Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence

2019 ◽  
Vol 34 (2) ◽  
pp. 197-210 ◽  
Author(s):  
María del Pilar Navarrete-Meneses ◽  
Patricia Pérez-Vera
Keyword(s):  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Molecular Evidence ◽  
Hematological Cancer ◽  
Pyrethroid Insecticides ◽  
Cellular Effects ◽  
Chronic Effects ◽  
Pyrethroid Pesticide ◽  
Carcinogenic Process ◽  
Genetic Rearrangements

Abstract Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the molecular and cellular effects of pyrethroids is helpful to guide the study of the biological plausibility of the association of pyrethroids with hematological cancer. We reviewed studies suggesting that pyrethroids are genotoxic, induce genetic rearrangements, alter gene expression and modify DNA. All of these biological modifications could potentially contribute to the carcinogenic process in hematopoietic cells.

scholarly journals Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Christina Coughlan ◽  
Douglas I. Walker ◽  
Kelly M. Lohr ◽  
Jason R. Richardson ◽  
Laura M. Saba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Cytoskeletal Proteins ◽  
Synaptic Function ◽  
Behavioral Alterations ◽  
Mechanisms Of Toxicity ◽  
Kegg Pathways ◽  
Increased Risk ◽  
Proteomic Analyses

Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson’s disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigrostriatal dopamine system in PD and pesticide exposure. Enhanced oxidative stress leads to lipid peroxidation and production of reactive aldehydes; therefore, we conducted proteomic analyses to identify carbonylated proteins in the striatum and cortex of pesticide-treated mice in order to elucidate possible mechanisms of toxicity. Male C57BL/6J mice were treated biweekly for 6 weeks with saline, PQ (10 mg/kg), MB (30 mg/kg), or the combination of PQ and MB (PQMB). Treatments resulted in significant behavioral alterations in all treated mice and depleted striatal dopamine in PQMB mice. Distinct differences in 4-hydroxynonenal-modified proteins were observed in the striatum and cortex. Proteomic analyses identified carbonylated proteins and peptides from the cortex and striatum, and pathway analyses revealed significant enrichment in a variety of KEGG pathways. Further analysis showed enrichment in proteins of the actin cytoskeleton in treated samples, but not in saline controls. These data indicate that treatment-related effects on cytoskeletal proteins could alter proper synaptic function, thereby resulting in impaired neuronal function and even neurodegeneration.

scholarly journals O1A.1 Pesticide exposure of workers during treatment and re-entry tasks in apple-growing: results from the canepa study in france

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A2.2-A2
Author(s):  
Mathilde Bureau ◽  
Béatrix Béziat ◽  
Geoffroy Duporté ◽  
Yannick Lecluse ◽  
Xavier Schwall ◽  
...  
Keyword(s):  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Dermal Exposure ◽  
Relative Contribution ◽  
Hail Net ◽  
South West ◽  
Pesticide Exposures ◽  
Fruit Samples ◽  
Main Determinants ◽  
Opening And Closing

Few studies were performed to assess workers’ exposure to pesticides in orchards and even less during re-entry activities. However, nearly 40 pesticide treatments per year are carried out in apple-growing especially against fungal diseases, mainly scab. In order to characterize pesticide exposures of farmers in epidemiological studies, we performed a non-controlled field study in 3 regions of France (Normandy, South-West and Rhône-Alpes) in apple orchards during the 2016 and 2017 seasons. We observed the activity of the workers trying to disrupt it as little as possible. Workers’ external contamination and their determinants were assessed during 158 working days, corresponding to 31 treatment days (including mixing, spraying and equipment cleaning), 69 re-entry days (including apple hand-thinning, anti-hail net opening and closing tasks) and 58 harvesting days. We performed both detailed observations of work characteristics on the whole day (including an ergonomic approach) and pesticide measurements for dermal contamination during each task (following the OCDE guidelines). Potential dermal exposure was measured with cotton pads placed onto the skin (11 body areas), and cotton gloves or hand rinsing for each task. Captan and dithianon, fungicides representative of pesticide use in apple-growing, were used as markers for exposure. Relative contribution of the different body areas to total exposure was assessed. In addition, to investigate potential sources of contamination, we measured dislodgeable residues in the environment of the workers by analyzing leaf and fruit samples and surfaces of work equipment. Results indicated that workers’ dermal exposure was higher during re-entry tasks than treatments and harvests. The median dermal contamination during treatment was 4.03 mg of active ingredients per day, levels ranging from 0.95 mg to 64.19 mg. Most of the contamination was observed on the hands, especially during mixing. We will focus our presentation on levels and main determinants of pesticide exposure during treatment tasks.

