Pulmonary function severity in relation to interleukin-23 levels in patients with psoriasis vulgaris

AbstractBackgroundInterleukin-23 (IL-23), a key inflammatory regulator in the pathogenesis of psoriasis, is suspected to play a role in the onset of pulmonary dysfunction (chronic obstructive pulmonary disease) in psoriasis. Despite that, pulmonary function tests are rarely studied in these subjects. This study aims to seek a possible relation between pulmonary function in psoriasis patients serum IL-23.MethodsFor this analytical cross-sectional study, male psoriasis patients in the age group of 25–45 years were recruited from dermatology out patient department (n = 40). Age and BMI matched apparently healthy individuals were recruited as control group (n = 40). After obtaining demographic and personal details, anthropometric parameters and blood pressure were recorded. The severity of psoriasis was assessed using Psoriasis Area and Severity Index score. Pulmonary function was assessed using computerized spirometry, and serum IL-23 was measured using ELISA.ResultsForced vital capacity, forced expiratory volume in 1 s, peak expiratory flow rate, and forced expiratory flow at 25%–75% of the pulmonary volume (FEF25%–75%) were significantly reduced in psoriasis. Based on the percentage of predicted values FEF25%–75% was significantly reduced in psoriasis. Serum IL-23 (pg/mL) was significantly higher in psoriasis. The increase in IL-23 in psoriasis subjects does not correlate with their pulmonary function.ConclusionsPsoriasis may be associated with a reduced lung function even when the disease is in the mild stage. Increased IL-23 found in these subjects is suggestive of systemic inflammation, which indirectly lowers lung function.

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Prevalence and analysis of respiratory and anthropometric parameters in patients with obstructive sleep apnea

Research Society and Development ◽

10.33448/rsd-v10i3.13455 ◽

2021 ◽

Vol 10 (3) ◽

pp. e32410313455

Author(s):

Danilo Sobral da Silva Fernandes ◽

Manoel Pereira Guimarães ◽

Einstein Zeus Alves de Brito ◽

João Diego Cabral Lima ◽

Mateus de Sousa Rodrigues ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Lung Function ◽

Pulmonary Function ◽

Forced Expiratory Volume ◽

Apnea Hypopnea Index ◽

Anthropometric Parameters ◽

Cross Sectional ◽

Obstructive Sleep Apnea Severity ◽

Obstructive Sleep

Introduction: Obstructive sleep apnea is a condition characterized by frequent respiratory pauses lasting ≥ 10 seconds, accompanied by desaturation/reoxygenation cycles and repetitive arousals triggered by complete (apnea) or partial (hypopnea) cessation of airflow during sleep. Objective: To determine the prevalence and to assess the respiratory and anthropometric parameters of patients with obstructive sleep apnea in Vale do São Francisco area. Methods: This is a descriptive, cross-sectional study using secondary data collected from 466 patients between June 2015 and June 2017. Patients who underwent home polysomnography were included while those who did not perform the lung function test and/or failed to present a medical report were excluded. Results: Obstructive sleep apnea was observed in 79.2% (n = 126) of the patients enrolled. Cases with greater severity were observed in males and were more prevalent among those aged 60 years or above. Forced expiratory volume in 1 second (P = 0.006) and forced vital capacity (P = 0.001) decreased with increased obstructive sleep apnea severity. Significant correlations were observed between the severity of obstructive sleep apnea and age, body mass index and Apnea-Hypopnea Index, while pulmonary function variables presented a low negative correlation with obstructive sleep apnea severity. Conclusion: Greater severity of obstructive sleep apnea was more prevalent in males and the involvement of the pulmonary function was more pronounced in the groups with severe obstructive sleep apnea. Reductions in lung function were also found in this population, with negative linear correlations between ventilatory parameters and obstructive sleep apnea severity.

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Reversive Loss of Pulmonary Function Induced by Acute Chest Syndrome: A Report from the National Acute Chest Syndrome Study Group (NACSG).

Blood ◽

10.1182/blood.v106.11.315.315 ◽

2005 ◽

Vol 106 (11) ◽

pp. 315-315 ◽

Cited By ~ 2

Author(s):

Lynne Neumayr ◽

C. Morris ◽

A. Wen ◽

A. Earles ◽

S. Robertson ◽

...

