An experimental setup for traceable measurement and calibration of liquid flow rates down to 5 nl/min

2015 ◽  
Vol 60 (4) ◽  
Author(s):  
Martin Ahrens ◽  
Bodo Nestler ◽  
Stephan Klein ◽  
Peter Lucas ◽  
Harm Tido Petter ◽  
...  
Keyword(s):  
Imaging System ◽  
Infusion Pump ◽  
Flow Sensor ◽  
Low Flow ◽  
Experimental Setup ◽  
Syringe Pump ◽  
Glass Capillary ◽  
Flow Rates ◽  
Ccd Imaging ◽  
Thermal Flow Sensor

AbstractThis work presents the improvements of an experimental setup for measuring ultra-low flow rates down to 5 nl/min. The system uses a telecentric CCD imaging system mounted on a high-precision, computer-controlled linear stage to track a moving liquid meniscus inside a glass capillary. Compared to the original setup, the lowest attainable expanded uncertainty at any flow rate has been reduced from 5.4% to 2%. In addition, the conformity with specification of three commercial micro-fluidic devices was evaluated using the new setup: one syringe pump, one implantable infusion pump and one thermal flow sensor. The flow sensor and the implantable infusion pump met the compliance criteria (coverage probability 95%). The syringe pump however, failed to meet the specifications at 5 nl/min and 10 nl/min. No assessment could be made at higher flow rates.

Fabrication and Multiphysics Modeling of MEMS Thermal Flow Sensor

2019 ◽  
Author(s):  
Justin Cable ◽  
Kevin R. Anderson
Keyword(s):  
Microelectromechanical Systems ◽  
Flow Direction ◽  
Flow Sensor ◽  
Constant Current ◽  
Thermal Flow ◽  
Maximum Heat ◽  
Flow Rates ◽  
Maximum Heat Transfer ◽  
Thermal Flow Sensor ◽  
Hot Film

Abstract A micromachined thermal flow sensor is presented demonstrating sensing liquid flow rates as low as 2 microliters per minute capable of being used for biomedical applications. These flow sensors rely on the varying electrical resistance of sensors generated by forced convection at different flow rates. The sensor array presented was constructed using microelectromechanical systems (MEMS) techniques including micro-molding, wet etching and dry etching utilizing biocompatible materials. A numerical model was built using COMSOL multi-physics in order to predict and optimize the electrical, thermal and fluid behavior of the sensor, which was verified with experimental data. The construction allowed for multiple thermal flow sensing operational modes. Here, constant current hot film and constant current calorimetric were simulated and tested. A variety of flow sensor geometries were compared to investigate maximum heat transfer to the sensors, thermal insultation, size, sensitivity and range capabilities. The sensor design is such that it is capable of detecting different flow direction and various flow ranges for different fluids. In addition to the performance capabilities outlined, the sensor is relatively inexpensive and should have a long lifetime due to the lack of moving parts.

Evaluation of a novel flow‐controlled syringe infusion pump for precise and continuous drug delivery at low flow rates: a laboratory study

Anaesthesia ◽  
2019 ◽  
Vol 74 (11) ◽  
pp. 1425-1431 ◽  
Author(s):  
M. Batliner ◽  
M. Weiss ◽  
S. A. Dual ◽  
B. Grass ◽  
M. Meboldt ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laboratory Study ◽  
Infusion Pump ◽  
Low Flow ◽  
Flow Rates ◽  
Continuous Drug Delivery

Assessment of the Use of Humidified Nasal Cannulas for Oxygen Therapy in Patients with Epistaxis

ORL ◽  
2021 ◽  
pp. 1-5
Author(s):  
Jingjing Liu ◽  
Tengfang Chen ◽  
Zhenggang Lv ◽  
Dezhong Wu
Keyword(s):  
Flow Rate ◽  
Oxygen Therapy ◽  
Preliminary Investigation ◽  
Nasal Cannula ◽  
Low Flow ◽  
Antiplatelet Drugs ◽  
Flow Rates ◽  
The Past ◽  
Oxygen Inhalation ◽  
Significant Difference

