scholarly journals Ginger (Zingiber officinale) and turmeric (Curcuma longa L.) supplementation effects on quality of life, body composition, bone mineral density and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis: a study protocol for a randomized controlled clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Dawood Aghamohammadi ◽  
Neda Dolatkhah ◽  
Seyed Kazem Shakouri ◽  
Pernille Hermann ◽  
Fariba Eslamian
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Body Composition ◽  
Curcuma Longa ◽  
Controlled Trial ◽  
Zingiber Officinale ◽  
Mineral Density ◽  
Randomized Controlled ◽  
Micro Rnas

AbstractObjectivesPhytomedicine is widely suggested for the prevention of chronic disease, but evidence for a favorable effect on bone health is lacking. The present study will investigate the Zingiber officinale (ZO) and Curcuma longa L. (CL) supplementation effects on quality of life, body composition, bone mineral density (BMD) and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis (PMO).MethodsThis study protocol is designed as prospective triple-blind randomized controlled trial. One hundred and 20 patients with PMO will be enrolled in a 4 month, prospective, triple-blind, placebo-controlled trial and randomly assigned to four groups: ZO (500 mg b.i.d.) + CL (500 mg b.i.d.) (ZO + CL); ZO (500 mg b.i.d.) + placebo CL (b.i.d.) (ZO + P); placebo ZO (b.i.d.) + CL (500 mg b.i.d.) (CL + P); and placebo ZO (b.i.d.) + placebo CL (b.i.d.) (P + P). Quality of life, body composition and BMD will be defined as the primary endpoints and osteoporosis related serum biomarkers and circulating micro-RNAs will be defined as the secondary endpoints. The ANCOVA statistical method will be used to investigate the effect of the interventional variables on the response variable.ConclusionTo our knowledge, this trial is the first clinical study exploring the effect of Ginger and turmeric on quality of life, body composition, BMD and osteoporosis related biomarkers and micro-RNAs in women with PMO. The findings of this trial could be the basis for the development of harmless and inexpensive preventive and therapeutic approaches for PMO.

scholarly journals Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial

2019 ◽  
Vol 104 (9) ◽  
pp. 3701-3712 ◽  
Author(s):  
Jesper F Christensen ◽  
Anna Sundberg ◽  
Jens Osterkamp ◽  
Sarah Thorsen-Streit ◽  
Anette B Nielsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Randomized Controlled Trial ◽  
Body Composition ◽  
Glycemic Control ◽  
Metabolic Diseases ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Home Based

Abstract Context Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. Objective To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. Design Randomized controlled trial. Setting Clinical research center. Participants Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. Intervention Home-based interval walking 150 min/wk or usual care for 12 weeks. Main Outcome Measures Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. Results Compared with control, interval walking had no effect on VO2peak [mean between-group difference: −0.32 mL O2 · kg−1 · min−1 (−2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [−126 mM · min (−219 to −33); P = 0.009], 2-hour glucose concentration [−1.1 mM (−2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [−1.47 kg (−2.74 to −0.19); P = 0.025]. Conclusion A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.

scholarly journals Effects of 12 Weeks of Strength Training and Gluten-Free Diet on Quality of Life, Body Composition and Strength in Women with Celiac Disease: A Randomized Controlled Trial

2021 ◽  
Vol 11 (22) ◽  
pp. 10960
Author(s):  
Alejandro Martínez-Rodríguez ◽  
Daniela Alejandra Loaiza-Martínez ◽  
Javier Sánchez-Sánchez ◽  
Jacobo A. Rubio-Arias ◽  
Fernando Alacid ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Randomized Controlled Trial ◽  
Body Composition ◽  
Celiac Disease ◽  
Controlled Trial ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Randomized Controlled ◽  
Group 1

Celiac disease (CD) is an autoimmune disease characterized by gluten-induced intestinal inflammation. Dietary restrictions and symptoms may have a significant impact on the patient’s quality of life, body composition (BC), and strength. This study was designed to assess the impact of an isocaloric gluten free diet and resistance exercise in women. A total of 28 Spanish women, aged 40 years old or more, took part in a randomized controlled trial. Each group received a different intervention: group 1, gluten-free nutrition plan + exercise (GFD + E); group 2, gluten-free nutrition plan (GFD); group 3, celiac controls (NO-GFD); and group 4, non-celiac controls (CONTROL). The variables studied were quality of life, BC and isometric hand strength. After 12 weeks of intervention, celiac women that followed a gluten-free diet and exercise showed higher scores on the psychological health scale than celiac women without intervention. The women in group 1 were the only ones who presented improvements in BC variables; fat mass, BMI, and fat-free mass. Negative correlations were found between the perception of quality of life and age, however a positive correlation between quality of life and isometric strength test results was found. In addition to a gluten-free diet, resistance training is essential to improve BC, strength, and gastrointestinal symptoms.

scholarly journals The effect of herbal formula consisting of Curcuma xanthorrhiza, Curcuma longa and Phyllanthus niruri on quality of life: Randomized controlled trial

2021 ◽  
Vol 913 (1) ◽  
pp. 012088
Author(s):  
F Novianto ◽  
Z Zulkarnain ◽  
D Ardiyanto ◽  
A Triyono ◽  
U Nisa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Randomized Controlled Trial ◽  
Physical Fitness ◽  
Curcuma Longa ◽  
Controlled Trial ◽  
Herbal Formula ◽  
Phyllanthus Niruri ◽  
Randomized Controlled ◽  
Curcuma Xanthorrhiza

Abstract The herbal ingredients consisting of temulawak (Curcuma xanthorrhiza Roxb.), turmeric (Curcuma longa L.), and meniran (Phyllanthus niruri L.) have been used to improve physical fitness. However, the effect of these herbs on the quality of life is not yet known. This study aims to assess the effect of physical fitness herbal formula on quality of life. This study used a randomized controlled trial design. A total of 100 subjects were given herbal formula and 101 subjects were given a placebo. Herbal formula was made by boiling 4 cups (800 ml) of water until it boils, adding simplicia then reducing the heat, waiting for about 15-30 minutes until only two cups (400 ml) of water remained, filtered and put in a special thermos. The herbs and placebo were taken twice a day for 42 days. Before the study and on day 42th, subjects were examined for their quality of life using the Short Form 36 (SF-36) questionnaire. The results showed that there were no significant changes in the mental component summary and the dimensions of physical function, role of emotions, energy, mental health, social function, and general health. However, in the physical component summary and the dimensions of physical role and pain there was a significant increase in the quality of life (p=0,032; p=0.005; p=0.017). In conclusion, the physical fitness herbal formula can improve the physical component summary of quality of life, especially the dimensions of physical roles and pain.

Sign in / Sign up

Export Citation Format

Share Document