Keyword(s):

Lung Function ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Therapeutic Interventions ◽

Acute Chest Syndrome ◽

P Value ◽

Lung Volumes ◽

Expiratory Flow

Abstract Acute Chest Syndrome (ACS) remains the leading cause of death and hospitalization in patients (pts) with sickle cell disease (SCD). There is limited data on the effects of ACS on lung function. From 1993 to 1997, 30 centers participated in the NACSG and prospectively analyzed 671 episodes of ACS in 538 pts. Pulmonary function tests (PFTs) included forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), forced expiratory flow during 25% to 75% of FVC (FEF 25–75), peak expiratory flow rate (PEF) and the ratio of FEV1/FVC. Data is reported as percent-predicted of normal values based on age and height. 128 pts (mean 16yrs, 4 to 52 yr range) had PFTs during an ACS episode (within a mean of 2.5 days of diagnosis) and then 12 weeks later. 94% of pts had abnormal lung volumes, defined as either FEV1 or FVC < 80%. Mean lung volumes during ACS and at follow-up are shown below. Table 1: Decreased Lung Volumes During ACS PFT During ACS Follow-up p-value FEV1 52% 79% <.0001 FVC 55% 83% <.0001 FEF 25–75 50% 69% <.0001 PEF 61% 83% <.0001 Pts with abnormal lung volumes (FEV1 or FVC < 80%) and considered to have an obstructive pattern if the FEV1/FVC ratio was < to 85. Obstructive patterns in pts with abnormal lung volumes and the percent of pts who responded to bronchodilators (15% improvement in either FEV1 or FVC) are shown below. Table 2: Patterns of Abnormal Lung Volumes in SCD SCD Patients During ACS Follow-up Abnormal PFTs 94% 45% Obstructive Pattern 48% 46% Respond to bronchodilators 25% 8% In summary, ACS resulted in decreased pulmonary function in 94% of pts. It is striking that 49% pts had their PFTs reduced by half (FEV1 52% and FVC 55%). In pts with abnormal PFTs, 48% had evidence of obstruction and 25% of all pts tested improved with a bronchodilator. This is the first description of reversible abnormalities of pulmonary function occurring during ACS compared to baseline. An obstructive pattern is identified in a higher percentage of pts with SCD than in the local Oakland African American population (asthma prevalance 16%). While some pts PFTs improved with time, 45% remained abnormal at 12-week follow-up. ACS results in acute and chronic worsening of lung function. Future studies of ACS may reveal common pathogenic mechanisms with asthma, and lead to improved therapeutic interventions.

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Chronic obstructive pulmonary disease patients and steroids: benefit or harm

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20194265 ◽

2019 ◽

Vol 8 (10) ◽

pp. 2247

Author(s):

Abdul Hamid Khan ◽

Mehwish Majeed

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Function ◽

Pulmonary Disease ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Control Group ◽

Chronic Obstructive ◽

Case Group ◽

Obstructive Pulmonary Disease ◽

Function Tests

Background: Corticosteroids are being widely used in conditions related to allergy and inflammation. There are great species differences in the responses to glucocorticoids that mean a “steroid resistant” species. Steroids have profound effect on inflammatory response by way of vasoconstriction, decreased chemotaxis and interference with macrophages. There still are enormous gaps in our knowledge of the action of glucocorticosteroids in patients of chronic obstructive lung disease (COPD).Methods: This study was done in the department of general medicine at SKIMS, Srinagar from December 2017 to December 2018 on patients of chronic obstructive pulmonary disease. A total number of 100 patients were enrolled for the study but 20 patients, 10 from each group lost their follow up. To see the effect of steroids on pulmonary function tests, patients were divided into case and control group. Patients in case group were given prednisolone 30 mg orally for two week (tapering dose). Patients in control group were given placebo for the same duration of two weeks. Steroid response was defined as 15% improvement in baseline forced expiratory volume (FEV).Results: Steroid response was defined as 15% increase in forced expiratory volume in one second/forced vital capacity (FEV1/FVC) after receiving tapering dose of prednisone 30 mg for 2 weeks, no patients in case group showed increase in FEV1/FVC of 15%. The change in pulmonary function tests was comparable in each group (p>0.5).Conclusions: The change in pulmonary function tests were comparable in each group (p>0.5). So, steroids in stable patients of COPD are best to be avoided.

