National survey on appropriateness of clinical biochemistry reporting in China

AbstractAccurate and reliable testing reports play an important role in the prevention, diagnosis, treatment and prognosis of disease. However, little is known about the appropriateness of laboratory testing reporting in China. This national survey takes clinical biochemistry as an example to investigate the state of reporting appropriateness in our country.An electronic questionnaire was sent to 1209 laboratories. The participants were asked to retrospectively evaluate the error rates of the following quality indicators: report template integrity, report content filling integrity, report delay, report recall, non-conformities between instrument and laboratory information system (LIS) data, non-conformities between report and request, report notification error, and report modification. Mann-Whitney and Kruskal-Wallis tests were used to identify the potential impacts of reporting appropriateness.A total of 662 of the 1209 laboratories (55%) submitted the survey results, with three returning incomplete data. For the integrity of the report, only 31% of the laboratories had a complete report template that contained all of 21 elements. In addition, the overall error rate of content filling integrity was 45.9% for 19,770 pieces of reports. The overall σ-values of other six quality indicators were all >4, and no significant difference was found among different departments. Group comparison suggested that reporting electronically had a better performance.The laboratory reporting system in China needs to improve, particularly the integrity of the report. Strengthening information technology will not only promote reporting appropriateness, but also guarantee accurate, standardized and traceable data collection and long-term monitoring.

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AGROCHEMICAL PROPERTIES MONITORING OF THE VARIOUS LANDS WITHIN THE AGROLANDSCAPE

Vestnik of the Russian agricultural science ◽

10.30850/vrsn/2020/1/27-30 ◽

1970 ◽

pp. 27-30

Author(s):

D. A. Ivanov ◽

O. V. Karaseva ◽

M. V. Rublyuk

Keyword(s):

Soil Loss ◽

Granulometric Composition ◽

Land Allocation ◽

Initial State ◽

Agrochemical Properties ◽

Significant Difference ◽

Long Term Monitoring ◽

Output Field ◽

Term Monitoring

The paper presents the results of a statistical analysis of data on long-term monitoring of the agrochemical properties of soils of various lands within the reclaimed agrolandscape. Research was conducted in 1997-2012. on the agroecological transect of the VNIIMZ polygon - a narrow field 1300 m long that intersects all the main landscape positions of the end moraine hill. During the monitoring, two rounds of agrochemical surveys of the transect territory were carried out: 1. In 1997, the initial state of the soils was investigated; 2. In 2012, the state of the soils of the output field and crop rotation array. Agrochemical parameters of soils (various types of acidity, content of plant nutrients and humus) were determined at the sampling points regularly located along the transect. The research results were statistically processed based on the STATGRAPHICS plus package. It was revealed that during the research, the same type of evolution of the agrochemical parameters of soils of different lands occurred - acidification of soils, loss of the basic elements of plant nutrition during the accumulation of humus are observed everywhere. By 2012, the spatial variability of most agrochemical parameters of soils of different lands mainly began to depend on the granulometric composition of soils. A significant difference was found in the mechanism of soil loss of potassium and phosphorus - potassium migration mainly depends on the intensity of eluvial processes in the agrolandscape, and phosphorus moves laterally along the plow sole. Based on the results obtained, it is possible to develop a system of adaptive land allocation in an agrolandscape, which allows controlling degradation processes in soils.

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Durability of ChAdOx1 nCov-19 (AZD1222) vaccination in people living with HIV - responses to SARS-CoV-2, variants of concern and circulating coronaviruses

10.1101/2021.09.28.21264207 ◽

2021 ◽

Author(s):

Ane Ogbe ◽

Matthew Pace ◽

Mustapha Bittaye ◽

Timothy Tipoe ◽

Sandra Adele ◽

...

