Platelet volume is associated with the Framingham risk score for cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2016 ◽  
Vol 54 (5) ◽  
Author(s):  
Chams B. Maluf ◽  
Sandhi M. Barreto ◽  
Rodrigo C.P. dos Reis ◽  
Pedro G. Vidigal
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Linear Regression Analysis ◽  
Adult Health ◽  
Platelet Volume ◽  
Cvd Risk ◽  
Distribution Width ◽  
Framingham Risk

AbstractBackground:Platelet volume indices (PVI), an easy and inexpensive surrogate measure of platelet function, have been associated with cardiovascular diseases (CVD) and their risk factors. However, results are conflicting because of the lack of standardized procedures. The purpose of this study is to investigate the relationship of PVI with the Framingham risk score (FRS).Methods:Baseline data (2008–2010) of 3115 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were used. PVI measurements were strictly controlled. The cohort was distributed according to risk factors and the general FRS was estimated. Multiple linear regression analysis was used to estimate the association between PVI and FRS.Results:Mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR) independently correlated (p≤0.01) with FRS after adjustment for confounding variables. One unit increase in MPV, PDW, or P-LCR increased the FRS by 0.59%, 0.40%, and 0.08%, respectively. Diabetics had higher (p≤0.004) MPV, PDW, and P-LCR, and hypertensive individuals had higher (p≤0.045) PDW and P-LCR.Conclusions:Increased PVI was independently correlated with higher CVD risk based on the FRS, diabetes, and systolic hypertension. Prospective follow up of this cohort is warranted to confirm that PVI is associated with the development of CVD.

scholarly journals Does Adding Adverse Pregnancy Outcomes Improve the Framingham Cardiovascular Risk Score in Women? Data from the Tehran Lipid and Glucose Study

2022 ◽  
Author(s):  
Marzieh Saei Ghare Naz ◽  
Ali Sheidaei ◽  
Ali Aflatounian ◽  
Fereidoun Azizi ◽  
Fahimeh Ramezani Tehrani
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Pregnancy Outcomes ◽  
Framingham Risk Score ◽  
Adverse Pregnancy Outcomes ◽  
Proportional Hazard ◽  
Cvd Risk ◽  
C Statistic ◽  
Framingham Risk ◽  
Adverse Pregnancy

Background Limited and conflicting evidence is available regarding the predictive value of adding adverse pregnancy outcomes (APOs) to established cardiovascular disease (CVD) risk factors. Hence, the objective of this study was to determine whether adding APOs to the Framingham risk score improves the prediction of CVD events in women. Methods and Results Out of 5413 women who participated in the Tehran Lipid and Glucose Study, 4013 women met the eligibility criteria included for the present study. The exposure and the outcome variables were collected based on the standard protocol. Cox proportional hazard model was used to evaluate the association of APOs and CVDs. The variant of C‐statistic for survivals and reclassification of subjects into Framingham risk score categories after adding APOs was reported. Out of the 4013 eligible subjects, a total of 1484 (36.98%) women reported 1 APO, while 395 (9.84%) of the cases reported multiple APOs. Univariate proportional hazard Cox models showed the significant relations between CVD events and APOs. The enhanced model had a higher C‐statistic indicating more acceptable discrimination as well as a slight improvement in discrimination (C‐statistic differences: 0.0053). Moreover, we observed a greater risk of experiencing a CVD event in women with a history of multiple APOs compared with cases with only 1 APO (1 APO: hazard ratio [HR] = 1.22; 2 APOs: HR; 1.94; ≥3 APOs: HR = 2.48). Conclusions Beyond the established risk factors, re‐estimated CVDs risk by adding APOs to the Framingham risk score may improve the accurate risk estimation of CVD. Further observational studies are needed to confirm our findings.

scholarly journals Cardiovascular Risk Factors in HIV-Infected Adults in North-Central Nigeria: Prevalence, Associated Factors and Assessment of Risk Using the Framingham Risk Score – Preliminary Results from a Survey

2021 ◽  
Vol 4 (1) ◽  
pp. 71-83
Author(s):  
GA Amusa ◽  
G Osaigbovo ◽  
L Imoh ◽  
B Awokola
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Local Environment ◽  
University Teaching ◽  
P Value ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Framingham Risk

