scholarly journals Notizen: Trennung und biologische Wirksamkeit der Enantiomeren eines chiralen Thiadiazolylsulfoxides/Separation and Biological Activity of the Enantiomers of a Chiral Thiadiazolyl Sulfoxide

1992 ◽  
Vol 47 (4) ◽  
pp. 597-599 ◽  
Author(s):  
Wolfgang Walek ◽  
Christine Fieseler ◽  
Peter Schneider ◽  
Gerhard W. Fischer
Keyword(s):  
Biological Activity ◽  
Liquid Chromatography ◽  
Racemic Mixture ◽  
Biologische Wirksamkeit

The enantiomers of the fungicidal and bactericidal (3-chloro-1,2,4-thiadiazol-5-yl)-(3´-chloro-1´,2´,4´-thiadiazoyl-5´-ylthiomethyl)-sulfoxide (2) have been separated by liquid chromatography on triacetylcellulose. Tested in a photometer assay on Torulopsis H 24 and Erwinia carotovorum (+)-2 and (-)-2 show practically the same activity and do not differ from the racemic mixture.

scholarly journals A Pair of Novel Sulfonyl-Containing N-Acetyldopamine Dimeric Enantiomers From Aspongopus chinensis

2020 ◽  
Vol 15 (3) ◽  
pp. 1934578X2091127
Author(s):  
Li Liao ◽  
Yong-Ming Yan ◽  
Te Xu ◽  
Hou-Lin Xia ◽  
Yong-Xian Cheng
Keyword(s):  
High Performance Liquid Chromatography ◽  
Biological Activity ◽  
Liquid Chromatography ◽  
Renal Fibrosis ◽  
High Performance ◽  
Racemic Mixture ◽  
Spectroscopic Methods ◽  
Liquid Chromatography Separation ◽  
New Compounds ◽  
First Time

A pair of novel sulfonyl-containing N-acetyldopamine dimer enanitomers, (±)-aspongamide E (1), a new ester 2-aminoethyl ( E)-hex-2-enoate (2), along with 3 known compounds (3-5) were isolated from Aspongopus chinensis. Their structures were determined by spectroscopic methods. Compound 1 is a racemic mixture, chiral high-performance liquid chromatography separation followed by electronic circular dichroism calculations assigned the absolute configurations of 2 enantiomers of 1. Compounds 3-5 were isolated from A. chinensis for the first time. The biological activity of the selected new compounds against renal fibrosis was evaluated.

scholarly journals Transformation of Amoxapine byCunninghamella elegans

2000 ◽  
Vol 66 (8) ◽  
pp. 3646-3649 ◽  
Author(s):  
Joanna D. Moody ◽  
Donglu Zhang ◽  
Thomas M. Heinze ◽  
Carl E. Cerniglia
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
High Performance Liquid Chromatography ◽  
Biological Activity ◽  
Liquid Chromatography ◽  
Magnetic Resonance ◽  
High Performance ◽  
Tricyclic Antidepressant ◽  
Cunninghamella Elegans ◽  
Toxicological Evaluation

ABSTRACT We examined Cunninghamella elegans to determine its ability to transform amoxapine, a tricyclic antidepressant belonging to the dibenzoxazepine class of drugs. Approximately 57% of the exogenous amoxapine was metabolized to three metabolites that were isolated by high-performance liquid chromatography and were identified by nuclear magnetic resonance and mass spectrometry as 7-hydroxyamoxapine (48%),N-formyl-7-hydroxyamoxapine (31%), andN-formylamoxapine (21%). 7-Hydroxyamoxapine, a mammalian metabolite with biological activity, now can be produced in milligram quantities for toxicological evaluation.

STUDIES ON THE DISSIPATION OF DIFLUBENZURON AND METHOPRENE FROM SHALLOW PRAIRIE POOLS

1980 ◽  
Vol 112 (2) ◽  
pp. 173-177 ◽  
Author(s):  
D. J. Madder ◽  
W. L. Lockhart
Keyword(s):  
Biological Activity ◽  
Liquid Chromatography ◽  
Growth Regulator ◽  
Mosquito Control ◽  
Parent Compound ◽  
Gas Liquid Chromatography ◽  
Mosquito Larvae ◽  
Canadian Prairie ◽  
Repeated Applications

AbstractA series of sod-lined pools were constructed and used to monitor repeated applications of diflubenzuron as Dimilin WP-25 and mefhoprene as Altosid SR-10. Diflubenzuron and methoprene "disappeared" rapidly from the pool water as determined by bioassays using Aedes aegypti (L.) (Culicidae) larvae and by gas-liquid chromatography (GLC). Chemical assays for a diflubenzuron derivative were positive for several days; bioassay indicated the presence of diflubenzuron (or at least growth regulator activity) at levels toxic to mosquito larvae for up to 16 days. In contrast methoprene "fell" below GLC detection within 2 days although biological activity persisted for approximately a week after treatment. Neither parent compound should cause a long-term persistence hazard when used for mosquito control in Canadian prairie waters.

