Childhood Craniopharyngioma – Current Strategies in Laboratory Diagnostics and Endocrine Treatment/Kraniopharyngeon im Kindes- und Jugendalter – Laboratoriumsdiagnostik und hormonelle Therapie

2003 ◽  
Vol 27 (9/10) ◽  
pp. 377-385
Author(s):  
H. L. Müller
Keyword(s):  
Endocrine Treatment ◽  
Laboratory Diagnostics ◽  
Hormonelle Therapie

Endometriose

2020 ◽  
Vol 77 (2) ◽  
pp. 57-61
Author(s):  
Svea-Vivica Mathieu ◽  
Adrian Kobe ◽  
Thomas Pfammatter ◽  
Andreas Hötker
Keyword(s):  
Hormonelle Therapie ◽  
Chirurgische Exzision

Zusammenfassung. Die Endometriose als Absiedlung funktionalen Endometriumgewebes ausserhalb der Gebärmutterhöhle zählt zu den häufigsten gynäkologischen Erkrankungen. Dennoch vergehen aufgrund der unspezifischen Symptome häufig mehr als 10 Jahre zwischen Symptombeginn und Diagnosestellung, was insbesondere an der variablen Ausprägung der Symp­tomatik in Abhängigkeit von der Lokalisation liegt. Zu den Manifestationsorten gehört neben den klassischen Endometriomen des Ovars vor allem auch die tiefe pelvine Endometriose, die zu narbigen Veränderungen und chronischen Unterbauchschmerzen führen kann. In der Diagnostik und insbesondere zum Staging der Erkrankung kommt zunehmend die MRI aufgrund ihres hervorragenden Weichteilkontrastes zum Einsatz. Hierfür wurden neben spezifischen Scoring-Systemen zur strukturierten Befundung (z. B. ENZIAN- Score) auch europäische Richtlinien erstellt. Therapeutisch kann, neben einer symptomorientierten Therapie, bei schwereren Fällen eine anti-hormonelle Therapie bzw. die chirurgische Exzision der Läsionen erfolgen. Im Falle einer Adenomyose, des Befalls des Myometriums des Uterus, hat sich neuerdings die Embolisation der Aae. uterinae als minimalinvasives Therapieverfahren mit guten Ergebnissen etabliert.

Laboratory diagnostics for HIV infection

2010 ◽  
Vol 46 (1) ◽  
Author(s):  
Stefano Buttò ◽  
Barbara Suligoi ◽  
Emanuele Fanales-Belasio ◽  
Mariangela Raimondo
Keyword(s):  
Hiv Infection ◽  
Laboratory Diagnostics

Application of flow systems in laboratory diagnostics for the integral evaluation of the hemostatic system

2018 ◽  
Vol 17 (1) ◽  
pp. 117-129
Author(s):  
O.E. Ushakova ◽  
◽  
D.Y. Nechipurenko ◽  
A.A. Butylin ◽  
M.A. Panteleev ◽  
...  
Keyword(s):  
Laboratory Diagnostics ◽  
Integral Evaluation ◽  
Hemostatic System ◽  
Flow Systems

Relationships among macro-minerals, other selected serum markers of bone profile and milk components of dairy cows during late-lactation

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ryszard Mordak ◽  
Zbigniew Dobrzański ◽  
Robert Kupczyński
Keyword(s):  
Dairy Cows ◽  
Milk Fat ◽  
Dry Matter ◽  
Inorganic Phosphorus ◽  
Serum Markers ◽  
Laboratory Diagnostics ◽  
Lactation Period ◽  
Milk Samples ◽  
Milk Components ◽  
Macro Mineral

AbstractTesting blood and milk parameters as well as analysing the relationships among these markers is very useful for monitoring the internal homeostasis and health in high-yielding dairy cows during various production periods. The aim of the study was to assess the correlations (relationships) among macro-minerals, such as calcium (Ca), inorganic phosphorus (P), magnesium (Mg), other selected bone profile markers, such as total protein (TP), albumin, activity of alkaline phosphatase (ALP) measured in serum and selected milk components such as number of somatic cells (SCC), colony-forming units (CFU), milk fat (MF), milk protein (MP), milk lactose (ML), dry matter (DM), non-fat dry matter (FDM) and milk production in late-lactation cows. Both blood and milk samples were collected from 11 clinically healthy milking cows during the late-lactation period. The cows were examined once a day for 3 consecutive days resulting in 33 sets of blood and milk samples for laboratory and statistical analysis. Significant correlations were observed between: Mg and MP, Mg and FDM, ALP and SCC, TP and SCC, TP and MP, TP and FDM, albumin and MP, albumin and FDM, P and Mg, Mg and albumin, and between TP and albumin. When monitoring macro-mineral homeostasis and mammary gland health, especially in intensively fed high-yielding dairy cows correlations between these markers should be considered. The revealed correlations can allow for deeper comparative laboratory diagnostics of homeostasis and can be especially useful for laboratory monitoring of the potential risk of subclinical macro-mineral deficiency in high-yielding dairy cows.

