A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test

AbstractMany in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.

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A Review on Antimicrobial Properties of Metal Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.17677 ◽

2020 ◽

Vol 20 (6) ◽

pp. 3303-3339 ◽

Cited By ~ 10

Author(s):

Saee Gharpure ◽

Aman Akash ◽

Balaprasad Ankamwar

Keyword(s):

Titanium Dioxide ◽

Metal Oxide ◽

Biomedical Applications ◽

Antimicrobial Agents ◽

Metal Oxide Nanoparticles ◽

Antimicrobial Properties ◽

Multidrug Resistant ◽

Oxide Nanoparticles ◽

Synthesis Methods ◽

Micro Organisms

The field of nanotechnology elaborates the synthesis, characterization as well as application of nanomaterials. Applications of nanoparticles in various fields have interested scientists since decades due to its unique properties. Combination of pharmacology with nanotechnology has helped in development of newer antimicrobial agents in order to control the ever increasing multidrug resistant micro-organisms. Properties of metal and metal oxide nanoparticles like silver, gold, titanium dioxide as well as magnesium oxide as antimicrobial agents are very well known. This review elaborates synthesis methods and antimicrobial mechanisms of various metal as well as metal oxide nanoparticles for better understanding in order to utilize their potentials in various biomedical applications.

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A comprehensive review on green synthesis of titanium dioxide nanoparticles and their diverse biomedical applications

Green Processing and Synthesis ◽

10.1515/gps-2022-0005 ◽

2022 ◽

Vol 11 (1) ◽

pp. 44-63

Author(s):

Suresh Sagadevan ◽

Shahla Imteyaz ◽

Baranya Murugan ◽

Jayasingh Anita Lett ◽

Nanthini Sridewi ◽

...

Keyword(s):

Titanium Dioxide ◽

Metal Oxide ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Metal Oxide Nanoparticles ◽

Cost Effective ◽

Biological Synthesis ◽

Synthesis Methods ◽

Environmental Friendliness ◽

Environmentally Safe

Abstract Metal oxide nanoparticles (NPs) have found a variety of applications in numerous industrial, medical, and environmental fields s, attributable to recent advances in the nanotechnology field. Titanium dioxide nanoparticles (TiO2-NPs) have gained importance as metal oxide NPs due to their potential in various fields, particularly nanomedicine and other biomedicine fields. Several studies have confirmed that NPs produced via the biosynthesis route using natural resources have significant advantages such as fewer toxic contaminants, less subsequent complex chemical synthesis, environmental friendliness, cost-effectiveness, and stability when compared to NPs produced by conventional methods, and its production with controlled shapes and sizes. Therefore, considerable effort is being expended to implement biological synthesis methods with these proven advantages. TiO2-NPs can be made using a variety of biological, chemical, and physical methods. Physicochemical methods are costly, emit high levels of toxic chemicals into the atmosphere, and consume a lot of energy. On the other hand, the biological approach is an environmentally safe, cost-effective, dependable, convenient, and easy way to synthesize TiO2-NPs. In this review, the bio-mediated synthesis, as well as various biomedical applications of TiO2-NPs, were discussed.

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A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test

nano Online ◽

10.1515/nano.0005.00007 ◽

2016 ◽

Author(s):

Lucia Vecchione ◽

Micol Massimiani ◽

Antonella Camaioni ◽

Luna Sifrani ◽

Andrea Magrini ◽

...

Keyword(s):

Stem Cell ◽

Metal Oxide ◽

Comparative Study ◽

Embryonic Stem Cell ◽

Metal Oxide Nanoparticles ◽

Embryonic Stem ◽

Oxide Nanoparticles ◽

Cell Test

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Surface coating and functionalization of metal and metal oxide nanoparticles for biomedical applications

10.1016/b978-0-12-823033-6.00007-7 ◽

2022 ◽

pp. 205-231

Author(s):

Raj Kumar ◽

Guruprasad Reddy Pulikanti ◽

Konathala Ravi Shankar ◽

Darsi Rambabu ◽

Venkateswarulu Mangili ◽

...

Keyword(s):

Metal Oxide ◽

Surface Coating ◽

Biomedical Applications ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles

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Utility of Zinc Oxide Nanoparticles Catalytic Activity in the Electrochemical Determination of Minocycline Hydrochloride

Polymers ◽

10.3390/polym12112505 ◽

2020 ◽

Vol 12 (11) ◽

pp. 2505

Author(s):

Amal M. Al-Mohaimeed ◽

Wedad A. Al-Onazi ◽

Maha F. El-Tohamy

Keyword(s):

Zinc Oxide ◽

Metal Oxide ◽

Zinc Oxide Nanoparticles ◽

Metal Oxide Nanoparticles ◽

Electrochemical Determination ◽

Electrochemical Sensing ◽

Oxide Nanoparticles ◽

Regression Equations ◽

Minocycline Hydrochloride

The current work described the synthesis and characterization of zinc oxide nanoparticles (ZnONPs) and their electrocatalytic activity in the determination of minocycline hydrochloride (MCL). The unique features of metal oxide nanoparticles such as zinc oxide encourage the researchers to investigate the activity of metal oxide nanoparticles as remarkable semiconductor materials active in the electrochemical sensing determination. Herein, the suggested study displayed a comparative determination of minocycline hydrochloride using two conventional and modified ZnONPs-coated wire sensors. The recorded results showed the linear behavior of the enriched ZnONPs sensor over the 1.0 × 10−10–1.0 × 10−2 mol L−1 with respect to 1.0 × 10−6–1.0 × 10−2 mol L−1 for the conventional sensor. The two sensors are working in the pH range of 3–5 with regression equations EmV = (53.2 ± 0.5) log [MCL] + 448.8 and EmV = (58.7 ± 0.2) log [MCL] + 617.76 for conventional and enriched ZnONPs, respectively. The correlation coefficients were 0.9995 and 0.9998 for the previously mentioned sensors, respectively. The validity of the suggested analytical method was evaluated according to the recommended guidelines for methodology and drug analysis. The developed sensors were also used in the quantification of MCL in commercial formulations.

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