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Pulmonary functions in car air conditioner users and non-air conditioner users in tertiary care centre, South Tamilnadu, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20193938 ◽

2019 ◽

Vol 7 (9) ◽

pp. 3510

Author(s):

Hoshea Jeba Ruth S. ◽

Lisha Vincent

Keyword(s):

Pulmonary Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Control Group ◽

Air Conditioner ◽

Air Conditioners ◽

Function Tests ◽

Expiratory Flow

Background: Air conditioners are used extensively these days of the modern lifestyle. Inhalation of cold dry air while using Air conditioners causes bronchoconstriction due to which alteration may occur in pulmonary function. This study was aimed to compare the Pulmonary Function tests of Car AC users and non AC users. Methods: The Study included 52 employees not exposed to car air conditioner as a control (group I) and 52 employees exposed to car air conditioner with minimum exposure of 1 hour per day for 6 months as a subject (group II). Pulmonary function tests were performed using computerised spirometer. Statistical analysis was done by unpaired t test.Results: Age, Height and weight are not statistically significant between study group and control group. Forced vital capacity, forced expiratory volume in 1 second, Ratio of Forced vital capacity and Forced expiratory volume in 1 second, Inspiratory reserve volume, Expiratory reserve volume, Maximum voluntary ventilation are decreased in car air conditioner users compared to non-users, but was not significant. Forced expiratory flow (FEF), Peak expiratory flow rate (PEFR) values shows statistically significant decreased in car air conditioner users.Conclusions: The present study shows hyper-responsive airways on exposure to cold air which leads to bronchoconstriction. The significant decrease in PEFR, FEF suggest that upper airways as well as smaller airways are affected on exposure to car AC. So, Exposure to car Air Conditioner leads to risk of developing respiratory dysfunction.

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Validation of a portable game controller to assess peak expiratory flow against conventional spirometry in children: A cross-sectional study (Preprint)

10.2196/preprints.25052 ◽

2020 ◽

Author(s):

Khadidja Chelabi ◽

Fabio Balli ◽

Myriam Bransi ◽

Yannick Gervais ◽

Clement Marthe ◽

...

Keyword(s):

Pulmonary Function ◽

Peak Expiratory Flow ◽

Pulmonary Function Tests ◽

Airflow Obstruction ◽

Forced Expiratory Volume ◽

Cross Sectional ◽

Disease Evolution ◽

Game Controller ◽

Feedback Questionnaire ◽

Expiratory Flow

BACKGROUND International asthma guidelines recommend the monitoring of peak expiratory flow (PEF) as part of asthma self-management in children and adolescents who poorly perceive airflow obstruction, those with a history of severe exacerbations, or have difficult to control asthma. Measured with a peak flow meter, PEF represents a person’s maximum speed of expiration and helps individuals to follow their disease evolution and ultimately to prevent asthma exacerbations. However, adherence to this practice is poor, particularly in the pediatric population. To address this, we developed an interactive serious game consisting of a portable game controller that can transduce a signal from the breath to generate a PEF value when coupled with a tablet-based game. OBJECTIVE We evaluated the concordance between PEF values obtained with the game controller (PEFGC) and various measures derived from conventional pulmonary function tests (i.e spirometry) and we synthesized the participants’ feedback. METHODS In this cross-sectional multicenter study, 158 children aged 8-15 years old with a diagnosis or suspicion of asthma performed spirometry and played with the game in one of 2 hospital university centers. We evaluated the correlation between PEFGC and spirometry measurements, including PEF values (PEFspiro), forced expiratory volume in 1 second (FEV1) and forced expiratory volume at 25-75% of pulmonary volume (FEF25-75), using Spearman correlation. A Bland-Altman plot was generated for comparison of PEFGC against PEFspiro. A post-game user feedback questionnaire was administered and analyzed. RESULTS The participants had a mean age (SD) of 10.9 2.5) years, 44% were female, and 88.6% Caucasians. On average, their pulmonary function were normal, including FEV1, PEF and FEV1/FVC. The PEFGC was reproducible in 96.2% of participants according to standardized criteria. The PEFGC presented a good correlation with PEFspiro (r=0.83, p<0.001), with FEV1 (r=0.74, p<0.001) and with FEF25-75 (r=0.65, p<0.001). The PEFGC presented an expected mean bias of -36.4 L/min as compared to PEFspiro. The participants’ feedback was strongly positive with 78.4% reporting they would use the game if they had it at home. CONCLUSIONS The game controller developed is an interactive tool appreciated by children with asthma and whose values are reproducible with a good correlation when compared to conventional spirometry. Future studies are necessary to evaluate the clinical impact this novel tool might have on asthma management and its potential use in an out-of-hospital setting. CLINICALTRIAL

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Dietary and supplemental antioxidant and anti-inflammatory nutrient intakes and pulmonary function

Public Health Nutrition ◽

10.1017/s1368980013002590 ◽

2013 ◽

Vol 17 (9) ◽

pp. 2081-2086 ◽

Cited By ~ 17

Author(s):

Tze Pin Ng ◽

Mathew Niti ◽

Keng Bee Yap ◽

Wan Cheng Tan

Keyword(s):

Pulmonary Function ◽

Fruits And Vegetables ◽

Dairy Product ◽

Population Based ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Chronic Obstructive ◽