Occupational pesticide use and self-reported olfactory impairment in US farmers

2020 ◽  
pp. oemed-2020-106818
Author(s):  
Srishti Shrestha ◽  
David M Umbach ◽  
Laura E Beane Freeman ◽  
Stella Koutros ◽  
Michael C R Alavanja ◽  
...  
Keyword(s):  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Health Study ◽  
Dichlorophenoxyacetic Acid ◽  
Pesticide Use ◽  
Response Patterns ◽  
Logistic Regression Models ◽  
Petroleum Distillates ◽  
Olfactory Impairment ◽  
2,4 Dichlorophenoxyacetic Acid

ObjectivesPesticide exposure may impair human olfaction, but empirical evidence is limited. We examined associations between occupational use of 50 specific pesticides and olfactory impairment, both self-reported, among 20 409 participants in the Agricultural Health Study, a prospective cohort of pesticide applicators (mostly farmers, 97% male).MethodsWe used logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between pesticide use at enrolment (1993–1997) and olfactory impairment reported two decades later (2013–2016), adjusting for baseline covariates.ResultsAbout 10% of participants reported olfactory impairment. The overall cumulative days of any pesticide use at enrolment were associated with a higher odds of reporting olfactory impairment (OR (highest vs lowest quartile): 1.17 (95% CI: 1.02 to 1.34), p-trend = 0.003). In the analyses of 50 specific pesticides, ever-use of 20 pesticides showed modest associations with olfactory impairment, with ORs ranging from 1.11 to 1.33. Of these, higher lifetime days of use of 12 pesticides were associated with higher odds of olfactory impairment compared with never use (p-trend ≤ 0.05), including two organochlorine insecticides (dichlorodiphenyltrichloroethane and lindane), two organophosphate insecticides (diazinon and malathion), permethrin, the fungicide captan and six herbicides (glyphosate, petroleum distillates, 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid and metribuzin), although many of these did not exhibit clear, monotonic exposure-response patterns.ConclusionOverall, we found relatively broad associations between pesticides and olfactory impairment, involving many individual pesticides and covering several chemical classes, suggesting that pesticides could affect olfaction through multiple pathways. Future epidemiological studies with objective measurement of olfaction are required to confirm these findings.

In utero pyrethroid pesticide exposure and child cognitive development from 6 to 36 months in the MARBLES longitudinal cohort

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Jacqueline Barkoski* ◽  
Deborah Bennett ◽  
Daniel Tancredi ◽  
Dana Barr ◽  
Irva Hertz-Picciotto
Keyword(s):  
Cognitive Development ◽  
Pesticide Exposure ◽  
In Utero ◽  
Longitudinal Cohort ◽  
Pyrethroid Pesticide ◽  
Child Cognitive Development

Agricultural Activities and Pesticide Exposure: Elaboration of a Matrix for Use in Epidemiological Studies

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S367
Author(s):  
M Barrau ◽  
P Lebailly ◽  
P Fabbro-Peray ◽  
A Gruber ◽  
E Boutet ◽  
...  
Keyword(s):  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Agricultural Activities

Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies

2012 ◽  
Vol 117 ◽  
pp. 112-119 ◽  
Author(s):  
Angela M. Malek ◽  
Aaron Barchowsky ◽  
Robert Bowser ◽  
Ada Youk ◽  
Evelyn O. Talbott
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Risk Factor ◽  
Pesticide Exposure ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Lateral Sclerosis

scholarly journals Penyuluhan Risiko Keracunan Pestisida dan Pemeriksaan Kesehatan pada Ibu Hamil

2021 ◽  
Vol 2 (3) ◽  
pp. 215-224
Author(s):  
Prayudhy Yushananta ◽  
Iwan Sariyanto ◽  
Yetti Anggraini ◽  
Mei Ahyanti ◽  
Enro Sujito ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pesticide Exposure ◽  
P Value ◽  
Growth Disorders ◽  
Pesticide Poisoning ◽  
Intrauterine Growth ◽  
Pesticide Management ◽  
Chronic Effects ◽  
Handling Methods ◽  
Self Protection

Abstrak: Keracunan pestisida merupakan masalah kesehatan yang kritis pada pertanian hortikultura, akibat dari penggunaan dosis berlebihan, cara penanganan yang salah, dan tidak menggunakan APD secara lengkap. Salah satu efek kronis keracunan pestisida adalah anemia. Pada kehamilan, anemia menyebabkan gangguan pertumbuhan intrauterin sehingga bayi lahir BBLR dan pendek (stunted). Pengabdian masyarakat bertujuan untuk meningkatkan pengetahuan ibu hamil tentang risiko paparan pestisida, serta memeriksa kadar kolinesterase dan Hb. Penyuluhan dengan penilaian diberikan kepada 50 orang ibu hamil, dan dilanjutkan dengan pengambilan sampel darah untuk pemeriksaan kesehatan. Hasil pengabdian menunjukkan peningkatan pengetahuan yang signifikans pada sebagian besar peserta (p-value0,01). Pada pemeriksaan kesehatan, didapatkan sebanyak 30% ibu hamil mengalami keracunan pestisida dan 16% anemia, menunjukkan paparan pestisida yang tinggi dan perlindungan diri yang rendah. Pada akhir kegiatan, seluruh peserta diberikan buku saku tentang pengelolaan pestisida yang aman, sebagai media pembelajaran dan perluasan informasi. Sebanyak 500 eksemplar juga diserahkan kepada Dinas Kesehatan Lampung Barat, untuk dibagikan kepada ibu hamil di kecamatan lainnya. Penyuluhan yang disertai dengan penyampaian bukti gangguan kesehatan telah mampu memicu perubahan perilaku sasaran, terlihat dari peningkatan penggunaan APD selama bekerja, dan pemeriksaan kehamilan. Pengabdian diharapkan dapat dilakukan secara berkelanjutan dan melibatkan banyak mitra.Abstract: Pesticide poisoning is a critical health problem in horticultural agriculture due to excessive doses, wrong handling methods, and incompletely using PPE. One of the chronic effects of pesticide poisoning is anemia. In pregnancy, anemia causes intrauterine growth disorders, so that the baby is born LBW dan stunted. This community service aims to increase pregnant women's knowledge about pesticides' risks and check cholinesterase dan Hb levels. Counseling with assessments was given to 50 pregnant women, followed by taking blood samples for health checks. The services results showed a significant increase in knowledge in most participants (p-value 0.01). On the medical check, it was found that 30% of pregnant women experienced pesticide poisoning dan 16% anemia, indicating high pesticide exposure dan low self-protection. At the end of the activity, all participants were given pocketbooks on safe pesticide management as a medium for learning and expanding information. A total of 500 copies were also handed over to the West Lampung Health Office to be distributed to pregnant women in other districts. Counseling accompanied by the delivery of evidence of health problems has triggered changes in the target behavior, as seen in the increased use of PPE during work dan antenatal care. The service is expected to be carried out sustainably and involves many partners.

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