scholarly journals Physical properties and caffeine release from creams prepared with different oils

2014 ◽  
Vol 27 (4) ◽  
pp. 224-228 ◽  
Author(s):  
Katarzyna Wojciechowska ◽  
Maria Zun ◽  
Dorota Dwornicka ◽  
Katarzyna Swiader ◽  
Regina Kasperek ◽  
...  
Keyword(s):  
Mode Of Delivery ◽  
Coconut Oil ◽  
Sesame Oil ◽  
Jojoba Oil ◽  
Walnut Oil ◽  
Almond Oil ◽  
Coffee Arabica ◽  
The Central Nervous System ◽  
Physical Tests ◽  
Sweet Almond

Abstract Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams. The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).

scholarly journals Multi-Center Randomized Clinical Study of The Effects of Natural Oils on Xerosis and Skin Barrier Properties

2018 ◽  
Vol 2 (5) ◽  
Author(s):  
Alexandra Vaughn ◽  
Mimi Nguyen ◽  
Melody Maarouf ◽  
Melisa Van Skiver ◽  
Khiem Tran ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Initial Increase ◽  
Jojoba Oil ◽  
Open Label ◽  
Almond Oil ◽  
Natural Oils ◽  
Randomized Clinical Study

Objective: To compare the effect of natural oils and white petrolatum on skin barrier function in patients with xerosis.Design, Setting, and Participants: Randomized, open label, comparison pilot study (NCT03093597).Interventions: Participants were randomized to apply 1 of 4 moisturizers to assigned treatment areas twice daily for 2 weeks. Clinical dry skin score, stratum corneum hydration, and transepidermal water loss (TEWL) were assessed at baseline, 1 week, and 2 weeks.Results: Thirty-two participants completed the study. Neither TEWL nor hydration were statistically different among the moisturizers at each visit. All four moisturizers led to significant initial increase in TEWL at week 1 (p < 0.05) with an associated increase in hydration for coconut oil, jojoba oil, and white petrolatum. All four moisturizers led to significant increase in hydration by week 2 (p < 0.01). The preferred moisturizers were almond oil and coconut oil, which were most “liked” by 38% and 31% of the participants, respectively. The least preferred moisturizer was white petrolatum.  Conclusions: Almond oil, jojoba oil, and coconut oil significantly increased hydration after 2 weeks, and are as effective as white petrolatum as daily moisturizers for xerosis. The participants preferred natural oils to white petrolatum, implying that these moisturizer options may improve patient compliance.

scholarly journals Optimization of Fluconazole Pickering Emulsion Using Taguchi Orthogonal Array Design

2020 ◽  
Vol 19 (2) ◽  
pp. 169-178
Author(s):  
D Prasanthi ◽  
N Varsha Priya ◽  
Amoolya Chennuri ◽  
PK Lakshmi
Keyword(s):  
Orthogonal Array ◽  
Free Particle ◽  
Coconut Oil ◽  
Topical Delivery ◽  
Pickering Emulsion ◽  
Homogenization Method ◽  
Sesame Oil ◽  
Pickering Emulsions ◽  
Independent Variables ◽  
Dependent Variables

Emulsifier-free, particle-stabilised emulsions called Pickering emulsions of fluconazole for topical delivery, were studied using Taguchi L9 orthogonal array (OA) design. Formulations were prepared by homogenization method, using bentonite in the concentration range of 2-4% w/v, oil phase (coconut oil, oleic acid, sesame oil). In Taguchi L9 OA experimental design, independent variables (oil phase & concentration of bentonite) effect on dependent variables (drug content & release rate) was studied. All the formulations have shown good physicochemical properties. The PS3 formulation containing sesame oil and 4% bentonite was optimized as particle size was found to be 758.0 nm, zeta potential -48 mv, with Q8 of 166.70±0.15μg/cm2, flux of 17.33±0.02 μg/cm2/hr, permeability coefficient of 3.46±0.015 cm/hr×10-3 and skin content of 4.01±0.24 mg/g. The formulations were stable and non-irritant. Hence pickering emulsion of fluconazole using sesame oil can be used for topical delivery as the drug release was maintained at the localised site. Dhaka Univ. J. Pharm. Sci. 19(2): 169-178, 2020 (December)

scholarly journals Effect of Body Lotions on Capillary Blood Glucose Measurement – Interference of Hydroquinone-containing Body Lotion with Capillary Glucose Measurement