Cross Sectional ◽

Pulmonary Risk ◽

Anti Inflammatory

AbstractObjectiveA limited but growing body of evidence supports a significant role of antioxidant and anti-inflammatory micronutrients in pulmonary health. We investigated the associations of dietary and supplemental intakes of vitamins A, C, E and D, Se and n-3 PUFA with pulmonary function in a population-based study.DesignPopulation-based, cross-sectional study and data analysis of fruits and vegetables, dairy products and fish, vitamins A, C, E and D, Se and n-3 PUFA supplemental intakes, pulmonary risk factors and spirometry.SubjectsChinese older adults (n 2478) aged 55 years and above in the Singapore Longitudinal Ageing Studies.ResultsIn multiple regression models that controlled simultaneously for gender, age, height, smoking, occupational exposure and history of asthma/chronic obstructive pulmonary disease, BMI, physical activity, and in the presence of other nutrient variables, daily supplementary vitamins A/C/E (b = 0·044, se = 0·022, P = 0·04), dietary fish intake at least thrice weekly (b = 0·058, se = 0·016, P < 0·0001) and daily supplementary n-3 PUFA (b = 0·068, se = 0·032, P = 0·034) were individually associated with forced expiratory volume in the first second. Supplemental n-3 PUFA was also positively associated with forced vital capacity (b = 0·091, se = 0·045, P = 0·045). No significant association with daily dairy product intake, vitamin D or Se supplements was observed.ConclusionsThe findings support the roles of antioxidant vitamins and n-3 PUFA in the pulmonary health of older persons.

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IMPACT OF OBESITY ON PULMONARY FUNCTIONS AMONG YOUNG NON-SMOKER HEALTHY FEMALE OF SHAH ALAM, MALAYSIA

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.27234 ◽

2018 ◽

Vol 11 (10) ◽

pp. 465

Author(s):

Aniruddha Bhattacharjee ◽

Ariitharan A/l Thygoo ◽

Subramanian Rammohan

Keyword(s):

Pulmonary Function ◽

Flow Rate ◽

Inverse Correlation ◽

Forced Expiratory Volume ◽

Female Students ◽

Control Group ◽

Contributing Factors ◽

Cross Sectional ◽

Pulmonary Functions ◽

Healthy Female

Objectives: The sedentary lifestyle, physical inactivity, and unhealthy diet of Malaysian female have become important contributing factors to the rise of obesity. Studies on pulmonary function in relation to obesity are very few in Malaysia. Therefore, the study was aimed to evaluate the effect of obesity on pulmonary functions among young adult healthy female students of Shah Alam, Malaysia.Methods: A cross-sectional comparative study was conducted in a total of 100 (50 obese and 50 non-obese) adult non-smoker healthy female students aged 18–25 years. Forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), FEV1 as a percentage of FVC (FEV1/FVC%), maximum midexpiratory flow rate (FEF 25–75%), and peak expiratory flow rate (PEFR) were measured using a computerized spirometer. Body weight, height, waist circumference (WC), and hip circumference (HC) were measured.Results: The mean FVC (L), FEV1 (L), FEV1/FVC ratio, FEF 25–75% (L/s), and PEFR (L/s) of obese group were marginally lower than non-obese control group, but the differences were not statistically significant. WC and waist–hip ratio exhibited significant (p<0.05) inverse correlation with all pulmonary function measurements except FEV1/FVC%. However, body mass index had no significant correlation with any spirometric variables in studied obese females.Conclusion: There was no significant effect of obesity on pulmonary functions in the studied Malaysian females. However, abdominal obesity had more impact on the impairment of pulmonary functions than overall relative obesity.

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Respiratory Symptoms and Lung Function among Ethiopian Women in Relation to Household Fuel Use

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17010041 ◽

2019 ◽

Vol 17 (1) ◽

pp. 41 ◽

Cited By ~ 3

Author(s):

Mulugeta Tamire ◽

Adamu Addissie ◽

Abera Kumie ◽

Emma Husmark ◽

Susann Skovbjerg ◽

...