HIV/AIDS is an increasingly important cause of cardiovascular (CVD) morbidity world-wide. We sought to evaluate the prevalence of CVD risk factors in HIV positive (HIV+) adults and assessment of these risks using the Framingham risk score (FRS). A cross-sectional study of adult clients of the HIV clinic at Jos University Teaching Hospital. One hundred and fifty HIV+ selected randomly with 50 (age and sex matched) HIV negative (HIV-) participants were enrolled. Relevant history, physical examination and biochemical investigations and 12-lead electrocardiography were performed. Data was analyzed using Epi-info 7.2 statistical software and P value < 0.05 was considered significant. The prevalent major CVD risk factors were dyslipidaemia (30.0% versus 6.0%), hypertension (34.0% versus 10.0%) and diabetes mellitus (10.0% versus 2.0%) among the HIV+ and HIV- participants respectively. The FRS of the HIV+, 3 (IQR 3-28) were statistically significantly higher than that of the HIV- participants, 2 (IQR 1-13); P=0.001. Furthermore, 32% of the HIV+ had moderate-high FRS compared to 2% of HIV- participants. CD4 count ≤ 200 cells/ml, use of anti-retroviral (ART), ART use ≥ 2 years and use of protease inhibitors (PI) emerged as predictors of moderate-high FRS among the HIV+ participants. In conclusion, a high prevalence of CVD risk factors exists among HIV+ population in our local environment. These risk factors can be identified early by baseline/periodic cardiovascular work-up which should include use of CVD risk tools. Early diagnosis and treatment will significantly reduce morbidity and mortality in these patients.

scholarly journals A comparative study of cardiovascular disease risk among bus drivers and bus conductors of a state transport corporation in North Goa

2021 ◽  
Vol 8 (6) ◽  
pp. 3023
Author(s):  
Shefalee Pai Vernekar ◽  
Hemangini Kishore Shah
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Bus Drivers ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Framingham Risk ◽  
The Difference ◽  
Bus Conductors

Background: Bus drivers and bus conductors are predisposed to increased cardiovascular disease (CVD) risks.Driving for long duration involves prolonged sitting, which enforces sedentary behavior among drivers in comparison to conductors who have the freedom to move aboutBackground: Bus drivers and bus conductors are predisposed to increased cardiovascular disease (CVD) risks.Driving for long duration involves prolonged sitting, which enforces sedentary behavior among drivers in comparison to conductors who have the freedom to move about in the bus. The aim and objectives of the study were to identify selected risk factors for CVDs among bus drivers and bus conductors; to estimate the CVDs risk among them using Framingham risk score and to study the difference of risk factors and CVDs risk between bus drivers and conductors.Methods: The present study was a comparative cross-sectional study among 105 bus drivers and 105 bus conductors at the Panaji bus depot of Goa. A pre-designed semi-structured questionnaire was used to collect data along with anthropometric, clinical examination and blood investigations. The Framingham risk score with BMI and lipids was used to compare the CVD risk.Results: Higher percentage of bus drivers had diabetes, hypertension, obesity and dyslipidemia. When the CVD risk was compared using the Framingham risk score, 63.8% bus drivers had intermediate-high CVD risk using FRS-BMI compared to 46.7% bus conductors and the difference is found to be significant. Using FRS- lipids, 65.7% bus drivers had intermediate-high risk compared to 53.3% bus conductors.Conclusions: The behavioral risk factors for CVD were higher among bus drivers compared to bus conductors. in the bus. Aims and objectives: 1) To identify selected risk factors for CVDs among bus drivers and bus conductors 2) To estimate the CVDs risk among them using Framingham risk score 3)To study the difference of risk factors and CVDs risk between bus drivers and conductors.Methods: The present study is a comparative cross sectional study among 105 bus drivers and 105 bus conductors at the Panaji bus depot of Goa.  A predesigned semi structured questionnaire was used to collect data along with anthropometric, clinical examination and blood investigations. The Framingham risk score with BMI and Lipids was used to compare the CVD riskResults:Higher percentage of bus drivers had diabetes, hypertension, obesity and dyslipidemia. When the CVD risk was compared using the Framingham risk score, 63.8 % bus drivers had intermediate-high CVD risk using FRS-BMI compared to 46.7 % bus conductors and the difference is found to be significant. Using FRS-Lipids, 65.7 % bus drivers had intermediate-high risk compared to 53.3 % bus conductors.Conclusion: The behavioural risk factors for CVD were higher among bus drivers compared to bus conductors.