<b><i>Introduction:</i></b> In China, nasal cannula oxygen therapy is typically humidified. However, it is difficult to decide whether to suspend nasal cannula oxygen inhalation after the nosebleed has temporarily stopped. Therefore, we conducted a preliminary investigation on whether the use of humidified nasal cannulas in our hospital increases the incidence of epistaxis. <b><i>Methods:</i></b> We conducted a survey of 176,058 inpatients in our hospital and other city branches of our hospital over the past 3 years and obtained information concerning their use of humidified nasal cannulas for oxygen inhalation, nonhumidified nasal cannulas, anticoagulant and antiplatelet drugs, and oxygen inhalation flow rates. This information was compared with the data collected at consultation for epistaxis during these 3 years. <b><i>Results:</i></b> No significant difference was found between inpatients with humidified nasal cannulas and those without nasal cannula oxygen therapy in the incidence of consultations due to epistaxis (χ<sup>2</sup> = 1.007, <i>p</i> &#x3e; 0.05). The same trend was observed among hospitalized patients using anticoagulant and antiplatelet drugs (χ<sup>2</sup> = 2.082, <i>p</i> &#x3e; 0.05). Among the patients with an inhaled oxygen flow rate ≥5 L/min, the incidence of ear-nose-throat (ENT) consultations due to epistaxis was 0. No statistically significant difference was found between inpatients with a humidified oxygen inhalation flow rate &#x3c;5 L/min and those without nasal cannula oxygen therapy in the incidence of ENT consultations due to epistaxis (χ<sup>2</sup> = 0.838, <i>p</i> &#x3e; 0.05). A statistically significant difference was observed in the incidence of ENT consultations due to epistaxis between the low-flow nonhumidified nasal cannula and nonnasal cannula oxygen inhalation groups (χ<sup>2</sup> = 18.428, <i>p</i> &#x3c; 0.001). The same trend was observed between the 2 groups of low-flow humidified and low-flow nonhumidified nasal cannula oxygen inhalation (χ<sup>2</sup> = 26.194, <i>p</i> &#x3c; 0.001). <b><i>Discussion/Conclusion:</i></b> Neither high-flow humidified nasal cannula oxygen inhalation nor low-flow humidified nasal cannula oxygen inhalation will increase the incidence of recurrent or serious epistaxis complications; the same trend was observed for patients who use anticoagulant and antiplatelet drugs. Humidification during low-flow nasal cannula oxygen inhalation can prevent severe and repeated epistaxis to a certain extent.

An anti-settling sample delivery instrument for serial femtosecond crystallography

2012 ◽  
Vol 45 (4) ◽  
pp. 674-678 ◽  
Author(s):  
Lukas Lomb ◽  
Jan Steinbrener ◽  
Sadia Bari ◽  
Daniel Beisel ◽  
Daniel Berndt ◽  
...  
Keyword(s):  
Constant Flow ◽  
Syringe Pump ◽  
Experimental Conditions ◽  
Flow Rates ◽  
X Ray ◽  
Constant Flow Rate ◽  
Significant Impairment ◽  
Working Principle ◽  
After Hours ◽  
Serial Femtosecond Crystallography

Serial femtosecond crystallography (SFX) using X-ray free-electron laser (FEL) sources has the potential to determine the structures of macromolecules beyond the limitation of radiation damage and without the need for crystals of sufficient size for conventional crystallography. In SFX, a liquid microjet is used to inject randomly oriented crystals suspended in their storage solution into the FEL beam. Settling of crystals in the reservoir prior to the injection has been found to complicate the data collection. This article details the development of an anti-settling sample delivery instrument based on a rotating syringe pump, capable of producing flow rates and liquid pressures necessary for the operation of the injector. The device has been used successfully with crystals of different proteins, with crystal sizes smaller than 20 µm. Even after hours of continuous operation, no significant impairment of the experiments due to sample settling was observed. This article describes the working principle of the instrument and sets it in context with regard to the experimental conditions used for SFX. Hit rates for longer measuring periods are compared with and without the instrument operating. Two versions of the instrument have been developed, which both deliver sample at a constant flow rate but which differ in their minimum liquid flow rates and maximum pressures.

