2010 ◽  
Vol 35 (5) ◽  
pp. 598-606 ◽  
Author(s):  
Beatrice Y. Lau ◽  
Val Andrew Fajardo ◽  
Lauren McMeekin ◽  
Sandra M. Sacco ◽  
Wendy E. Ward ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Safflower Oil ◽  
High Fat ◽  
Mineral Density ◽  
High Fat Diets ◽  
Fat Diets

Previous studies have suggested that high-fat diets adversely affect bone development. However, these studies included other dietary manipulations, including low calcium, folic acid, and fibre, and (or) high sucrose or cholesterol, and did not directly compare several common sources of dietary fat. Thus, the overall objective of this study was to investigate the effect of high-fat diets that differ in fat quality, representing diets high in saturated fatty acids (SFA), n-3 polyunsaturated fatty acids (PUFA), or n-6 PUFA, on femur bone mineral density (BMD), strength, and fatty acid composition. Forty-day-old male Sprague–Dawley rats were maintained for 65 days on high-fat diets (20% by weight), containing coconut oil (SFA; n = 10), flaxseed oil (n-3 PUFA; n = 10), or safflower oil (n-6 PUFA; n = 11). Chow-fed rats (n = 10), at 105 days of age, were included to represent animals on a control diet. Rats fed high-fat diets had higher body weights than the chow-fed rats (p < 0.001). Among all high-fat groups, there were no differences in femur BMD (p > 0.05) or biomechanical strength properties (p > 0.05). Femurs of groups fed either the high n-3 or high n-6 PUFA diets were stronger (as measured by peak load) than those of the chow-fed group, after adjustment for significant differences in body weight (p = 0.001). As expected, the femur fatty acid profile reflected the fatty acid composition of the diet consumed. These results suggest that high-fat diets, containing high levels of PUFA in the form of flaxseed or safflower oil, have a positive effect on bone strength when fed to male rats 6 to 15 weeks of age.

scholarly journals Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice

2014 ◽  
Vol 61 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Shiva PD Senthil Kumar ◽  
Minqian Shen ◽  
Elizabeth G Spicer ◽  
Ashley J Goudjo-Ako ◽  
Justin D Stumph ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
High Fat ◽  
Short Term ◽  
Male And Female ◽  
Female Mice ◽  
Short Term Exposure ◽  
High Fat Diets ◽  
Fat Diets

Vertebral growth disturbance in rapidly growing rats during 14 days of spaceflight

1996 ◽  
Vol 81 (1) ◽  
pp. 156-163 ◽  
Author(s):  
I. Kitajima ◽  
I. Semba ◽  
T. Noikura ◽  
K. Kawano ◽  
Y. Iwashita ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Short Term ◽  
Growth Disturbance ◽  
Growing Rats ◽  
Mechanical Hardness ◽  
Short Term Exposure ◽  
Significant Difference ◽  
Knoop Microhardness

The effect of 14 days of spaceflight on the vertebrae of rapidly growing rats was studied. The hardness of the vertebrae was measured with a Knoop microhardness tester, and bone mineral density was measured from X-ray photographs. Histomorphometric examination was performed with a microcomputer-aided system. No significant difference (P > 0.05) was observed between flight rats and ground controls with regard to mechanical hardness or bone mineral density. However, histological examination revealed irregular thickening of the endosteal surface of cortical bone in the flight rats, whereas it was uniform in the ground controls. The relative area of lamellar bone showed a significant reduction (P < 0.001) in the flight rats. These findings suggest that the structural disturbances were due to retardation of endosteal modeling and remodeling. We conclude that delay of vertebral maturation can occur in rapidly growing rats after even short-term exposure to microgravity.

scholarly journals Teriparatide Increases Bone Formation and Bone Mineral Density in Adult Women With Anorexia Nervosa