Keyword(s):

Lung Function ◽

Rural Areas ◽

Respiratory Symptoms ◽

Respiratory Health ◽

Forced Expiratory Volume ◽

Solid Fuels ◽

Chronic Obstructive ◽

European Respiratory Society ◽

Cross Sectional ◽

Validated Questionnaire

Exposure to household air pollution has been linked to chronic obstructive pulmonary disease, respiratory symptoms and reduced lung function. This study aims to assess respiratory symptoms and lung function among Ethiopian women in relation to exposure to HAP. We conducted a cross-sectional study among non-smoking women responsible for household cooking. Data was collected on socio-demographic characteristics, respiratory symptoms and risk factors using a validated questionnaire. Spirometry with reversibility testing was performed according to American Thoracic Society/European Respiratory Society guidelines. We used independent t-test and multivariable logistic regression to compare the means and measure association respectively. A total of 545 women participated in the study out of which 231 (42.3%) performed spirometry with at least three acceptable manoeuvres. Everyone in the rural group and 43% of the urban group were exposed to HAP from solid fuels during cooking. The odds of developing at least one respiratory symptom when compared with those using cleaner fuels are twice as high for women cooking within the living house. We also found significantly lower forced expiratory volume in the first second (FEV1) (L) among solid fuels users compared with cleaner energy users. Given the larger population settlement in the rural areas and the use of solid fuel as the only energy source, there is a higher risk of developing chronic respiratory health problems for those women in Ethiopia.

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Socioeconomic status and pulmonary function, transition from childhood to adulthood: cross-sectional results from the polish part of the HAPIEE study

BMJ Open ◽

10.1136/bmjopen-2018-022638 ◽

2019 ◽

Vol 9 (1) ◽

pp. e022638 ◽

Cited By ~ 1

Author(s):

Maciej Polak ◽

Krystyna Szafraniec ◽

Magdalena Kozela ◽

Renata Wolfshaut-Wolak ◽

Martin Bobak ◽

...

Keyword(s):

Socioeconomic Status ◽

Lung Function ◽

Pulmonary Function ◽

Life Course ◽

Social Mobility ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Low Ses ◽

Cross Sectional ◽

Downward Social Mobility

ObjectivePrevious studies have reported inverse associations between socioeconomic status (SES) and lung function, but less is known about whether pulmonary function is affected by SES changes. We aimed to describe the relationship of changes of SES between childhood and adulthood with pulmonary function.DesignCross-sectional study.ParticipantsThe study sample included 4104 men and women, aged 45–69 years, residents of Krakow, participating in the Polish part of the Health, Alcohol and Psychosocial Factors in Eastern Europe Project.Main outcomeForced expiratory volume (FEV1) and forced vital capacity (FVC) were assessed by the standardised spirometry procedure. Participants were classified into three categories of SES (low, moderate or high) based on information on parent’s education, housing standard during childhood, own education, employment status, household amenities and financial status.ResultsThe adjusted difference in mean FVC between persons with low and high adulthood SES was 100 mL (p=0.005) in men and 100 mL (p<0.001) in women; the differences in mean FEV1were 103 mL (p<0.001) and 80 mL (p<0.001), respectively. Upward social mobility and moderate or high SES at both childhood and adulthood were related to significantly higher FEV1and FVC compared with low SES at both childhood and adulthood or downward social mobility.ConclusionsLow SES over a life course was associated with the lowest lung function. Downward social mobility was associated with a poorer pulmonary function, while upward mobility or life course and moderate or high SES were associated with a better pulmonary function.

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Airway reactivity and lung function in triiodothyronine-induced thyrotoxicosis

Journal of Applied Physiology ◽

10.1152/jappl.1985.58.5.1485 ◽

1985 ◽

Vol 58 (5) ◽

pp. 1485-1488 ◽

Cited By ~ 12

Author(s):

R. S. Irwin ◽

M. R. Pratter ◽

D. H. Stivers ◽

L. E. Braverman

Keyword(s):

Lung Function ◽

Pulmonary Function ◽

Respiratory Symptoms ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Base Line ◽

Airway Reactivity ◽

Percent Change ◽

Serum T3 ◽

The Mean

To evaluate the possible relationship between asthma and hyperthyroidism, airway reactivity and lung function were prospectively compared in healthy volunteers before, during, and after liothyronine (triiodothyronine, T3)-induced hyperthyroidism. Base-line evaluation of the 10 subjects included clinical evaluation, thyroid and pulmonary function tests, and airway reactivity assessed by methacholine inhalational challenge (MIC). All studies were normal. During T3-induced hyperthyroidism, no subject developed respiratory symptoms or changes in pulmonary function or airway reactivity. The mean percent change in forced expiratory volume at 1 s from base line (delta FEV1) of -2.4 +/- 3.0 after MIC was not significantly different from that obtained before T3 administration (-1.4 +/- 1.5, P greater than 0.2). When all serum T3 concentrations and delta FEV1 values before, during and after T3-induced hyperthyroidism were compared, there was no significant correlation. We conclude that T3-induced hyperthyroidism of 3-wk duration has no effect on airway reactivity or lung function in normal volunteers.

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