Abstract P332: Framingham Risk Score to Predict Subsequent Coronary Artery Calcification in a Young Adult Population

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Jia Pu ◽  
Dave Vanness ◽  
Heather Johnson ◽  
David Kreling ◽  
Henry Young ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
Coronary Artery ◽  
Risk Score ◽  
African American Males ◽  
Framingham Risk Score ◽  
Adult Population ◽  
Framingham Risk ◽  
Young Adult Population ◽  
Subclinical Cvd

Introduction: Coronary artery calcification (CAC) has been identified as an independent predictor of coronary events, suggesting the potential use of CAC for risk assessment in asymptomatic individuals. However, ionizing radiation exposure associated with CAC CT scans remains a concern. If elevated risk for developing subclinical cardiovascular disease (CVD) could be identified based on less invasive risk assessment, such as the Framingham risk score, intensified prevention and screening services could be provided to this targeted population. Hypothesis: This study aims to assess the association between the Framingham risk score in early adulthood and subsequent subclinical CVD measured by CAC. Additional risk factors including demographics, socioeconomic status and health behaviors were tested in terms of their capabilities to enhance prediction of subclinical CVD beyond the Framingham risk score. Methods: This study used the Coronary Artery Risk Development in Young Adults (CARDIA) data, with a total of 5,115 Caucasian and African American males and females. Information collected at examination year 10 was used to calculate the Framingham risk score. CAC was measured ten years later (examination year 20). Participants’ demographics, health behaviors (alcohol consumption, BMI, and exercise), socioeconomic status and medical needs at year 10 were identified as potential risk factors associated with the subsequent presence of CAC beyond the Framingham risk score. Multiple logistic regression was used to examine the adjusted association between CAC, Framingham risk score and proposed risk factors. Model comparison was estimated using the area under the receiver operating characteristic curve (AUC) and Akaike information criterion (AIC). Results: By year 20, CAC was present in 19% of the CARDIA population. The Framingham risk score in young adulthood was strongly associated with the subsequent presence of CAC ten years later, regardless of race and gender. Overall, 42% of the CARDIA participants with elevated Framingham risk scores at year 10 had CAC at year 20, compared to 16% of participants with normal scores. The Framingham risk score may underestimate the risk of CAC for males compared to females (Negative Predictive Value: 75% vs. 91%). Beyond the Framingham risk score, the subsequent presence of CAC was associated with being overweight or obese in all populations, at-risk alcohol consumption in African American males, and having high school level or lower education and financial hardship in African American females. Conclusions: Our findings support the potential use of the Framingham risk score as a screening tool for subsequent subclinical atherosclerosis in a young adult population. However, other gender-specific risk factors beyond the Framingham risk score such as obesity also may be important to better predict subclinical CVD risk, especially in male populations.

Cardiovascular Disease Risk Predicts Health Perception in Prison Inmates

2017 ◽  
Vol 28 (2) ◽  
pp. 235-251 ◽  
Author(s):  
Zyad T. Saleh ◽  
Alison Connell ◽  
Terry A. Lennie ◽  
Alison L. Bailey ◽  
Rami A. Elshatarat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Short Form ◽  
Health Perception ◽  
Health Perceptions ◽  
Prison Inmates ◽  
Framingham Risk ◽  
Starting Point

We hypothesized that risk factors for cardiovascular disease (CVD) would be associated with worse health perceptions in prison inmates. This study included 362 inmates recruited from four medium security prisons in Kentucky. Framingham Risk Score was used to estimate the risk of developing CVD within the next 10 years. A single item on self-rated health from the Medical Outcomes Survey–Short Form 36 was used to measure health perception. Multinomial logistic regression showed that for every 1-unit increase in Framingham Risk Score, inmates were 23% more likely to have rated their health as fair/poor and 11% more likely to rate their health as good rather than very good/excellent. These findings demonstrate that worse health perceptions may serve as a starting point for discussing cardiovascular risk factors and prevention with inmates.