Keyword(s):

T Cell ◽

Cell Mediated Immunity ◽

People Living With Hiv ◽

Viral Loads ◽

Cell Responses ◽

Significant Difference ◽

Duration Of Protection ◽

Living With Hiv ◽

Term Monitoring

Duration of protection from SARS-CoV-2 infection in people with HIV (PWH) following vaccination is unclear. In a sub-study of the phase 2/3 the COV002 trial (NCT04400838), 54 HIV positive male participants on antiretroviral therapy (undetectable viral loads, CD4+ T cells >350 cells/ul) received two doses of ChAdOx1 nCoV-19 (AZD1222) 4-6 weeks apart and were followed for 6 months. Responses to vaccination were determined by serology (IgG ELISA and MesoScale Discovery (MSD)), neutralisation, ACE-2 inhibition, gamma interferon ELISpot, activation-induced marker (AIM) assay and T cell proliferation. We show that 6 months after vaccination the majority of measurable immune responses were greater than pre-vaccination baseline, but with evidence of a decline in both humoral and cell mediated immunity. There was, however, no significant difference compared to a cohort of HIV-uninfected individuals vaccinated with the same regimen. Responses to the variants of concern were detectable, although were lower than wild type. Pre-existing cross-reactive T cell responses to SARS-CoV-2 spike were associated with greater post-vaccine immunity and correlated with prior exposure to beta coronaviruses. These data support the on-going policy to vaccinate PWH against SARS-CoV-2, and underpin the need for long-term monitoring of responses after vaccination.

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Progress of site survey for large solar telescopes in western China

Proceedings of the International Astronomical Union ◽

10.1017/s1743921316000375 ◽

2015 ◽

Vol 11 (S320) ◽

pp. 447-449 ◽

Cited By ~ 1

Author(s):

Yu Liu ◽

Tengfei Song ◽

Xuefei Zhang ◽

Shunqing Liu ◽

Mingyu Zhao ◽

...

Keyword(s):

Western China ◽

The Tibetan Plateau ◽

Solar Observations ◽

Site Survey ◽

Survey Results ◽

Solar Telescopes ◽

Large Telescopes ◽

Term Monitoring ◽

Very High

AbstractExcellent sites are necessary for developing and installing ground-based large telescopes. For very-high-resolution solar observations, it had been unclear whether there exist good candidate sites in the west areas in China, including the Tibetan Plateau and the Pamirs Plateau. The project of solar site survey for the next-generation large solar telescopes, i.e., the Chinese Giant Solar Telescope (CGST) and the large coronagraph, has been launched since 2011. Based on the close collaboration among Chinese solar society and the scientists from NSO, HAO and other institutes, we have successfully developed the standard instruments for solar site survey and applied them to more than 50 different sites distributed in Xinjiang, Tibet, Qinghai, Sichuan, Yunnan and Ningxia provinces. We have built two long-term monitoring sites in Tibet and the large Shangri-La to take systematic site data. Clear evidence, including the key parameters of seeing factor, sky brightness and water vapor content, has indicated that a few potential sites in the large Tibetan areas should obtain the excellent astronomical conditions for our purpose to develop CGST and large coronagraph. We introduce the fresh site survey results in this report.

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Survey assessment of organizational resiliency potential of a group of Seveso organizations in Turkey

Proceedings of the Institution of Mechanical Engineers Part O Journal of Risk and Reliability ◽

10.1177/1748006x18802655 ◽

2018 ◽

Vol 233 (3) ◽

pp. 470-486

Author(s):

Hatice Şengül ◽

Dilem Marşan ◽

Tuğçe Gün

Keyword(s):

