S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giorgia Gasparroni ◽  
Alessandro Graziosi ◽  
Iliana Bersani ◽  
Massimo Caulo ◽  
Bashir Moataza ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
At Risk ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Clinical Laboratory ◽  
Standard Of Care ◽  
S100b Protein ◽  
Resonance Imaging ◽  
Cerebral Mri ◽  
Cerebral Ultrasound

Abstract Objectives The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures. Methods We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40–42 weeks of corrected gestational age. Results Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI. Conclusions The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.

scholarly journals Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging.

2008 ◽  
Vol 158 (4) ◽  
pp. 459-465 ◽  
Author(s):  
Flávia R B van Haute ◽  
Giselle F Taboada ◽  
Lívia L Corrêa ◽  
Giovanna A B Lima ◽  
Rosita Fontes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Magnetic Resonance ◽  
Clinical Laboratory ◽  
Significant Risk ◽  
Apnea Hypopnea Index ◽  
Resonance Imaging ◽  
Cross Sectional ◽  
Igf I

ObjectivesTo determine the prevalence of sleep apnea (SA) and SA syndrome (SAS) in patients with acromegaly and correlate SA with clinical, laboratory, and cephalometric parameters.Design and methodsProspective and cross-sectional study of 24 patients with active acromegaly evaluated by clinical and laboratory (GH, IGF-I) parameters, polysomnography and magnetic resonance imaging (MRI) of the pharynx.ResultsOut of 24 patients, 21 had SA (87.5%), of which 20 (95.3%) had the predominant obstructive type. Median age of these 21 patients was 54 years (range 23–75) and median estimated disease duration was 60 months (range 24–300). The frequency in SA patients of impaired glucose tolerance, diabetes mellitus (DM), and hypertension was 19, 33.3, and 71.4% respectively. Goiter was found in 10 patients (47.6%) and obesity in 18 (90%). Median GH level was 14 μg/l (1.4–198) and median %IGF-I (percentage above the upper limit of normal range of IGF-I) was 181% (−31.6 to 571.2). The prevalence of SAS was 52.4%. Apnea–hypopnea index (AHI) correlated significantly with age, waist circumference, body mass index, and hypopharynx area. The AHI was significantly higher in patients with hypertension and DM.ConclusionsThe prevalence of SA and SAS in acromegaly was similar to the one previously described in other series. Age was a significant risk factor, and hypertension and DM were significantly associated complications of SA. Obesity was also significantly related to SA, as a risk factor, a complication or both. Overall, cephalometric parameters by MRI did not correlate with SA.

Predictive Value of Neonatal Magnetic Resonance Imaging in Preterm Infants

NeoReviews ◽  
2013 ◽  
Vol 14 (10) ◽  
pp. e490-e500 ◽  
Author(s):  
Cynthia M. Ortinau ◽  
Terrie E. Inder ◽  
Christopher D. Smyser
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Predictive Value ◽  
Resonance Imaging

Magnetic resonance imaging versus ultrasound at early post-term age in brain imaging of preterm infants

2012 ◽  
Vol 5 (4) ◽  
pp. 363-371 ◽  
Author(s):  
C. Petropoulou ◽  
H. Bouza ◽  
I. Nikas ◽  
G. Chrousos ◽  
M. Anagnostakou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Imaging ◽  
Preterm Infants ◽  
Resonance Imaging

scholarly journals Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State

2020 ◽  
Vol 46 (4) ◽  
pp. 834-845
Author(s):  
Daiki Sasabayashi ◽  
Yoichiro Takayanagi ◽  
Tsutomu Takahashi ◽  
Naoyuki Katagiri ◽  
Atsushi Sakuma ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
At Risk ◽  
Magnetic Resonance ◽  
Globus Pallidus ◽  
Mental State ◽  
Lateral Ventricle ◽  
Psychotic Disorders ◽  
Resonance Imaging ◽  
Significant Difference ◽  
At Risk Mental State

Abstract Previous structural magnetic resonance imaging studies of psychotic disorders have demonstrated volumetric alterations in subcortical (ie, the basal ganglia, thalamus) and temporolimbic structures, which are involved in high-order cognition and emotional regulation. However, it remains unclear whether individuals at high risk for psychotic disorders with minimal confounding effects of medication exhibit volumetric changes in these regions. This multicenter magnetic resonance imaging study assessed regional volumes of the thalamus, caudate, putamen, nucleus accumbens, globus pallidus, hippocampus, and amygdala, as well as lateral ventricular volume using FreeSurfer software in 107 individuals with an at-risk mental state (ARMS) (of whom 21 [19.6%] later developed psychosis during clinical follow-up [mean = 4.9 years, SD = 2.6 years]) and 104 age- and gender-matched healthy controls recruited at 4 different sites. ARMS individuals as a whole demonstrated significantly larger volumes for the left caudate and bilateral lateral ventricles as well as a smaller volume for the right accumbens compared with controls. In male subjects only, the left globus pallidus was significantly larger in ARMS individuals. The ARMS group was also characterized by left-greater-than-right asymmetries of the lateral ventricle and caudate nucleus. There was no significant difference in the regional volumes between ARMS groups with and without later psychosis onset. The present study suggested that significant volume expansion of the lateral ventricle, caudate, and globus pallidus, as well as volume reduction of the accumbens, in ARMS subjects, which could not be explained only by medication effects, might be related to general vulnerability to psychopathology.

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