P4450Atherosclerosis in women with systemic lupus erythematosus with and without nephritis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Panafidina ◽  
T V Popkova ◽  
D S Novikova
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Blood Pressure ◽  
Disease Activity ◽  
Risk Score ◽  
Lupus Erythematosus ◽  
Framingham Risk Score ◽  
Systemic Lupus ◽  
Framingham Risk ◽  
Coronary Events

Abstract Background Nephritis in systemic lupus erythematosus (SLE) is a factor contributing to early development of atherosclerosis (AS). Objectives The aim of the study is to determine differences in cardiovascular risk factors and AS in SLE pts with and without lupus nephritis (LN). Methods The study included 162 females, age 35 [26–43] years (median [interquartile range 25–75%])) with SLE (ACR,1997). We divided SLE pts on two groups, comparable in age: the 1st group is the pts with LN (n=84, 52%), the 2nd - without LN (n=78, 48%). We considered traditional factors of cardiovascular disease (CVD): (smoking, family history of CVD, blood pressure, cholesterol (total, HDL, LDL) and triglyceride (TG) levels, body mass index, diabetes mellitus) and SLE-related factors (age at onset, duration, clinical features, SLE Disease Activity Index (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics damage index (SLICC/DI), treatment with steroids); intima-media thickness (IMT) and the 10-year risk for coronary events. Carotid intima-media wall thickness of common carotid arteries was measured by high resolution B-mode ultrasound. The 10-year risk for coronary events was estimated by the Framingham risk equation. Results Median SLE duration was 8,0 [2,3–17,0] years, SLEDAI 2K – 8 [3–16], SLICC/DI score – 2 [0–3], duration of prednisone treatment – 72 [26–141] months. SLE pts from the 1st group had higher prevalence of hypertension (61% vs 36%, p<0,01), systolic blood pressure (130 [110–150] vs 120 [110–130]mm Hg, p<0,01), diastolic blood pressure (80 [70–95] vs 70 [70–80] mm Hg, p<0,05), TG concentration (136 [98–184] vs 100 [61–162] mg/dl, p<0,01), Framingham Risk Score (5 [1–30] vs 1 [1–27]%, p<0,05), SLEDAI-2K (12 [5–19] vs 4 [2–10], p<0,ehz745.08501), SLICC/DI score (2 [0–4] vs 0 [0–2], p<0,01), prednisone therapy duration (95 [26–192] vs 44 [14–98] months, p<0,05), prednisone cumulative dose (34,4 [13,6–82,5] vs 15,7 [6,2–35,2] g, p<0,001), mean IMT (0,73 [0,65–0,83] vs 0,67 [0,61–0,75] mm, p<0,01), than the pts from the 2nd group. There is no difference in CVD frequency in these groups (17% vs 8%, p=0,084). Conclusions SLE patients with and without LN had no difference in frequency of clinical manifestations of AS (CVD), but had a greater value of mean IMT, Framingham Risk Score and a higher incidence of both traditional (hypertension, TG concentration) and SLE-related (disease activity, prednisone therapy) risk factors for AS.

scholarly journals Prediksi Tingkat Risiko Penyakit Kardiovaskuler Aterosklerotik pada Pasien yang Berobat di Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Engelin E. Emor ◽  
Agnes L. Panda ◽  
Janry Pangemanan
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Low Risk ◽  
Risk Level ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Framingham Risk