Employee Engagement ◽

Dynamic Capabilities ◽

Earthquake Risk ◽

Second Phase ◽

Uncertain Environments ◽

Significant Difference ◽

Survey Results ◽

Organizational Resiliency

Organizational resilience is vital for long-term value creation in organizations, as they continuously face many obstacles due to fast evolving, complex, and uncertain environments. Resilience is also important for managing hazmat and oil spill risks, given the expected increase in frequency and magnitude of natural disasters due to climatic extremes. Organizations with higher resiliency potential are more likely to manage these challenges effectively. Recently developing literature indicates that development of dynamic capabilities, which are different from ordinary capabilities, leads to greater organizational resiliency potential. This study assesses organizational resiliency potential of a group of Seveso organizations in Turkey via a 5-point Likert-type-scale survey designed toward measuring four important dimensions of dynamic capabilities including anticipation capabilities, adaptive culture, networking capabilities, and organizational learning. Cluster analysis of survey results revealed that there are significant differences in organizational resiliency potential among organizations, as evidenced by the distance plot. While participating organizations have scored relatively high resiliency potentials, there are areas that need improvement including increasing anticipation and networking capabilities and strengthening employee engagement to further enhance resilience of organizations. In the second phase of the study, the effect of three factors on organizational resiliency potential that includes socioeconomic level and earthquake risk of the region that the organization is located, and Seveso Directive status of the organization were assessed. While organizational resiliency potential scores among groups of organizations that fall under different categories for these three factors did not show any statistically significant difference, follow-up focused interview revealed that respondents believed there may be differences in resiliency potential. Both survey and follow-up focused interview assessments showed the complexity and multiple aspects involved in developing adequate organizational resiliency potential. Organizational resiliency potential research is still in its infancy and both theoretical and technical sides of the equation requires further development.

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ANALYSIS OF SHORT-TERM VARIATION AND LONG-TERM DRIFT DURING REAGENT KIT LOT CHANGE IN AN NABL ACCREDITED CLINICAL BIOCHEMISTRY LABORATORY

Journal of Medical Biochemistry ◽

10.5937/jomb0-25597 ◽

2020 ◽

Author(s):

Sibin Madathan Kandi

Keyword(s):

Statistical Analysis ◽

Clinical Biochemistry ◽

Short Term ◽

Significant Difference ◽

Term Variation ◽

Clinical Biochemistry Laboratory

Background: Kit lot change in clinical biochemistry labsleads to variations in patient results. This study planned toidentify variations during 60 reagent lot changes in our laboratory during the period from June 2018 to May 2019.Methods: A statistical analysis was performed to identifythe difference between patient samples results variationsand QC results. The long term drift was analyzed using aregression test.Results: There was a significant difference between thepatient and QC results in 16.7% of reagent lot changes.Moreover, the extent of variation in QC results was 3.3%.No long-term drift was seen in three analytes which werestudied using regression analysis.Conclusions: Our results showed that, during reagent kit lotchange, along with QC material, the patient samplesshould also be run in order to identify the variation.However, this practice is presently ignored by most of thelaboratories. There was no accumulated effect in our laboratory due to reagent kit lot change.

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Abstract 13716: Racial Differences in Patients With Cryptogenic Stroke With Insertable Cardiac Monitors

Circulation ◽

10.1161/circ.142.suppl_3.13716 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

mark heckle ◽

Eva Ingram ◽

Issa Pour-Ghaz ◽

Andrei V Alexandrov ◽

Sunil K Jha ◽

...

Keyword(s):