32-megapixel dual-color CCD imaging system

1993 ◽  
Author(s):  
Christopher W. Stubbs ◽  
Stuart L. Marshall ◽  
Kenneth H. Cook ◽  
Robert Hills ◽  
Joseph P. Noonan ◽  
...  
Keyword(s):  
Imaging System ◽  
Ccd Imaging ◽  
Dual Color

Effect of Tip Clearance on Suction Performance at Different Flow Rates in a Mixed Flow Pump

2014 ◽  
Author(s):  
Yo Han Jung ◽  
Young Uk Min ◽  
Jin Young Kim
Keyword(s):  
Performance Test ◽  
Stokes Equations ◽  
Flow Characteristics ◽  
Tip Clearance ◽  
Low Flow ◽  
Tip Leakage Flow ◽  
Mixed Flow ◽  
Flow Rates ◽  
Suction Performance ◽  
Flow Pump

This paper presents a numerical investigation of the effect of tip clearance on the suction performance and flow characteristics at different flow rates in a vertical mixed-flow pump. Numerical analyses were carried out by solving three-dimensional Reynolds-averaged Navier-Stokes equations. Steady computations were performed for three different tip clearances under noncavitating and cavitating conditions at design and off-design conditions. The pump performance test was performed for the mixed-flow pump and numerical results were validated by comparing the experimental data for a system characterized by the original tip clearance. It was shown that for large tip clearance, the head breakdown occurred earlier at the design and high flow rates. However, the head breakdown was quite delayed at low flow rate. This resulted from the cavitation structure caused by the tip leakage flow at different flow rates.

Experimental Investigation of Pressure Fluctuations on Inner Wall of a Centrifugal Pump

2019 ◽  
Vol 36 (4) ◽  
pp. 401-410 ◽  
Author(s):  
Xiao-Qi Jia ◽  
Bao-Ling Cui ◽  
Zu-Chao Zhu ◽  
Yu-Liang Zhang
Keyword(s):  
Centrifugal Pump ◽  
Flow Rate ◽  
Pressure Fluctuation ◽  
Pressure Fluctuations ◽  
High Flow ◽  
Low Flow ◽  
Centrifugal Pumps ◽  
Flow Rates ◽  
Pressure Distributions ◽  
Blade Passing Frequency

Abstract Affected by rotor–stator interaction and unstable inner flow, asymmetric pressure distributions and pressure fluctuations cannot be avoided in centrifugal pumps. To study the pressure distributions on volute and front casing walls, dynamic pressure tests are carried out on a centrifugal pump. Frequency spectrum analysis of pressure fluctuation is presented based on Fast Fourier transform and steady pressure distribution is obtained based on time-average method. The results show that amplitudes of pressure fluctuation and blade-passing frequency are sensitive to the flow rate. At low flow rates, high-pressure region and large pressure gradients near the volute tongue are observed, and the main factors contributing to the pressure fluctuation are fluctuations in blade-passing frequency and high-frequency fluctuations. By contrast, at high flow rates, fluctuations of rotating-frequency and low frequencies are the main contributors to pressure fluctuation. Moreover, at low flow rates, pressure near volute tongue increases rapidly at first and thereafter increases slowly, whereas at high flow rates, pressure decreases sharply. Asymmetries are observed in the pressure distributions on both volute and front casing walls. With increasing of flow rate, both asymmetries in the pressure distributions and magnitude of the pressure decrease.

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