2014 ◽  
Vol 99 (4) ◽  
pp. 1322-1329 ◽  
Author(s):  
Pouneh K. Fazeli ◽  
Irene S. Wang ◽  
Karen K. Miller ◽  
David B. Herzog ◽  
Madhusmita Misra ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Anorexia Nervosa ◽  
Bone Formation ◽  
Bone Mineral ◽  
Adult Women ◽  
Mineral Density

scholarly journals Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

2018 ◽  
Vol 18 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Mehmet Dagli ◽  
Ali Kutlucan ◽  
Sedat Abusoglu ◽  
Abdulkadir Basturk ◽  
Mehmet Sozen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Formation ◽  
Bone Mass ◽  
Bone Mineral ◽  
Type I ◽  
Healthy Controls ◽  
Mineral Density ◽  
Lymphocyte Ratio ◽  
Significant Difference

A decrease in bone mass is observed in hemophilic patients. The aim of this study was to evaluate bone mineral density (BMD), parathyroid hormone (PTH), 25-hydroxy vitamin D (vitamin D), and a bone formation and resorption marker, procollagen type I N-terminal propeptide (PINP) and urinary N-terminal telopeptide (uNTX) respectively, in hemophilic patients and healthy controls. Laboratory parameters related to the pathogenesis of bone loss such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were also evaluated. Thirty-five men over 18 years of age, with severe hemophilia (A and B) and receiving secondary prophylaxis, were included in the study. The same number of age-, sex-, and ethnicity-matched healthy controls were evaluated. Anthropometric, biochemical, and hormonal parameters were determined in both groups. No significant difference in anthropometric parameters was found between the two groups. The BMD was low in 34% of hemophilic patients. Vitamin D, calcium, and free testosterone levels were significantly lower (p < 0.001, p = 0.011, p < 0.001, respectively), while PTH, PINP, and activated partial thromboplastin time (aPTT) levels were significantly higher (p < 0.014, p = 0.043, p < 0.001, respectively), in hemophilic patients compared to controls. There was no significant difference between the two groups in NLR, PLR, phosphorus, thyroid-stimulating hormone, and uNTX level. The reduction of bone mass in hemophilic patients may be evaluated using the markers of bone formation and resorption, enabling early detection and timely treatment.

A Systematic Review of Low-Carbohydrate High-Fat Diets: Does the Research Evidence Support Practice?

2018 ◽  
Vol 118 (10) ◽  
pp. A126
Author(s):  
L. Ross ◽  
J. Musial ◽  
R. Hay ◽  
A. Cawte ◽  
D. McDermid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research Evidence ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Inulin supplementation reduces the negative effect of a high-fat diet rich in SFA on bone health of growing pigs

2018 ◽  
Vol 119 (10) ◽  
pp. 1111-1118 ◽  
Author(s):  
Monika Sobol ◽  
Stanisława Raj ◽  
Grzegorz Skiba
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
High Fat Diet ◽  
Growing Pigs ◽  
Whole Body ◽  
Standard Diet ◽  
High Fat ◽  
Mineral Density ◽  
Negative Effect

AbstractConsumption of a high-fat diet, rich in SFA, causes deterioration of bone properties. Some studies suggest that feeding inulin to animals may increase mineral absorption and positively affect bone quality; however, these studies have been carried out only on rodents fed a standard diet. The primary objective of this study was to determine the effect of inulin on bone health of pigs (using it as an animal model for humans) fed a high-fat diet rich in SFA, having an unbalanced ratio of lysine:metabolisable energy. It was hypothesised that inulin reduces the negative effects of such a diet on bone health. At 50 d of age, twenty-one pigs were randomly allotted to three groups: the control (C) group fed a standard diet, and two experimental (T and TI) groups fed a high-fat diet rich in SFA. Moreover, TI pigs consumed an extra inulin supply (7 % of daily feed intake). After 10 weeks, whole-body bone mineral content (P=0·0054) and bone mineral density (P=0·0322) were higher in pigs of groups TI and C compared with those of group T. Femur bone mineral density was highest in pigs in group C, lower in group TI and lowest in group T (P=0·001). Femurs of pigs in groups TI and C had similar, but higher, maximum strength compared with femurs of pigs in group T (P=0·0082). In conclusion, consumption of a high-fat diet rich in SFA adversely affected bone health, but inulin supplementation in such a diet diminishes this negative effect.

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