Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish

nano Online ◽  
2016 ◽  
Author(s):  
Zitao Zhou ◽  
Jino Son ◽  
Bryan Harper ◽  
Zheng Zhou ◽  
Stacey Harper
2015 ◽  
Vol 6 ◽  
pp. 1568-1579 ◽  
Author(s):  
Zitao Zhou ◽  
Jino Son ◽  
Bryan Harper ◽  
Zheng Zhou ◽  
Stacey Harper

Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of comprehensive in vivo and in vitro toxic responses are beneficial in determining potential nanoparticle impacts. To achieve or enhance their desired function, chemical modifications are often performed on the NPs surface; however, the roles of these alterations play in determining the toxicity of ZnO NPs are still not well understood. As such, we investigated the toxicity of 17 diverse ZnO NPs varying in both size and surface chemistry to developing zebrafish (exposure concentrations ranging from 0.016 to 250 mg/L). Despite assessing a suite of 19 different developmental, behavioural and morphological endpoints in addition to mortality in this study, mortality was the most common endpoint observed for all of the ZnO NP types tested. ZnO NPs with surface chemical modification, regardless of the type, resulted in mortality at 24 hours post-fertilization (hpf) while uncoated particles did not induce significant mortality until 120 hpf. Using eight intrinsic chemical properties that relate to the outermost surface chemistry of the engineered ZnO nanoparticles, the highly dimensional toxicity data were converted to a 2-dimensional data set through principal component analysis (PCA). Euclidean distance was used to partition different NPs into several groups based on converted data (score) which were directly related to changes in the outermost surface chemistry. Kriging estimations were then used to develop a contour map based on mortality data as a response. This study illustrates how the intrinsic properties of NPs, including surface chemical modifications and capping agents, are useful to separate and identify ZnO NP toxicity to zebrafish (Danio rerio).


2019 ◽  
Vol 54 (3) ◽  
pp. 331-343 ◽  
Author(s):  
Hoda A. Abdel-Rahman ◽  
Eman H. Awad ◽  
Rasha M. Fathy

The present study aims to investigate the influence of modified zinc oxide nanoparticles content on the physico-chemical properties of sawdust/epoxy composite specimens. The results show an improvement in the mechanical properties in terms of flexural strength, impact strength, and hardness with increasing the modified zinc oxide nanoparticles content up to 5%, while the physical properties such as water absorption and thickness swelling percentages are decreased directly with increasing the content of modified zinc oxide. In addition, the behavior of irradiated composite specimens containing 5% modified zinc oxide nanoparticles at different gamma-irradiation doses, 10, 30, and 50 kGy, has been studied. The results indicate that the irradiated composite specimens at 10 kGy have better physico-chemical properties as compared to the unirradiated specimens. Furthermore, the antimicrobial properties of composite specimens containing 5% modified zinc oxide at 0 kGy and 10 kGy against different plant pathogenic fungi and bacteria are also discussed. The results demonstrate that the growth activity of fungi and bacteria on the composite specimens are reduced to a great extent as compared to the control composite specimens (0% of zinc oxide nanoparticles). Thermal behavior and morphology of the prepared specimens are detected using thermogravimetric analysis and scanning electron microscopy technique.


2017 ◽  
Vol 44 (10) ◽  
pp. 13-18
Author(s):  
N.S. Serkhacheva ◽  
N.I. Prokopov ◽  
A.Yu. Gerval'd ◽  
N.A. Lobanov ◽  
I.A. Gritskova

Heterophase polymerisation of styrene was carried out, and nanocomposite polystyrene microspheres with a controllable content of ZnO nanoparticles were synthesised. The colloid chemical properties of the obtained polymer suspensions were studied, and it was shown that the particles have a ‘core–shell’ structure with a ZnO content of up to 30%.