Abstract: Atherosclerotic cardiovascular disease is caused by the accumulation of plaque on the artery wall causing dysfunction of anatomical and hemodynamic system of the heart and blood flow. There are many risk factors that cause atherosclerotic cardiovascular disease which are divided into modifiable and unmodifiable risk factors. Prevention of this disease can be achieved with early detection, such as prediction the risk level of 10 years ahead of atherosclerotic cardiovascular disease by using the Framingham Risk Score (FRS). This study was aimed to obtain the risk level of atherosclerotic cardiovascular disease in patients at Internal Medicine Polyclinic of Prof. Dr. R. D. Kandou Hospital Manado by using their medical records from September to October 2017. This was a descriptive study with a cross sectional design. There were 100 samples obtained by using conclusive sampling technique. Of the 100 patients, 42 (42%) patients had low risk, 27 (27%) patients had moderate risk, and 31 (31%) patients had high risk of atherosclerotic cardiovascular disease in 10 years ahead. Conclusion: In this study, the highest percentage was in patients with low risk, followed by patients with high risk, and moderate risk.Keywords: ASCVD, Framingham Risk Score, Risk of atherosclerotic cardiovascular sisease. Abstrak: Penyakit kardiovaskuler aterosklerotik adalah penyakit yang disebabkan oleh adanya timbunan plak pada dinding arteri sehingga menyebabkan gangguan fungsional, anatomis serta sistem hemodinamis jantung dan pembuluh darah. Terdapat banyak faktor risiko yang menyebabkan terjadinya penyakit kardiovaskuler aterosklerotik yang dibagi menjadi faktor risiko yang dapat dimodifikasi dan yang tidak dapat dimodifikasi. Pencegahan penyakit ini dapat dilakukan dengan deteksi dini, salah satunya yaitu dengan memrediksi tingkat risiko 10 tahun kedepan terjadinya penyakit kardiovaskuler aterosklerotik dengan menggunakan Framingham Risk Score. Penelitian ini bertujuan untuk mengetahui tingkat risiko penyakit kardiovaskuler ateroskerotik pada pasien di Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang menggunakan data rekam medik pasien Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode September - Oktober 2017. Sampel penelitian berjumlah 100 orang dengan teknik pengambilan conclusive sampling. Terdapat 42 pasien (42%) dengan tingkat risiko rendah, 27 pasien (27%) dengan risiko sedang, dan 31 pasien (31%) dengan risiko tinggi terkena penyakit kardiovaskuler aterosklerotik 10 tahun kedepan. Simpulan: Pada studi ini, persentase tertinggi ialah pasien dengan tingkat risiko rendah terjadinya penyakit kardiovaskuler aterosklerotik, diikuti tingkat risiko tinggi dan risiko sedang.Kata kunci: ASCVD, Framingham Risk Score, tingkat risiko penyakit kardiovaskuler aterosklerotik

scholarly journals 7500 steps per day is associated with lower cardiovascular risk in rural residents with a high prevalence of sedentary lifestyle

2021 ◽  
Vol 20 (Supplement_1) ◽  
Author(s):  
I Madujibeya ◽  
L Misook ◽  
T Lennie ◽  
G Mudd-Martin ◽  
M Biddle ◽  
...  
Keyword(s):  
Risk Score ◽  
Rural Areas ◽  
Framingham Risk Score ◽  
Step Count ◽  
Daily Step ◽  
Cvd Risk ◽  
Rural Residents ◽  
Physically Active ◽  
Framingham Risk ◽  
Daily Step Count

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Sedentary lifestyle is one of the modifiable risk factors that account for the high prevalence of cardiovascular diseases (CVD) in the rural areas.1,2 Daily step counting, using wearable devices, is increasingly used to monitor physical activity levels in interventions targeting CVD risk reduction in the rural areas.3,4 However, there is a lack of evidence to support a daily step count threshold that may reduce CVD risk among rural residents. The purpose of this study was to examine the relationship between daily step count cut-points and CVD risk. Methods This secondary analysis included 312 adults living in the rural areas in the southern United States. Daily step counts from pedometers were collected for 14 consecutive days. Established cut-points were used to categorize participants into groups based on mean daily step count as sedentary (≤ 5000 steps/day), less active (5000 -7499 steps/per), and physically active (≥7500 steps/day).5-7 CVD risk was measured with the Framingham risk score. Generalized additive models were used to examine differences among the 3 activity groups in Framingham risk score, controlling for educational level, perceived physical health status, depressive, marital status, and years of residence in a rural county. Results Among the participants (75% female, mean age 50.1 (±13.6) years), 40.7% were sedentary, 35.2% were less active, and 24.0% were physically active. The average Framingham risk score was 11.2% (±9.4%). Framingham risk scores were 1.7% lower in the less active compared to the sedentary group, but the effect was not significant (p &lt;  .11), and 2.6% lower in the physically active compared to the sedentary group (p &lt; .04). The model accounted for 22% of the variation in Framingham risk scores. Conclusion These findings indicate that rural residents who averaged 7500 steps or more per day had lower CVD risk, and the difference is clinically significant.

Sign in / Sign up

Export Citation Format

Share Document