Racial Differences ◽

Demographic Data ◽

Cryptogenic Stroke ◽

Health Science ◽

University Hospital ◽

Science Center ◽

Significant Difference ◽

Long Term Monitoring ◽

Term Monitoring

Introduction: African American (AA) patients have a higher incidence of stroke but lower prevalence of atrial fibrillation (AF). Studies involving long term monitoring with implantable cardiac monitors (ICM) for AF after cryptogenic stroke are limited by the under-representation of the AA population. Objective: We sought to assess racial differences in the diagnosis of AF by implantable cardiac monitors in patients with cryptogenic stroke. Methods: We performed a retrospective chart review study at Methodist University Hospital, University of Tennessee Health Science Center, Memphis TN. We included patients with cryptogenic stroke who received an ICM from September 2014 to June 2019 to assess for AF. Race and additional demographic characteristics were obtained from the electronic medical records. Interrogation reports from the ICMs were obtained by remote monitoring as well as clinic visits. Fisher exact and student t test were used to compare demographic data as well as the incidence of AF in these patients. Results: A total of 219 patients with cryptogenic stroke who underwent ICM implantation were included, of which 129 (58.9%) were AA. In the AA cohort, the patients were significantly younger than (62.3 versus 65.8 years; p =0.04) and had a significantly higher prevalence of hypertension (92.2% versus 68.5%; p <0.01) and diabetes mellitus (40.3% versus 27.3%; p =0.04). Upon a mean follow up of 10.6 months, a total of 39 patients (17.8%) were diagnosed with AF on ICM monitoring. The mean time to the incidence of AF was 7.4 months. There was no significant difference in the incidence of AF in the AA population (17.8%) as compared to the rest of the population (17.8%) ( p =1.00). Conclusion: In this single center study of patients with cryptogenic stroke who underwent long term monitoring with ICM, there was no significant difference in the incidence of AF between AA and the rest of the population. We conclude that ICM’s have an equally important role in AF detection in AA patients as in the general population with cryptogenic stroke.

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Influence of the decontamination work on suspended sediment dynamics and 137Cs migration after the Fukushima nuclear accident

10.5194/egusphere-egu21-14891 ◽

2021 ◽

Author(s):

Bin Feng ◽

Yuichi Onda ◽

Yuki Yamanaka ◽

Keisuke Taniguchi

Keyword(s):

Estimation Method ◽

Sediment Supply ◽

Potential Health ◽

Study Region ◽

Local Soil ◽

Significant Difference ◽

Long Term Monitoring ◽

The Impact ◽

Term Monitoring

The FDNPP-derived 137Cs triggers significant concern due to its potential health risk and on-going environmental pollution. Approximately 27% of 137Cs are deposited in the terrestrial environment, and most of them remain in catchment until now. This severe radioactive contamination situation has driven government-led decontamination efforts to be implemented since 2012. Earlier studies reveal the influence of decontamination on local soil erosion, thereby changing the fluvial sediment supply and 137Cs concentration. However, the dynamic transport process of suspended sediments (SS) and particulate 137Cs remains unknown and the resulting variation of particulate 137Cs fluxes into the ocean hasn&#8217;t been totally evaluated because of the unavailable decontamination relevant materials and long-term monitoring data. Moreover, the shortcomings in the present SS load estimation method limited the possibility for further qualifying the impact of anthropogenic perturbation on SS load and their relative contribution by anthropogenic perturbations.Here, combining the GIS and aerial photography, we report government-scheduled decontamination dataset for the Nidda river basin and exhibit the significant difference in their land covers in spatiotemporal scales, revealing the existence of different soil erosivity therein. Through a long-term monitoring campaign spanning decontamination and post-decontamination stages, we systematically explore the dynamic influence of decontamination on SS and particulate 137Cs transport. Our results show SS load (normalized by precipitation factor) gradually increased but particulate 137Cs concentration dropped sharply with the processing of decontamination, which probably is attributable to the increasing supply of 137Cs-depleted eroded soil particulate from decontaminated land. We estimate the range of 137Cs fluxes within 122 to 588 GBq&#183;a-1 in 2013-2018 and find a continuous declination tendency in 137Cs load after 2015, suggesting that decontamination restraining fluvial 137Cs into the ocean. Based on the normalized difference vegetation index (NDVI), we evaluate the land cover changes in the decontaminated regions and applied them in the universal soil loss equation (ULSE) for estimating the fluvial load of SS during the study period. In comparison with the total SS flux in the study region, about 32%~71% of fluvial SS were thought from decontaminated land, highlighting the important role of decontamination in SS supply.&#160;&#160;Scientifically, our findings not only fill the knowledge gap in the influence of decontamination but also respond to the global concern about yearly variations of 137Cs fluxes into the ocean under the influence of decontamination. More importantly, we propose and validate an approach for evaluating the input of SS and particulate 137Cs to the ocean, which is extendable to apply in other interested catchment and forest.

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