2020 ◽  
Vol 2 (1) ◽  
pp. 54

Nanotoxicology refers to the study of the interaction of nanostructure with a biological system with an emphasis on elucidating the relationship between the physical and chemical properties of nanostructure with the induction of toxic biological responses. In this study, an attempt has been made to understand the protective effect of fruit juices on the reduction of ZnO nanoparticle-induced toxicity. Zinc oxide nanoparticles were synthesized by chemical reaction of zinc nitrate with sodium hydroxide as the reducer. Synthesized nanoparticles were characterized by suitable analytical techniques. UV-Vis spectroscopy study reveals the Plasmon absorption maxima at 200-600 nm, and X-ray diffraction and Atomic Force Microscopic analyses revealed the highly stable nanoparticles. Nanoparticles coated fruit juices was confirmed by changes or shift in the absorption spectra. Phytotoxicity studies indicated that the fruit juices coated zinc oxide nanoparticles were not inducing any effect on seedling emergence and plant growth. Cytotoxicity studies using RAW 264.7 cell lines were done by MTT Assay, where the IC50 values.


2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Ayesha Naveed Ul Haq ◽  
Akhtar Nadhman ◽  
Ikram Ullah ◽  
Ghulam Mustafa ◽  
Masoom Yasinzai ◽  
...  

Human’s quest for innovation, finding solutions of problems, and upgrading the industrial yield with energy efficient and cost-effective materials has opened the avenues of nanotechnology. Among a variety of nanoparticles, zinc oxide nanoparticles (ZnO) have advantages because of the extraordinary physical and chemical properties. It is one of the cheap materials in cosmetic industry, nanofertilizers, and electrical devices and also a suitable agent for bioimaging and targeted drug and gene delivery and an excellent sensor for detecting ecological pollutants and environmental remediation. Despite inherent toxicity of nanoparticles, synthetic routes are making use of large amount of chemical and stringent reactions conditions that are contributing as environmental contaminants in the form of high energy consumption, heat generation, water consumption, and chemical waste. Further, it is also adding to the innate toxicity of nanoparticles (NPs) that is either entirely ignored or poorly investigated. The current review illustrates a comparison between pollutants and hazards spawned from chemical, physical, and biological methods used for the synthesis of ZnO. Further, the emphasis is on devising eco-friendly techniques for the synthesis of ZnO especially biological methods which are comparatively less hazardous and need to be optimized by controlling the reaction conditions in order to get desired yield and characteristics.


2017 ◽  
Vol 899 ◽  
pp. 248-253 ◽  
Author(s):  
Jair J. Fiori ◽  
Lucinao Luiz Silva ◽  
K.C. Picolli ◽  
R. Ternus ◽  
J. Ilha ◽  
...  

Currently the use of nanotechnology has been seeking to develop additives that have antimicrobial and low toxicity, enabling applications in various industrial sectors, in particular the paint industry. Inks with antimicrobial properties enable greater security to the user, eliminating pathogens that can cause disease when in contact with humans and animals. Thus, the zinc oxide nanoparticles have attracted a great scientific and technological interest as inorganic antimicrobial agent due to its oligodynamic effect. This work aims to study the effect oligodynamic zinc oxide nanoparticles in antimicrobial properties of acrylic paints. The acrylic paints were developed with various concentrations of zinc oxide nanoparticles, and were subsequently conducted microbiological characterization of death curve and agar diffusion. To evaluation the physico-chemical properties were used the techniques differential scanning calorimetry (DSC); Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The results demonstrate that there was a reduction in the high antimicrobial activity of paints containing zinc oxide nanoparticles as compared to standard paint. Even with the addition of zinc oxide nanoparticles did not change the microstructure and chemical properties of acrylic coatings.


2018 ◽  
Vol 53 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Vandana Parihar ◽  
Mohan Raja ◽  
Rini Paulose

Abstract Nanotechnology allocate with the production and usage of material with nanoscale dimension, nanoparticles are large surface area to volume ratio and thus very specific properties. Zinc oxide (ZnO) nanoparticles had been in current studies due to its large bandwidth and high exciton binding energy and it has prospective applications such as electronic, optical, mechanical, magnetic and chemical properties that are significantly different from those of bulk counterpart. The aims of this review to provide a comprehensive view on structural, synthesis and electrochemical properties of the ZnO nanoparticles, which were synthesized by different methods.


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