2018 ◽  
Vol 14 (1) ◽  
pp. 44
Author(s):  
Andrea MA Omengue ◽  
Eugène Sobngwi ◽  
Mesmin Dehayem ◽  
Eric V Balt ◽  
Anne MO Boli ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose ◽  
Almond Oil ◽  
Patients With Diabetes ◽  
Capillary Glucose ◽  
The Impact ◽  
Sweet Almond

The reliability of capillary blood glucose measurements is tremendously important for patients’ care and follow-up. Some factors independent of glucose control could however affect readings during ambulatory monitoring of capillary glucose levels in patients with diabetes mellitus. We sought to evaluate the impact of three body lotions commonly used in Cameroon on different strata of glycaemia. We explored their influence over time on measured capillary glucose values. We enrolled 16 participants. Eligible individuals were adult patients with diabetes (n=12) stratified into three levels of capillary glucose values (100 ± 40 mg/dL [5.55 ± 2.22 mmol/L], 200 ± 40 mg/dL [11.1 ± 2.22 mmol/L] and 300 ± 40 mg/dL [16.65 ± 2.22 mmol/L]) and normoglycaemic individuals (n=4). We measured capillary blood glucose before application, immediately after, then 5, 30 and 60 minutes after application of sweet almond oil, corticosteroid cream and hydroquinone lotion. The measurements made on impregnated body lotion-permeated fingers were compared to that of a clean finger. We observed a significant increase (delta [95% confidence interval, CI]: 119.5% [77.4–222.1]) of capillary glucose level immediately after administration of hydroquinone-containing body lotion (p<0.001). Capillary glucose values after the use of corticoid cream and sweet almond oil was stable 5, 30 and 60 minutes after application (p=0.875 and p=0.883 respectively). In the case of the hydroquinone-containing body lotion, there was a significant difference between capillary glucose level at 5 minutes (delta [95%CI]: 81.6% [55.3–214.2]; p<0.001), 30 minutes (delta [95%CI]: 71.6% [21.8–134.6]; p<0.001) and 60 minutes (delta [95%CI]: 58.3% [2.8–133.3]; p=0.013) after application compared to the value obtained from the clean finger. We observed from our study that there were significant variations in capillary blood glucose measurements induced by the use of hydroquinone lotion.

The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women

2017 ◽  
Vol 31 (13) ◽  
pp. 1703-1708 ◽  
Author(s):  
Maryam Hajhashemi ◽  
Mahmoud Rafieian ◽  
Hojjat Allah Rouhi Boroujeni ◽  
Sepideh Miraj ◽  
Shadman Memarian ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Almond Oil ◽  
Nulliparous Women ◽  
Aloe Vera Gel ◽  
Striae Gravidarum ◽  
Sweet Almond

scholarly journals Improvement of Oxidative Stability and Microbial Shelf Life of Vanilla Cake by Coconut Oil Meal and Sesame Oil Meal Phenolic Extracts

2019 ◽  
Author(s):  
Chathuri Senanayake ◽  
Harshani Algama ◽  
Ruwani Wimalasekara ◽  
W. N. M. T. D. N. Weerakoon ◽  
Nimanthi Jayathilaka ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Oxidative Stability ◽  
Shelf Life ◽  
Chemical Stability ◽  
Coconut Oil ◽  
Sesame Oil ◽  
Colony Count ◽  
Synthetic Antioxidants ◽  
Microbial Spoilage ◽  
Phenolic Extracts

<p></p><p>Phenolic extracts of coconut oil meal (CME) and sesame oil meal (SME) were compared with synthetic antioxidants for the potential of improving shelf life of vanilla cake. CME maintained hexanal (product of chemical spoilage) levels below 0.3 mg/kg in cake up to 14 days. BHT- and SME-added cakes maintained hexanal levels below 2 mg/kg while control cake with no added antioxidants exceeded this level by day 14. Both CME and SME extended the microbial shelf life up to 13 days while control and BHT-added cake exceeded the maximum allowed colony count by day 7 and day 11 respectively. The results indicate that the onset of microbial spoilage of vanilla cake is faster than the chemical spoilage and addition of CME and SME extend both microbiological and chemical stability of cakes beyond day 7 during storage. Over 90% of the antioxidant activity of CME and SME retained after heating at 180 °C for 2 h. CME and SME are ideal thermally stable natural alternatives for synthetic antioxidants in vanilla cake. <br></p><br><p></p>

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