Biosynthesis of Gibberellins in Barley and Dwarf Rice Seedlings

1974 ◽  
Vol 1 (2) ◽  
pp. 199 ◽  
Author(s):  
KF Faull ◽  
BG Coombe ◽  
LG Paleg
Keyword(s):  
Biological Activity ◽  
Liquid Chromatography ◽  
Retention Time ◽  
De Novo ◽  
Mevalonic Acid ◽  
Biologically Active ◽  
Gas Liquid Chromatography ◽  
Rice Seedlings ◽  
Kaurenoic Acid ◽  
Gibberellin A1

Incorporation studies with 14 CO2 suggested that 11-day-old barley seedlings biosynthesized an A1- like gibberellin de novo and that the biosynthesized gibberellin completely turned over within 12 h. Exogenous [14C]mevalonic acid, supplied in a variety of ways, was not incorporated into the gibberellins of barley seedlings. Barley seedlings, which failed to elongate in response to exogenous ent-kaurenoic acid, metabolized exogenous [17-14C]ent-kaurenoic acid to a few compounds, but not to a biologically active gibberellin. Dwarf rice seedlings (cv. Tan-ginbozu), which elongated in response to exogenous ent-kaurenoic acid, metabolized exogenous [17-14C]ent-kaurenoic acid to a number of radioactive compounds, one of which behaved like [14C]gibberellin A1 in that it showed radioactivity and biological activity at the expected retention time during gas-liquid chromatography.

Origin of bistramide a identified in Lissoclinum bistratum (Urochordata): possible involvement of symbiotic Prochlorophyta

1990 ◽  
Vol 70 (4) ◽  
pp. 741-746 ◽  
Author(s):  
J.-F. Biard ◽  
C. Grivois ◽  
J.-F. Verbist ◽  
C. Debitus ◽  
J. B. Carre
Keyword(s):  
High Pressure ◽  
Biological Activity ◽  
Liquid Chromatography ◽  
High Pressure Liquid Chromatography ◽  
Bistramide A

An attempt was made to determine whether bistramide A (=bistratene A), a polycycloether with biological activity isolated from Lissodinum bistratum Sluiter, originates from the ascidian itself or from its symbiont Prochlorophyta. A high-pressure liquid chromatography assay carried out on the whole ascidian, the ascidian without a portion of its Prochloron and the Prochloron themselves gave concentrations respectively of 0.182,0.166 and 0.850%. In view of these results, as well as of the capacity of Prochloron to synthesize complex nitrogenous products and the cytotoxicity of these products, it is hypothesized that bistramide A originates exclusively in Prochloron.

scholarly journals PHYTOECDYSTEROIDS OF SERRATULA L. AND KLASEA CASS. GENERA: CHEMODIVERSITY, METHODS OF ISOLATION AND ANALYSIS

2017 ◽  
pp. 123-135
Author(s):  
Даниил (Daniil) Николаевич (Nikolaevich) Оленников (Olennikov) ◽  
Нина (Nina) Игоревна (Igorevna) Кащенко (Kashchenko)
Keyword(s):  
High Performance Liquid Chromatography ◽  
Biological Activity ◽  
Liquid Chromatography ◽  
High Performance ◽  
Structural Features ◽  
Side Chain ◽  
Individual Species ◽  
Hydroxyl Groups ◽  
Asteraceae Family ◽  
Methods Of Isolation

Serratula L. and Klasea Cass. are two systematically related genera of Asteraceae family containing phytoecdysteroids, a group of natural terpene compounds with various biological activity. Beginning from the 1970s, 76 phytoecdysteroids were isolated and identified in 13 species of Serratula and 5 species of Klasea. This review presented information on the chemodiversity of phytoecdysteroids of Serratula and Klasea genera and their occurrence in individual species. It was shown that the structural features of Serratula and Klasea phytoecdysteroids include the presence of a complete side chain at C-20 atom as well as 5 to 7 hydroxyl groups. Among the species studied, the most investigated were S. coronata, S. tinctoria and S. chinensis with 50, 21 and 19 known compounds, respectively. Also in the review the information on the methods of extraction, isolation and analysis of phytoecdysteroids of the Serratula and Klasea genera was included. The special attention was paid to the data on chromatographic separation of phytoecdysteroids using column, thin-layer and high-performance liquid chromatography on the various sorbents. The information presented in the review demonstrated the perspectiveness of Serratula and Klasea species as sources of phytoecdysteroids.

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