Endocrine Treatment of Breast Cancer: Current Perspectives, Future Directions

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Tazia Irfan ◽  
Mainul Haque ◽  
Sayeeda Rahman ◽  
Russell Kabir ◽  
Nuzhat Rahman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Endocrine Therapy ◽  
Ovarian Function ◽  
Premenopausal Women ◽  
New Drugs ◽  
Effective Control ◽  
Endocrine Treatment ◽  
Estrogen Production ◽  
Hormone Sensitive

Breast cancer remains one of the major causes of death in women, and endocrine treatment is currently one of the mainstay of treatment in patients with estrogen receptor positive breast cancer. Endocrine therapy either slows down or stops the growth of hormone-sensitive tumors by blocking the body’s capability to yield hormones or by interfering with hormone action. In this paper, we intended to review various approaches of endocrine treatments for breast cancer highlighting successes and limitations. There are three settings where endocrine treatment of breast cancer can be used: neoadjuvant, adjuvant, or metastatic. Several strategies have also been developed to treat hormone-sensitive breast cancer which include ovarian ablation, blocking estrogen production, and stopping estrogen effects. Selective estrogen-receptor modulators (SERMs) (e.g. tamoxifen and raloxifene), aromatase inhibitors (AIs) (e.g. anastrozole, letrozole and exemestane), gonadotropin-releasing hormone agonists (GnRH) (e.g. goserelin), and selective estrogen receptor downregulators (SERDs) (e.g. fulvestrant) are currently used drugs to treat breast cancer. Tamoxifen is probably the first targeted therapy widely used in breast cancer treatment which is considered to be very effective as first line endocrine treatment in previously untreated patients and also can be used after other endocrine therapy and chemotherapy. AIs inhibit the action of enzyme aromatase which ultimately decrease the production of estrogen to stimulate the growth of ER+ breast cancer cells. GnRH agonists suppress ovarian function, inducing artificial menopause in premenopausal women. Endocrine treatments are cheap, well-tolerated and have a fixed single daily dose for all ages, heights and weights of patients. Endocrine treatments are not nearly as toxic as chemotherapy and frequent hospitalization can be avoided. New drugs in preliminary trials demonstrated the potential for improvement of the efficacy of endocrine therapy including overcoming resistance. However, the overall goals for breast cancer including endocrine therapy should focus on effective control of cancer, design personalized medical therapeutic approach, increase survival time and quality of life, and improve supportive and palliative care for end-stage disease.

REORGANIZATION OF A MULTI-SPECIALTY HOSPITAL IN AN UNFAVORABLE EPIDEMIOLOGICAL SITUATION

2020 ◽  
pp. 43-46
Author(s):  
Nikitin A.E. ◽  
Znamenskiy I.А ◽  
Shikhova Yu.A. ◽  
Kuzmina I.V. ◽  
Melchenko D.S. ◽  
...  
Keyword(s):  
Contact Time ◽  
Laboratory Diagnostics ◽  
Protective Equipment ◽  
Timely Manner ◽  
High Quality ◽  
Institu Tions ◽  
Quality Of Medical Care ◽  
Spread Of Infection ◽  
Epidemiological Situation

This study provides a retrospective analysis of work to ensure high quality of medical care in an unfavorable epidemic situation. The consequence of COVID-19 was the implementation of a program to prevent the spread of infection, the re-profiling of medical institu-tions, and the introduction of restrictive and anti-epidemic measures. The experience of our work has shown the effectiveness of changing the order of med-ical care, the organization of the functioning of de-partments and patient routing. The study reflects the measures implemented in the hospital departments, the Department of clinical and laboratory diagnostics, radiation diagnostics and pathology Department. To ensure the safety of patients, it was decided to place patients on a single bed according to the type of infec-tious boxes. The safety of employees was ensured by the use of personal protective equipment, minimiza-tion of contact time with patients, and preventive weekly examination of staff for SARS-CoV-2 infection. The organized and well-coordinated work of the en-tire staff of the institution made it possible to prevent the spread of COVID-19 among employees, to detect cases of infection in a timely manner, and to carry out appropriate isolation and monitoring measures. At the time of completion of infectious diseases departments, the mortality rate among patients was less than 9%. Our experience in reorganizing a multi-specialty facil-ity can be used in the future when working with pa-tients who have undergone COVID-19, as well as in the context of a worsening epidemic situation.

The generalized regularities of damageability and integrity in estimations of the endurance in conditions of variability of loading regimes

2019 ◽  
Vol 85 (9) ◽  
pp. 61-65
Author(s):  
N. A. Makhutov
Keyword(s):  
Life Time ◽  
Cyclic Strength ◽  
Laboratory Diagnostics ◽  
Methodological Issues ◽  
Break Points ◽  
Number Of Cycles ◽  
Cyclic Damage ◽  
Damage Summation ◽  
Temperature Factors

We consider and analyze general methodological issues regarding the strength and endurance (life-time) of the materials and structure elements under a combined effect of various force, deformation and temperature factors. The Journal "Zavodskaya laboratoriya. Diagnostika materialov" (Industrial laboratory. Diagnostics of materials) has launched systematic publications on this problematic since 2018. For many decades, domestic and foreign laboratory studies have gleaned to a traditional methodology for obtaining initial curves of the long-term and cyclic strength that related the breaking stresses with time or number of cycles. These curves, with the characteristic sections and break points, separating the areas of elastic and inelastic (plastic strain or creep strain) strain, are used in analysis of long-term and cyclic damage. Using the elementary linear law of damage summation, it is possible to calculate at a first approximation the strength and endurance under varying conditions of loading. Stepping up the requirements to the accuracy of calculations necessitates a transition from force fracture criteria (at stresses a) to deformation criteria (in elastic and inelastic deformations e). Thus, it becomes possible to construct and use a unified expression for the curve of the long-term cyclic fracture (taking into account the temporal x and cyclic N factors) and a long-term cyclic damage. With such approach it is possible to remain the linear law of damage summation though those damages are obviously nonlinear. The goal of the study is to continue and support the discussion of the most complex problems of a comprehensive assessment of the strength, resource, survivability and safety of high-risk engineering equipment within the journal pages.

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