scholarly journals Acrylate copolymer: a rate-controlling membrane in the transdermal drug delivery system

e-Polymers ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Xiaoping Zhan ◽  
Zhenmin Mao ◽  
Jian Chen ◽  
Yuankui Zhang
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Contact Angles ◽  
Transdermal Drug Delivery System ◽  
Scanning Calorimetry ◽  
Acrylate Copolymer ◽  
Transdermal Drug Delivery Systems ◽  
Clonidine Hydrochloride ◽  
New Applications ◽  
Cyclohexyl Methacrylate

AbstractA film-like copolymer composed of 2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate and cyclohexyl methacrylate was synthesized and exploited as a rate-controlling membrane in the transdermal drug delivery systems (TDDs). A series of acrylate copolymers with different formulations were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and tensile strength, and then evaluated by clonidine hydrochloride transporting through the films. It was found that the formulation M2 composed of three monomers at a ratio of 4:4:2 (w/w/w) showed excellent mechanical and permeation properties. The optimal formulation M2 was further characterized by scanning electron microscopy, contact angles and swelling ratio, and then the permeation behaviors of five different physicochemical drugs transporting through the M2 were evaluated. The results showed that the permeation behaviors were influenced by many factors including the thickness of the membrane, the physicochemical properties of the drugs, the dose of the drugs and the interactions between the drugs and the membrane. This type of copolymer membrane might open new applications in the field of TDDs.

NUMERICAL ESTIMATION OF DRUG DIFFUSION AT DERMAL REGIONS OF HUMAN BODY IN TRANSDERMAL DRUG DELIVERY SYSTEM

2016 ◽  
Vol 16 (03) ◽  
pp. 1650022 ◽  
Author(s):  
M. A. KHANDAY ◽  
AASMA RAFIQ
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Finite Element ◽  
Analytical Solution ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Numerical Estimation ◽  
Transdermal Drug Delivery System ◽  
Drug Diffusion ◽  
Transdermal Drug Delivery Systems

A mathematical model is proposed to study the amount of drug concentration at various regions of human dermal system. The model is based on the mechanism of transdermal drug delivery systems (TDDS) with appropriate boundary conditions. The analytical solution for such problems either does not exist or is too complicated to handle. In this paper, finite element and Crank–Nicholson methods were used to find the solution of the formulated model with greater accuracy.

scholarly journals Formulation, Characterization, and Herbal Drug Delivery Applications of Ethosome, Transfersome, and Transethosome

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Luthfia Azzahra ◽  
Soraya Ratnawulan Mita ◽  
Sriwidodo Sriwidodo
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Skin Layer ◽  
Herbal Drugs ◽  
Transdermal Drug Delivery System ◽  
Transdermal Drug Delivery Systems ◽  
Edge Activator

Herbal compounds have different physicochemical properties. Its use on the oral route often has low biological availability. Therefore, alternative transdermal routes are used through the skin. The stratum corneum skin layer is the most difficult layer to penetrate. Therefore it is necessary to use a drug delivery system such as ethosome, transfersome or transethosome to increase transdermal drug delivery. This review article aims to look at the potential of ethosome, transfersome, and transethosome in increasing their ability to deliver herbal drugs in terms of their formulation and characterization. Literature searches were performed using online search engines namely NCBI and Google Scholar with the keywords ‘Transdermal Drug Delivery System’, 'Ethosome', 'Transfersome', and 'Transethosome'. The result showed compositions of ethosomes are phospholipids, water, and ethanol. The composition of transfersome is phospholipid, water, and edge activator. Transethosomes are a combination of phospholipids, water, ethanol, and edge activators. The role of ethanol and edge activator is thought to increase skin permeation. Transdermal drug delivery systems can be used on herbal drugs to increase transdermal drug delivery.Keywords: Transdermal, Ethosome, Transfersome, Transethosome, Herbal.

scholarly journals Recent advances in transdermal drug delivery systems: a review

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Woo Yeup Jeong ◽  
Mina Kwon ◽  
Hye Eun Choi ◽  
Ki Su Kim
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
High Efficiency ◽  
Critical Discussion ◽  
Alternative Methods ◽  
Transdermal Drug Delivery System ◽  
Characterization Methods ◽  
Advantages And Disadvantages ◽  
Transdermal Drug Delivery Systems ◽  
Wide Range

