Biodegradable polycaprolactone (PCL) based polymer and composites

Abstract Polycaprolactone (PCL) is a biodegradable polyester that has advantages over other biopolymers, making it an extensively researched polymer. PCL is a hydrophobic, slow-degrading, synthetic polymer making it particularly interesting for the preparation of long-term implantable devices and a variety of drug delivery systems. Recently, PCL has been used for additional applications including food packaging and tissue engineering. In this chapter, the processing methods and characterization of PCL will be discussed. The chapter will summarize the synthesis of poly(α-hydroxy acid) and the ring-opening polymerization of PCL. Discussion on the biodegradability of PCL will be reviewed. The biomedical applications of PCL, such as, drug-delivery systems, medical devices, and tissue engineering will be also summarized. Finally, the chapter will conclude with a characterization section outlining recent studies focusing on PCL based composites and films.

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Bi-functional peptide-based 3D hydrogel-scaffolds

Soft Matter ◽

10.1039/d0sm00825g ◽

2020 ◽

Vol 16 (30) ◽

pp. 7006-7017

Author(s):

Carlo Diaferia ◽

Francesca Netti ◽

Moumita Ghosh ◽

Teresa Sibillano ◽

Cinzia Giannini ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Hydrogel Scaffolds ◽

Functional Peptide

Over the last few years, hydrogels have been proposed for many biomedical applications, including drug delivery systems and scaffolds for tissue engineering.

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Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

Canadian Journal of Chemistry ◽

10.1139/v09-158 ◽

2010 ◽

Vol 88 (3) ◽

pp. 173-184 ◽

Cited By ~ 27

Author(s):

Jung Kwon Oh

Keyword(s):

Mechanical Properties ◽

Drug Delivery ◽

Tissue Engineering ◽

Water Content ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

High Water ◽

Delivery Systems ◽

High Water Content ◽

Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

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Template-assisted extrusion of biopolymer nanofibers under physiological conditions

Integrative Biology ◽

10.1039/c6ib00045b ◽

2016 ◽

Vol 8 (10) ◽

pp. 1059-1066 ◽

Cited By ~ 13

Author(s):

Mohammad Raoufi ◽

Neda Aslankoohi ◽

Christine Mollenhauer ◽

Heike Boehm ◽

Joachim P. Spatz ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Physiological Conditions

Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions.

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Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Marine Drugs ◽

10.3390/md18110583 ◽

2020 ◽

Vol 18 (11) ◽

pp. 583

Author(s):

Edisson-Mauricio Pacheco-Quito ◽

Roberto Ruiz-Caro ◽

María-Dolores Veiga

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Physicochemical Properties ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Pharmaceutical Formulations ◽

Delivery Systems ◽

Marine Resources ◽

Renewable Source ◽

Pharmaceutical Applications

Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

Revista de Chimie ◽

10.37358/rc.18.7.6411 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1756-1759 ◽

Cited By ~ 1

Author(s):

Luminita Confederat ◽

Iuliana Motrescu ◽

Sandra Constantin ◽

Florentina Lupascu ◽

Lenuta Profire

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Average Diameter ◽

Delivery Systems ◽

Cross Linking ◽

Low Molecular Weight ◽

Polymeric Systems ◽

Chitosan Microparticles ◽

Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

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Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

Current Drug Targets ◽

10.2174/1389450121666200611140425 ◽

2020 ◽

Vol 21 ◽

Author(s):

Dickson Pius Wande ◽

Qin Cui ◽

Shijie Chen ◽

Cheng Xu ◽

Hui Xiong ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Dissolution ◽

Glycol Succinate ◽

Permeation Enhancer ◽

P Glycoprotein ◽

Us Fda ◽

Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

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