AbstractVarious non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.

scholarly journals An updated review on transdermal drug delivery systems

2015 ◽  
Vol 1 (6) ◽  
pp. 244 ◽  
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Bathe ◽  
Manojkumar Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery System ◽  
Transdermal Drug Delivery Systems ◽  
Novel Drug

Transdermal drug delivery systems (TDDS), also known as patches, are dosage forms designed to deliver a therapeutically effective amount of drug across a patients skin. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. The TDDS review articles provide valuable information regarding the transdermal drug delivery systems and its evaluation process details as a ready reference for the research scientist who is involved in TDDS. With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery system. One of greatest innovation of novel drug delivery is transdermal patch. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs.

Effect of Edge Activator on Characteristic and in Vitro Skin Permeation of Meloxicam Loaded in Elastic Liposomes

2011 ◽  
Vol 194-196 ◽  
pp. 537-540 ◽  
Author(s):  
Sureewan Duangjit ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Cetylpyridinium Chloride ◽  
Entrapment Efficiency ◽  
Molar Ratio ◽  
Transdermal Drug Delivery System ◽  
Scanning Calorimetry ◽  
In Vitro Skin Permeation

The aim of this study was to prepare and investigate the potential use of liposomes in the transdermal drug delivery of meloxicam (MX). The vesicles containing a constant amount of MX, phosphatidylcholine (PC), cholesterol (Chol) and cetylpyridinium chloride (CPC) (1:5:1:1 MX/PC/Chol/CPC molar ratio) to obtain liposomes. MX loaded liposomes were investigated for particle size, zeta potential, entrapment efficiency (%EE) and in vitro skin permeation. The results indicated that the liposomes were spherical in structure, 77 to 100 nm in size and charged. The %EE of MX in the vesicles ranged from 55 to 56%. The elastic liposomes consisting of MX/PC/Chol/CPC provided a significantly higher skin permeation of MX compared to the other formulations. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) analysis indicated that the application of liposomes may disrupt the stratum corneum lipid. Our research suggests that MX loaded elastic liposomes can be potentially used as a transdermal drug delivery system.

scholarly journals Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Sureewan Duangjit ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Transdermal Drug Delivery System ◽  
Scanning Calorimetry ◽  
Stratum Corneum Lipid ◽  
In Vitro Skin Permeation ◽  
Ft Ir

The goal of this study was to develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of meloxicam (MX). MX-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), loading efficiency, stability, and in vitro skin permeation. The vesicles were spherical in structure, 90 to 140 nm in size, and negatively charged ( to  mV). The %EE of MX in the vesicles ranged from 40 to 70%. Transfersomes provided a significantly higher skin permeation of MX compared to liposomes. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) analysis indicated that the application of transfersomes significantly disrupted the stratum corneum lipid. Our research suggests that MX-loaded transfersomes can be potentially used as a transdermal drug delivery system.

A Smart and Potential approach for Transdermal Drug Delivery using Microneedles: A Review

2021 ◽  
Vol 11 (2) ◽  
pp. 113-120
Author(s):  
Neha Sharma ◽  
Tarun Kumar Sharma ◽  
Vinay Pandit ◽  
M. S Ashawat
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Transdermal Drug Delivery System ◽  
Drug Molecules ◽  
Transdermal Drug Delivery Systems ◽  
Materials Used

Transdermal drug delivery system used to transport the drug across the skin deep into systemic circulation. The main advantages of Transdermal drug delivery system improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. But most of therapeutic agents is limited due to thickness of stratum corneum, which act as a barrier for the delivery of various drug molecules and only few molecules are able to reach the action site. Microneedles are the new form of delivery system, which are used to increase the delivery of drug through this route and overcoming the number of problems related to conventional drug delivery system the main aim of this review to focus on new innovation in transdermal drug delivery systems. In the microneedle drug delivery system, the skin is temporarily broken, that creating micron size pathways that deliver the sufficient amount of drug directly into the stratum corneum from which the drug can directly go into the systemic circulation. In this review, we describe different type of microneedles can be solid, coated, dissolving and biodegradable microneedles and their method of fabrication. Microneedles can be manufactured in different forms like hollow, solid, and dissolving. Also describe materials used for fabrication, fabrication techniques, methodology of drug delivery such as Poke and patch, Coat and poke, Poke and release, Poke and flow and evaluation parameters.

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